Research Topics
| Z MeraliSummaryAffiliation: University of Ottawa Country: Canada Publications
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Publications
Role of bombesin-related peptides in the control of food intakeZ Merali
School of Psychology, University of Ottawa, Ottawa, Ontario, K1N 6N5
Neuropeptides 33:376-86. 1999..Hence, pharmacological targeting of these systems may be of therapeutic value...- Differential involvement of amygdaloid CRH system(s) in the salience and valence of the stimuliZul Merali
Institute of Mental Health Research, Royal Ottawa Hospital, University of Ottawa, 1145 Carling Avenue, K1Z 7K4, Ottawa, ON, Canada
Prog Neuropsychopharmacol Biol Psychiatry 27:1201-12. 2003..We suggest that the CRH responses at the CeA may be involved in a preparatory capacity and, as such, may accompany a range of emotionally significant stimuli, be they appetitive or aversive... - Impact of repeated stressor exposure on the release of corticotropin-releasing hormone, arginine-vasopressin and bombesin-like peptides at the anterior pituitaryZ Merali
University of Ottawa, Department of Psychology, Ottawa, Ontario, K1N 6N5, Canada
Behav Brain Res 198:105-12. 2009.... - Nesfatin-1 increases anxiety- and fear-related behaviors in the ratZ Merali
Department of Psychology, University of Ottawa, Ottawa, ON, Canada
Psychopharmacology (Berl) 201:115-23. 2008..However, the relation between nesfatin-1 and stressor-related behaviors like anxiety and/or fear has not yet been investigated... - Effects of corticosterone on corticotrophin-releasing hormone and gastrin-releasing peptide release in response to an aversive stimulus in two regions of the forebrain (central nucleus of the amygdala and prefrontal cortex)Zul Merali
Department of Psychology, University of Ottawa, Ottawa, Canada
Eur J Neurosci 28:165-72. 2008.... - Effects of intracerebral ventricular administration of gastrin-releasing peptide and its receptor antagonist RC-3095 on learned fear responses in the ratZul Merali
Department of Psychology, University of Ottawa, Ottawa, ON, Canada K1N 6N5
Behav Brain Res 216:519-24. 2011..0 nmol) significantly increased the basal startle amplitude without affecting fear-potentiation, suggesting elevated fear at the onset of testing. These data provide further evidence that GRP is involved in conditioned fear responses... - Bombesin receptors as a novel anti-anxiety therapeutic target: BB1 receptor actions on anxiety through alterations of serotonin activityZul Merali
Institute of Mental Health Research and Department of Psychiatry, School of Psychology, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5
J Neurosci 26:10387-96. 2006..The finding that this action was attenuated by BB receptor (BB1 and/or BB2) antagonists suggests that these compounds may represent a novel class of anxiolytic agents... - Corticotropin-releasing hormone, arginine vasopressin, gastrin-releasing peptide, and neuromedin B alterations in stress-relevant brain regions of suicides and control subjectsZul Merali
Institute of Mental Health Research, University of Ottawa, Ontario, Canada
Biol Psychiatry 59:594-602. 2006..Postmortem levels of several stress- and depression-relevant neuropeptides were assessed in brain regions of depressed suicides relative to control subjects that had died of other causes... - Does amygdaloid corticotropin-releasing hormone (CRH) mediate anxiety-like behaviors? Dissociation of anxiogenic effects and CRH releaseZ Merali
Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada K1N 6 N5
Eur J Neurosci 20:229-39. 2004..Rather than provoking anxiety, these systems might serve to draw attention to events or cues of biological significance, including those posing a threat to survival... - Anticipatory cues differentially provoke in vivo peptidergic and monoaminergic release at the medial prefrontal cortexZul Merali
School of Psychology, University of Ottawa, Ottawa, Ontario, Canada
Neuropsychopharmacology 29:1409-18. 2004..The activity of DA and 5-HT neurons, in contrast, is more closely aligned with the cognitive appraisal of predictor stimuli... - Differential impact of predator or immobilization stressors on central corticotropin-releasing hormone and bombesin-like peptides in Fast and Slow seizing ratZ Merali
School of Psychology, University of Ottawa, 11 Marie Curie, Ottawa, ON, Canada K1N 6N5
