Shanelle W Ko

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi Pavlovian fear memory induced by activation in the anterior cingulate cortex
    Jianrong Tang
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, University of Toronto, Medical Sciences Building, Rm 3342, 1 King s College Circle, Toronto, ON M5S 1A8, Canada
    Mol Pain 1:6. 2005
  2. ncbi Cingulate NMDA NR2B receptors contribute to morphine-induced analgesic tolerance
    Shanelle W Ko
    Department of Physiology, University of Toronto, University of Toronto Centre for the Study of Pain, Canada
    Mol Brain 1:2. 2008
  3. ncbi Contribution of CaMKIV to injury and fear-induced ultrasonic vocalizations in adult mice
    Shanelle W Ko
    Department of Physiology, University of Toronto, Centre for the Study of Pain, Faculty of Medicine, Medical Science Building, Room 3342, 1 King s College Circle, Toronto, Ontario, M5S 1A8, Canada
    Mol Pain 1:10. 2005
  4. ncbi Increased anxiety-like behavior and enhanced synaptic efficacy in the amygdala of GluR5 knockout mice
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 2:e167. 2007
  5. ncbi Alteration of cingulate long-term plasticity and behavioral sensitization to inflammation by environmental enrichment
    Fanny W F Shum
    Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, 1 King s College Circle, University of Toronto, Toronto, Canada
    Learn Mem 14:304-12. 2007
  6. ncbi Enhanced presynaptic neurotransmitter release in the anterior cingulate cortex of mice with chronic pain
    Ming Gao Zhao
    Department of Physiology, Faculty of Medicine, and Centre for the Study of Pain, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Neurosci 26:8923-30. 2006
  7. ncbi Evidence for a role of CaMKIV in the development of opioid analgesic tolerance
    Shanelle W Ko
    Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, 1 King s College Circle, Medical Sciences Building Rm3342, Toronto, Canada, M5S 1A8
    Eur J Neurosci 23:2158-68. 2006
  8. ncbi Deficits in trace fear memory and long-term potentiation in a mouse model for fragile X syndrome
    Ming Gao Zhao
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    J Neurosci 25:7385-92. 2005
  9. ncbi Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, Toronto, Ontario, M5S 1A8, Canada
    J Neurosci 25:11107-16. 2005
  10. ncbi Genetic alteration of anxiety and stress-like behavior in mice lacking CaMKIV
    Fanny W F Shum
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    Mol Pain 1:22. 2005

