Research Topics
| P E LightSummaryAffiliation: University of Alberta Country: Canada Publications
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Detail Information
Publications
Molecular basis of protein kinase C-induced activation of ATP-sensitive potassium channelsP E Light
Departments of Physiology and Biophysics, Pharmacology and Therapeutics, and Biochemistry and Molecular Biology, University of Calgary, Calgary, AB, Canada T2N 4N1
Proc Natl Acad Sci U S A 97:9058-63. 2000..The high degree of conservation of this site among different K(ATP) channel isoforms suggests that this pathway may have wide significance for the physiological regulation of K(ATP) channels in various tissues and organelles...- Activation of adenosine triphosphate-sensitive potassium channels by acyl coenzyme A esters involves multiple phosphatidylinositol 4,5-bisphosphate-interacting residuesJocelyn E Manning Fox
Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
Mol Endocrinol 18:679-86. 2004..2. We propose a model in which these residues mediate both direct electrostatic interactions and allosteric modulations of open state stability... - Familial Wolff-Parkinson-White Syndrome: a disease of glycogen storage or ion channel dysfunction?Peter E Light
Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada
J Cardiovasc Electrophysiol 17:S158-S161. 2006..It is the aim of this review to discuss our current knowledge of the cellular disturbances underlying the induction of arrhythmias in patients with PRKAG2 mutations... - The ATP-sensitive K(+) channel ABCC8 S1369A type 2 diabetes risk variant increases MgATPase activityMohammad Fatehi
Alberta Diabetes Institute, Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada
Diabetes 61:241-9. 2012.... - Distinct myoprotective roles of cardiac sarcolemmal and mitochondrial KATP channels during metabolic inhibition and recoveryP E Light
Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada
FASEB J 15:2586-94. 2001..Our data suggest that sarc and mitoKATP channel populations play distinct protective roles, triggered by PKC and/or adenosine, during chemically induced hypoxia/reoxygenation... - Constitutively active adenosine monophosphate-activated protein kinase regulates voltage-gated sodium channels in ventricular myocytesPeter E Light
Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
Circulation 107:1962-5. 2003..Some PRKAG2 mutations in the human gene encoding for the gamma-subunit of the adenosine monophosphate-activated protein kinase (AMPK) recently have been shown to cause rhythm disturbances (often fatal) in affected patients... - Glucagon-like peptide-1 inhibits pancreatic ATP-sensitive potassium channels via a protein kinase A- and ADP-dependent mechanismPeter E Light
Department of Pharmacology Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
Mol Endocrinol 16:2135-44. 2002..The marked alteration of the PKA-mediated effects at different ADP levels may provide a cellular mechanism for the glucose-sensitivity of GLP-1... - Identification and properties of ATP-sensitive potassium channels in myocytes from rabbit Purkinje fibresP E Light
Department of Physiology and Biophysics, University of Calgary, Alberta, Canada
Cardiovasc Res 44:356-69. 1999..Our goal was to identify the ATP-sensitive potassium (KATP) channels in cardiac Purkinje cells and to document the functional properties that might distinguish them from KATP channels in other parts of the heart... - Inhibition by protein kinase C of the K(NDP) subtype of vascular smooth muscle ATP-sensitive potassium channelW C Cole
Smooth Muscle Research Group, Faculty of Medicine, University of Calgary, Alberta, Canada
Circ Res 87:112-7. 2000..Control of K(NDP) activity by intracellular signaling cascades involving PKC may, therefore, contribute to control of tone and arterial diameter by vasoconstrictors... - Leptin reduces glucose transport and cellular ATP levels in INS-1 beta-cellsN T Lam
Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
J Mol Endocrinol 32:415-24. 2004..In addition, leptin reduced glucose transport by 35% in isolated rat hepatocytes that also express GLUT2, suggesting that glucose transport may also be altered by leptin in other glucose-responsive tissues such as the liver... - Inhibition of matrix metalloproteinases prevents peroxynitrite-induced contractile dysfunction in the isolated cardiac myocyteH Leon
