Research Topics
| George MutwiriSummaryAffiliation: University of Saskatchewan Country: Canada Publications
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Detail Information
Publications
Approaches to enhancing immune responses stimulated by CpG oligodeoxynucleotidesGeorge Mutwiri
Vaccine and Infectious Disease Organization International Vaccine Center, University of Saskatchewan, SK, Canada
Adv Drug Deliv Rev 61:226-32. 2009..We will discuss these approaches and the mechanisms involved, with emphasis on what we have learned from large animal models...- Co-administration of polyphosphazenes with CpG oligodeoxynucleotides strongly enhances immune responses in mice immunized with Hepatitis B virus surface antigenGeorge Mutwiri
Vaccine and Infectious Disease Organization International Vaccine Center, 120 Veterinary Road, Saskatoon, Sask, Canada S7N 5E3
Vaccine 26:2680-8. 2008..In addition, we provide evidence that PCEP and PCPP can stimulate innate cytokine production, suggesting a potential mechanism by which polyphosphazenes achieve their potent adjuvant effects... - Microparticles for oral delivery of vaccinesGeorge Mutwiri
Vaccine and Infectious Disease Organization, Saskatoon, Canada
Expert Opin Drug Deliv 2:791-806. 2005..In addition, possible approaches that have the potential to significantly improve microparticle delivery of oral vaccines will be suggested... - Combination adjuvants: the next generation of adjuvants?George Mutwiri
Vaccines and Infectious Disease Organization International Vaccine Center, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 5E3, Canada
Expert Rev Vaccines 10:95-107. 2011..This approach is promising and presents tremendous opportunities for vaccinologists to tailor immune responses to specific vaccines. In this article, adjuvant combinations at different stages of development will be reviewed... - Poly[di(sodium carboxylatoethylphenoxy)phosphazene] (PCEP) is a potent enhancer of mixed Th1/Th2 immune responses in mice immunized with influenza virus antigensGeorge Mutwiri
Vaccine and Infectious Disease Organization, 120 Veterinary Road, Saskatoon, SK, Canada S7N 5E3
Vaccine 25:1204-13. 2007..In contrast, PCEP was associated with production of both IFNgamma and IL-4. We conclude that PCEP is a potent enhancer of antigen-specific Th1 and Th2 immune responses and is a promising adjuvant for vaccine applications... - PCEP enhances IgA mucosal immune responses in mice following different immunization routes with influenza virus antigensNelson F Eng
Vaccine and Infectious Disease Organization International Vaccine Center, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Saskatchewan, S7N 5E3, Canada
J Immune Based Ther Vaccines 8:4. 2010..The objective of the present study was to investigate the efficacy of polyphosphazenes as adjuvants when delivered through different routes of vaccine administration... - Intranasal immunization of mice with a formalin-inactivated bovine respiratory syncytial virus vaccine co-formulated with CpG oligodeoxynucleotides and polyphosphazenes results in enhanced protectionJohn W Mapletoft
Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Road, Saskatoon, SK S7N 5E3, Canada
J Gen Virol 89:250-60. 2008..Co-formulation of CpG ODN and PP is a promising new vaccine platform technology that may have applications in mucosal immunization in humans... - All three classes of CpG ODNs up-regulate IP-10 gene in pigsArshud Dar
Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Road, Saskatoon, SK, Canada
Res Vet Sci 88:242-50. 2010..These in vitro and in vivo observations suggest that interferon-gamma inducible protein 10 (IP-10) may be a reliable biomarker for immune activity induced by CpG ODNs in pigs... - Strategies to link innate and adaptive immunity when designing vaccine adjuvantsSrinivas Garlapati
Vaccine and Infectious Disease Organization, Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada
Vet Immunol Immunopathol 128:184-91. 2009..Using a neonatal pig model for pertussis, we are currently analyzing the effectiveness of host defence peptides (HDPs), bacterial DNA and polyphosphazenes as vaccine adjuvants... - Protection of neonatal broiler chicks against Salmonella Typhimurium septicemia by DNA containing CpG motifsAzita Taghavi
Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK S7N 5B4, Canada
Avian Dis 52:398-406. 2008..This is the first time that CpG-ODN has been demonstrated to have an immunoprotective effect against an intracellular bacterial infection in neonatal broiler chickens following in ovo delivery... - Enhancement of immunoprotective effect of CpG-ODN by formulation with polyphosphazenes against E. coli septicemia in neonatal chickensAzita Taghavi
Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada S7N 5B4
Curr Drug Deliv 6:76-82. 2009..This is the first time that CpG-ODN formulated with polyphosphazene has been demonstrated to have an immunoprotective effect against an extra cellular bacterial infection in neonatal broiler chickens following in ovo delivery... - Bovine toll-like receptor 9: a comparative analysis of molecular structure, function and expressionPhilip J Griebel
Vaccine and Infectious Disease Organization, 120 Veterinary Road, Saskatoon, Sask, Canada S7N 5E3
Vet Immunol Immunopathol 108:11-6. 2005..Collectively, these analyses revealed substantial conservation of TLR9 structure and TLR9 function in blood leukocytes of humans, cattle and other domestic species... - Pathotypic and molecular characterization of a fowl adenovirus associated with inclusion body hepatitis in Saskatchewan chickensArshud Dar
Vaccine and Infectious Disease Organization, 120 Veterinary Road, University of Saskatchewan, Saskatoon, SK, Canada S7N 5E3
Avian Dis 56:73-81. 2012.... - CpG oligodeoxynucleotides activate innate immune response that suppresses infectious bronchitis virus replication in chicken embryosArshud Dar
Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Saskatchewan, Canada S7N 5E3
Avian Dis 53:261-7. 2009.... - Oligodeoxynucleotides containing CpG motifs (CpG-ODN) predominantly induce Th1-type immune response in neonatal chicksBhavini A Patel
Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Dev Comp Immunol 32:1041-9. 2008..To our knowledge, this is the first report evaluating the induction of cytokines/chemokines in neonatal chicks following administration of CpG-ODN... - Immunogenicity of a receptor-binding domain of SARS coronavirus spike protein in mice: implications for a subunit vaccineAlexander N Zakhartchouk
Vaccine and Infectious Disease Organization VIDO, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Sask, Canada S7N 5E3
Vaccine 25:136-43. 2007..This finding suggests that carbohydrate is important for the immunogenicity of the S318-510 protein fragment and provide useful information for designing an effective and safe SARS subunit vaccine... - CpG oligodeoxynucleotide induction of antiviral effector molecules in sheepAnil K Nichani
Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E3
Cell Immunol 227:24-37. 2004..These observations support the conclusion that localized cell recruitment and activation contribute to CpG ODN induction of antiviral effector molecules, such as interferon and 2'5'-A synthetase... - Response of calves to challenge exposure with virulent bovine respiratory syncytial virus following intranasal administration of vaccines formulated for parenteral administrationJohn Ellis
Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK S7N 5B4, Canada
J Am Vet Med Assoc 230:233-43. 2007.... - The potential of polyphosphazenes for delivery of vaccine antigens and immunotherapeutic agentsNelson F Eng
Vaccine and Infectious Disease Organization International Vaccine Center, University of Saskatchewan, Saskatchewan, Canada
Curr Drug Deliv 7:13-20. 2010..Further research and development of polyphosphazene adjuvants is warranted to fully explore their potential in the delivery of vaccines and immunotherapeutic agents...