Research Topics
Genomes and Genes | Shaf KeshavjeeSummaryAffiliation: University of Toronto Country: Canada Publications
| Collaborators
|
Detail Information
Publications
Prevalence of gastroesophageal reflux in end-stage lung disease candidates for lung transplantFrank D'Ovidio
Toronto Lung Transplant Program, University of Toronto, Toronto, Ontario, Canada
Ann Thorac Surg 80:1254-60. 2005..It is not clear whether gastroesophageal reflux is a preexisting condition or secondary to intraoperative vagal injury or drug-induced prolonged gastric emptying...- Impact of donors aged 60 years or more on outcome after lung transplantation: results of an 11-year single-center experienceMarc de Perrot
Toronto Lung Transplant Program, Toronto General Hospital, University of Toronto, Toronto, Canada
J Thorac Cardiovasc Surg 133:525-31. 2007..We examined the outcome of lung transplantation with the use of donors aged 60 years or more... - Activated protein C in ischemia-reperfusion injury after experimental lung transplantationShin Hirayama
Latner Thoracic Surgery Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Ontario, Canada
J Heart Lung Transplant 28:1180-4. 2009..Activated protein C (APC) has been demonstrated to attenuate various acute inflammation-related injuries in the lung and other organs... - Risk factors for major complications after extrapleural pneumonectomy for malignant pleural mesotheliomaMarc de Perrot
Division of Thoracic Surgery, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
Ann Thorac Surg 85:1206-10. 2008.... - Induction chemoradiation therapy followed by surgical resection for non-small cell lung cancer (NSCLC) invading the thoracic inletStefan Fischer
Division of Thoracic Surgery, Toronto General Hospital, University of Toronto, University Health Network, 200 Elizabeth Street, 9th Floor, Toronto, Ontario, Canada M5G 2C4
Eur J Cardiothorac Surg 33:1129-34. 2008..The role of induction therapy for non-small cell lung cancer (NSCLC) invading the thoracic inlet is unclear. We reviewed our experience with induction chemoradiation followed by surgical resection for NSCLC invading the thoracic inlet... - Trimodality therapy with induction chemotherapy followed by extrapleural pneumonectomy and adjuvant high-dose hemithoracic radiation for malignant pleural mesotheliomaMarc de Perrot
Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
J Clin Oncol 27:1413-8. 2009..We examined the results of trimodality therapy with cisplatin-based chemotherapy followed by extrapleural pneumonectomy (EPP) and adjuvant high-dose (50 to 60 Gy) hemithoracic radiation therapy for MPM... - Induction chemoradiotherapy facilitates radical resection of T4 non-small cell lung cancer invading the spineMasaki Anraku
Division of Thoracic Surgery, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
J Thorac Cardiovasc Surg 137:441-447.e1. 2009..We evaluated the outcome, long-term results, and factors affecting outcome of induction chemoradiotherapy followed by surgical resection for T4 non-small cell lung cancer invading the spine... - Regression of allograft airway fibrosis: the role of MMP-dependent tissue remodeling in obliterative bronchiolitis after lung transplantationMasaaki Sato
Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
Am J Pathol 179:1287-300. 2011..Thus, modulating MMP activity might reverse established allograft airway fibrosis by regulating inflammation and tissue remodeling... - Bile acid aspiration and the development of bronchiolitis obliterans after lung transplantationMarco Mura
Toronto Lung Transplant Program, University of Toronto, Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
J Thorac Cardiovasc Surg 129:1144-52. 2005..Elevated BALF bile acids may promote early BOS development via an inflammatory process, possibly mediated by IL-8 and alveolar neutrophilia... - Normothermic ex vivo lung perfusion in clinical lung transplantationMarcelo Cypel
Toronto Lung Transplant Program, University of Toronto, ON, Canada
N Engl J Med 364:1431-40. 2011..In this study, we examined the feasibility of transplanting high-risk donor lungs that have undergone EVLP... - Reperfusion-induced gene expression profiles in rat lung transplantationMasaomi Yamane
Thoracic Surgery Research Laboratory, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
Am J Transplant 5:2160-9. 2005..Reperfusion-induced genes related to inflammatory response may contribute to graft dysfunction in LTx... - XB130, a novel adaptor protein for signal transductionJing Xu
Division of Cellular and Molecular Biology, University Health Network Toronto General Research Institute, and Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada
J Biol Chem 282:16401-12. 2007..These data suggest that XB130 as an adaptor may play an important role in the regulation of signal transduction and cellular functions... - Improved results of induction chemoradiation before surgical intervention for selected patients with stage IIIA-N2 non-small cell lung cancerKarl L Uy
Division of Thoracic Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada
