W R Wayne Martin

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. ncbi Is brain lactate increased in Huntington's disease?
    W R Wayne Martin
    Division of Neurology, University of Alberta, Edmonton, Alberta, Canada
    J Neurol Sci 263:70-4. 2007
  2. ncbi Quantitative estimation of regional brain iron with magnetic resonance imaging
    W R Wayne Martin
    Movement Disorders Program, Division of Neurology, University of Alberta, Edmonton, AB, Canada
    Parkinsonism Relat Disord 15:S215-8. 2009
  3. ncbi Temporal lobe changes in early, untreated Parkinson's disease
    W R Wayne Martin
    Division of Neurology, University of Alberta, Edmonton, Alberta, Canada
    Mov Disord 24:1949-54. 2009
  4. ncbi Intact presupplementary motor area function in early, untreated Parkinson's disease
    W R Wayne Martin
    Division of Neurology, University of Alberta, Edmonton, Alberta, Canada
    Mov Disord 23:1756-9. 2008
  5. ncbi Dihydrotetrabenazine positron emission tomography imaging in early, untreated Parkinson's disease
    W R Wayne Martin
    Division of Neurology, University of Alberta, Edmonton, Alberta
    Ann Neurol 63:388-94. 2008
  6. ncbi Midbrain iron content in early Parkinson disease: a potential biomarker of disease status
    W R Wayne Martin
    Division of Neurology, University of Alberta, Edmonton, Canada
    Neurology 70:1411-7. 2008
  7. ncbi MR spectroscopy in neurodegenerative disease
    W R Wayne Martin
    Movement Disorders Clinic, University of Alberta Glenrose Rehabilitation Hospital, Edmonton, Alberta, Canada
    Mol Imaging Biol 9:196-203. 2007
  8. ncbi Voxel-based morphometry reveals extra-nigral atrophy patterns associated with dopamine refractory cognitive and motor impairment in parkinsonism
    Richard Camicioli
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Parkinsonism Relat Disord 15:187-95. 2009
  9. ncbi Ventricular dilatation and brain atrophy in patients with Parkinson's disease with incipient dementia
    Richard Camicioli
    Department of Medicine Neurology, University of Alberta, Edmonton, Alberta, Canada
    Mov Disord 26:1443-50. 2011
  10. ncbi Magnetic resonance spectroscopic evidence for presupplementary motor area neuronal dysfunction in Parkinson's disease
    Richard M Camicioli
    Department of Medicine Neurology, University of Alberta, Edmonton, Alberta, Canada
    Mov Disord 22:382-6. 2007

