Walter P Maksymowych

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. ncbi Biochemical markers of ongoing joint damage in rheumatoid arthritis--current and future applications, limitations and opportunities
    Morten A Karsdal
    Nordic Bioscience, Herlev Hovedgade 207, DK 2730 Herlev, Denmark
    Arthritis Res Ther 13:215. 2011
  2. ncbi Assessment of radiographic progression in the spines of patients with ankylosing spondylitis treated with adalimumab for up to 2 years
    Desiree van der Heijde
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Res Ther 11:R127. 2009
  3. ncbi Association of the IL1 gene cluster with susceptibility to ankylosing spondylitis: an analysis of three Canadian populations
    Walter P Maksymowych
    University of Alberta, Edmonton, Alberta, Canada
    Arthritis Rheum 54:974-85. 2006
  4. ncbi Association of a specific ERAP1/ARTS1 haplotype with disease susceptibility in ankylosing spondylitis
    W P Maksymowych
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Arthritis Rheum 60:1317-23. 2009
  5. ncbi MRI in ankylosing spondylitis
    Walter P Maksymowych
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Curr Opin Rheumatol 21:313-7. 2009
  6. ncbi Spondyloarthritis research Consortium of Canada magnetic resonance imaging index for assessment of sacroiliac joint inflammation in ankylosing spondylitis
    Walter P Maksymowych
    University of Alberta, Edmonton, Canada
    Arthritis Rheum 53:703-9. 2005
  7. ncbi Progress in spondylarthritis. Spondyloarthritis: lessons from imaging
    Walter P Maksymowych
    Department of Medicine, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    Arthritis Res Ther 11:222. 2009
  8. ncbi Etanercept exerts beneficial effects on articular cartilage biomarkers of degradation and turnover in patients with ankylosing spondylitis
    Walter P Maksymowych
    Department of Medicine, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    J Rheumatol 32:1911-7. 2005
  9. ncbi Spondyloarthritis Research Consortium of Canada magnetic resonance imaging index for assessment of spinal inflammation in ankylosing spondylitis
    Walter P Maksymowych
    University of Alberta, Edmonton, Alberta, Canada
    Arthritis Rheum 53:502-9. 2005
  10. ncbi Novel therapies for ankylosing spondylitis
    Walter P Maksymowych
    Alberta Heritage Foundation for Medical Research, University of Alberta, 562 Heritage Medical Research Building, Edmonton, Alberta T6G 2S2, Canada
    Curr Rheumatol Rep 7:182-7. 2005

Detail Information

Publications102 found, 100 shown here

  1. ncbi Biochemical markers of ongoing joint damage in rheumatoid arthritis--current and future applications, limitations and opportunities
    Morten A Karsdal
    Nordic Bioscience, Herlev Hovedgade 207, DK 2730 Herlev, Denmark
    Arthritis Res Ther 13:215. 2011
    ....
  2. ncbi Assessment of radiographic progression in the spines of patients with ankylosing spondylitis treated with adalimumab for up to 2 years
    Desiree van der Heijde
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Res Ther 11:R127. 2009
    ..Our objective was to compare the progression of structural damage in the spine in patients with AS treated with adalimumab for up to 2 years versus patients who had not received TNF antagonist therapy...
  3. ncbi Association of the IL1 gene cluster with susceptibility to ankylosing spondylitis: an analysis of three Canadian populations
    Walter P Maksymowych
    University of Alberta, Edmonton, Alberta, Canada
    Arthritis Rheum 54:974-85. 2006
    ..To examine the association between the IL1 gene cluster and susceptibility to ankylosing spondylitis (AS) in 3 independent case-control cohorts...
  4. ncbi Association of a specific ERAP1/ARTS1 haplotype with disease susceptibility in ankylosing spondylitis
    W P Maksymowych
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Arthritis Rheum 60:1317-23. 2009
    ....
  5. ncbi MRI in ankylosing spondylitis
    Walter P Maksymowych
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Curr Opin Rheumatol 21:313-7. 2009
    ..Studies using new MRI-based technologies in ankylosing spondylitis have also been described...
  6. ncbi Spondyloarthritis research Consortium of Canada magnetic resonance imaging index for assessment of sacroiliac joint inflammation in ankylosing spondylitis
    Walter P Maksymowych
    University of Alberta, Edmonton, Canada
    Arthritis Rheum 53:703-9. 2005
    ....
  7. ncbi Progress in spondylarthritis. Spondyloarthritis: lessons from imaging
    Walter P Maksymowych
    Department of Medicine, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    Arthritis Res Ther 11:222. 2009
    ..Ultrasound may be the preferred approach to the assessment of peripheral inflammation, especially enthesitis. Scintigraphy and computed tomography offer few advantages over MRI...
  8. ncbi Etanercept exerts beneficial effects on articular cartilage biomarkers of degradation and turnover in patients with ankylosing spondylitis
    Walter P Maksymowych
    Department of Medicine, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    J Rheumatol 32:1911-7. 2005
    ..The low sensitivity to change over time of plain radiographic instruments mandates a search for the effects of these therapies on possible biomarkers of cartilage damage...
