Research Topics
Genomes and GenesSpecies | Niranjan KissoonSummaryAffiliation: University of British Columbia Country: Canada Publications
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Publications
Diagnosis and therapy for the disruptive physicianNiranjan Kissoon
Wolfson Children s Hospital, Jacksonville, Fla, USA
Physician Exec 28:54-8. 2002..A disruptive physician can alienate staff, drive away patients, and even land your organization in a lawsuit. Consider some practical advice on how to identify and deal with disruptive physicians...- A comparison of decision-making by physicians and administrators in healthcare settingsDavid S Matheson
Department of Pediatrics, University of British Columbia, Children's Hospital Rm K4-105, 4480 Oak Street, Vancouver, British Columbia, Canada V6H 3V4
Crit Care 10:163. 2006..Their perceptions of each other and their resulting behaviors, however, may lead to conflict. We offer some insight into these perceptions and behaviors, and provide a framework to improve communication and to reduce misunderstanding... - World Federation of Pediatric Intensive Care and Critical Care Societies: Global Sepsis InitiativeNiranjan Kissoon
University of British Columbia, BC Children s Hospital, Vancouver, BC, Canada
Pediatr Crit Care Med 12:494-503. 2011.... - Bench-to-bedside review: humanism in pediatric critical care medicine - a leadership challengeNiranjan Kissoon
Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada
Crit Care 9:371-5. 2005..Ultimately, humanistic leadership creates an ICU culture that supports all, is conducive to enriching lives, and is sensitive to the needs of patients and their families... - The pediatric emergency department/pediatric intensive care unit interface: "the double door mentality"Niranjan Kissoon
Acute and Critical Care Program, British Columbia's Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada
Pediatr Emerg Care 22:613-5. 2006 - Adjunct pharmacotherapy in acute lung disease in childrenN Kissoon
Acute and Critical Care Programs, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada
Minerva Pediatr 59:379-88. 2007..However, the use in other respiratory conditions has led to mixed results and hence paucity of firm recommendations... - Silence and the physician executiveNiranjan Kissoon
Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada
Physician Exec 34:40-2. 2008..Silence can be an indication that things are running smoothly; on the other hand it can be an ominous sign that there is dissent among your staff... - Noninvasive ventilation in infants and childrenN Kissoon
Acute and Critical Care Programs, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada
Minerva Pediatr 60:211-8. 2008..It is also difficult to apply in conditions when there is a potential infection such as facial trauma or burns. In this manuscript, the authors discuss the role of noninvasive ventilation in infants and children... - Galileo's blunders--lessons for physician executivesNiranjan Kissoon
Department of Pediatrics, University of British Columbia, Vancouver, Canada
Physician Exec 33:32-4. 2007 - Ventilation strategies and adjunctive therapy in severe lung diseaseNiranjan Kissoon
Department of Pediatrics, University of British Columbia, Children s Hospital, Room K4 105, 4480 Oak Street, Vancouver, BC V6H 3V4, Canada
Pediatr Clin North Am 55:709-33, xii. 2008..This article discusses the rationale for and experience with some of these techniques... - Updated American College of Critical Care Medicine--pediatric advanced life support guidelines for management of pediatric and neonatal septic shock: relevance to the emergency care clinicianNiranjan Kissoon
Division of Critical Care, BC Children s Hospital, The University of British Columbia, Vancouver, British Columbia, Canada
Pediatr Emerg Care 26:867-9. 2010..For newborns, in addition to fluids, antibiotics, and inotropes, a prostaglandin infusion should be available within 10 minutes if duct-dependent congenital heart disease is a possibility... - Out of Africa--a mother's journeyNiranjan Kissoon
Acute and Critical Care Medicine, British Columbia s Children s Hospital, University of British Columbia, Vancouver, BC, Canada
Pediatr Crit Care Med 12:73-9. 2011..This paper is not intended to review preventive strategies and simple inexpensive treatments that may prevent diseases and diminish critical illnesses... - Juggling career aspirations with quality and relevance to the CaribbeanN Kissoon
Department of Paediatrics, Division of Critical Care Medicine, Health Science Center, Jacksonville, FL, USA
West Indian Med J 54:77-81. 2005 - World Federation of Pediatric Intensive and Critical Care Societies-its global agendaNiranjan Kissoon
