Research Topics
| Young In KimSummaryAffiliation: University of Toronto Country: Canada Publications
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Publications
Severe folate deficiency impairs natural killer cell-mediated cytotoxicity in ratsYoung In Kim
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
J Nutr 132:1361-7. 2002..These data collectively suggest that NK-mediated cytotoxicity is not a likely mechanism by which folate status modulates carcinogenesis...- Role of the MTHFR polymorphisms in cancer risk modification and treatmentYoung In Kim
Department of Medicine, Room 7258, Medical Sciences Building, University of Toronto, 1 King s College Circle, Toronto, Ontario, M5S 1A8, Canada
Future Oncol 5:523-42. 2009..As such, largescale human studies and in vitro mechanistic studies are warranted to clarify the pharmacogenetic role of the MTHFR SNPs... - Folate and DNA methylation: a mechanistic link between folate deficiency and colorectal cancer?Young In Kim
Departments of Medicine and Nutritional Sciences, University of Toronto, Medical Sciences Building Room 7258, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
Cancer Epidemiol Biomarkers Prev 13:511-9. 2004..However, there is still a possibility that sequence-specific alterations of DNA methylation in critical cancer-related genes might be mechanistically involved in the folate deficiency-mediated colorectal carcinogenesis... - Folate, colorectal carcinogenesis, and DNA methylation: lessons from animal studiesYoung In Kim
Departments of Medicine and Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
Environ Mol Mutagen 44:10-25. 2004..A mechanistic understanding of how folate status modulates colorectal carcinogenesis further strengthens the case for a causal relationship and provides insight into a possible chemopreventive role of folate... - Will mandatory folic acid fortification prevent or promote cancer?Young In Kim
Department of Medicine and Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
Am J Clin Nutr 80:1123-8. 2004..The potential cancer-promoting effect of folic acid supplementation needs to be considered in carefully monitoring the long-term effect of folic acid fortification on the vast majority of the US population, who are not at risk of NTDs... - Cell and stage of transformation-specific effects of folate deficiency on methionine cycle intermediates and DNA methylation in an in vitro modelJoanne M Stempak
Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada, M5S 1A8
Carcinogenesis 26:981-90. 2005..Moreover, the effect of folate deficiency on DNA methylation appears to be mediated by both methionine cycle intermediate-dependent and independent pathways... - Folate: a magic bullet or a double edged sword for colorectal cancer prevention?Y-I Kim
University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada
Gut 55:1387-9. 2006 - Nutritional epigenetics: impact of folate deficiency on DNA methylation and colon cancer susceptibilityYoung In Kim
Departments of Medicine and Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
J Nutr 135:2703-9. 2005.... - 5,10-Methylenetetrahydrofolate reductase polymorphisms and pharmacogenetics: a new role of single nucleotide polymorphisms in the folate metabolic pathway in human health and diseaseYoung In Kim
Department of Medicine, University of Toronto, Division of Gastroenterology, St Michael s Hospital, Room 7258, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
Nutr Rev 63:398-407. 2005.... - Does a high folate intake increase the risk of breast cancer?Young In Kim
Department of Medicine and Nutritional Sciences, University of Toronto, Division of Gastroenterology, St Michael s Hospital, Toronto, Canada
Nutr Rev 64:468-75. 2006..Based on the lack of compelling supportive evidence, routine folic acid supplementation should not be recommended as a chemopreventive measure against breast cancer at present... - Folate and colorectal cancer: an evidence-based critical reviewYoung In Kim
Department of Medicine and Nutritional Sciences, Medical Sciences Building, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada
Mol Nutr Food Res 51:267-92. 2007..Based on the lack of compelling supportive evidence and on the potential tumor-promoting effect, routine folic acid supplementation should not be recommended as a chemopreventive measure against CRC at present... - Folic acid fortification and supplementation--good for some but not so good for othersYoung In Kim
Department of Medicine, University of Toronto, Toronto, Canada
Nutr Rev 65:504-11. 2007.... - Folic acid supplementation and cancer risk: pointYoung-In Kim