  9. ncbi Spondyloarthritis Research Consortium of Canada magnetic resonance imaging index for assessment of spinal inflammation in ankylosing spondylitis
    Walter P Maksymowych
    University of Alberta, Edmonton, Alberta, Canada
    Arthritis Rheum 53:502-9. 2005
    ....
  10. ncbi Novel therapies for ankylosing spondylitis
    Walter P Maksymowych
    Alberta Heritage Foundation for Medical Research, University of Alberta, 562 Heritage Medical Research Building, Edmonton, Alberta T6G 2S2, Canada
    Curr Rheumatol Rep 7:182-7. 2005
    ..Conventional second line therapies typically used in rheumatoid arthritis have also been examined and while leflunomide appears to possess limited efficacy, there may be a case for re-examining the value of methotrexate...
  11. ncbi Reappraisal of OMERACT 8 draft validation criteria for a soluble biomarker reflecting structural damage endpoints in rheumatoid arthritis, psoriatic arthritis, and spondyloarthritis: the OMERACT 9 v2 criteria
    Walter P Maksymowych
    Heritage Medical Research Building, University of Alberta, Edmonton, Alberta, Canada
    J Rheumatol 36:1785-91. 2009
    ..At OMERACT 9 we aimed to scrutinize the necessity for each of these criteria according to the objectives of the working group...
  12. ncbi Proposal for levels of evidence schema for validation of a soluble biomarker reflecting damage endpoints in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis, and recommendations for study design
    Walter P Maksymowych
    Heritage Medical Research Building, University of Alberta, Edmonton, Alberta, Canada
    J Rheumatol 36:1792-9. 2009
    ..We also aimed to generate consensus on minimum standards for the design of longitudinal studies aimed at validating biomarkers...
  13. ncbi Inflammatory lesions of the spine on magnetic resonance imaging predict the development of new syndesmophytes in ankylosing spondylitis: evidence of a relationship between inflammation and new bone formation
    Walter P Maksymowych
    University of Alberta, Department of Medicine, Edmonton, Alberta, Canada
    Arthritis Rheum 60:93-102. 2009
    ....
  14. ncbi Imaging in ankylosing spondylitis
    Walter P Maksymowych
    Department of Medicine, University of Alberta, 562 Heritage Medical Research Building, Edmonton, Alta, Canada T6G 2S2
    Best Pract Res Clin Rheumatol 20:507-19. 2006
    ..The prognostic significance of acute changes on MRI remains unclear. Reliable approaches to the evaluation of chronic changes are yet to be developed. MRI represents a major advance in the diagnostic evaluation of AS...
  15. ncbi Validation of the spondyloarthritis research consortium of Canada magnetic resonance imaging spinal inflammation index: is it necessary to score the entire spine?
    Walter P Maksymowych
    University of Alberta, Edmonton, Alberta, Canada
    Arthritis Rheum 57:501-7. 2007
    ..Scoring of the entire spine limits feasibility and a scoring method that records inflammation in only the more severely affected spinal segments may improve feasibility without sacrificing performance...
  16. ncbi Development of draft validation criteria for a soluble biomarker to be regarded as a valid biomarker reflecting structural damage endpoints in rheumatoid arthritis and spondyloarthritis clinical trials
    Walter P Maksymowych
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Rheumatol 34:634-40. 2007
    ..Our objective was to develop validation criteria for a soluble biomarker to be regarded as a valid biomarker reflecting radiological endpoints in RA and SpA clinical trials...
  17. ncbi Development and validation of the Spondyloarthritis Research Consortium of Canada (SPARCC) Enthesitis Index
    W P Maksymowych
    Department of Medicine, University of Alberta, Canada
    Ann Rheum Dis 68:948-53. 2009
    ..Enthesitis is a recommended core domain for assessment of ankylosing spondylitis (AS), but no measurement has yet been validated according to Outcome Measures in Rheumatoid Arthritis Clinical Trials (OMERACT) criteria...
  18. ncbi Beneficial effects of adalimumab on biomarkers reflecting structural damage in patients with ankylosing spondylitis
    Walter P Maksymowych
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Rheumatol 35:2030-7. 2008
    ..We analyzed the effects of adalimumab on biomarkers predictive of structural damage in inflammatory arthritis...
  19. ncbi Evaluation and validation of the patient acceptable symptom state (PASS) in patients with ankylosing spondylitis
    Walter P Maksymowych
    University of Alberta, Edmonton, Canada
    Arthritis Rheum 57:133-9. 2007
    ..We explored contributors to PASS, validated the PASS concept, and assessed thresholds of self-reported outcomes below which patients considered themselves in PASS...
  20. ncbi Do bisphosphonates and statins have a role in spondyloarthritis management?
    Walter P Maksymowych
    University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    Curr Rheumatol Rep 10:364-70. 2008
    ..Primarily open-label data in spondylo-arthritis suggests mild to moderate efficacy on symptoms and function but their primary clinical role may be as adjunctive therapy to manage systemic osteoporosis and risk for cardiovascular events...
  21. ncbi Development and validation of a simple tape-based measurement tool for recording cervical rotation in patients with ankylosing spondylitis: comparison with a goniometer-based approach
    Walter P Maksymowych
    Department of Medicine, Heritage Medical Research Building, University of Alberta, Edmonton, Alberta, Canada
    J Rheumatol 33:2242-9. 2006
    ..To compare a tape-based tool for measuring cervical mobility in patients with ankylosing spondylitis (AS) with the widely practiced goniometer-based approach...