J Thorac Cardiovasc Surg 134:188-93. 2007..The surgical arm of the North American Intergroup 0139 trial was adopted as the standard treatment for patients with resectable N2 disease at the University Health Network. Results after 7 years of experience are reported... - Venous thromboembolism in patients receiving multimodality therapy for thoracic malignanciesApurva Patel
Toronto General Hospital and Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
J Thorac Cardiovasc Surg 138:843-8. 2009..The rate of venous thromboembolism in patients undergoing multimodality therapy for lung malignancy and the impact of preoperative venous thromboembolism on postoperative outcome have not been analyzed systematically... - Impact of human interleukin-10 on vector-induced inflammation and early graft function in rat lung transplantationMarc de Perrot
Thoracic Surgery Research Laboratory, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Ontario, Canada
Am J Respir Cell Mol Biol 28:616-25. 2003..The period between delivery of AdhIL-10 and lung retrieval can be reduced if the early inflammatory response is suppressed with methylprednisolone... - Functional repair of human donor lungs by IL-10 gene therapyMarcelo Cypel
Latner Thoracic Surgery Research Laboratories, McEwen Centre for Regenerative Medicine, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, Ontario, Canada
Sci Transl Med 1:4ra9. 2009..Thus, treatment of injured human donor lungs with the cytokine IL-10 can improve lung function, potentially rendering injured lungs suitable for transplantation into patients... - Extracorporeal membrane oxygenation for primary graft dysfunction after lung transplantation: analysis of the Extracorporeal Life Support Organization (ELSO) registryStefan Fischer
The Toronto Lung Transplant Program, Division of Thoracic Surgery, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
J Heart Lung Transplant 26:472-7. 2007..A few single-center experiences have been reported with relatively few cases of ECMO after LTx... - Increased levels of interleukin-1? and tumor necrosis factor-? in donor lungs rejected for transplantationMarcelo Cypel
Latner Thoracic Surgery Research Laboratories, Division of Thoracic Surgery, Toronto General Research Institute, University Health Network, Toronto General Hospital, Ontario, Canada
J Heart Lung Transplant 30:452-9. 2011..This study compared gene expression levels of inflammatory cytokines between clinically rejected and transplanted donor lungs... - Endobronchial ultrasound-guided transbronchial needle aspiration in the management of previously treated lung cancerMasaki Anraku
Division of Thoracic Surgery, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
Ann Thorac Surg 92:251-5; discussion 255. 2011..This study evaluated the role of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the assessment of newly developed mediastinal/hilar abnormalities in patients with previously treated lung cancer... - Transcriptional signatures in donor lungs from donation after cardiac death vs after brain death: a functional pathway analysisChang Hyun Kang
Latner Thoracic Surgery Research Laboratories, Division of Thoracic Surgery, Toronto General Research Institute, Toronto Lung Transplant Program, University Health Network, Toronto General Hospital, Toronto, ON, Canada
J Heart Lung Transplant 30:289-98. 2011..We aimed to study the differential gene expression profiles in lungs of DCD and DBD patients and interpreted the differences using functional pathway analysis... - Restrictive allograft syndrome (RAS): a novel form of chronic lung allograft dysfunctionMasaaki Sato
University Health Network, University of Toronto, Ontario, Canada
J Heart Lung Transplant 30:735-42. 2011..Characteristics of a form of CLAD consisting of restrictive functional changes involving peripheral lung pathology were investigated... - Impact of extracorporeal life support on outcome in patients with idiopathic pulmonary arterial hypertension awaiting lung transplantationMarc de Perrot
Toronto Lung Transplant Program, University of Toronto, Toronto, Ontario, Canada
J Heart Lung Transplant 30:997-1002. 2011.... - Technique for prolonged normothermic ex vivo lung perfusionMarcelo Cypel
Latner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Ontario, Canada
J Heart Lung Transplant 27:1319-25. 2008..The aim of this study was to develop a technique of extended (12-hour) ex vivo lung perfusion (EVLP) at normothermia for assessment and protective maintenance of the donor lung... - Targeted cell replacement with bone marrow cells for airway epithelial regenerationAmy P Wong
Latner Thoracic Surgery Research Laboratories, McEwen Centre for Regenerative Medicine, Toronto Lung Transplant Program, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Canada
Am J Physiol Lung Cell Mol Physiol 293:L740-52. 2007..Some BMC cultured in vitro over time also expressed GFP transgene, suggesting epithelial transdifferentiation of the BMC. The results indicate that targeted delivery of BMC can promote airway regeneration... - A prospective controlled trial of endobronchial ultrasound-guided transbronchial needle aspiration compared with mediastinoscopy for mediastinal lymph node staging of lung cancerKazuhiro Yasufuku