Acute and Critical Care Programs, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada
Pediatr Crit Care Med 10:597-600. 2009..We feel that this document while imperfect is a good starting point and hope that it will stimulate more discussion to guide the agenda of the federation for years to come... - Sepsis and septic shock. A global perspective and initiativeNiranjan Kissoon
Department of Pediatrics, University of British Columbia, Room K4 105, 4480 Oak Street, Vancouver, British Columbia V6H 3V4, Canada
Saudi Med J 29:1383-7. 2008..In this manuscript, the significant gains over the last few years are outlined, and issues to consider in resource limited environments are discussed. In addition, an invitation is extended to participate in a global sepsis initiative... - An international fellowship training program in pediatric emergency medicine: establishing a new subspecialty in the Land of the DragonRan D Goldman
Division of Pediatric Emergency Medicine, BC Children s Hospital, Vancouver, British Columbia, Canada
Pediatr Emerg Care 27:1208-12. 2011..The main objective was to upgrade the professional and clinical experience of emergency physicians practicing PEM and build PEM capacity throughout China by training the future trainers... - Effect of beta2-agonist treatment and spirometry on exhaled nitric oxide in healthy children and children with asthmaNiranjan Kissoon
Department of Pediatrics, University of Florida Health Science Center Jacksonville, Jacksonville, Florida 32207, USA
Pediatr Pulmonol 34:203-8. 2002..Alternatively, changes in FE(NO) values should be interpreted in relationship to the timing of these maneuvers... - Effect of oral arginine supplementation on exhaled nitric oxide concentration in sickle cell anemia and acute chest syndromeKevin Joseph Sullivan
Department of Anesthesia and Critical Care Medicine, Nemours Children s Clinic, Jacksonville, Florida 32207, USA
J Pediatr Hematol Oncol 32:e249-58. 2010..Oral arginine supplementation has been shown to increase FE(NO) in healthy participants, but its effect in SCD patients is not known... - Sepsis and septic shock: progress and future considerationsPeter Skippen
Division of Critical Care, BC Children s Hospital, Vancouver, Canada
Indian J Pediatr 75:599-607. 2008..To define sepsis and septic shock in children, to outline an approach to treatment in the emergency, critical care units and to outline a global sepsis initiative... - Continuous central venous saturation monitoring in pediatrics: a case reportNeil Spenceley
Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada
Pediatr Crit Care Med 9:e13-6. 2008..To report the use of a new pediatric central venous catheter that offers continuous central venous saturation (ScVO2) monitoring in the critically ill child... - Association analyses of adrenergic receptor polymorphisms with obesity and metabolic alterationsJohn J Lima
Pharmacogenetics Center, Nemours Children s Clinic, Jacksonville, FL 32207, USA
Metabolism 56:757-65. 2007..Because of the limited size of our populations, our results should be interpreted with caution and should be replicated in larger populations... - Exhaled nitric oxide reflects asthma severity and asthma controlClaudia Delgado-Corcoran
University of Florida Health Sciences Center at Jacksonville, Jacksonville, FL, USA
Pediatr Crit Care Med 5:48-52. 2004..DISCUSSION: Our data suggest that a) FENO may be a practical tool to evaluate asthma severity and asthma control over time and b) FENO may be used as a marker of compliance with steroids even when FEV1 has not decreased significantly... - Impact of an observation unit and an emergency department-admitted patient transfer mandate in decreasing overcrowding in a pediatric emergency department: a discrete event simulation exerciseGeoffrey R Hung
Division of Emergency Medicine, Department of Pediatrics, BC Children s Hospital, Vancouver, British Columbia, Canada
Pediatr Emerg Care 25:160-3. 2009..The secondary objective was to report on the occupancy rate of the simulated OU... - Physician-diagnosed asthma and acute chest syndrome: associations with NOS polymorphismsLaurie Duckworth
Pharmacogenetics Center, Nemours Children s Clinic, Jacksonville, Florida 32207, USA
Pediatr Pulmonol 42:332-8. 2007..No associations were found between the genotype of the NOS3 T-786C SNP and ACS. Physician-diagnosed asthma is a major risk factor for ACS. NOS1 AAT repeat polymorphism may contribute to physician-diagnosed asthma... - Effect of montelukast on time-course of exhaled nitric oxide in asthma: influence of LTC4 synthase A(-444)C polymorphismGlenn J Whelan