Detail Information

Publications19

  1. ncbi Pavlovian fear memory induced by activation in the anterior cingulate cortex
    Jianrong Tang
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, University of Toronto, Medical Sciences Building, Rm 3342, 1 King s College Circle, Toronto, ON M5S 1A8, Canada
    Mol Pain 1:6. 2005
    ..Our results provide strong evidence that the excitatory activity in the ACC contribute to pain-related fear memory as well as descending facilitatory modulation of spinal nociception...
  2. ncbi Cingulate NMDA NR2B receptors contribute to morphine-induced analgesic tolerance
    Shanelle W Ko
    Department of Physiology, University of Toronto, University of Toronto Centre for the Study of Pain, Canada
    Mol Brain 1:2. 2008
    ....
  3. ncbi Contribution of CaMKIV to injury and fear-induced ultrasonic vocalizations in adult mice
    Shanelle W Ko
    Department of Physiology, University of Toronto, Centre for the Study of Pain, Faculty of Medicine, Medical Science Building, Room 3342, 1 King s College Circle, Toronto, Ontario, M5S 1A8, Canada
    Mol Pain 1:10. 2005
    ..Our results provide a new approach for investigating the molecular mechanism for emotional vocalization in mice and suggest that CaMKIV dependent signaling pathways play an important role in the emotional response to pain and fear...
  4. ncbi Increased anxiety-like behavior and enhanced synaptic efficacy in the amygdala of GluR5 knockout mice
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 2:e167. 2007
    ..Our results suggest that GluR5 is a key regulator of inhibitory circuits in the amygdala and highlight the potential use of GluR5-specific drugs in the treatment of pathological anxiety...
  5. ncbi Alteration of cingulate long-term plasticity and behavioral sensitization to inflammation by environmental enrichment
    Fanny W F Shum
    Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, 1 King s College Circle, University of Toronto, Toronto, Canada
    Learn Mem 14:304-12. 2007
    ..Our findings suggest that exposure to EE alters physiological properties within the ACC which results in enhanced responses to inflammation...
  6. ncbi Enhanced presynaptic neurotransmitter release in the anterior cingulate cortex of mice with chronic pain
    Ming Gao Zhao
    Department of Physiology, Faculty of Medicine, and Centre for the Study of Pain, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Neurosci 26:8923-30. 2006
    ..Our findings provide strong evidence that presynaptic alterations caused by peripheral inflammation contribute to memory impairments after injury...
  7. ncbi Evidence for a role of CaMKIV in the development of opioid analgesic tolerance
    Shanelle W Ko
    Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, 1 King s College Circle, Medical Sciences Building Rm3342, Toronto, Canada, M5S 1A8
    Eur J Neurosci 23:2158-68. 2006
    ..Our results provide novel evidence for the role of CaMKIV in the development of opioid analgesic tolerance but not physical dependence...
  8. ncbi Deficits in trace fear memory and long-term potentiation in a mouse model for fragile X syndrome
    Ming Gao Zhao
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    J Neurosci 25:7385-92. 2005
    ..This suggests that synaptic plasticity in the ACC and amygdala of FMR1 KO mice plays an important role in the expression of behavioral phenotypes similar to the symptoms of fragile X syndrome...
  9. ncbi Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, Toronto, Ontario, M5S 1A8, Canada
    J Neurosci 25:11107-16. 2005
    ..Our results demonstrate that the upregulation of NR2B receptors in the ACC contributes to behavioral sensitization caused by inflammation...
  10. ncbi Genetic alteration of anxiety and stress-like behavior in mice lacking CaMKIV
    Fanny W F Shum
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    Mol Pain 1:22. 2005
    ..In addition, CaMKIV(-/-) mice displayed a lack of stress-induced analgesia following restraint or cold swim stress. Our results demonstrate a key role for CaMKIV in anxiety and stress-related behavior...
  11. ncbi A new assay of thermal-based avoidance test in freely moving mice
    Hoi-Ki Ding
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, Toronto, Ontario, Canada
    J Pain 6:411-6. 2005
    ..The measure of escape responses might be useful in the assessment of memory defects, evaluation of drug therapies, and the behavioral characterization of transgenic mice...
  12. ncbi Genetic reduction of chronic muscle pain in mice lacking calcium/calmodulin-stimulated adenylyl cyclases
    Kunjumon I Vadakkan
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, University of Toronto, ON, Canada
    Mol Pain 2:7. 2006
    ..Muscle pain is different from cutaneous pain in its characteristics as well as conducting fibers. Therefore, we conducted the present work to test the role of AC1 and AC8 in both acute persistent and chronic muscle pain...
  13. ncbi Kainate receptor-mediated synaptic transmission in the adult anterior cingulate cortex
    Long Jun Wu
    Department of Physiology, University of Toronto, Medical Sciences Bldg, Rm 3342, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    J Neurophysiol 94:1805-13. 2005
    ..Our results show that KA receptors contribute to synaptic transmission in adult ACC pyramidal neurons and provide a synaptic basis for the physiology and pathology of KA receptors in ACC-related functions...
  14. ncbi Feed-forward inhibition: a novel cellular mechanism for the analgesic effect of substance P
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, Medical Science Building, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pain 1:34. 2005
    ..It is believed that through this inhibition, substance P can balance nociceptive output from the spinal cord...
  15. ncbi Kainate receptors and pain: from dorsal root ganglion to the anterior cingulate cortex
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, Medical Science Building, 1 King s College Circle, Toronto, Ontario, Canada
    Curr Pharm Des 13:1597-605. 2007
    ..Recent genetic and pharmacological studies suggest that kainate receptors can regulate nociceptive responses. These results highlight kainate receptors as a target for the development of new treatments for chronic pain...
  16. ncbi Hot receptors in the brain
    Hendrik W Steenland
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Canada
    Mol Pain 2:34. 2006
    ..In addition, some regions of the brain utilize the TRPV1 receptor for functions apparently unrelated to pain...
  17. ncbi CREB activity maintains the survival of cingulate cortical pyramidal neurons in the adult mouse brain
    Hushan Ao
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, 1 King s College Circle, Toronto, Ontario, M5S 1A8, Canada
    Mol Pain 2:15. 2006
    ..Our findings suggest that constitutively active CREB phosphorylation is important for the survival of mammalian cells in the brain...
  18. ncbi Selective contribution of Egr1 (zif/268) to persistent inflammatory pain
    Shanelle W Ko
    Department of Physiology, University of Toronto, Faculty of Medicine, University of Toronto Centre for the Study of Pain, Toronto, Ontario, Canada
    J Pain 6:12-20. 2005
    ..Egr1 knockout mice showed reduced nociceptive behaviors to persistent inflammatory pain and inflammation increased Egr1 expression in the anterior cingulate cortex of wild-type mice...
  19. ncbi Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory
    Ming Gao Zhao
    Laboratory of Higher Brain Functions, Institute of Neurobiology, Fudan University, 220 Han Dan Road, Shanghai 200433, China
    Neuron 47:859-72. 2005
    ..Our results demonstrate that the NR2B subunit of the NMDA receptor in the prefrontal cortex is critically involved in both LTP and contextual memory...