Division of Thoracic Surgery, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
J Thorac Cardiovasc Surg 142:1393-1400.e1. 2011..The study objective was to compare endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) with mediastinoscopy for mediastinal lymph node staging of potentially resectable non-small cell lung cancer... - PTX3 as a potential biomarker of acute lung injury: supporting evidence from animal experimentationXiaolin He
Latner Thoracic Surgery Research Laboratory, Toronto General Research Institute, University Health Network, Toronto, ON, Canada
Intensive Care Med 36:356-64. 2010..Tissue factor (TF) activation plays an important role in the pathogenesis of acute lung injury. The present study sought to determine the relationship between PTX3 expression and TF activation in acute lung injury... - Treatment of the elderly when cure is the goal: the influence of age on treatment selection and efficacy for stage III non-small cell lung cancerLinda E Coate
Department of Medical Oncology and Hematology, University Health Network, Princess Margaret Hospital, Toronto, Ontario, Canada
J Thorac Oncol 6:537-44. 2011..Treatment of elderly patients with stage III NSCLC is controversial. Limited data exist, as the elderly are underrepresented in clinical trials... - Intestinal ischemia-reperfusion-induced acute lung injury and oncotic cell death in multiple organsMarco Mura
Thoracic Surgery Research Laboratories, Toronto General Hospital, University Health Network, Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, Canada
Shock 28:227-38. 2007..These results indicate that, although lung injury is the most significant manifestation after IIR, oncotic cell death occurs in the lung, heart, and kidney, which may be related to ischemia and inflammation... - Functions of type II pneumocyte-derived vascular endothelial growth factor in alveolar structure, acute inflammation, and vascular permeabilityMarco Mura
University of Toronto, Toronto General Hospital, M5G 1L7, Toronto, Ontario, Canada
Am J Pathol 176:1725-34. 2010..We conclude that VEGF in type II cells helps protect alveolar epithelial cells from caspase-dependent apoptosis. However, VEGF produced from type II cells may contribute to increased vascular permeability during acute lung injury... - Interleukin 10 gene transfection of donor lungs ameliorates posttransplant cell death by a switch from cellular necrosis to apoptosisStefan Fischer
Thoracic Surgery Research Laboratory, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
J Thorac Cardiovasc Surg 126:1174-80. 2003.... - Stability and heterogeneity of expression profiles in lung cancer specimens harvested following surgical resectionFiona H Blackhall
University Health Network, Ontario Cancer Institute/Princess Margaret Hospital, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada M5G 2M9
Neoplasia 6:761-7. 2004..However, sampling and pooling from multiple sites of each tumor may be necessary for expression profiling studies to overcome the molecular heterogeneity present in tumor specimens... - High-volume ventilation induces pentraxin 3 expression in multiple acute lung injury models in ratsDaisuke Okutani
Thoracic Surgery Research Laboratory, Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
Am J Physiol Lung Cell Mol Physiol 292:L144-53. 2007..A local expression of PTX3 induced by high-volume ventilation, either alone or in combination with other pathological conditions, suggests that it may be an important mediator in ventilator-induced lung injury... - Transfusion-related acute lung injury (TRALI) in graft by blood donor antibodies against host leukocytesJodi Goodwin
Department of Respirology, McMaster University, Hamilton, Ontario, Canada
J Heart Lung Transplant 29:1067-70. 2010.... - Synergistic antitumor effects of regulatory T cell blockade combined with pemetrexed in murine malignant mesotheliomaMasaki Anraku
Latner Thoracic Surgery Research Laboratories, University Health Network, University of Toronto, Ontario, Canada
J Immunol 185:956-66. 2010..This study also validates a new intrathoracic tumor model of pleural effusion to explore the role of antitumor immunity in murine MM... - Activation of mitogen-activated protein kinases during human lung transplantationShoji Sakiyama
Thoracic Surgery Research Laboratory, University Health Network Toronto General Hospital and Department of Surgery and Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
J Heart Lung Transplant 24:2079-85. 2005..CONCLUSIONS: We speculate that the rapid and sustained activation of ERK and JNK during the early reperfusion period may contribute to acute inflammatory responses and cell death of lung grafts... - Novel approaches to expanding the lung donor pool: donation after cardiac death and ex vivo conditioningMarcelo Cypel
Division Thoracic Surgery, Toronto Lung Transplant Program, Toronto General Hospital, University of Toronto, Toronto, M5G 2C4, Canada