Cardiovascular Research Group, University of Alberta, Edmonton, Alberta, Canada
Br J Pharmacol 153:676-83. 2008..The purpose of this study was to examine the effects of ONOO(-) on contractile function at the level of the single cardiac myocyte and whether this includes the action of MMPs... - Inhibition of cardiac voltage-gated sodium channels by grape polyphenolsC H R Wallace
Department of Pharmacology, University of Alberta, 9-58 Medical Sciences Building, Edmonton, Alberta, Canada
Br J Pharmacol 149:657-65. 2006..CONCLUSIONS AND IMPLICATIONS: Our results indicate that several red grape polyphenols inhibit cardiac VGSCs and that this effect may contribute to the documented cardioprotective efficacy of red grape products... - Cardiac KATP channels and ischemic preconditioning: current perspectivesP E Light
University of Calgary, Calgary, Canada
Can J Cardiol 15:1123-30. 1999..Because KATP channels are rich and varied pharmacologically, it may be possible to target therapeutic agents at the cardiac channel isoform. Such compounds would likely meet the pharmacological criteria for a 'conditioning' agent... - Electrophysiological characterization and ionic stoichiometry of the rat brain K(+)-dependent NA(+)/CA(2+) exchanger, NCKX2H Dong
Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta T2N 4N1, Canada
J Biol Chem 276:25919-28. 2001.... - Variations in tissue selectivity amongst insulin secretagogues: a systematic reviewA S Abdelmoneim
Faculty of Pharmacy and Pharmaceutical Sciences, 3126 Dentistry Pharmacy Centre, University of Alberta, Edmonton, Alberta, Canada
Diabetes Obes Metab 14:130-8. 2012..This study was designed to identify insulin secretagogues that selectively bind to SUR1 when given at therapeutic doses... - The multiple actions of GLP-1 on the process of glucose-stimulated insulin secretionPatrick E MacDonald
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Diabetes 51:S434-42. 2002..The present article will focus principally on the mechanisms proposed to underlie the glucose dependence of GLP-1's insulinotropic effect... - Metabolic regulation of sodium-calcium exchange by intracellular acyl CoAsMichael J Riedel
Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada
EMBO J 25:4605-14. 2006..Additionally, our findings have broad implications for the coupling of Ca(2+) homeostasis to fat metabolism in a variety of tissues... - Ranolazine decreases diastolic calcium accumulation caused by ATX-II or ischemia in rat heartsHeather Fraser
CV Therapeutics Inc, Palo Alto, CA 94304, USA
J Mol Cell Cardiol 41:1031-8. 2006..The beneficial effects of ranolazine in reducing Ca2+ overload and LV mechanical dysfunction during ischemia/reperfusion is consistent with the inhibition of late INa mechanism of action... - Carbonic anhydrase inhibition prevents and reverts cardiomyocyte hypertrophyBernardo V Alvarez
Department of Physiology, Membrane Protein Research Group, University of Alberta, Edmonton, Canada T6G2H7
J Physiol 579:127-45. 2007..Our study demonstrates a novel role for CA in mediating the hypertrophic response of cardiac myocytes to PE and suggests that CA inhibition represents an effective therapeutic approach towards mitigation of the hypertrophic phenotype... - Elevation in intracellular long-chain acyl-coenzyme A esters lead to reduced beta-cell excitability via activation of adenosine 5'-triphosphate-sensitive potassium channelsNicola J Webster
Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada
Endocrinology 149:3679-87. 2008..These results suggest a direct link between intracellular fatty ester accumulation and K(ATP) channel activation, which may contribute to beta-cell dysfunction in type 2 diabetes... - Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and AktAnita Y M Chan
Cardiovascular Research Group and the Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
J Biol Chem 283:24194-201. 2008..Taken together, our data suggest that resveratrol exerts anti-hypertrophic effects by activating AMPK via LKB1 and inhibiting Akt, thus suppressing protein synthesis and gene transcription... - Splice variant-dependent regulation of beta-cell sodium-calcium exchange by acyl-coenzyme AsKevin S C Hamming
Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
Mol Endocrinol 22:2293-306. 2008.... - Identification and pharmacological characterization of sarcolemmal ATP-sensitive potassium channels in the murine atrial HL-1 cell lineJocelyn E Manning Fox
Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada
J Cardiovasc Pharmacol 45:30-5. 2005.... - The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanismWasim El-kholy
Department of Medicine, University of Toronto, Ontario, Canada
FASEB J 17:720-2. 2003..Furthermore, LY294002 may represent a novel structure from which future Kv channel blockers may be developed... - Protein kinase C modulation of recombinant ATP-sensitive K(+) channels composed of Kir6.1 and/or Kir6.2 expressed with SUR2BKevin S Thorneloe
Smooth Muscle Research Group and Canadian Institutes of Health Research Group in Regulation of Vascular Contractility, University of Calgary, Calgary, Alberta, Canada
J Physiol 541:65-80. 2002..1 and their associated SUR2B subunits... - Experiments to test the role of phosphatidylinositol 4,5-bisphosphate in neurotransmitter-induced M-channel closure in bullfrog sympathetic neuronsChristopher P Ford
Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
J Neurosci 23:4931-41. 2003..These are the results that might be expected if agonist-induced activation of PLC and the concomitant depletion of PIP2 contribute to the excitatory action of neurotransmitters that suppress gM... - Kir6.2 polymorphisms sensitize beta-cell ATP-sensitive potassium channels to activation by acyl CoAs: a possible cellular mechanism for increased susceptibility to type 2 diabetes?Michael J Riedel
Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada
Diabetes 52:2630-5. 2003.... - Acyl coenzyme A esters differentially activate cardiac and beta-cell adenosine triphosphate-sensitive potassium channels in a side-chain length-specific mannerJocelyn E Manning Fox
Department of Pharmalology, University of Alberta, Edmonton, Alberta, Canada
Metabolism 52:1313-9. 2003..We propose that fatty acid metabolism, and the resultant generation of acyl CoAs of varying side-chain length, may be an important regulator of cellular excitability via interactions with the K(ATP) channel... - Cardioselectivity of the sulphonylurea HMR 1098: studies on native and recombinant cardiac and pancreatic K(ATP) channelsJocelyn E Manning Fox
Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada
Br J Pharmacol 135:480-8. 2002..The non-aromatic substitutions in the sulphonylurea moiety greatly increase the cardioselectivity of this compound while reducing the overall blocking potency of this sulphonylurea derivative... - Syntaxin-1A inhibits cardiac KATP channels by its actions on nucleotide binding folds 1 and 2 of sulfonylurea receptor 2AYouhou Kang
Department of Medicine, University of Toronto, Toronto M5S 1A8, Canada
J Biol Chem 279:47125-31. 2004.... - Upper intestinal lipids trigger a gut-brain-liver axis to regulate glucose productionPenny Y T Wang
Toronto General Hospital Research Institute, University Health Network, Toronto M5G 1L7, Canada
Nature 452:1012-6. 2008..These findings indicate that upper intestinal lipids activate an intestine-brain-liver neural axis to inhibit glucose production, and thereby reveal a previously unappreciated pathway that regulates glucose homeostasis... - Hypothalamic protein kinase C regulates glucose productionRachel Ross
Departments of Molecular Pharmacology, Medicine, and Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA
Diabetes 57:2061-5. 2008..2 ATP-sensitive K(+) (K(ATP)) channels inhibit hepatic glucose production. The mechanisms that link the ability of hypothalamic lipid metabolism to the activation of K(ATP) channels remain unknown... - Current status of the E23K Kir6.2 polymorphism: implications for type-2 diabetesMichael J Riedel
Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada, T6G 2H7
Hum Genet 116:133-45. 2005.... - Saturated and cis/trans unsaturated acyl CoA esters differentially regulate wild-type and polymorphic beta-cell ATP-sensitive K+ channelsMichael J Riedel
Department of Pharmacology, University of Alberta, 9 58 Medical Sciences Building, Edmonton, Alberta T6G 2H7, Canada
Diabetes 54:2070-9. 2005....