  22. ncbi Spinal inflammation in ankylosing spondylitis--how and why should it be measured by MRI?
    Walter P Maksymowych
    Department of Medicine, University of Alberta, in Edmonton, AB, Canada
    Nat Clin Pract Rheumatol 2:232-3. 2006
  23. ncbi Does height influence the assessment of spinal and hip mobility measures used in ankylosing spondylitis?
    Walter P Maksymowych
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Rheumatol 33:2035-40. 2006
    ..We examined the contribution of height to the variability of mobility measures in patients with a diverse spectrum of AS disease...
  24. ncbi Development and validation of the Edmonton Ankylosing Spondylitis Metrology Index
    Walter P Maksymowych
    University of Alberta, Edmonton, Alberta, Canada
    Arthritis Rheum 55:575-82. 2006
    ..Our objective was to validate a simple, 4-item composite measure of spinal and hip mobility, the Edmonton AS Metrology Index (EDASMI)...
  25. ncbi Serum matrix metalloproteinase 3 is an independent predictor of structural damage progression in patients with ankylosing spondylitis
    Walter P Maksymowych
    University of Alberta, Edmonton, Alberta, Canada
    Arthritis Rheum 56:1846-53. 2007
    ..This study was undertaken to analyze serologic biomarkers as predictors of radiographic progression in AS...
  26. ncbi Imaging in spondyloarthritis
    Walter P Maksymowych
    Alberta Heritage Foundation for Medical Research, University of Alberta, Edmonton, Alberta, Canada
    Adv Exp Med Biol 649:17-36. 2009
    ..Ultrasound provides a more feasible and cost-effective approach to the assessment of peripheral inflammation, especially enthesitis...
  27. ncbi Thresholds of patient-reported outcomes that define the patient acceptable symptom state in ankylosing spondylitis vary over time and by treatment and patient characteristics
    Walter P Maksymowych
    University of Alberta, Edmonton, Alberta, Canada
    Arthritis Care Res (Hoboken) 62:826-34. 2010
    ..We evaluated whether ankylosing spondylitis (AS) patient characteristics were associated with attaining the PASS and whether these characteristics influenced PASS thresholds for patient-reported outcome (PRO) tools...
  28. ncbi Disease modification in ankylosing spondylitis
    Walter P Maksymowych
    Department of Medicine, 562 Heritage Medical Research Building, University of Alberta, Edmonton, Alberta, Canada
    Nat Rev Rheumatol 6:75-81. 2010
    ..Therapeutic trials recruiting patients early in their disease course and at high risk of radiographic progression constitute a high priority for clinical research in AS...
  29. ncbi Biomarkers in spondyloarthritis
    Walter P Maksymowych
    Department of Medicine, University of Alberta, 562 Heritage Medical Research Building, Edmonton, AB, T6G 2S2, Canada
    Curr Rheumatol Rep 12:318-24. 2010
    ....
  30. ncbi Amelioration of accelerated collagen induced arthritis by a novel calcineurin inhibitor, ISA(TX)247
    Walter P Maksymowych
    Department of Medicine, University of Alberta, Edmonton, Canada
    J Rheumatol 29:1646-52. 2002
    ..ISA(TX)247 has up to 3-fold greater potency than CSA in an in vitro whole blood calcineurin inhibition assay and in in vivo solid organ and cell transplantation models. Phase I clinical trials show no discernible nephrotoxicity...
  31. ncbi Novel therapies in the treatment of spondyloarthritis
    Walter P Maksymowych
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    Expert Opin Investig Drugs 11:937-46. 2002
    ..Significant costs and the requirement for continuous therapy are likely to spur the development of orally bioavailable agents targeting TNF- alpha expression...
  32. ncbi Infliximab in ankylosing spondylitis: a prospective observational inception cohort analysis of efficacy and safety
    Walter P Maksymowych
    Department of Medicine, University of Alberta, Edmonton, Canada
    J Rheumatol 29:959-65. 2002
    ..We also used a lower dose, 3 mg/kg, than has been evaluated to date in AS...
  33. ncbi A six-month randomized, controlled, double-blind, dose-response comparison of intravenous pamidronate (60 mg versus 10 mg) in the treatment of nonsteroidal antiinflammatory drug-refractory ankylosing spondylitis
    Walter P Maksymowych
    University of Alberta, Edmonton, Alberta, Canada
    Arthritis Rheum 46:766-73. 2002
    ..To determine the safety and efficacy of intravenous (IV) pamidronate treatment in ankylosing spondylitis (AS) patients who have had a suboptimal response to nonsteroidal antiinflammatory drugs (NSAIDs)...
  34. ncbi A randomized, placebo controlled trial of an antisense oligodeoxynucleotide to intercellular adhesion molecule-1 in the treatment of severe rheumatoid arthritis
    Walter P Maksymowych
    Department of Medicine, University of Alberta, Edmonton, Canada
    J Rheumatol 29:447-53. 2002
    ....
  35. ncbi Diagnostic utility of MRI in early spondyloarthritis
    Walter P Maksymowych
    Department of Medicine, University of Alberta, Edmonton, AB, T6G 2S2, Canada
    Curr Rheumatol Rep 13:402-8. 2011
    ..Interest in MRI for SpA is poised for substantial growth...