Centers for Pediatric Pharmacology Research and Pharmacogenetics, Nemours Children s Clinic, Jacksonville, Florida 32207, USA
Pediatr Pulmonol 36:413-20. 2003..We further conclude that the A(-444)C polymorphism in the LTC(4) synthase gene probably contributes to interpatient variability in montelukast-evoked changes in FE(NO)* and warrants further study... - Ultrasound guidance for central vascular access in the pediatric emergency departmentPeter Skippen
Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada
Pediatr Emerg Care 23:203-7. 2007..A sound educational and quality assurance program is necessary for US-guided cannulation in the pediatric emergency department... - Nitric oxide metabolism and the acute chest syndrome of sickle cell anemiaKevin J Sullivan
Department of Anesthesia and Critical Care Medicine, Nemours Children s Clinic, Jacksonville, FL, USA
Pediatr Crit Care Med 9:159-68. 2008..To review the role of endothelial dysfunction and nitric oxide metabolism in the pathogenesis of the acute chest syndrome... - Education in a pediatric emergency mass critical care settingKen Tegtmeyer
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
Pediatr Crit Care Med 12:S135-40. 2011..Educational strategies and tactics should be developed at multiple levels for a comprehensive approach to preparing for pediatric emergency mass critical care... - Pediatric self-inflating resuscitators: the dangers of improper setupJames O'Neill
Department of Emergency Medicine, University of Florida at Jacksonville, Jacksonville, Florida, USA
J Emerg Med 41:607-12. 2011..Self-inflating resuscitators (SIRs) are often used in pediatric resuscitation. Improper setup of the SIR can lead to inadequate ventilation and oxygenation... - Predicting endotracheal tube size by length in newbornsRobert Luten
Department of Emergency Medicine, Shands Jacksonville University of Florida, Jacksonville, Florida 32209, USA
J Emerg Med 32:343-7. 2007..We concluded that length is an accurate predictor of ETT size and weight in term and preterm newborns and may be useful in situations in which weights are unobtainable, such as emergency resuscitation... - Influence of sex and beta2 adrenergic receptor haplotype on resting and terbutaline-stimulated whole body lipolysisJohn J Lima
Centers for Clinical Pediatric Pharmacology and Pharmacogenetics, Nemours Children s Clinic, Jacksonville, FL 32207, USA
Metabolism 54:492-9. 2005..We conclude that compared to haplotype, sex is a more important determinant of basal lipolysis after a 12-hour fast in healthy, non-obese individuals... - Politics of health care are pulling doctors downNiranjan Kissoon
Department of Pediatrics, University of Bristish Columbia, Vancouver, British Columbia, Canada
Physician Exec 32:40-3. 2006 - End-tidal carbon dioxide monitoring in pediatric emergenciesKevin J Sullivan
Mayo School of Medicine, Jacksonville, FL, USA
Pediatr Emerg Care 21:327-32; quiz 333-5. 2005..This review examines the basic physiology pertinent to end-tidal CO2 monitoring, its clinical applications, and evidence supporting its use in infants and children... - Relevance of type of catheters for central venous pressure measurementSamuel Santelices
University of Florida, Health Science Center, Jacksonville, FL, USA
Pediatr Emerg Care 20:448-52. 2004..CONCLUSION: Silicone and polyurethane catheters yield similar values of central venous pressures. Permanently implanted silicone elastomere catheters can be used to measure central venous pressure in the emergency setting... - Culture, communication and safety: lessons from the airline industryLori G d'Agincourt-Canning
Department of Pediatrics and Ethics Services, British Columbia Children s Hospital, 4500 Oak Street, Room B245, Vancouver, BC, V6H 3N1, Canada
Indian J Pediatr 78:703-8. 2011..Yet, communication is not an innate skill but a process influenced by internal (personal/cultural values) as well as external (professional roles and hierarchies) factors... - A simulation-based acute care curriculum for pediatric emergency medicine fellowship training programsAdam Cheng
Division of Emergency Medicine, British Columbia Children s Hospital, Vancouver, British Columbia, Canada
Pediatr Emerg Care 26:475-80. 2010..Our objective was to outline our experience with the development, integration, and evaluation of a simulation-based, acute care curriculum into our current PEM fellowship training program... - A randomized, controlled trial of the impact of early and rapid diagnosis of viral infections in children brought to an emergency department with febrile respiratory tract illnessesQuynh H Doan
Pediatric Emergency Department, BC Children s Hospital, Vancouver, British Columbia, Canada