Clin Chest Med 32:233-44. 2011..This EVLP technique can also act as a platform for the delivery of novel therapies to repair injured organs ex vivo... - Impact of lymph node metastasis on outcome after extrapleural pneumonectomy for malignant pleural mesotheliomaMarc de Perrot
Division of Thoracic Surgery, Toronto General Hospital, University of Toronto, Canada
J Thorac Cardiovasc Surg 133:111-6. 2007..The impact of lymph node metastasis on the site of recurrence and the role of mediastinoscopy in the selection of patients for extrapleural pneumonectomy, however, remain unclear... - Upper lobe fibrosis: a novel manifestation of chronic allograft dysfunction in lung transplantationSmita Sakha Pakhale
Toronto Lung Transplant Program, University Health Network, Toronto, Ontario, Canada
J Heart Lung Transplant 24:1260-8. 2005..CONCLUSION: Upper lobe fibrosis is a novel presentation of chronic allograft dysfunction in lung transplant recipients and is differentiated from bronchiolitis obliterans syndrome on the basis of physiologic and radiologic findings... - 15 years single center experience with surgical resection of the superior vena cava for non-small cell lung cancerYaron Shargall
Division of Thoracic Surgery, University Health Network (Princess Margaret Hospital and Toronto General Hospital) and the University of Toronto, 10EN-233, Toronto, ON M5G 2C4, Canada
Lung Cancer 45:357-63. 2004..CONCLUSIONS: Carefully selected patients with NSCLC and SVC involvement can be operated upon with acceptable postoperative morbidity and mortality. Induction therapy appears to delay recurrence... - Accommodation after lung xenografting from hamster to ratToshiharu Tabata
Thoracic Surgery Research Laboratory, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
Transplantation 75:607-12. 2003..CONCLUSIONS: Accommodation may be a general phenomenon for all organs, mediated through protective genes. Induction of accommodation does not require disruption of the complement system... - Recipient T cells mediate reperfusion injury after lung transplantation in the ratMarc de Perrot
Thoracic Surgery Research Laboratory and Department of Laboratory Medicine, Toronto General Hospital Research Institute, University of Toronto, Toronto, Canada
J Immunol 171:4995-5002. 2003..The effect of T cells was independent of neutrophil recruitment and activation in the transplanted lung. These results demonstrate that recipient T cells are activated and mediate IR injury during lung transplantation in rats... - Validating the prognostic value of marker genes derived from a non-small cell lung cancer microarray studyFiona H Blackhall
Division of Cellular and Molecular Biology, University Health Network, Ontario Cancer Institute, Princess Margaret Hospital and University of Toronto, Toronto, Ontario, Canada M5G 2M9
Lung Cancer 46:197-204. 2004.... - Long pentraxin PTX3 deficiency worsens LPS-induced acute lung injuryBing Han
Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, Toronto, ON, Canada
Intensive Care Med 37:334-42. 2011..However, the role of PTX3 in the pathogenesis of ALI is not fully understood. We hypothesized that PTX3, as an important immune modulator, may determine the severity of ALI... - Twenty-year experience of lung transplantation at a single center: Influence of recipient diagnosis on long-term survivalMarc de Perrot
Toronto Lung Transplant Program, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
J Thorac Cardiovasc Surg 127:1493-501. 2004..Differences in the complications and long-term survival show the important contribution of the recipient diagnosis to the success of lung transplantation... - Stromal activation and formation of lymphoid-like stroma in chronic lung allograft dysfunctionMasaaki Sato
Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, Institute of Medical Science, Toronto, ON, Canada
Transplantation 91:1398-405. 2011..Lymphoid neogenesis is associated with the development of chronic lung allograft dysfunction (CLAD). Activation of stromal resident cells may be an important mechanism of lymphoid neogenesis... - TNFalpha-induced long pentraxin PTX3 expression in human lung epithelial cells via JNKBing Han
Thoracic Surgery Research Laboratory, University Health Network Toronto General Research Institute, Department of Surgery, University of Toronto, Toronto, Ontario, Canada
J Immunol 175:8303-11. 2005..The importance of the JNK pathway for the regulated PTX3 expression may be a potential target for its regulation in the lung... - Phase 2 trial of preoperative irinotecan plus cisplatin and conformal radiotherapy, followed by surgery for esophageal cancerJennifer J Knox
Department of Medical Oncology, Princess Margaret and Toronto General Hospitals of the University Health Network, Toronto, Ontario, Canada
Cancer 116:4023-32. 2010..Newer regimens may impact these poor outcomes. This phase 2 trial assessed the feasibility and efficacy of induction chemoradiotherapy with cisplatin and irinotecan followed by esophagectomy... - Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndromeYumiko Imai