Brain Res 906:60-73. 2001..Taken together, the results demonstrate that these two lines of rats show differential endocrinological and neurochemical response patterns to these stressors... - Effects of interleukin-1beta and mild stress on alterations of norepinephrine, dopamine and serotonin neurotransmission: a regional microdialysis studyZ Merali
School of Psychology, University of Ottawa, Ont, Canada
Brain Res 761:225-35. 1997..These data also lend support to the contention that neurogenic stressors may have a much greater impact on central neurotransmission under conditions of immune activation... - Aversive and appetitive events evoke the release of corticotropin-releasing hormone and bombesin-like peptides at the central nucleus of the amygdalaZ Merali
School of Psychology, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5
J Neurosci 18:4758-66. 1998..Rather than evoking feelings of fear and anxiety, these systems may serve to draw attention to events or cues of biological significance, such as those associated with food availability as well as those posing a threat to survival... - Pharmaco-ontogenic modulation of feeding by oxytocin, bombesin, and their antagonistsZ Merali
School of Psychology, University of Ottawa, Ontario, Canada
Peptides 17:1119-26. 1996..These results suggest that pharmacological effects to OX and BN are apparent from hours after birth and that these peptides may play a role in the regulation of ingestive behavior from early on in ontogeny... - Stressor-induced corticotropin-releasing hormone, bombesin, ACTH and corticosterone variations in strains of mice differentially responsive to stressorsH Anisman
Institute of Neurosciences, Carleton University, Ottawa, Ontario
Stress 2:209-20. 1998.... - Acoustic startle and fear-potentiated startle in rats selectively bred for fast and slow kindling rates: relation to monoamine activityH Anisman
Institute of Neuroscience, Carleton University, Ottawa, Ontario K1S 5B6, Canada
Eur J Neurosci 12:4405-16. 2000..This suggested that relative to Slow rats, dopamine neurons in prefrontal cortex of Fast rats do not react normally to environmental stimuli, and this phenomenon could lead to disturbances of attention or impulsivity... - Plasticity of the GABA(A) receptor subunit cassette in response to stressors in reactive versus resilient miceM O Poulter
Molecular Brain Research Group, Robarts Research Institute, Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada
Neuroscience 165:1039-51. 2010..These findings support the view that analyses involving subunit organization, rather than just differences in absolute levels, may be expedient in assessing GABA(A) functioning in stressor-related psychological disturbances... - Psychogenic, neurogenic, and systemic stressor effects on plasma corticosterone and behavior: mouse strain-dependent outcomesH Anisman
Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
Behav Neurosci 115:443-54. 2001..It appears that whereas stressor reactivity and adrenal glucocorticoid release may be exaggerated in BALB/cByJ mice, such effects may be dependent on the specific characteristic of the stressor situation... - Central bombesin activates the hypothalamic-pituitary-adrenal axis. Effects on regional levels and release of corticotropin-releasing hormone and arginine-vasopressinP Kent
School of Psychology, University of Ottawa, Ottawa, Ontario, K1N 6N5, Canada
Neuroendocrinology 73:203-14. 2001.... - Influence of psychogenic and neurogenic stressors on neuroendocrine and central monoamine activity in fast and slow kindling ratsD C McIntyre
Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
Brain Res 840:65-74. 1999..Similarly, DA alterations also were greater in the left medial amygdala in response to stressors. Despite very different behavioral styles, however, the two lines often exhibited similar amine alterations in response to both stressors... - Central monoamine and plasma corticosterone changes induced by a bacterial endotoxin: sensitization and cross-sensitization effectsS Hayley
Institute of Neuroscience, Carleton University, Ottawa, Ontario K1S 5B6, Canada
Eur J Neurosci 13:1155-65. 2001.... - Endocrine and cytokine correlates of major depression and dysthymia with typical or atypical featuresH Anisman
Institute of Neurosciences, Carleton University, Ottawa, Ontario, Canada
Mol Psychiatry 4:182-8. 1999..Given that circulating cytokines influence neuroendocrine functioning, and may affect neurovegetative features, a role for interleukins may exist with respect to the pathophysiology of certain subtypes of depression... - Time-dependent sensitization of corticotropin-releasing hormone, arginine vasopressin and c-fos immunoreactivity within the mouse brain in response to tumor necrosis factor-alphaS Hayley
