Research Topics
Genomes and Genes | Abhijit GuhaSummaryAffiliation: University of Toronto Country: Canada Publications
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Publications
Advances in the biology of astrocytomasAbhijit Guha
Western Hospital, University of Toronto, Toronto, Ontario M5T 2S8, Canada
Curr Opin Neurol 17:655-62. 2004..This review highlights some of the findings over the past year (June 2003-2004) that have contributed to this slow but essential journey towards our understanding of the biology of astrocytomas...- Loss of collapsin response mediator Protein1, as detected by iTRAQ analysis, promotes invasion of human gliomas expressing mutant EGFRvIIIJoydeep Mukherjee
Arthur and Sonia Labatts Brain Tumor Research Center, Hospital for Sick Children s Research Institute, University of Toronto, Toronto, Canada
Cancer Res 69:8545-54. 2009..Collectively, these results show that the loss of CRMP1 contribute to the increased invasive phenotype of human GBMs expressing mutant EGFRvIII... - Regulation of the pathological vasculature of malignant astrocytomas by angiopoietin-1Gelareh Zadeh
Arthur and Sonia Labatts Brain Tumor Center, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
Neoplasia 7:1081-90. 2005..Collectively, these results support our hypothesis that Ang1 is a key molecular regulator of pathological vascularization characteristic of malignant astrocytomas... - Role of Ang1 and its interaction with VEGF-A in astrocytomasGelareh Zadeh
From Arthur and Sonia Labatts Brain Tumor Center, Hospital for Sick Children, University of Toronto, Toronto, Canada
J Neuropathol Exp Neurol 63:978-89. 2004..Collectively, our data suggest that Ang1 regulates GBM vascularity in a VEGF-A dependent manner, synergizing the initial pro-angiogenic response that is triggered by VEGF-A and promoting the vascular growth of GBM... - Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiformeAmparo Wolf
The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children Research Institute, University of Toronto, Toronto, Ontario, Canada
J Exp Med 208:313-26. 2011..Collectively, these findings suggest that therapeutic strategies to modulate the Warburg effect, such as targeting of HK2, may interfere with growth and therapeutic sensitivity of some GBMs... - High-grade glioma formation results from postnatal pten loss or mutant epidermal growth factor receptor expression in a transgenic mouse glioma modelQingxia Wei
Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, University Health Network, Toronto, Ontario, Canada
Cancer Res 66:7429-37. 2006..This novel preclinical model of high-grade glioma will be useful in evaluating brain tumor therapies targeted to the pathways specifically dysregulated by EGFR expression or Pten loss... - Developmental profile and regulation of the glycolytic enzyme hexokinase 2 in normal brain and glioblastoma multiformeAmparo Wolf
The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children Research Institute, University of Toronto, Toronto, 11 401E, 101 College Street, East Tower, Ontario, Canada, M5G 1L7
Neurobiol Dis 44:84-91. 2011..Overall, our results demonstrate that proliferative states including the developing embryo and malignant gliomas, which rely on aerobic glycolysis, preferentially express the HK2 isoform, found to be regulated in part epigenetically... - Pathological and molecular progression of astrocytomas in a GFAP:12 V-Ha-Ras mouse astrocytoma modelPatrick Shannon
Department of Neuropathology, The University of Toronto, Toronto, Ontario, Canada, M5T 2S8
Am J Pathol 167:859-67. 2005..Of interest, many of these acquired alterations occur in human astrocytomas, further validating GFAP-RAS as a useful model for studying astrocytoma development and progression... - Preclinical in vivo evaluation of rapamycin in human malignant peripheral nerve sheath explant xenograftPriya Bhola
The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, University of Toronto, Ontario, Canada
Int J Cancer 126:563-71. 2010..This study demonstrates the therapeutic potential and limitations of rapamycin in NF1-associated, and likely sporadic, MPNSTs... - Comparisons of [18F]-1-deoxy-1-fluoro-scyllo-inositol with [18F]-FDG for PET imaging of inflammation, breast and brain cancer xenografts in athymic miceKristin McLarty