Department of Critical Care, St Michael's Hospital, University of Toronto, Toronto, Ontario
JAMA 289:2104-12. 2003..This may partially explain the high rate of MODS observed in patients with ARDS and the decrease in morbidity and mortality in patients treated with a lung protective strategy... - Surgical techniques: lung transplant and lung volume reductionCarlos Henrique R Boasquevisque
Lung Transplant Program, Department of Surgery, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
Proc Am Thorac Soc 6:66-78. 2009..The objective of this chapter is to describe the surgical techniques of bilateral lung transplantation and lung volume reduction surgery as performed at the University of Toronto... - Impact of tumor-infiltrating T cells on survival in patients with malignant pleural mesotheliomaMasaki Anraku
Division of Thoracic Surgery, Toronto General Hospital, University Health Network, University of Toronto, Ontario, Canada
J Thorac Cardiovasc Surg 135:823-9. 2008..The aim of the study was to determine the impact of tumor-infiltrating lymphocytes on survival in patients with malignant pleural mesothelioma treated with induction chemotherapy followed by extrapleural pneumonectomy... - Referral patterns for adjuvant chemotherapy in patients with completely resected non-small cell lung cancerFarrah Kassam
Division of Medical Oncology, Princess Margaret Hospital University Health Network, University of Toronto, Ontario, Canada
J Thorac Oncol 2:39-43. 2007..This study examines whether referral patterns for adjuvant therapy in NSCLC have changed since the presentation of confirmatory trials... - Intermediate-term outcome in lung transplantation from a donor with glioblastoma multiformeFengshi Chen
Toronto Lung Transplant Program, Division of Thoracic Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada
J Heart Lung Transplant 28:1116-8. 2009..This patient was critically ill with extracorporeal membrane oxygenation support before transplantation, but is well without any sign of malignancy 20 months after transplantation... - XB130, a novel adaptor protein, promotes thyroid tumor growthAtsushi Shiozaki
Latner Thoracic Surgery Research Laboratories, University Health Network, Toronto General Research Institute, Toronto, Ontario, Canada
Am J Pathol 178:391-401. 2011..These observations suggest that the expression of XB130 in these cancer cells may affect cell proliferation and survival by controlling the expression of multiple genes, especially transcription regulators... - Caspase inhibition improves ischemia-reperfusion injury after lung transplantationSyed M Quadri
Thoracic Surgery Research Laboratory, Toronto General Research Institute, University Health Network - Toronto General Hospital, Toronto, Ontario, Canada
Am J Transplant 5:292-9. 2005..Clearly, this needs to be investigated further with more experiments to validate the potential role of caspase inhibition as a therapeutic modality in ischemia-reperfusion-induced lung injury... - Ischemia-reperfusion decreases protein tyrosine phosphorylation and p38 mitogen-activated protein kinase phosphorylation in rat lung transplantsShoji Sakiyama
University Health Network Toronto General Hospital, Department of Surgery, University of Toronto, Toronto, Ontario, Canada
J Heart Lung Transplant 22:338-46. 2003..The lack of p38 activation suggests that activity of mitogen-activated protein kinase pathways in the lung transplantation setting may be different from other IR processes... - Pre-transplant panel reactive antibody in lung transplant recipients is associated with significantly worse post-transplant survival in a multicenter studyDenis Hadjiliadis
Department of Medicine, Division of Respirology, Toronto General Hospital, Toronto, Ontario, Canada
J Heart Lung Transplant 24:S249-54. 2005..This may be due to a direct effect of anti-HLA antibodies on the allograft. The effectiveness of treatments such as plasmapheresis and intravenous immunoglobulin prior to transplantation needs to be evaluated... - Independent ventilation of the graft and native lungs in vivo after rat lung transplantationMarc de Perrot
Thoracic Surgery Research Laboratory, Toronto General Hospital Research Institute, University of Toronto, Toronto, Ontario, Canada
Ann Thorac Surg 79:2169-71. 2005.... - Risk quantification of early outcome after lung transplantation: donor, recipient, operative, and post-transplant parametersYasuo Sekine
Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
J Heart Lung Transplant 23:96-104. 2004..This scoring system also will facilitate standardization among transplant centers in evaluating post-transplant severity of illness... - Role of lung transplantation in the treatment of bronchogenic carcinomas for patients with end-stage pulmonary diseaseMarc de Perrot
Toronto Lung Transplant Program, University of Toronto, Canada