Institute of Neuroscience, Life Science Research Building, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada K1S 5B6
Neuroscience 106:137-48. 2001..It is suggested that such a sensitization may influence the response to immunological and traumatic insults and may thus be relevant to behavioral pathology... - Bombesin-induced HPA and sympathetic activation requires CRH receptorsP Kent
School of Psychology, University of Ottawa, 11 Marie Curie, Ottawa, Ontario, Canada
Peptides 22:57-65. 2001..These findings support the notion that BN-induced HPA axis and sympathetic activation are mediated, at least in part, via activation of CRH neurons... - Role of bombesin-related peptides in the mediation or integration of the stress responseZ Merali
School of Psychology, University of Ottawa, Ontario, Canada
Cell Mol Life Sci 59:272-87. 2002..Several hypothetical mechanisms for such peptidergic interactions are discussed as to the implications of considering BN-LPs as 'stress peptides'... - Do early-life events permanently alter behavioral and hormonal responses to stressors?H Anisman
Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
Int J Dev Neurosci 16:149-64. 1998..In contrast, in relatively hardy animals the early-life manipulations may have less obvious effects... - Influence of psychosocial, psychogenic and neurogenic stressors on several aspects of immune functioning in miceZ W Lu
Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
Stress 3:55-70. 1999..It is suggested that analysis of stressor effects need to consider in greater detail the characteristics of the organism being stressed, as well as the characteristics of the stressor itself... - Rodent models of depression: learned helplessness induced in miceH Anisman
Carleton University, Ottawa, Ontario, Canada
Curr Protoc Neurosci . 2001..This unit describes the procedure used to assess the effects of controllable and uncontrollable shock on subsequent shock escape performance in mice using an escape-delay procedure... - Evaluation of anxiolytic properties of Gotukola--(Centella asiatica) extracts and asiaticoside in rat behavioral modelsP Wijeweera
Ottawa-Carleton Institute of Biology, University of Ottawa Institute of Mental Health Research, Royal Ottawa Hospital, Canada
Phytomedicine 13:668-76. 2006..Furthermore, the asiaticoside did not affect locomotor activity, suggesting these compounds do not have sedative effects in rodents... - Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) systemR Awad
Ottawa Carleton Institute of Biology, University of Ottawa, Ottawa, ON K1N6N5, Canada
Can J Physiol Pharmacol 85:933-42. 2007..11-0.65 mg/mL). Several of these species may therefore warrant further pharmacological investigation. The relation between enzyme activity and possible in vivo mode of action is discussed... - Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): a medicinal plant with anxiolytic propertiesR Awad
Ottawa-Carleton Institute of Biology, University of Ottawa, Ottawa, Canada
Phytomedicine 10:640-9. 2003..These compounds may play a role in anxiolytic activity since baicalin and baicalein are known to bind to the benzodiazepine site of the GABAA receptor and since GABA is the main inhibitory neurotransmitter... - Effects of central neuromedin B and related peptides on blood glucoseH Plamondon
School of Psychology, University of Ottawa, Canada
Regul Pept 47:133-40. 1993..31 nM) NB analogues elevate blood glucose with a lower efficacy than Bn (Bn > NB-32 > NB-10 > or = NAcNB-10). NB-32 appears more potent and efficacious than the other NB congeners used.(ABSTRACT TRUNCATED AT 250 WORDS).. - Individual differences in sucrose consumption in the rat: motivational and neurochemical correlates of hedoniaK Brennan
Institute of Neuroscience, Carleton University, School of Psychology, University of Ottawa, Ottawa, Ontario, Canada
Psychopharmacology (Berl) 157:269-76. 2001.... - Neurochemical sensitization associated with systemic administration of tumor necrosis factor-alpha: adjuvant action in combination with bovine serum albuminHymie Anisman
Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada K1S 5B6
J Neuroimmunol 145:91-102. 2003..It is suggested that mTNF-alpha acts as an adjuvant to the anaphylactic actions elicited by BSA, but may provoke a sensitization of monoamine activity which is time-dependent and varies across brain regions... - Maternal factors and monoamine changes in stress-resilient and susceptible mice: cross-fostering effectsPriya Prakash