Department of Psychiatry, University of Toronto, Toronto, ON, Canada M5T 1R8
Nucl Med Biol 38:953-9. 2011..Studies of [(18)F]-2-fluoro-2-deoxy-d-glucose ([(18)F]-FDG) under the same conditions were also performed... - Human schwannomas express activated platelet-derived growth factor receptors and c-kit and are growth inhibited by Gleevec (Imatinib Mesylate)Joydeep Mukherjee
Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children Research Institute, University of Toronto, Toronto, Ontario, Canada
Cancer Res 69:5099-107. 2009..However, the established long track record and tolerable toxicity of Gleevec already in clinical use and our preclinical data lead us to propose that Gleevec should be evaluated in human schwannomas with shown progressive growth... - A GATA4-regulated tumor suppressor network represses formation of malignant human astrocytomasSameer Agnihotri
The Arthur and Sonia Labatt s Brain Tumor Research Centre, The Hospital for Sick Children s Research Institute, Toronto Western Hospital, University of Toronto, Toronto M5A 2N4, Ontario, Canada
J Exp Med 208:689-702. 2011..Identification and validation of GATA4 as a TSG and its downstream targets in GBM may yield promising novel therapeutic strategies... - GATA6 is an astrocytoma tumor suppressor gene identified by gene trapping of mouse glioma modelDeepak Kamnasaran
The Arthur and Sonia Labatts Brain Tumor Research Centre, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada M5G 1X8
Proc Natl Acad Sci U S A 104:8053-8. 2007..This work also demonstrates the utility of random mutagenesis strategies, such as gene trapping, on murine cancer models toward discovery of novel genetic alterations in corresponding human cancers... - Targeting the Tie2/Tek receptor in astrocytomasGelareh Zadeh
Arthur and Sonia Labatt Brain Tumor Center, Hospital for Sick Children, Toronto, Ontario, Canada
Am J Pathol 164:467-76. 2004..We postulate that targeting Tie2 activation, either independently or in conjunction with other anti-angiogenic therapies, such as against vascular endothelial growth factor, is of potential clinical interest... - A human transferrin-vascular endothelial growth factor (hnTf-VEGF) fusion protein containing an integrated binding site for (111)In for imaging tumor angiogenesisConrad Chan
Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
J Nucl Med 46:1745-52. 2005.... - Glioblastoma multiforme after stereotactic radiotherapy for acoustic neuroma: case report and review of the literatureAnandh Balasubramaniam
Arthur and Sonia Labatt Brain Tumor Center, Hospital for Sick Children, University of Toronto, 399 Bathurst St, 4W 446, Toronto, ON M5T 2S8, Canada
Neuro Oncol 9:447-53. 2007..However, the risk is not zero and requires discussion with the patient, with specific consideration in young patients and those with a cancer predisposition... - High-resolution longitudinal screening with magnetic resonance imaging in a murine brain cancer modelNicholas A Bock
Department of Medical Biophysics, University of Toronto, Toronto, Canada
Neoplasia 5:546-54. 2003.... - Potential role of 18fluorodeoxyglucose-positron emission tomography/computed tomography in differentiating benign neurofibroma from malignant peripheral nerve sheath tumor associated with neurofibromatosis 1Konstantina Karabatsou
Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Canada
Neurosurgery 65:A160-70. 2009..18FDG-PET/CT has the added advantage of fusing metabolic and anatomic imaging data sets... - Molecular regulators of angiogenesis in the developing nervous system and adult brain tumors (review)Gelareh Zadeh
Arthur and Sonia Labatt Brain Tumor Center, Hospital for Sick Children, Toronto, Ontario, Canada
Int J Oncol 23:557-65. 2003..In this review we summarize the role of the main angiogenic factors in both normal embryonal vascularization of the embryonal nervous system together with the main brain tumors seen in adults... - Targeting metabolic remodeling in glioblastoma multiformeAmparo Wolf
The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children Research Institute, University of Toronto, Toronto, Ontario, Canada
Oncotarget 1:552-62. 2010..Targeting key metabolic enzymes involved in modulating the "Warburg Effect" may provide a novel therapeutic approach either singularly or in combination with existing therapies in GBMs... - Role of angiopoietin-2 in regulating growth and vascularity of astrocytomasGelareh Zadeh
