Research Topics
Species | H MoldofskySummaryAffiliation: University of Toronto Country: Canada Publications
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Detail Information
Publications
The significance, assessment, and management of nonrestorative sleep in fibromyalgia syndromeHarvey Moldofsky
Sleep Disorders Clinic of the Centre for Sleep and Chronobiology, Toronto, Ontario, Canada
CNS Spectr 13:22-6. 2008....
Management of sleep disorders in fibromyalgiaHarvey Moldofsky
Sleep Disorders Clinic of the Centre for Sleep and Chronobiology, 340 College Street, Suite 580, Toronto, ON M5T 3A9, Canada
Rheum Dis Clin North Am 28:353-65. 2002..No systematic studies have been reported on the use of remedial measures for the management of PLMS/restless legs syndrome and sleep apnea that occur in some patients with FM...
The significance of the sleeping-waking brain for the understanding of widespread musculoskeletal pain and fatigue in fibromyalgia syndrome and allied syndromesHarvey Moldofsky
Faculty of Medicine, University of Toronto, Sleep Disorders Clinic of the Centre for Sleep and Chronobiology, 340 College Street, Suite 580, Toronto, ON MST 3A9, Canada
Joint Bone Spine 75:397-402. 2008..g., pregabalin, serotonin/noradrenaline compounds and sodium oxybate that are shown to improve many of the symptoms of such patients...
Sleep assessment in a population-based study of chronic fatigue syndromeElizabeth R Unger
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
BMC Neurol 4:6. 2004..Conversely, many sleep disorders present similarly to CFS. Few studies characterizing sleep in unselected CFS subjects have been published and none have been performed in cases identified from population-based studies...
Effect of duloxetine in patients with fibromyalgia: tiredness subgroupsLaurence A Bradley
Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, Alabama 35294, USA
Arthritis Res Ther 12:R141. 2010..This study tested the hypothesis that baseline ratings of fatigue/tiredness would be negatively associated with the efficacy of duloxetine on measures of pain and functional ability in patients with fibromyalgia...
Effects of bedtime very low dose cyclobenzaprine on symptoms and sleep physiology in patients with fibromyalgia syndrome: a double-blind randomized placebo-controlled studyHarvey Moldofsky
Sleep Disorders Clinics, Centre for Sleep and Chronobiology, University of Toronto, Toronto, Ontario, Canada
J Rheumatol 38:2653-63. 2011....
The significance of dysfunctions of the sleeping/waking brain to the pathogenesis and treatment of fibromyalgia syndromeHarvey Moldofsky
Sleep Disorders Clinics of the Centre for Sleep and Chronobiology, University of Toronto, Toronto, Ontario, Canada
Rheum Dis Clin North Am 35:275-83. 2009....
Rheumatic manifestations of sleep disordersHarvey Moldofsky
Faculty of Medicine, University of Toronto, Canada
Curr Opin Rheumatol 22:59-63. 2010..This paper reviews the accumulating evidence from human and animal experimental research studies that show a bidirectional relationship of disordered sleep to pain and fatigue...
Disordered sleep in fibromyalgia and related myofascial facial pain conditionsH K Moldofsky
Sleep Disorders Clinic, Centre for Sleep and Chronobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Dent Clin North Am 45:701-13. 2001..This awareness results in more comprehensive management and an improved opportunity for optimal patient management as well as improved sleep and diminished pain levels...
The contribution of sleep medicine to the assessment of the tired patientH Moldofsky
University of Toronto, Toronto, Ontario
Can J Psychiatry 45:798-802. 2000....
Effects of sodium oxybate on sleep physiology and sleep/wake-related symptoms in patients with fibromyalgia syndrome: a double-blind, randomized, placebo-controlled studyHarvey Moldofsky
Centre for Sleep and Chronobiology and Toronto Psychiatric Research Foundation, Toronto, Ontario, Canada
J Rheumatol 37:2156-66. 2010..To determine the effects of sodium oxybate (SXB) on sleep physiology and sleep/wake-related symptoms in patients with fibromyalgia syndrome (FM)...
Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post-SARS syndrome; a case-controlled studyHarvey Moldofsky
Sleep Disorders Clinic of the Centre for Sleep and Chronobiology, 340 College St, Suite 580, Toronto, ON M5T 3A9, Canada
BMC Neurol 11:37. 2011..The long term adverse effects of Severe Acute Respiratory Syndrome (SARS), a viral disease, are poorly understood...