Institute of Neuroscience, Carleton University, Life Science Research Bldg, Ottawa, Ontario, Canada
Brain Res 1111:122-33. 2006..Although monoamine variations were largely determined by genetic factors, maternal influences contributed to stressor-elicited neurochemical changes in some regions, particularly dopamine activation within the prefrontal cortex... - Role of gastrin-releasing peptide and neuromedin B in anxiety and fear-related behaviorTania Bedard
University of Ottawa, Department of Psychology, Ottawa, Ontario, Canada K1N 6N5
Behav Brain Res 179:133-40. 2007..These data suggest that NMB and GRP do affect the stress response. However, whereas NMB manipulations affected both anxiety and fear responses, GRP alterations selectively affected fear-related responses... - Further evidence for the depressive effects of cytokines: anhedonia and neurochemical changesHymie Anisman
Institute of Neuroscience, Life Science Research Building, Carleton University, Ottawa, ON, Canada
Brain Behav Immun 16:544-56. 2002.... - The effects of chronic mild stress on male Sprague-Dawley and Long Evans rats: I. Biochemical and physiological analysesC Bielajew
School of Psychology, University of Ottawa, 11 Marie Curie, Ottowa, ON, Canada K1N 6N5
Behav Brain Res 136:583-92. 2002..Physiological indices however are less influenced by this experience, at least when the exposure is limited to 3 weeks... - The pathogenesis of clinical depression: stressor- and cytokine-induced alterations of neuroplasticityS Hayley
Institute of Neuroscience, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada K1S 5B6
Neuroscience 135:659-78. 2005..Thus, depressive illness may be considered a disorder of neuroplasticity as well as one of neurochemical imbalances, and cytokines may act as mediators of both aspects of this illness... - Functional interactions between dopamine, serotonin and norepinephrine neurons: an in-vivo electrophysiological study in rats with monoaminergic lesionsBruno P Guiard
Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada
Int J Neuropsychopharmacol 11:625-39. 2008..Indeed, based on the understanding of such interactions, it may be possible to develop strategies to improve the effectiveness of antidepressant drugs by preventing counter-productive negative feedback actions... - Differential impact of audiogenic stressors on Lewis and Fischer rats: behavioral, neurochemical, and endocrine variationsDavid S Michaud
Consumer and Clinical Radiation Protection Bureau, Health Canada, Ottawa, Ontario, Canada
Neuropsychopharmacology 28:1068-81. 2003..Behaviorally, the Fischer rats displayed an active stress response, whereas the Lewis strain adopted freezing as a defensive style. The role of CRH in the genesis of the overall strain-dependent response to stressors is discussed... - Anxiety in rats selectively bred for Fast and Slow kindling rates: situation-specific outcomesOwen P Kelly
Institute of Neuroscience, Carleton University, Ottawa, Ont, Canada
Stress 6:289-95. 2003..These data indicate the need to differentiate subtypes of anxiety in animal models, and raise the issue that anxiety elicited by specific environmental triggers may interact with genetically determined trait characteristics... - Posttraumatic stress symptoms and salivary cortisol levelsH Anisman
Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
Am J Psychiatry 158:1509-11. 2001..This study assessed the relationship between posttraumatic stress symptoms and salivary cortisol levels after a severe ice storm... - Serotonin receptor subtype and p11 mRNA expression in stress-relevant brain regions of suicide and control subjectsHymie Anisman
Institute of Neuroscience, Carleton University, Ottawa, ON, Canada
J Psychiatry Neurosci 33:131-41. 2008..Our objective was to investigate which 5-HT receptor subtypes might be associated with depression and suicide, whether receptor differences vary across brain regions and whether they are moderated by sex... - GABAA receptor promoter hypermethylation in suicide brain: implications for the involvement of epigenetic processesMichael O Poulter
Molecular Brain Research Group, Robarts Research Institute, Department of Physiology and Pharmacology University of Western Ontario, London, Ontario, Canada
Biol Psychiatry 64:645-52. 2008..Epigenetic mechanisms may be involved in the reprogramming of gene expression in response to stressful stimuli. This investigation determined whether epigenetic phenomena might similarly be associated with suicide/depression... - Influence of poly I:C on sickness behaviors, plasma cytokines, corticosterone and central monoamine activity: moderation by social stressorsReno Gandhi