J Clin Oncol 22:4351-6. 2004..CONCLUSION: This study demonstrates that long-term survival can be achieved after lung transplantation in patients with stage I bronchogenic carcinoma or with advanced multifocal BAC... - A novel model for post-transplant obliterative airway disease reveals angiogenesis from the pulmonary circulationAndre E Dutly
Thoracic Surgery Research Laboratory, Toronto General Hospital Research Institute, Toronto, ON, Canada
Am J Transplant 5:248-54. 2005..This model has revealed new insights into angiogenic potential of the pulmonary circulation... - The role of intrapulmonary de novo lymphoid tissue in obliterative bronchiolitis after lung transplantationMasaaki Sato
Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
J Immunol 182:7307-16. 2009..This de novo lymphoid tissue may play a critical role in chronic local immune responses after lung transplantation... - Role of angiopoietin-1 in experimental and human pulmonary arterial hypertensionLakshmi Kugathasan
Terrence Donnelly Heart Centre, Division of Cardiology, St. Michael's Hospital, Queen Wing, Toronto, ON, Canada, M5B 1W8
Chest 128:633S-642S. 2005..CONCLUSIONS: Decreased activity of the Tie2 pathway with hypoxia may contribute to PAH, possibly by loss of EC survival signaling, which can be overcome by Ang1 gene transfer... - Soluble transforming growth factor-beta type III receptor gene transfection inhibits fibrous airway obliteration in a rat model of Bronchiolitis obliteransMingyao Liu
Thoracic Surgery Research Laboratory, University Health Network, Toronto General Hospital, Room 1 816, 200 Elizabeth Street, Toronto, Ontario, M5G 2C4 Canada
Am J Respir Crit Care Med 165:419-23. 2002..Adenoviral-mediated soluble TGFBIIIR gene transfection should be further explored as a potential therapeutic modality for BO and other conditions involving chronic fibrosis... - Differential gene profiling in acute lung injury identifies injury-specific gene expressionClaudia C dos Santos
Thoracic Surgery Research Laboratory, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
Crit Care Med 36:855-65. 2008..Physiologic and morphologic manifestations of disparate forms of injury are often indistinguishable. We sought to demonstrate that acute lung injury resulting from distinct insults may lead to different gene expression profiles... - Lung transplantation: donor and recipient critical care aspectsAndrew F Pierre
Division of Thoracic Surgery, University of Toronto, Toronto, Ontario, Canada
Curr Opin Crit Care 11:339-44. 2005..SUMMARY: Patients undergoing lung transplantation continue to be very challenging in the intensive care unit. A multidisciplinary approach to care, and early recognition of serious problems, will help improve outcomes... - Bronchiolitis obliterans syndrome: alloimmune-dependent and -independent injury with aberrant tissue remodelingMasaaki Sato
Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
Semin Thorac Cardiovasc Surg 20:173-82. 2008..From this viewpoint, we review current therapeutic strategies and revisit the role of transplant surgeons in attenuating the initial transplant-related injuries to prevent the lung grafts from entering the remodeling-injury cycle... - Clinical impact of community-acquired respiratory viruses on bronchiolitis obliterans after lung transplantDeepali Kumar
Infectious Diseases and Multi Organ Transplant, University of Toronto, Toronto, Ontario, Canada
Am J Transplant 5:2031-6. 2005..Community-acquired respiratory viruses may be associated with the development of acute rejection and BOS... - Lung transplantation. Lung preservationMarc de Perrot
Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, 200 Elizabeth Street, EN 10-224, Toronto, Ontario M5G 2C4, Canada
Chest Surg Clin N Am 13:443-62. 2003..Hopefully, this information will provide new insights into the mechanisms of injury and reveal potential new strategies and targets for therapies to improve lung preservation... - Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part VI: treatmentYaron Shargall
Division of Thoracic Surgery, Toronto General Hospital, Toronto, Ontario, Canada
J Heart Lung Transplant 24:1489-500. 2005 - Surfactant palmitoylmyristoylphosphatidylcholine is a marker for alveolar size during diseaseRoss Ridsdale
Lung Biology Program, Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada
Am J Respir Crit Care Med 172:225-32. 2005..These data are compatible with extracellular surfactant 16:0/14:0PC content being an indicator of alveolar architecture of the lung... - Ischemia-reperfusion-induced lung injuryMarc de Perrot
Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
Am J Respir Crit Care Med 167:490-511. 2003.... - Mycobacterium abscessus infections in lung transplant recipients: the international experienceSusan M Chernenko
Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Ontario, Canada
J Heart Lung Transplant 25:1447-55. 2006..Concurrent infections are common and may contribute to mortality in this immunosuppressed population... - Interferon-mediated immunopathological events are associated with atypical innate and adaptive immune responses in patients with severe acute respiratory syndromeMark J Cameron