Research Grants

  1. Parkinson's Disease Neuroprotection Trial: Clinical Center
    W Martin; Fiscal Year: 2007

Detail Information

Publications22

  1. ncbi Is brain lactate increased in Huntington's disease?
    W R Wayne Martin
    Division of Neurology, University of Alberta, Edmonton, Alberta, Canada
    J Neurol Sci 263:70-4. 2007
    ..Regardless, this supports the possibility of impaired mitochondrial function resulting in abnormal brain energy metabolism in HD...
  2. ncbi Quantitative estimation of regional brain iron with magnetic resonance imaging
    W R Wayne Martin
    Movement Disorders Program, Division of Neurology, University of Alberta, Edmonton, AB, Canada
    Parkinsonism Relat Disord 15:S215-8. 2009
    ..We suggest that this may ultimately provide an imaging marker for disease progression in PD, although longitudinal studies are required...
  3. ncbi Temporal lobe changes in early, untreated Parkinson's disease
    W R Wayne Martin
    Division of Neurology, University of Alberta, Edmonton, Alberta, Canada
    Mov Disord 24:1949-54. 2009
    ..These results suggest that right anterior temporal lobe changes occur in untreated patients with PD. The earliest changes may occur in subcortical white matter rather than temporal cortex...
  4. ncbi Intact presupplementary motor area function in early, untreated Parkinson's disease
    W R Wayne Martin
    Division of Neurology, University of Alberta, Edmonton, Alberta, Canada
    Mov Disord 23:1756-9. 2008
    ..We suggest that pre-SMA dysfunction is in part responsible for the dopamine nonresponsive features associated with disease progression...
  5. ncbi Dihydrotetrabenazine positron emission tomography imaging in early, untreated Parkinson's disease
    W R Wayne Martin
    Division of Neurology, University of Alberta, Edmonton, Alberta
    Ann Neurol 63:388-94. 2008
    ....
  6. ncbi Midbrain iron content in early Parkinson disease: a potential biomarker of disease status
    W R Wayne Martin
    Division of Neurology, University of Alberta, Edmonton, Canada
    Neurology 70:1411-7. 2008
    ....
  7. ncbi MR spectroscopy in neurodegenerative disease
    W R Wayne Martin
    Movement Disorders Clinic, University of Alberta Glenrose Rehabilitation Hospital, Edmonton, Alberta, Canada
    Mol Imaging Biol 9:196-203. 2007
    ..This review discusses the application of these techniques to patients with neurodegenerative disorders, including Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis...
  8. ncbi Voxel-based morphometry reveals extra-nigral atrophy patterns associated with dopamine refractory cognitive and motor impairment in parkinsonism
    Richard Camicioli
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Parkinsonism Relat Disord 15:187-95. 2009
    ..To determine overall patterns of brain atrophy associated with memory, executive function (EF) and dopamine non-responsive motor measures in older parkinsonian patients...
  9. ncbi Ventricular dilatation and brain atrophy in patients with Parkinson's disease with incipient dementia
    Richard Camicioli
    Department of Medicine Neurology, University of Alberta, Edmonton, Alberta, Canada
    Mov Disord 26:1443-50. 2011
    ..Ventricular dilatation occurs early in the course of significant cognitive decline in patients with Parkinson's disease, possibly reflecting both cortical gray and white matter loss...
  10. ncbi Magnetic resonance spectroscopic evidence for presupplementary motor area neuronal dysfunction in Parkinson's disease
    Richard M Camicioli
    Department of Medicine Neurology, University of Alberta, Edmonton, Alberta, Canada
    Mov Disord 22:382-6. 2007
    ..AC and PC NAA/Cr and Cho/Cr in any region did not differ (P > 0.05). In conclusion, pre-SMA NAA/Cr was selectively decreased in PD, consistent with neuronal dysfunction. This should be further examined as a biomarker of disease in PD...
  11. ncbi Age and dementia-associated atrophy predominates in the hippocampal head and amygdala in Parkinson's disease
    Thomas P Bouchard
    Department of Medicine Neurology, University of Alberta, 10230, 111th Avenue, Edmonton, Alberta, Canada
    Neurobiol Aging 29:1027-39. 2008
    ..35, p=0.02); AG volumes correlated with CVLT-II recall (r=0.35, p=0.02). No correlations were found in non-PD (p>0.4). In conclusion, functionally meaningful age-associated hippocampal and amygdala atrophy occurs in PD...
  12. ncbi Early, untreated Parkinson's disease patients show reaction time variability
    Richard M Camicioli
    Department of Medicine Neurology, University of Alberta, Edmonton, Alberta, Canada
    Neurosci Lett 441:77-80. 2008
    ..In the PD group neither the motor nor the executive measures correlated significantly with any of the reaction time measures. We conclude that CRT intraindividual variability and latencies are increased in untreated PD...
  13. ncbi Reduction in metabolite transverse relaxation times in amyotrophic lateral sclerosis
    Christopher C Hanstock
    Department of Biomedical Engineering, University of Alberta, Edmonton, Canada
    J Neurol Sci 198:37-41. 2002
    ..The objective of the present study was to determine if any T(2) changes might affect the apparent metabolite ratio measures, which we have previously reported as being abnormal in amyotrophic lateral sclerosis (ALS)...
  14. ncbi Detection of cerebral degeneration in amyotrophic lateral sclerosis using high-field magnetic resonance spectroscopy
    Sanjay Kalra
    Division of Neurology, Department of Medicine, University of Alberta, Walter C Mackenzie Health Sciences Centre, 8440 112th Street, Edmonton, Alberta, Canada
    Arch Neurol 63:1144-8. 2006
    ....
  15. ncbi Botulinum toxin injections do not improve freezing of gait in Parkinson disease
    Marguerite Wieler
    Department of Medicine, University of Alberta, Edmonton, Canada
    Neurology 65:626-8. 2005
    ..The authors conducted a randomized double-blind placebo-controlled crossover study of BTX-A vs placebo in 12 subjects with PD and FOG. No significant improvement with BTX-A was found using subjective and objective measures...
  16. ncbi Valvular heart disease in pergolide-treated Parkinson's disease
    James Scozzafava
    Division of Neurology, University of Alberta, Edmonton, Alberta, Canada
    Can J Neurol Sci 33:111-3. 2006
    ..Subsequent discontinuation of pergolide was associated with symptomatic improvement. CONCLUSIONS: This case illustrates the severity and rapidity with which cardiac valvular abnormalities can develop in patients receiving pergolide...
  17. ncbi Treatment of Parkinson's disease
    W R Wayne Martin
    Division of Neurology, University of Alberta, Edmonton, AB, Canada
    Can J Neurol Sci 30:S27-33. 2003
    ..All therapeutic interventions must be tailored to the individual and modified as the disease progresses, with the goal of minimizing significant functional disability as much as possible...
  18. ncbi Value of an enzymatic assay for the determination of serum ceruloplasmin
    Georgina Macintyre
    Department of Medical Genetics, University of Alberta, Edmonton, Canada
    J Lab Clin Med 144:294-301. 2004
    ....
  19. ncbi Excessive daytime sleepiness and sudden-onset sleep in Parkinson disease: a survey by the Canadian Movement Disorders Group
    Douglas E Hobson
    Department of Medicine, University of Maitoba, Winnipeg
    JAMA 287:455-63. 2002
    ..The frequency of these spells and whether driving should be restricted has yet to be established...
  20. ncbi Excessive sleepiness in Parkinson's disease: a wake-up call
    W R Wayne Martin
    Can J Neurol Sci 34:401. 2007
  21. ncbi Subthalamic nucleus stimulation in Parkinson disease: exciting or depressing?
    W R Wayne Martin
    Neurology 71:704-5. 2008
  22. ncbi Is there seasonal variation in risk of Parkinson's disease?
    Ronald B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    Mov Disord 22:1097-101. 2007
    ..We found no evidence of systematic seasonal variation in PD incidence by birth date, or of clustering of birth dates during influenza pandemic years in PD patients...

Research Grants3

  1. Parkinson's Disease Neuroprotection Trial: Clinical Center
    W Martin; Fiscal Year: 2007
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