  36. ncbi Anti-inflammatory and immunomodulatory therapies in spondyloarthropathies
    W P Maksymowych
    Associate Professor of Medicine, Rheumatic Disease Unit, University of Alberta, 562 Heritage Medical Research Center, Edmonton, AB T6G 2S2, Canada
    Curr Opin Investig Drugs 1:63-9. 2000
    ..However, the recent development of internationally standardized and validated clinical outcome assessment tools as well as sophisticated magnetic resonance imaging are rekindling interest in these disorders...
  37. ncbi HLA and cytokine gene polymorphisms in relation to occurrence of palindromic rheumatism and its progression to rheumatoid arthritis
    Walter P Maksymowych
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Rheumatol 29:2319-26. 2002
    ..Our objective was to determine the contribution of HLA and cytokine gene polymorphisms implicated in RA to predisposition to PR and to progression of PR to chronic joint inflammation...
  38. ncbi Low-dose infliximab (3 mg/kg) significantly reduces spinal inflammation on magnetic resonance imaging in patients with ankylosing spondylitis: a randomized placebo-controlled study
    Walter P Maksymowych
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Rheumatol 37:1728-34. 2010
    ..The dose recommended for rheumatoid arthritis (3 mg/kg) is also clinically effective for ankylosing spondylitis (AS), although effects on spinal inflammation as defined by MRI have yet to be described in a placebo-controlled trial...
  39. ncbi Validation of definitions for structural lesions detected by magnetic resonance imaging in the spine of patients with spondyloarthritis
    Praveena Chiowchanwisawakit
    Address correspondence to Dr W P Maksymowych, 562 Heritage Medical Research Building, University of Alberta, Edmonton, Alberta T6G 2S2, Canada E mail
    J Rheumatol Suppl 84:39-47. 2009
    ..Despite rigorous standardization of definitions, substantial calibration is required for vertebral corner erosions and bone spurs...
  40. ncbi Validation of definitions for active inflammatory lesions detected by magnetic resonance imaging in the spine of patients with spondyloarthritis
    Susanne J Pedersen
    Address correspondence to Dr W Maksymowych, 562 Heritage Medical Research Building, University of Alberta, Edmonton, Alberta T6G 2S2, Canada E mail
    J Rheumatol Suppl 84:35-8. 2009
    ..Despite rigorous standardization of definitions, detection of active inflammatory lesions is difficult and requires substantial calibration...
  41. ncbi Ankylosing spondylitis. Not just another pain in the back
    Walter P Maksymowych
    Department of Medicine, University of Alberta, Edmonton
    Can Fam Physician 50:257-62. 2004
    ..To review recent developments in diagnosis and treatment of ankylosing spondylitis (AS)...
  42. ncbi Update in spondylarthropathy
    Walter P Maksymowych
    University of Alberta, Edmonton, Alberta, Canada
    Arthritis Rheum 51:143-6. 2004
  43. ncbi High-throughput single-nucleotide polymorphism analysis of the IL1RN locus in patients with ankylosing spondylitis by matrix-assisted laser desorption ionization-time-of-flight mass spectrometry
    Walter P Maksymowych
    University of Alberta, Edmonton, Alberta, Canada
    Arthritis Rheum 48:2011-8. 2003
    ....
  44. ncbi Impact of age, sex, physical function, health-related quality of life, and treatment with adalimumab on work status and work productivity of patients with ankylosing spondylitis
    Walter P Maksymowych
    University of Alberta, Alberta, Canada
    J Rheumatol 37:385-92. 2010
    ..To determine factors associated with work in patients with ankylosing spondylitis (AS)...
  45. ncbi Canadian Rheumatology Association Consensus on the use of anti-tumor necrosis factor-alpha directed therapies in the treatment of spondyloarthritis
    Walter P Maksymowych
    The University of Alberta, Edmonton, Canada
    J Rheumatol 30:1356-63. 2003
    ..It is the position of the CRA that all therapeutic options should be equally available according to the best judgments of the treating physician and the informed decision of the patient...
  46. ncbi Development and Validation of Web-based Training Modules for Systematic Evaluation of Active Inflammatory Lesions in the Spine and Sacroiliac Joints in Spondyloarthritis
    Walter P Maksymowych
    Address correspondence to Dr W P Maksymowych, 562 Heritage Medical Research Building, University of Alberta, Edmonton, Alberta T6G 2S2, Canada E mail
    J Rheumatol Suppl 84:48-57. 2009
    ..CONCLUSION: Systematic evaluation of SIJ and spinal inflammation by MRI can be significantly improved using Web-based training modules...
  47. ncbi Systematic assessment of inflammation by magnetic resonance imaging in the posterior elements of the spine in ankylosing spondylitis
    Walter P Maksymowych
    University of Alberta, Edmonton, Alberta, Canada
    Arthritis Care Res (Hoboken) 62:4-10. 2010
    ....
  48. ncbi Adalimumab significantly reduces both spinal and sacroiliac joint inflammation in patients with ankylosing spondylitis: a multicenter, randomized, double-blind, placebo-controlled study
    Robert G W Lambert
    University of Alberta, Edmonton, Alberta, Canada
    Arthritis Rheum 56:4005-14. 2007
    ..To compare the efficacy of adalimumab versus placebo in reducing spinal and sacroiliac (SI) joint inflammation, by magnetic resonance imaging (MRI) in patients with active ankylosing spondylitis (AS)...