Department of Medicine, University of Toronto, St. Michael's Hospital, Toronto, Ontario, Canada
Cancer Epidemiol Biomarkers Prev 17:2220-5. 2008 - Role of folate in colon cancer development and progressionYoung In Kim
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
J Nutr 133:3731S-3739S. 2003..Notwithstanding the limitations associated with animal models, these animal studies suggest that the optimal timing and dose of folate intervention need to be established for safe and effective chemoprevention in humans... - Colonic mucosal concentrations of folate are accurately predicted by blood measurements of folate status among individuals ingesting physiologic quantities of folateY I Kim
Department of Medicine, University of Toronto and St Michael s Hospital, Toronto, Ontario, M5S 1A8 Canada
Cancer Epidemiol Biomarkers Prev 10:715-9. 2001..Our observations indicate that colonic mucosal concentrations of folate may be predicted accurately by blood measurements of folate status only among individuals not ingesting supraphysiological quantities of folate... - Effect of maternal and postweaning folic acid supplementation on colorectal cancer risk in the offspringKaren K Y Sie
St Michael s Hospital, 16CC 038, 30 Bond Street, Toronto, Ontario, Canada, M5B 1W8
Gut 60:1687-94. 2011..This protective effect may be mediated in part by increased global DNA methylation and decreased epithelial proliferation and DNA damage in the colorectum... - Colonic mucosal concentrations of folate correlate well with blood measurements of folate status in persons with colorectal polypsY I Kim
Department of Medicine, St Michael s Hospital, and the University of Toronto, Ontario, Canada
Am J Clin Nutr 68:866-72. 1998..This issue is important for assessing folate status in the colorectal mucosa because low dietary intake or blood concentrations of folate are associated with an increased risk of colorectal neoplasia... - Effects of dietary folate on DNA strand breaks within mutation-prone exons of the p53 gene in rat colonY I Kim
Division of Gastroenterology, Department of Medicine, St Michael s Hospital and University of Toronto, Toronto, Ontario, Canada
Gastroenterology 119:151-61. 2000..This study investigated the effects of dietary folate on DNA strand breaks in the p53 and Apc genes, and how these changes are related to steady-state levels of the corresponding transcripts... - The effect of dietary folate on genomic and p53-specific DNA methylation in rat colonKyoung Jin Sohn
Department of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada
Carcinogenesis 24:81-90. 2003..This implies that neither genomic or p53 hypomethylation within exons 6-7 nor aberrant p53 methylation within the promoter region is likely a mechanism by which folate deficiency enhances colorectal carcinogenesis in the rat... - The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: a possible molecular basis for the site-specific cancer risk modificationKyoung Jin Sohn
Department of Medicine, University of Toronto, St Michael s Hospital, Toronto, Ontario, Canada
Int J Cancer 124:1999-2005. 2009.... - Effect of maternal and postweaning folic acid supplementation on mammary tumor risk in the offspringAnna Ly
Department of Nutritional Sciences, University of Toronto, Ontario, Canada
Cancer Res 71:988-97. 2011..Further, they suggest that this tumor-promoting effect may be mediated in part by altered DNA methylation and DNMT activity... - Postweaning dietary folate deficiency provided through childhood to puberty permanently increases genomic DNA methylation in adult rat liverJoanne Kotsopoulos
Department of Nutritional Sciences, University of Toronto, Toronto, Canada, M5S 1A8
J Nutr 138:703-9. 2008..Our data suggest that early folate nutrition during postnatal development plays an important role in epigenetic programming that can have a permanent effect in adulthood... - Folate deficiency induces cell-specific changes in the steady-state transcript levels of genes involved in folate metabolism and 1-carbon transfer reactions in human colonic epithelial cellsInki Hayashi
Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada, M5S 1A8
J Nutr 137:607-13. 2007..In both HCT116 and Caco2 cells, folate depletion was associated with the conservation of the existing pattern and extent of DNA methylation... - Effect of folic acid supplementation on the progression of colorectal aberrant crypt fociGillian M Lindzon
Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada M5S 1A8