Division of Experimental Therapeutics, University Health Network, MaRS Centre, 3 916 TMDT, 101 College Street, Toronto, Ontario, Canada
J Virol 81:8692-706. 2007.... - A simplified model for en bloc double lung xenotransplantation from hamster to ratMarc de Perrot
Thoracic Surgery Research Laboratory, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
J Heart Lung Transplant 21:286-9. 2002..This technique provides a technically easier and more reliable model to study xenotransplantation of the lung... - A novel model to study bacterial adherence to the transplanted airway: inhibition of Burkholderia cepacia adherence to human airway by dextran and xylitolUmadevi Sajjan
Division of Structural Biology and Biochemistry, Hospital for Sick Children, Toronto, Ontario, Canada
J Heart Lung Transplant 23:1382-91. 2004..CONCLUSIONS: Treating donor lungs with dextran 40 kd or xylitol before (and possibly after) surgery may inhibit the adherence of Burkholderia cepacia complex to airways and may prevent or decrease subsequent infection of the allografts... - Constrictive pericarditis after lung transplantation: an under-recognized complicationWojtek Karolak
Division of Thoracic Surgery, Department of Surgery, University of Toronto, Toronto, Canada
J Heart Lung Transplant 29:578-81. 2010.... - Bilateral lung transplantation using a donor with a tracheal right upper lobe bronchusYasuo Sekine
Division of Thoracic Surgery, Toronto General Hospital, University Health Network, University of Toronto, Ontario, Canada
Ann Thorac Surg 73:308-10. 2002..The anastomosis was completed using a telescoping technique without any complication. This case demonstrates the possibility of successfully using donor lungs with such anatomic abnormality for transplantation... - Bilateral lung transplantation for metastatic leiomyosarcomaYaron Shargall
Toronto Lung Transplant Program, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
J Heart Lung Transplant 23:912-5. 2004..While lung transplantation for malignancy remains a controversial area, this case illustrates that lung transplantation can provide improved quality and quantity of life for highly selected patients with malignant disease... - De novo pulmonary capillary hemangiomatosis occurring rapidly after bilateral lung transplantationMarc de Perrot
Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
J Heart Lung Transplant 22:698-700. 2003..This case supports the theory that persistent infection or inflammation may be an inciting factor in uncontrolled angiogenesis, leading ultimately to diffuse pulmonary capillary hemangiomatosis... - Interleukin-8 release during early reperfusion predicts graft function in human lung transplantationMarc de Perrot
Division of Thoracic Surgery, Thoracic Surgery Research Laboratory and The Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Ontario, Canada
Am J Respir Crit Care Med 165:211-5. 2002..In addition, we showed that donor age and ischemic time may influence release of specific cytokines during ischemia-reperfusion... - Everting mattress running suture: an improved technique of atrial anastomosis in human lung transplantationMarc de Perrot
Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Ontario, Canada
Ann Thorac Surg 73:1663-4. 2002..This technique should help reduce the risk of venous anastomotic complications... - Molecular profiling of non-small cell lung cancer and correlation with disease-free survivalDennis A Wigle
Thoracic Oncology Site Group, Princess Margaret Hospital, Samuel Lunenfeld Research Institute of Mount Sinai Hospital, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
Cancer Res 62:3005-8. 2002..The results provide evidence that molecular subtyping of NSCLC can identify distinct profiles of gene expression correlating with disease-free survival... - Effect of ventilator-induced lung injury on the development of reperfusion injury in a rat lung transplant modelMarc de Perrot
Thoracic Surgery Research Laboratory, Toronto General Hospital, Toronto, Ontario, Canada
J Thorac Cardiovasc Surg 124:1137-44. 2002.... - The effect of regionalization on outcome in pulmonary lobectomy: a Canadian national studyChristian J Finley
Division of Thoracic Surgery, Toronto General Hospital, Toronto, Ontario, Canada
J Thorac Cardiovasc Surg 140:757-63. 2010..To examine the effect of regionalization of thoracic surgery services in Canada by evaluating change over time in hospital volumes of pulmonary lobectomy and its impact on length of stay and in-hospital mortality... - Update on donor assessment, resuscitation, and acceptance criteria, including novel techniques--non-heart-beating donor lung retrieval and ex vivo donor lung perfusionJonathan C Yeung
Toronto Lung Transplant Program, Toronto General Hospital, 200 Elizabeth Street, Toronto, ON, Canada
Thorac Surg Clin 19:261-74. 2009..With these new methods for assessing and resuscitating lungs accurately, it is hoped that inroads will be made toward providing every listed patient a chance for successful lung transplantation... - Passenger lymphocyte syndrome with or without immune hemolytic anemia in all Rh-positive recipients of lungs from rhesus alloimmunized donors: three new cases and a review of the literatureChristine M Cserti-Gazdewich