Sleep disturbances in children with attention-deficit/hyperactivity disorderP Corkum
Ontario Institute for Studies in Education, University of Toronto, Canada
J Am Acad Child Adolesc Psychiatry 37:637-46. 1998..To evaluate the relationship between sleep disturbances and attention-deficit/hyperactivity disorder (ADHD)...
Brain-blood permeability: TNF-alpha promotes escape of protein tracer from CSF to bloodJ B Dickstein
Centre for Sleep and Chronobiology, University of Toronto, Toronto, Ontario, Canada M5T 2S8
Am J Physiol Regul Integr Comp Physiol 279:R148-51. 2000..No significant changes were observed in control animals treated with saline. The data suggest that TNF-alpha promotes the clearance of protein macromolecules from the CSF to the venous blood...
Variants of the orexin2/hcrt2 receptor gene identified in patients with excessive daytime sleepiness and patients with Tourette's syndrome comorbidityMiles D Thompson
Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
Am J Med Genet B Neuropsychiatr Genet 129:69-75. 2004..Further work is warranted to study the variability of the orexin/hypocretin system in a variety of disorders characterized by EDS...
Periodic K-alpha sleep EEG activity and periodic limb movements during sleep: comparisons of clinical features and sleep parametersJ G MacFarlane
University of Toronto, Centre for Sleep and Chronobiology, Toronto Hospital (Western Division, Ontario, Canada
Sleep 19:200-4. 1996..The PLMS group was predominantly male, showed greater sleep disruption and presented with a variety of sleep-related symptoms...
Sleep problems in children with attention-deficit/hyperactivity disorder: impact of subtype, comorbidity, and stimulant medicationP Corkum
Ontario Institute for Studies in Education, University of Toronto, Canada
J Am Acad Child Adolesc Psychiatry 38:1285-93. 1999..To determine the relationship of sleep problems to attention-deficit/hyperactivity disorder (ADHD), diagnostic subtype, comorbid disorders, and the effects of stimulant treatment...
Fatigue in systemic lupus erythematosus: contributions of disordered sleep, sleepiness, and depressionAndrea Iaboni
University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
J Rheumatol 33:2453-7. 2006..Tiredness in SLE that is the result of excessive daytime sleepiness can be distinguished from tiredness of depression. Such distinctions will help identify appropriate treatment for tired patients with SLE...
The relationship of lymphocytes in blood and in lymph to sleep/wake states in sheepJ B Dickstein
Centre for Sleep and Chronobiology, Toronto Western Hospital, University of Toronto, Ontario, Canada
Sleep 23:185-90. 2000..There were no differences in lymphocyte subsets in the blood and in the lymph during sleep/wake brain states. These data indicate that migration of cells in the peripheral lymphatic system is altered during sleep compared to wakefulness...
Ottawa Panel evidence-based clinical practice guidelines for aerobic fitness exercises in the management of fibromyalgia: part 1Lucie Brosseau
Clinical Epidemiology Unit, Ottawa Hospital Research Institute, Ottawa Hospital, Civic Campus, Ottawa, Ontario, Canada
Phys Ther 88:857-71. 2008..The objective of this study was to create guidelines for the use of aerobic fitness exercises in the management of adult patients (>18 years of age) with fibromyalgia, as defined by the 1990 American College of Rheumatology criteria...
Ottawa Panel evidence-based clinical practice guidelines for strengthening exercises in the management of fibromyalgia: part 2Lucie Brosseau
Clinical Epidemiology Unit, Ottawa Hospital Research Institute, Ottawa Hospital, Civic Campus, Ottawa, Ontario, Canada
Phys Ther 88:873-86. 2008..The objective of this study was to create guidelines for the use of strengthening exercises in the management of adult patients (>18 years of age) with fibromyalgia (FM), as defined by the 1990 American College of Rheumatology criteria...
Special considerations in insomnia diagnosis and management: depressed, elderly, and chronic pain populationsRuth M Benca
University of Wisconsin, Madison, USA
J Clin Psychiatry 65:26-35. 2004..Conversely, there is evidence that appropriate recognition and management of the sleep complaint may alleviate other symptoms related to the associated condition and help interrupt this vicious cycle...
Panel discussion: changing how we think about insomniaSonia Ancoli-Israel
J Clin Psychiatry 65:44-6. 2004
Sleep disturbance induced by substance P in miceMonica L Andersen
Department of Psychobiology, Universidade Federal de Sao Paulo UNIFESP, Brazil
Behav Brain Res 167:212-8. 2006..Prior administration of the NK1 antagonist prevented the disturbances in sleep. CONCLUSIONS: The results suggest that SP produces disturbances in sleep, likely mediated by the NK1 receptor...