  49. ncbi Osteoporosis case manager for patients with hip fractures: results of a cost-effectiveness analysis conducted alongside a randomized trial
    Sumit R Majumdar
    Institute of Health Economics and Department of Medicine, University of Alberta, Edmonton, AB T6G 2B7, Canada
    Arch Intern Med 169:25-31. 2009
    ..001). Alongside that trial, we conducted an economic analysis...
  50. ncbi Facilitated bone mineral density testing versus hospital-based case management to improve osteoporosis treatment for hip fracture patients: additional results from a randomized trial
    Donald W Morrish
    University of Alberta, Edmonton, Alberta, Canada
    Arthritis Rheum 61:209-15. 2009
    ..The second phase of the randomized trial compared a less intensive intervention, facilitated bone mineral density (BMD) testing, with usual care and the case manager intervention...
  51. ncbi Association of interleukin 23 receptor variants with psoriatic arthritis
    Proton Rahman
    Department of Medicine, Memorial University, 154 Le Marchant Road, St John s, NL, Canada, A1C 5B8
    J Rheumatol 36:137-40. 2009
    ..Given the interplay between psoriasis and PsA, we examined the association of IL-23R variants in 2 independent Canadian Caucasian cohorts of patients with psoriatic arthritis (PsA)...
  52. ncbi Testing of the preliminary OMERACT validation criteria for a biomarker to be regarded as reflecting structural damage endpoints in rheumatoid arthritis clinical trials: the example of C-reactive protein
    Stephanie O Keeling
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Rheumatol 34:623-33. 2007
    ..2) To assess the strength of recommendation for inclusion of individual criteria in the draft set...
  53. ncbi Clinimetric evaluation of the bath ankylosing spondylitis metrology index in a controlled trial of pamidronate therapy
    Edwin Jauregui
    Heritage Medical Research Centre, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    J Rheumatol 31:2422-8. 2004
    ..Lumbar side flexion was the most responsive of the BASMI components. Changes in the BASMI and its individual components did not correlate well with changes in functional outcomes...
  54. ncbi Testing of the OMERACT 8 draft validation criteria for a soluble biomarker reflecting structural damage in rheumatoid arthritis: a systematic literature search on 5 candidate biomarkers
    Silje W Syversen
    Heritage Medical Research Building, University of Alberta, Edmonton, Alberta, Canada
    J Rheumatol 36:1769-84. 2009
    ..To test the OMERACT 8 draft validation criteria for soluble biomarkers by assessing the strength of literature evidence in support of 5 candidate biomarkers...
  55. ncbi Multifaceted intervention to improve diagnosis and treatment of osteoporosis in patients with recent wrist fracture: a randomized controlled trial
    Sumit R Majumdar
    Department of Medicine, University of Alberta, Edmonton, Alta
    CMAJ 178:569-75. 2008
    ....
  56. ncbi Educational intervention to reduce falls and fear of falling in patients after fragility fracture: results of a controlled pilot study
    Diana Rucker
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Prev Med 42:316-9. 2006
    ..Future strategies must address a number of dimensions beyond simple education...
  57. ncbi Steroid injection for osteoarthritis of the hip: a randomized, double-blind, placebo-controlled trial
    Robert G W Lambert
    Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada
    Arthritis Rheum 56:2278-87. 2007
    ..To determine the efficacy of fluoroscopically guided corticosteroid injection for hip osteoarthritis (OA) in a randomized, double-blind, placebo-controlled trial...
  58. ncbi The impact of MRI on the clinical management of inflammatory arthritides
    Ulrich Weber
    Department of Medicine, Division of Rheumatology, University of Alberta, 562 Heritage Medical Research Centre, Edmonton, Alberta, Canada
    Skeletal Radiol 40:1153-73. 2011
    ..Research should focus on the prognostic significance of MRI lesions in larger cohorts and whether adding MRI to routine care improves clinical and radiographic outcome in patients with inflammatory arthritides...
  59. ncbi Focal fat lesions at vertebral corners on magnetic resonance imaging predict the development of new syndesmophytes in ankylosing spondylitis
    Praveena Chiowchanwisawakit
    University of Alberta, Edmonton, Alberta, Canada
    Arthritis Rheum 63:2215-25. 2011
    ..To support the concept of coupling between inflammation and new bone formation, we tested the hypothesis that focal fat infiltration at a vertebral corner is more likely to evolve into a de novo syndesmophyte...
  60. ncbi The Canadian Rheumatology Association/ Spondyloarthritis Research Consortium of Canada treatment recommendations for the management of spondyloarthritis: a national multidisciplinary stakeholder project
    Walter P Maksymowych
    University of Alberta, Edmonton, Alberta, Canada
    J Rheumatol 34:2273-84. 2007
    ..2) To generate a procedural template for the multidisciplinary development of treatment recommendations...