Carcinogenesis 30:1536-43. 2009..34; P < 0.001) and inversely with plasma homocysteine concentrations (r = -0.37; P < 0.001). Our data suggest that folic acid supplementation may promote the progression of ACF to colorectal tumors... - Effects of folate and folylpolyglutamyl synthase modulation on chemosensitivity of breast cancer cellsRobert C Cho
Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
Mol Cancer Ther 6:2909-20. 2007..Whether or not FPGS modulation may be an important clinical determinant of chemosensitivity of breast cancer cells to 5FU and methotrexate-based chemotherapy needs further exploration... - Msh2 deficiency enhances somatic Apc and p53 mutations in Apc+/-Msh2-/- miceKyoung Jin Sohn
Department of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
Carcinogenesis 24:217-24. 2003..The nature and frequency of somatic Apc and p53 mutations in Apc+/-Msh2-/- mice suggest that many genomic sites, in addition to genes containing simple repeated sequences, are at risk of somatic mutations associated with Msh2 deficiency... - Folic acid supplementation provided in utero and during lactation reduces the number of terminal end buds of the developing mammary glands in the offspringKaren K Y Sie
Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
Cancer Lett 280:72-7. 2009..014). Our data suggest for the first time that folic acid supplementation provided in utero and during lactation may lower mammary tumor risk in the offspring... - Chemopreventive effects of dietary folate on intestinal polyps in Apc+/-Msh2-/- miceJ Song
Department of Nutritional Sciences, University of Toronto, Ontario, Canada
Cancer Res 60:3191-9. 2000.... - Effects of dietary folate on intestinal tumorigenesis in the apcMin mouseJ Song
Department of Medicine, University of Toronto, Ontario, Canada
Cancer Res 60:5434-40. 2000..Notwithstanding the limitations associated with this model, these data suggest that the optimal timing and dose of folate intervention need to be determined for safe and effective folate chemoprevention... - Effects of folate supplementation on two provisional molecular markers of colon cancer: a prospective, randomized trialY I Kim
Department of Medicine, University of Toronto and St Michael's Hospital, Ontario, Canada
Am J Gastroenterol 96:184-95. 2001..Therefore, potential confounding factors that seem to modulate these biomarkers need to be identified and corrected in order for these markers to serve as suitable surrogate endpoints in folate chemoprevention trials... - A pilot randomised controlled trial to reduce colorectal cancer risk markers associated with B-vitamin deficiency, insulin resistance and colonic inflammationW R Bruce
Department of Nutritional Sciences, University of Toronto, 150 College Street, and Division of Gastroenterology, St Michael s Hospital, Toronto, Ontario, Canada M5S 2E3
Br J Cancer 93:639-46. 2005..We suggest that long-term intervention studies with tumour-related end points should be undertaken when the intervention agents used are found effective in short-term biochemical risk marker trials... - Folate is absorbed across the colon of adults: evidence from cecal infusion of (13)C-labeled [6S]-5-formyltetrahydrofolic acidSusanne Aufreiter
Department of Nutritional Sciences, University of Toronto, Toronto, Canada
Am J Clin Nutr 90:116-23. 2009..It is well known that the microflora in the colon produce large quantities of folate that approach or exceed recommended dietary intakes; however, there is no direct evidence of the bioavailability of this pool in humans... - Molecular genetics of ulcerative colitis-associated colon cancer in the interleukin 2- and beta(2)-microglobulin-deficient mouseK J Sohn
Department of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8 Canada
Cancer Res 61:6912-7. 2001..As such, this model appears to be an excellent animal model to study UC-associated colorectal carcinogenesis... - Vegetables, fruits, and colorectal cancer risk: what should we believe?Y I Kim
Department of Medicine, University of Toronto, Ontario, Canada
Nutr Rev 59:394-8. 2001.... - Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexateKyoung-Jin Sohn
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
J Natl Cancer Inst 96:134-44. 2004..The MTHFR C677T polymorphism may be a useful pharmacogenetic determinant for providing rational and effective tailored chemotherapy... - Effects of dietary folate on ulcerative colitis-associated colorectal carcinogenesis in the interleukin 2- and beta(2)-microglobulin-deficient miceJulie Carrier
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Cancer Epidemiol Biomarkers Prev 12:1262-7. 2003..However, the high mortality observed in the folate-deficient group precludes a definitive conclusion concerning the effect of folate deficiency on UC-associated colorectal carcinogenesis in this model... - Is folic acid good for everyone?A David Smith