Institute of Neuroscience, Carleton University, Ottawa, Ont, Canada K1S 5B6
Brain Behav Immun 21:477-89. 2007..Mechanisms that might be responsible for the interactive effects of social disruption and immune activation are presented, and the data were related to depressive symptoms associated with stressor and cytokine treatments... - The role of gastrin-releasing peptide on conditioned fear: differential cortical and amygdaloid responses in the ratChristine Mountney
School of Psychology, University of Ottawa, Ottawa, ON, Canada
Psychopharmacology (Berl) 189:287-96. 2006.... - Evaluation of the effects of chronic mild stressors on hedonic and physiological responses: sex and strain comparedAnne T M Konkle
School of Psychology, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5
Brain Res 992:227-38. 2003..The usefulness of sucrose intake or preference as behavioral indices of CMS-induced anhedonia in males and females is modest at best... - Amygdala amino acid and monoamine levels in genetically Fast and Slow kindling rat strains during massed amygdala kindling: a microdialysis studyRick S Shin
Department of Psychology, Life Sciences Research Building, Carleton University, Ottawa, Ontario, K1S 5B6, Canada
Eur J Neurosci 20:185-94. 2004.... - Validation of a simple, ethologically relevant paradigm for assessing anxiety in miceZul Merali
Institute of Mental Health Research, Royal Ottawa Hospital, and Department of Cellular and Molecular Medicine, University of Ottawa, Ontario, Canada
Biol Psychiatry 54:552-65. 2003.... - Corticotropin releasing hormone receptor alterations elicited by acute and chronic unpredictable stressor challenges in stressor-susceptible and resilient strains of miceHymie Anisman
Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
Behav Brain Res 181:180-90. 2007.... - Cytokines as a stressor: implications for depressive illnessHymie Anisman
Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
Int J Neuropsychopharmacol 5:357-73. 2002..Given that the effects of cytokines are evident within hypothalamic, as well as extrahypothalamic sites, including various limbic regions, it is suggested that cytokines may impact on emotional changes, including depression... - Ethnopharmacology of Q'eqchi' Maya antiepileptic and anxiolytic plants: effects on the GABAergic systemRosalie Awad
Biology Department, University of Ottawa, Ontario, Canada
J Ethnopharmacol 125:257-64. 2009..The Q'eqchi' Maya possess a large selection of plants to treat neurological disorders, including epilepsy and susto (fright), a culture-bound illness related to anxiety disorders... - Effects of gastrin-releasing peptide agonist and antagonist administered to the basolateral nucleus of the amygdala on conditioned fear in the ratChristine Mountney
School of Psychology, University of Ottawa, Ottawa, Ontario, Canada
Psychopharmacology (Berl) 200:51-8. 2008..In line with this view, central administration of gastrin-releasing peptide (GRP; a mammalian analogue of BB) or its receptor antagonist (D-Tpi6, Leu13 psi[CH2NH]-Leu14) BB(6-14) (RC-3095) modulates conditioned fear... - Dysregulation in the suicide brain: mRNA expression of corticotropin-releasing hormone receptors and GABA(A) receptor subunits in frontal cortical brain regionZul Merali
University of Ottawa Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada
J Neurosci 24:1478-85. 2004.... - Changes in extracellular levels of amygdala amino acids in genetically fast and slow kindling rat strainsRick S Shin
Institute of Neuroscience, Department of Psychology, Life Sciences Research Building, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6, Canada
Brain Res 946:31-42. 2002.... - Sensitization associated with stressors and cytokine treatmentsHymie Anisman
Institute of Neurosciences, Carleton University, Ont, K1S 5B6, Ottawa, Canada
Brain Behav Immun 17:86-93. 2003..Cytokines may independently prime multiple regulatory systems, and by virtue of the neurochemical changes imparted, have both immediate and proactive influences on the evolution of psychopathology... - Dissociating anorexia and anhedonia elicited by interleukin-1beta: antidepressant and gender effects on responding for "free chow" and "earned" sucrose intakeZul Merali
Institute of Mental Health Research, Royal Ottawa Hospital, Ottawa, Canada