  61. ncbi The role of anti-cyclic citrullinated peptide antibodies in predicting progression of palindromic rheumatism to rheumatoid arthritis
    Anthony S Russell
    Department of Medicine, Division of Rheumatology, University of Alberta, Edmonton, Alberta, Canada
    J Rheumatol 33:1240-2. 2006
    ..To determine whether the presence of anti-cyclic citrullinated peptide (anti-CCP) antibodies at presentation is of prognostic value in patients with palindromic arthritis...
  62. ncbi The responsiveness of generic health status measures as assessed in patients with rheumatoid arthritis receiving infliximab
    Anthony S Russell
    Rheumatic Disease Unit, University of Alberta, Edmonton, Alberta Canada
    J Rheumatol 30:941-7. 2003
    ..There was a closer association of the patient centered measures of improvement with changes in pain score than with joint counts...
  63. ncbi Prospective observational analysis of the efficacy and safety of low-dose (3 mg/kg) infliximab in ankylosing spondylitis: 4-year followup
    Stephanie Keeling
    Department of Medicine, University of Alberta, Canada
    J Rheumatol 33:558-61. 2006
    ..CONCLUSION: Low-dose (3 mg/kg) infliximab therapy is associated with sustained effectiveness in patients with AS in the real-world setting...
  64. ncbi Use of a case manager to improve osteoporosis treatment after hip fracture: results of a randomized controlled trial
    Sumit R Majumdar
    Department of Medicine, 362 Heritage Medical Research Center, University of Alberta, Edmonton AB T6G 2S2, Canada
    Arch Intern Med 167:2110-5. 2007
    ..The case manager educated patients, arranged bone mineral density tests, provided prescriptions, and communicated with primary care physicians. The intervention was compared with usual care in a randomized controlled trial...
  65. ncbi High prevalence of symptomatic enthesopathy of the shoulder in ankylosing spondylitis: deltoid origin involvement constitutes a hallmark of disease
    Robert G W Lambert
    University of Alberta, Edmonton, Alberta, Canada
    Arthritis Rheum 51:681-90. 2004
    ..Intense acromial bone edema at the deltoid origin is a hitherto undescribed and highly specific feature of AS. Enthesopathy of the rotator cuff is underrecognized in AS and should be incorporated into instruments measuring enthesitis...
  66. ncbi Active inflammatory lesions detected by magnetic resonance imaging in the spine of patients with spondyloarthritis - definitions, assessment system, and reference image set
    Robert G W Lambert
    Address correspondence to Dr R G W Lambert, Department of Radiology and Diagnostic Imaging, University of Alberta, WMC 2A2 41, Edmonton, AB T6G 2B7, Canada E mail
    J Rheumatol Suppl 84:3-17. 2009
    ..The system is designed to study the temporal and spatial patterns of inflammation and their relation to the development of structural damage...
  67. ncbi A controlled trial to increase detection and treatment of osteoporosis in older patients with a wrist fracture
    Sumit R Majumdar
    Department of Medicine, University of Alberta, 2E3 07 Walter Mackenzie Health Sciences Centre, University of Alberta Hospital, 8440 112th Street, Edmonton, Alberta T6G 2B7, Canada
    Ann Intern Med 141:366-73. 2004
    ..Despite the high risk for future fractures and the availability of effective treatments, fewer than 10% to 20% of patients who sustain a fragility fracture are tested or treated for osteoporosis...
  68. ncbi In vivo microfocal computed tomography and micro-magnetic resonance imaging evaluation of antiresorptive and antiinflammatory drugs as preventive treatments of osteoarthritis in the rat
    Michael D Jones
    Pharmacy and Pharmaceutical Sciences, University of Alberta, Dentistry Pharmacy Centre, Edmonton, Alberta, Canada
    Arthritis Rheum 62:2726-35. 2010
    ..To determine whether treatment with an antiresorptive drug in combination with an antiinflammatory drug reduces periarticular bone and soft tissue adaptations associated with the progression of posttraumatic secondary osteoarthritis (OA)...
  69. ncbi Sensitivity and specificity of magnetic resonance imaging for axial spondyloarthritis
    Ulrich Weber
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Am J Med Sci 341:272-7. 2011
    ..Single MRI lesions suggestive of inflammation can be found in the SIJ and the spine in up to one quarter of healthy controls and young patients with mechanical back pain...
  70. ncbi Invasion by Salmonella typhimurium induces increased expression of the LMP, MECL, and PA28 proteasome genes and changes in the peptide repertoire of HLA-B27
    W P Maksymowych
    Departments of Medicine and Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada
    Infect Immun 66:4624-32. 1998
    ....
  71. ncbi Cost-effectiveness of a multifaceted intervention to improve quality of osteoporosis care after wrist fracture
    S R Majumdar
    Department of Medicine, University of Alberta, Edmonton, AB, Canada
    Osteoporos Int 22:1799-808. 2011
    ..An economic analysis of the trial now demonstrates that the intervention tested "dominates" usual care: over a lifetime horizon, it reduces fracture, increases quality-adjusted life years, and saves the healthcare system money...
  72. ncbi Persistence, reproducibility, and cost-effectiveness of an intervention to improve the quality of osteoporosis care after a fracture of the wrist: results of a controlled trial
    S R Majumdar
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Osteoporos Int 18:261-70. 2007
    ..Our objective was to examine longer-term outcomes, reproducibility, and cost-effectiveness of this intervention...