University Health Network Toronto General Hospital, Toronto, ON, Canada
Transfus Med Rev 23:134-45. 2009..A review of the phenomenon and its implications are discussed... - Lung cancer screening using low-dose computed tomography in at-risk individuals: the Toronto experienceRavi J Menezes
Department of Medical Imaging, University Health Network, Toronto, ON, Canada
Lung Cancer 67:177-83. 2010..Baseline and annual repeat results are reported on the first 3352 participants, enrolled between June 2003 and May 2007... - Lung preservationMarc de Perrot
Toronto Lung Transplant Program, Toronto General Hospital, University of Toronto, Ontario, Canada
Ann Thorac Surg 74:629-31. 2002 - Initial experience with lung donation after cardiocirculatory death in CanadaMarcelo Cypel
The Toronto Lung Transplant Program, University of Toronto, Toronto, Ontario, Canada
J Heart Lung Transplant 28:753-8. 2009..Only limited data describe outcomes after DCD lung transplantation. This study describes the early and intermediate outcomes after DCD lung transplantation in Canada... - Risk of a right pneumonectomy: role of bronchopleural fistulaGail E Darling
Division of Thoracic Surgery, Toronto General Hospital, Toronto, Ontario, Canada
Ann Thorac Surg 79:433-7. 2005..The purpose of this study is to compare the morbidity and mortality of right versus left pneumonectomy... - Gene therapy in lung transplantationMasaaki Sato
Thoracic Surgery Research Laboratory, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada
Curr Gene Ther 6:439-58. 2006..Based on our work and the work of others, over the last decade, we present the state of art of in gene therapy in lung transplantation and exciting future directions in the field... - The effect of gender combinations on outcome in human lung transplantation: the International Society of Heart and Lung Transplantation Registry experienceMasaaki Sato
Division of Thoracic Surgery, Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
J Heart Lung Transplant 25:634-7. 2006..Interestingly, F to F appears to be potentially beneficial in lung transplantation. Gender combinations do appear to significantly impact outcome after lung transplantation... - Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part I: introduction and methodsJason D Christie
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Heart Lung Transplant 24:1451-3. 2005 - International guidelines for the selection of lung transplant candidates: 2006 update--a consensus report from the Pulmonary Scientific Council of the International Society for Heart and Lung TransplantationJonathan B Orens
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
J Heart Lung Transplant 25:745-55. 2006 - Incidence and prevalence of diabetes mellitus in patients with cystic fibrosis undergoing lung transplantation before and after lung transplantationDenis Hadjiliadis
Division of Allergy, Pulmonary and Critical Care, Department of Medicine, University of Pennsylvania Lung Transplant Program, University of Pennsylvania, Philadelphia, PA 19104, USA
Clin Transplant 19:773-8. 2005..1%) of pancreatic insufficient patients who were non-diabetic prior to transplant, developed DM after transplant. DM is common in CF patients undergoing lung transplantation and the prevalence increases after transplant... - Retransplantation of the lung comes of ageShaf Keshavjee
J Thorac Cardiovasc Surg 132:226-8. 2006 - Non-utilization of hearts and lungs after consent for donation: a Canadian multicentre studyKaren Hornby
Division of Critical Care, Montreal Children's Hospital, McGill University Health Centre, Quebec, Canada
Can J Anaesth 53:831-7. 2006..Although there is considerable pressure to increase organs for transplantation, any such mechanism will not be judged successful unless recipient graft survival rates remain acceptable... - Donor-recipient gender mismatch in lung transplantation: Impact on obliterative bronchiolitis and survivalMasaaki Sato
J Heart Lung Transplant 24:2000-1. 2005 - GI complications after lung transplantation in patients with cystic fibrosisMarita Gilljam
Department of Respiratory Medicine and Allergology, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
Chest 123:37-41. 2003..Prevention and early medical treatment are important in order to avoid acute surgery. Close collaboration with the CF clinic, in order to diagnose and treat CF-related complications, is recommended... - Survival of lung transplant patients with cystic fibrosis harboring panresistant bacteria other than Burkholderia cepacia, compared with patients harboring sensitive bacteriaDenis Hadjiliadis
Department of Medicine, Division of Pulmonary Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 10104, USA
J Heart Lung Transplant 26:834-8. 2007..The impact of panresistant bacteria, other than Burkholderia cepacia, on the survival after lung transplantation in patients with cystic fibrosis (CF) remains controversial...