Psychopharmacology (Berl) 165:413-8. 2003..the anhedonic and anorexic effects of IL-1beta are dissociable, (b). the cytokine disturbs incentive motivation, and (c). antidepressant treatment preferentially influences the anhedonic effects elicited by IL-1beta... - Hypoxia alters the expression of inhibitor of apoptosis proteins after brain trauma in the mouseAngelo Mikrogianakis
Division of Pediatric Emergency Medicine, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada
J Neurotrauma 24:338-53. 2007..These findings show that IAPs have a potential role in the increased vulnerability of brain cells to hypoxia following TBI, and have implications for configuring future therapies for TBI... - Ethnopharmacological investigation of plants used to treat susto, a folk illnessNatalie Bourbonnais Spear
Ottawa Carleton Institute of Biology, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5
J Ethnopharmacol 109:380-7. 2007..In light of the available literature, this represents the first experimental investigation of the biological activity of plants specifically in the perspective of their use in treating a culture-bound syndrome... - Inhibition of calpains prevents neuronal and behavioral deficits in an MPTP mouse model of Parkinson's diseaseStephen J Crocker
Neuroscience Research Group, Ottawa Health Research Institute, Canada
J Neurosci 23:4081-91. 2003..Taken together, our findings provide a potentially novel correlation between calpain proteolytic activity in an MPTP model of PD and the etiology of neuronal loss in PD in humans... - Bombesin-like peptides and associated receptors within the brain: distribution and behavioral implicationsTerry W Moody
CCR, National Cancer Institute Office of the Director, National Institutes of Health, Department of Health and Human Services, Room 3A34, Building 31, 31 Center Drive, Bethesda, MD 20892, USA
Peptides 25:511-20. 2004..GRP and NMB modulate distinct biological processes through discrete brain regions or circuits, and globally these peptidergic systems may serve in an integrative or homeostatic function... - Therapeutic and protective effect of environmental enrichment against psychogenic and neurogenic stressCosette Fox
Wright Patterson Air Force Base (WPAFB, AFRL/HEPA Branch, 2800 Q Street, Building 824, OH 45433-7022, United States
Behav Brain Res 175:1-8. 2006.... - Interferon-alpha effects are exaggerated when administered on a psychosocial stressor backdrop: cytokine, corticosterone and brain monoamine variationsHymie Anisman
Institute of Neuroscience, Carleton University, Ontario, Canada K1S 5B6
J Neuroimmunol 186:45-53. 2007..It is suggested that the depressive effects of immunotherapy in humans likewise reflects the synergistic actions of the cytokine and the ongoing distress experienced by patients... - Cytokines as a precipitant of depressive illness: animal and human studiesHymie Anisman
Institute of Neuroscience, Carleton University, Ottawa, Ontario K1S 5B6, Canada
Curr Pharm Des 11:963-72. 2005..Further, the effects of the cytokine treatments may act synergistically with stressors, and cytokines may provoke a sensitization effect so that the effects of later stressor experiences are exacerbated... - Stress and cytokine-elicited neuroendocrine and neurotransmitter sensitization: implications for depressive illnessShawn Hayley
Institute of Neuroscience, Carleton University, Canada
Stress 6:19-32. 2003..It is suggested that by virtue of these neurochemical changes, cytokines may have both immediate and proactive effects on mood states... - Effects of short-term administration of valproate on serotonin-1A and dopamine receptor function in healthy human subjectsNicholas J Delva
Departments of Psychiatry and Physiology, Queen s University, Providence Continuing Care Centre, Mental Health Services, Kingston, ON
J Psychiatry Neurosci 27:429-37. 2002..To examine the effects of short-term valproate treatment on human brain serotonin and dopamine function by means of challenge tests with ipsapirone, a partial agonist at 5-HT1A receptors, and apomorphine, a dopamine receptor agonist... - Experiential and genetic contributions to depressive- and anxiety-like disorders: clinical and experimental studiesHymie Anisman
Institute of Neuroscience, Carleton University, Ottawa, Ontario K1S 5B6, Canada
Neurosci Biobehav Rev 32:1185-206. 2008..It is suggested that depression is a life-long disorder, which even after effective treatment, has a high rate of re-occurrence owing to sensitized processes or epigenetic factors that promote persistent alterations of gene expression...