N Maurer

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. ncbi Lipid-based systems for the intracellular delivery of genetic drugs
    N Maurer
    Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, Canada
    Mol Membr Biol 16:129-40. 1999
  2. ncbi Spontaneous entrapment of polynucleotides upon electrostatic interaction with ethanol-destabilized cationic liposomes
    N Maurer
    Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    Biophys J 80:2310-26. 2001
  3. ncbi Anomalous solubility behavior of the antibiotic ciprofloxacin encapsulated in liposomes: a 1H-NMR study
    N Maurer
    Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, Canada
    Biochim Biophys Acta 1374:9-20. 1998
  4. ncbi Ionophore-mediated uptake of ciprofloxacin and vincristine into large unilamellar vesicles exhibiting transmembrane ion gradients
    D B Fenske
    Liposome Research Unit, Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, B C V6T 1Z3, Canada
    Biochim Biophys Acta 1414:188-204. 1998
  5. ncbi On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids
    I M Hafez
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada
    Gene Ther 8:1188-96. 2001
  6. ncbi Factors influencing uptake and retention of amino-containing drugs in large unilamellar vesicles exhibiting transmembrane pH gradients
    E Maurer-Spurej
    University of British Columbia, Department of Biochemistry and Molecular Biology, Faculty of Medicine, 2146 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada
    Biochim Biophys Acta 1416:1-10. 1999
  7. ncbi Developments in liposomal drug delivery systems
    N Maurer
    Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, Canada
    Expert Opin Biol Ther 1:923-47. 2001

Collaborators

Detail Information

Publications7

  1. ncbi Lipid-based systems for the intracellular delivery of genetic drugs
    N Maurer
    Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, Canada
    Mol Membr Biol 16:129-40. 1999
    ..These carriers protect nucleic acid-based drugs from degradation by nucleases, are on average 70 nm in diameter, achieve long circulation lifetimes and are capable of transfecting cells...
  2. ncbi Spontaneous entrapment of polynucleotides upon electrostatic interaction with ethanol-destabilized cationic liposomes
    N Maurer
    Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    Biophys J 80:2310-26. 2001
    ..The high entrapment efficiencies achieved at high polyelectrolyte-to-lipid ratios and the small size and neutral character of these novel liposomal systems are of utility for liposomal delivery of macromolecular drugs...
  3. ncbi Anomalous solubility behavior of the antibiotic ciprofloxacin encapsulated in liposomes: a 1H-NMR study
    N Maurer
    Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, Canada
    Biochim Biophys Acta 1374:9-20. 1998
    ..This provides a rationale for the rapid leakage of this drug in response to serum destabilization or depletion of the pH gradient...
  4. ncbi Ionophore-mediated uptake of ciprofloxacin and vincristine into large unilamellar vesicles exhibiting transmembrane ion gradients
    D B Fenske
    Liposome Research Unit, Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, B C V6T 1Z3, Canada
    Biochim Biophys Acta 1414:188-204. 1998
    ..The unique features of this methodology and possible benefits are discussed...
  5. ncbi On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids
    I M Hafez
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada
    Gene Ther 8:1188-96. 2001
    ....
  6. ncbi Factors influencing uptake and retention of amino-containing drugs in large unilamellar vesicles exhibiting transmembrane pH gradients
    E Maurer-Spurej
    University of British Columbia, Department of Biochemistry and Molecular Biology, Faculty of Medicine, 2146 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada
    Biochim Biophys Acta 1416:1-10. 1999
    ..Taken together these results provide methodology for improving (weak base) drug retention in liposomes and indicate that drugs that can partition into the lipid bilayer exhibit improved uptake and retention characteristics...
  7. ncbi Developments in liposomal drug delivery systems
    N Maurer
    Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, Canada
    Expert Opin Biol Ther 1:923-47. 2001
    ..This paper reviews the liposomal drug delivery field, summarises the success of liposomes for the delivery of small molecules and indicates how this success is being built on to design effective carriers for genetic drugs...