  73. ncbi Nurse case-manager vs multifaceted intervention to improve quality of osteoporosis care after wrist fracture: randomized controlled pilot study
    S R Majumdar
    Department of Medicine, University of Alberta, 8440 112th Street, Edmonton, Alberta, T6G 2B7, Canada
    Osteoporos Int 22:223-30. 2011
    ....
  74. ncbi Clinical and radiological amelioration of refractory peripheral spondyloarthritis by pulse intravenous pamidronate therapy
    W P Maksymowych
    Department of Medicine, University of Alberta, Edmonton, Canada
    J Rheumatol 28:144-55. 2001
    ..CONCLUSION: Preliminary data from uncontrolled studies support the efficacy of pamidronate therapy for NSAID refractory SpA and warrant further evaluation in controlled trials...
  75. ncbi The dosage of infliximab in the treatment of ankylosing spondylitis: dollars and sense
    A S Russell
    Rheumatic Disease Unit, University of Alberta, Edmonton, Canada
    Clin Exp Rheumatol 20:S135-6. 2002
    ....
  76. ncbi Ankylosing spondylitis and current disease-controlling agents: do they work?
    Walter P Maksymowych
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    Best Pract Res Clin Rheumatol 16:619-30. 2002
    ..No conclusions can be drawn from the limited studies evaluating methotrexate...
  77. ncbi Treatment of refractory symphysitis pubis with intravenous pamidronate
    W P Maksymowych
    Department of Medicine, University of Alberta, Edmonton, Canada
    J Rheumatol 28:2754-7. 2001
    ..Remission was also evident in 2 patients on isotope bone scan. Followup has revealed no recurrence. Intravenous pamidronate may constitute a safe and effective treatment option for patients with refractory osteitis pubis...
  78. ncbi Genetics of ankylosing spondylitis and rheumatoid arthritis: where are we at currently, and how do they compare?
    W P Maksymowych
    Alberta Heritage Foundation for Medical Research, Professor of Medicine, University of Alberta, Canada
    Clin Exp Rheumatol 27:S20-5. 2009
    ..In AS, genes involved in response to IL12/IL23, and in endoplasmic reticulum peptide presentation, have been identified, but a full genomewide association study has not yet been reported...
  79. ncbi Mandatory pharmacosurveillance--a Canadian model for access to therapy and research
    S G Barr
    Department of Medicine, University of Calgary, Canada
    Clin Exp Rheumatol 22:S39-43. 2004
    ..The clinic data sheets are available at www. altarheum.com. The program also provides a sustainable model for promoting observational research on therapeutics in general...
  80. ncbi The clinical assessment of patients with psoriatic arthritis: results of a reliability study of the spondyloarthritis research consortium of Canada
    Dafna D Gladman
    The Psoriatic Arthritis Program, University of Toronto, Toronto, Ontario, Canada
    J Rheumatol 31:1126-31. 2004
    ..To evaluate whether rheumatologists experienced in psoriatic arthritis (PsA) assess peripheral and axial involvement in the same way and to consider core clinical measurements that should be included in clinical trials in PsA...
  81. ncbi Reporting process of randomized controlled trials
    Walter P Maksymowych
    CMAJ 170:1375. 2004
  82. ncbi Mandatory pharmacovigilance
    Walter P Maksymowych
    CMAJ 168:672; discussion 672-3. 2003
  83. ncbi Clues to pathogenesis of spondyloarthropathy derived from synovial fluid mononuclear cell gene expression profiles
    Jieruo Gu
    University of California Los Angeles, 90095, USA
    J Rheumatol 29:2159-64. 2002
    ..CONCLUSION: Previous data postulating UPR in SpA are based on in vitro experiments with transfected cell lines. Our patient derived data suggest that it also occurs in vivo in the macrophages of SpA joints...
  84. ncbi Bisphosphonates for arthritis--a confusing rationale
    Walter P Maksymowych
    J Rheumatol 30:430-4. 2003
  85. ncbi Scoring inflammatory activity of the spine by magnetic resonance imaging in ankylosing spondylitis: a multireader experiment
    Cédric Lukas
    Department of Internal Medicine, Division of Rheumatology, University Hospital Maastricht, The Netherlands
    J Rheumatol 34:862-70. 2007
    ..We investigated feasibility, inter-reader reliability, sensitivity to change, and discriminatory ability of 3 different scoring methods for MRI activity and change in activity of the spine in patients with AS...
  86. ncbi International spondyloarthritis interobserver reliability exercise--the INSPIRE study: I. Assessment of spinal measures
    Dafna D Gladman
    Division of Rheumatology, University of Toronto, Toronto, Ontario, Canada
    J Rheumatol 34:1733-9. 2007
    ..To determine whether the axial measures used in primary ankylosing spondylitis (AS) were reproducible for both AS and psoriatic arthritis (PsA) with axial disease...
  87. ncbi Is there a preferred method for scoring activity of the spine by magnetic resonance imaging in ankylosing spondylitis?
    Desiree van der Heijde
    Department of Internal Medicine, Division of Rheumatology, University Hospital Maastricht and CAPHRI Research Institute, University Maastricht, The Netherlands d vanderheijde kpnplanet nl
    J Rheumatol 34:871-3. 2007
    ..The Berlin and SPARCC methods were preferred most frequently. The development of a new method combining the best elements of all methods is an additional possibility...