Oxford Project to Investigate Memory and Ageing, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
Am J Clin Nutr 87:517-33. 2008..Only then can authorities develop the right strategies for the population as a whole... - Effects of dietary folate on the development and progression of mammary tumors in ratsJoanne Kotsopoulos
Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
Carcinogenesis 26:1603-12. 2005..However, the limitations associated with the route and dose of MNU administration preclude a definitive conclusion concerning the effect of folate status on the initiation of MNU-induced mammary tumorigenesis... - Folate and colo-rectal cancer riskPeter Sanderson
Nutrition Division, Food Standards Agency, London WC2 6NH, UK
Br J Nutr 98:1299-304. 2007..Also, the need to study further the influence of genetically defined subgroups was highlighted for future research... - Folate and methylenetetrahydrofolate reductase polymorphisms: new nutritional and genetic risk factors for pancreatic cancer?Young-In Kim
Clin Gastroenterol Hepatol 3:738-42. 2005 - Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cellsPetar Novakovic
Institute of Medical Science, Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada M5S 1A8
Carcinogenesis 27:916-24. 2006.... - Canadian Association of Gastroenterology and the Canadian Digestive Health Foundation: Guidelines on colon cancer screeningDesmond Leddin
Department of Medicine, Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia
Can J Gastroenterol 18:93-9. 2004 - L-ascorbic acid (vitamin C) induces the apoptosis of B16 murine melanoma cells via a caspase-8-independent pathwayJae Seung Kang
Department of Anatomy and Tumor Immunity Medical Research Center, Seoul National University College of Medicine, 110-799 Seoul, South Korea
Cancer Immunol Immunother 52:693-8. 2003.... - Resistance to cytotoxic chemotherapy is induced by NK cells in non-Hodgkin's Lymphoma CellsDaeho Cho
Department of Life Science, Sookmyung Women's University
J Clin Immunol 24:553-60. 2004..Taken together, these results suggest that B lymphoma cell resistance to doxorubicin-mediated cell death is induced by coculture with NK cells, because of TNF alpha secretion... - Protein kinase D1: a new component in TLR9 signalingJeoung Eun Park
Children s Foundation Research Center at Le Bonheur Children s Medical Center and Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38103, USA
J Immunol 181:2044-55. 2008..Our findings identify PKD1 as a key signaling modulator in TLR9-mediated macrophage activation... - CpG DNA prevents liver injury and shock-mediated death by modulating expression of interleukin-1 receptor-associated kinasesYoung In Kim
The Children s Foundation Research Center at Le Bonheur Children s Medical Center, and Department of Pediatrics, University of Tennessee Health Science Center, 50 N Dunlap Street, Memphis, TN 38103, USA
J Biol Chem 283:15258-70. 2008.... - CM1 ligation initiates apoptosis in a caspase 8-dependent manner in Ramos cells and in a mitochondria-controlled manner in Raji cellsDaejin Kim
Department of Anatomy, Seoul National University, College of Medicine and Institute of Allergy and Clinical Immunology, Medical Research Center, Seoul National University, Seoul, South Korea
Hum Immunol 63:576-87. 2002..Moreover, the effector caspase inhibitor, z-DEVD, blocked CM1-mediated apoptosis in both cell lines. We found that CM1-induced apoptosis is achieved via different initiation pathways, which are cell-type dependent... - Does perioperative immunonutrition reduce postoperative complications in patients with gastrointestinal cancer undergoing operations?David N Moskovitz
Department of Medicine, Division of Gastroenterology, University of Toronto, St. Michael's Hospital, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8
Nutr Rev 62:443-7. 2004..Both pre- and perioperative immunonutritional strategies were superior to the conventional approach (no artificial nutrition perioperatively)... - Point mutations affecting the oligomeric structure of Nm23-H1 abrogates its inhibitory activity on colonization and invasion of prostate cancer cellsYoung In Kim
Vascular System Research Center, Division of Life Sciences, College of Natural Sciences, Kangwon National University, Chunchon, Republic of Korea
Biochem Biophys Res Commun 307:281-9. 2003..These correlative data suggest that the metastasis-suppressing activity of Nm23-H1 may depend on its oligomeric structure, but not on its NDP kinase activity...