J Pediatr 154:91-5. 2009..We hypothesized that early and rapid diagnosis of a viral infection alleviates the need for ancillary testing and antibiotic treatment... - Fibreoptic and videoscopic indirect intubation techniques for intubation in childrenRichard Levin
Division of Critical Care, British Columbia Children s Hospital, Vancouver, British Columbia, Canada V6H 3V4
Pediatr Emerg Care 25:479; quiz 480-2. 2009..A wide range of instruments including flexible, rigid, and semirigid devices are available. Those who practice emergency medicine should be aware of these devices and be skilled in their use and aware of their limitations... - Computer modeling of patient flow in a pediatric emergency department using discrete event simulationGeoffrey R Hung
Division of Emergency Medicine, Department of Pediatrics, BC Children s Hospital, Vancouver, British Columbia, Canada
Pediatr Emerg Care 23:5-10. 2007.... - Management of cellulitis in a pediatric emergency departmentSimi Khangura
Division of Emergency Medicine, Departments of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada
Pediatr Emerg Care 23:805-11. 2007..2) To determine the number of visits and time spent in the emergency department (ED) for treatment... - Choosing a volume expander in critical care medicineNiranjan Kissoon
University of Florida HSC Jacksonville, Division of Pediatric Critical Care Medicine, Jacksonville, Florida 32207, USA
Indian J Pediatr 70:969-73. 2003..Alternatively synthetic colloids may be useful, however, concerns about coagulation problems and organ dysfunction persists... - Pediatric emergency care: Are family characteristics important?Niranjan Kissoon
Acute and Critical Care Program, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada
CJEM 8:275-6. 2006 - Low exhaled nitric oxide and a polymorphism in the NOS I gene is associated with acute chest syndromeK J Sullivan
Nemours Children's Clinic, Jacksonville, Florida, USA
Am J Respir Crit Care Med 164:2186-90. 2001..FE(NO) is a sensitive marker and may be a predictor of ACS prone children... - Toward the inclusion of parents on pediatric critical care unit roundsGladys McPherson
University of British Columbia School of Nursing, Vancouver, British Columbia, Canada
Pediatr Crit Care Med 12:e255-61. 2011..Creating policies and practices that welcome parents and their contributions into patient rounds has proven challenging in many settings... - Treatment of Persistent Pulmonary Hypertension of the Newborn (PPHN) is in its infancyNiranjan Kissoon
BC Children's Hospital Vancouver, British Columbia, Canada V6H 3V4; The University of British Columbia, Canada V6H 3V4
J Crit Care 21:223. 2006 - Exhaled nitric oxide concentrations: online versus offline values in healthy childrenNiranjan Kissoon
University of Florida Health Sciences Center Jacksonville, Howard Building Suite 203, 820 Presidential Drive, Jacksonville, FL 32207, USA
Pediatr Pulmonol 33:283-92. 2002..We have provided FE(NO) values in healthy children and propose that the ideal expiratory flow rate for FE(NO) measurements in children using the single breath technique is between 30-50 mL/sec... - Securing the child's airway in the emergency departmentKevin J Sullivan
Department of Pediatric Anesthesia, Nemours Children's Clinic, Jacksonville, Florida, USA
Pediatr Emerg Care 18:108-21; quiz 122-4. 2002..Emphasis is also placed on recognition of the difficult airway and methods to render the difficulty less daunting. Good judgment and the appropriate skills are the prerequisites for success... - Exhaled nitric oxide measurements in childhood asthma: techniques and interpretationN Kissoon
Department of Pediatrics, University of Florida Health Sciences Center Jacksonville, Jacksonville, Florida 32207, USA
Pediatr Pulmonol 28:282-96. 1999..Guidelines for measurements of exhaled nitric oxide based on our experience are provided, as well as suggestions for the use of this technique as a new "airway inflammation test.".. - Acute severe asthma in children. Issues related to managementN Kissoon
University of Florida HSC Jacksonville, Jacksonville, FL, USA
Minerva Pediatr 55:303-21. 2003.... - Plastic bottles as spacers for a pressurized metered-dose inhaler: in vitro characteristicsN Kissoon
University of Florida Health Sciences Center, Nemours Children s Clinic, Jacksonville, Florida, USA
West Indian Med J 50:189-93. 2001..The sizes of particles obtained from the bottle spacers are those that have a high probability of reaching the lower airway; however, the clinical relevance of these findings remains to be determined... - Noninvasive monitoring in the pediatric intensive care unitL K DeNicola
Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Florida Health Sciences Center, Jacksonville, USA
Pediatr Clin North Am 48:573-88. 2001..New modalities and the application of artificial intelligence may facilitate the interpretation of data, but the role of the bedside medical practitioner remains as the heart of pediatric critical care... - FE(NO): relationship to exhalation rates and online versus bag collection in healthy adolescentsN Kissoon
University of Florida HSC Jacksonville, Nemours Children s Clinic, and Wolfson Children s Hospital, Jacksonville, Florida, USA
Am J Respir Crit Care Med 162:539-45. 2000..On the basis of these results, we provide FE(NO) values for healthy adolescents and propose that the ideal flow rate for children is between 30 and 50 ml/s... - Clinical skills and caring professionalsN Kissoon
Department of Paediatrics, Office of Paediatric Critical Care Medicine, University of Florida, HSC/Jacksonville, 820 Prudential Drive, Suite 203, Howard Bldg, Jacksonville, FL 32207, USA
West Indian Med J 52:175-7. 2003 - Continuous central venous oxygen saturation monitoring under varying physiological conditions in an animal modelN Kissoon
Local Research Animal Lab, The University of British Columbia, Vancouver, British Columbia, Canada
Anaesth Intensive Care 38:883-9. 2010.... - Nitric oxide: to inhale or not to inhaleNiranjan Kissoon
Pediatr Crit Care Med 5:196-8. 2004 - Pediatric emergency medicine: a world of potentialNiranjan Kissoon
CJEM 9:453-8. 2007 - Acute asthma: under attackNiranjan Kissoon
University of Florida Health Sciences Center Jacksonville, and Wolfson Children s Hospital, 32207 8210, USA
Curr Opin Pediatr 14:298-302. 2002..Research into the genetics and pharmacogenetics of asthma and into the societal factors limiting the delivery of optimal care is likely to yield useful and practical information... - Discrete event simulation as a tool in optimization of a professional complex adaptive systemAnders Lassen Nielsen
Dept of Medicine, The University of the West Indies, St Augustine, Trinidad
Stud Health Technol Inform 136:247-52. 2008.... - Hypothermia therapy for cardiac arrest in pediatric patientsJames S Hutchison
Department of Critical Care Medicine, University of Toronto and Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
Pediatr Clin North Am 55:529-44, ix. 2008..We recommend further study before a strong recommendation can be made to use hypothermia therapy in children with cardiac arrest... - Dealing with aggressive behavior within the health care team: a leadership challengePatricia Hynes
Intensive Care Unit, Mount Sinai Hospital, Toronto, Ontario, Canada
J Crit Care 21:224-7. 2006..Additional education around communication and team interaction was felt to be a priority. In summary, clinical leaders probably have a great deal to gain from augmenting their leadership/management skills... - Pediatric critical care transport: diagnostic uncertainty--no worries, resource limitation--worryNiranjan Kissoon
Pediatr Crit Care Med 9:116-7. 2008 - Obesity and asthma--Take your breath awayNiranjan Kissoon
Pediatr Crit Care Med 7:603-4. 2006 - Dengue and dengue hemorrhagic fever: management issues in an intensive care unitSunit Singhi
The Department of Pediatrics, Advanced Pediatrics Centre, Postrgraduate Institute of Medical Education and Research, Chandigarh, India
J Pediatr (Rio J) 83:S22-35. 2007..To describe the epidemiology, clinical features and treatment of dengue fever and dengue shock syndrome... - Comparing therapies and outcomes: mirror, mirror on the wallNiranjan Kissoon
Crit Care Med 30:713-4. 2002 - Early differentiation between dengue and septic shock by comparison of admission hemodynamic, clinical, and laboratory variables: a pilot studySuchitra Ranjit
Pediatric Intensive Care Unit, Apollo Hospitals, Chennai, India
Pediatr Emerg Care 23:368-75. 2007..To compare the clinical, hemodynamic, and laboratory variables, treatment, and outcome in dengue shock syndrome (DSS) and septic shock (SS), with an aim to permit early differentiation at presentation to the emergency department... - Aggressive management of dengue shock syndrome may decrease mortality rate: a suggested protocolSuchitra Ranjit
Pediatric Intensive Care Unit, Apollo Hospitals, Chennai, India
Pediatr Crit Care Med 6:412-9. 2005..Survival was better for patients in the P group. Aggressive shock management and possibly the use of judicious fluid removal may decrease mortality rates in the severest forms of dengue shock syndrome... - Family presence during cardiopulmonary resuscitation: our anxiety versus their needsNiranjan Kissoon
Pediatr Crit Care Med 7:488-90. 2006