  88. ncbi Association of interleukin-23 receptor variants with ankylosing spondylitis
    Proton Rahman
    Memorial University, St John s, Newfoundland, Canada
    Arthritis Rheum 58:1020-5. 2008
    ....
  89. ncbi Evaluation of the patient acceptable symptom state as an outcome measure in patients with ankylosing spondylitis: data from a randomized controlled trial
    Maxime Dougados
    Hôpital Cochin and University of Paris, Paris, France
    Arthritis Rheum 59:553-60. 2008
    ..To evaluate the feasibility/acceptability, reliability, external validity, and discriminant capacity of the Patient Acceptable Symptom State (PASS) concept in patients with active ankylosing spondylitis (AS)...
  90. ncbi International spondyloarthritis interobserver reliability exercise--the INSPIRE study: II. Assessment of peripheral joints, enthesitis, and dactylitis
    Dafna D Gladman
    Centre for Prognosis Studies in the Rheumatic Diseases, University of Toronto, Toronto, Ontario, Canada
    J Rheumatol 34:1740-5. 2007
    ..To determine whether the assessments of peripheral joints and enthesitis were reproducible for both AS and PsA with axial disease, and whether dactylitis assessment is reproducible in patients with PsA...
  91. ncbi Rheumatoid arthritis association with the FCRL3 -169C polymorphism is restricted to PTPN22 1858T-homozygous individuals in a Canadian population
    William G Newman
    University of Manchester, Manchester, UK
    Arthritis Rheum 54:3820-7. 2006
    ..The aim of this study was to investigate these associations in a Canadian Caucasian cohort of RA cases and healthy controls...
  92. ncbi The cost-effectiveness of infliximab (Remicade) in the treatment of ankylosing spondylitis in Canada
    Gisela Kobelt
    European Health Economics SAS, Mulhouse, France
    J Rheumatol 33:732-40. 2006
    ..To estimate the cost-effectiveness of the treatment of ankylosing spondylitis (AS) with infliximab (Remicade) in Canada over the long term, with both international and Canadian treatment regimens...
  93. ncbi A randomized, multicenter, double-blind, placebo-controlled phase 2 trial of ISA247 in patients with chronic plaque psoriasis
    Robert Bissonnette
    Innovaderm Research, Montreal, Canada
    J Am Acad Dermatol 54:472-8. 2006
    ..Use of current oral calcineurin inhibitors for the treatment of psoriasis is limited by toxicity...
  94. ncbi Costs and quality of life of patients with ankylosing spondylitis in Canada
    Gisela Kobelt
    European Health Economics SAS, Mulhouse, France
    J Rheumatol 33:289-95. 2006
    ..Our findings provide information on the burden of AS and a baseline for assessing the cost-effectiveness of the new biological agents in this indication...
  95. ncbi Application of the OMERACT filter to scoring methods for magnetic resonance imaging of the sacroiliac joints and the spine. Recommendations for a research agenda at OMERACT 7
    Desiree M F M Van der Heijde
    Department of Internal Medicine, Division of Rheumatology, University Hospital Maastricht, University Maastricht, 6202 AZ Maastricht, The Netherlands
    J Rheumatol 32:2042-7. 2005
    ..Research on assessing structural damage was considered less important. The specific process and results of this initiative are discussed...
  96. ncbi Serum levels of matrix metalloproteinase 3 and macrophage colony-stimulating factor 1 correlate with disease activity in ankylosing spondylitis
    Chunhua Yang
    University of California Los Angeles, USA
    Arthritis Rheum 51:691-9. 2004
    ..CONCLUSION: MMP-3 and M-CSF are potentially useful markers of AS disease activity...
  97. ncbi Lack of linkage of IL1RN genotypes with ankylosing spondylitis susceptibility
    Li Jin
    University of Cincinnati Cincinnati, OH, USA
    Arthritis Rheum 50:3047-8. 2004
  98. ncbi Definitions and validation criteria for biomarkers and surrogate endpoints: development and testing of a quantitative hierarchical levels of evidence schema
    Marissa N Lassere
    Department of Rheumatology, St George Hospital, University of New South Wales, Sydney, Australia
    J Rheumatol 34:607-15. 2007
    ..Our objective was to review the literature on biomarkers and surrogates to develop a hierarchical schema that systematically evaluates and ranks the surrogacy status of biomarkers and surrogates; and to obtain feedback from stakeholders...
  99. ncbi Detection of high levels of 2 specific isoforms of 14-3-3 proteins in synovial fluid from patients with joint inflammation
    Ruhangiz T Kilani
    Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada
    J Rheumatol 34:1650-7. 2007
    ....
  100. ncbi Therapy for ankylosing spondylitis: new treatment modalities
    J Braun
    Rheumazentrum Ruhrgebiet, Landgrafenstr.15, 44652, Herne, Germany
    Best Pract Res Clin Rheumatol 16:631-51. 2002
    ..Hopefully, both agents will be approved soon for the short-term treatment of severe SpA. In parallel, studies should be performed to document the long-term efficacy and safety of this treatment...
  101. ncbi Magnetic resonance imaging for spondyloarthritis--avoiding the minefield
    Walter P Maksymowych
    J Rheumatol 34:259-65. 2007