Arthur and Sonia Labatts Brain Tumor Center, Hospital for Sick Children, University of Toronto, Toronto, Canada M5G 2G4
J Oncol 2010:659231. 2010.... - Multiphoton ANS fluorescence microscopy as an in vivo sensor for protein misfolding stressKevin C Hadley
Department of Medical Biophysics, University of Toronto Ontario Cancer Institute, 101 College Street, Toronto, ON, M5G 1L7, Canada
Cell Stress Chaperones 16:549-61. 2011..Multiphoton imaging of ANS binding should be a useful probe for monitoring protein misfolding stress in cells... - A proximity ligation assay using transiently transfected, epitope-tagged proteins: application for in situ detection of dimerized receptor tyrosine kinasesAaron Gajadhar
Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, University of Toronto, Canada
Biotechniques 48:145-52. 2010..This assay also holds promise as a general RTK dimerization screening tool in tissue specimens to identify potential dimerization inhibitors with clinical relevance... - Proteomics: present and future implications in neuro-oncologyJohann Micallef
Arthur and Sonia Labatt Brain Tumour Center, Hospital for Sick Children s Research Institute, University of Toronto, Toronto, Canada
Neurosurgery 62:539-55; discussion 539-55. 2008..In addition to reviewing the principles and potential utilization of these two techniques, we highlight their application in neuro-oncology research... - Rap1 activity is elevated in malignant astrocytomas independent of tuberous sclerosis complex-2 gene expressionNelson Lau
Arthur and Sonia Labatt Brain Tumor Research Center, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
Int J Oncol 22:195-200. 2003.... - Angiogenesis in nervous system disordersGelareh Zadeh
Arthur and Sonia Labatts Brain Tumor Center, Hospital for Sick Children's Research Institute, University of Toronto, Toronto, Ontario, Canada
Neurosurgery 53:1362-74; discussion 1374-6. 2003..This review summarizes the current understanding of the role of principal angiogenic factors relevant to neurosurgical abnormalities... - Malignant and benign ganglioglioma: a pathological and molecular studyAjay Pandita
Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada
Neuro Oncol 9:124-34. 2007..Deciphering the specific genes residing in these chromosomal regions may further our understanding of not only these rare tumors but also the more common gliomas... - Radiation induced peripheral nerve tumors: case series and review of the literatureGelareh Zadeh
Arthur and Sonia Labatts Brain Tumor Center, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
J Neurooncol 83:205-12. 2007..The clinical and pathologic features of six cases of post-radiation PNT's are reported here, more than doubling the number of known cases reported in the literature... - Neoangiogenesis in human astrocytomas: expression and functional role of angiopoietins and their cognate receptorsGelareh Zadeh
Arthur and Sonia Labatts Brain Tumor Center, Hospital for Sick Childrens, University of Toronto, 399 Bathurst Street, Toronto, Ontario, Canada
Front Biosci 8:e128-37. 2003.... - Mouse models to interrogate the implications of the differentiation status in the ontogeny of gliomasDiana Marcela Muñoz
The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children Research Institute, University of Toronto, Toronto, Ontario, Canada M5G 1L7
Oncotarget 2:590-8. 2011..This is an area of high interest in cancer in general, with potential significant therapeutic and prognostic implications... - Phosphatidylinositol 3'-kinase and MAPK/ERK kinase 1/2 differentially regulate expression of vascular endothelial growth factor in human malignant astrocytoma cellsStacy A Woods
The Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada
Neuro Oncol 4:242-52. 2002..This study suggests that modulation of signaling pathways implicated in proliferation of astrocytoma cell lines may have varying effects in vivo depending on the role these pathways play in regulating tumor angiogenesis... - Vestibular Schwannomas presenting with haemorrhage: clinical presentation and histopathological evaluation of an unusual entityAmir R Dehdashti
Division of Neurosurgery, University Health Network, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
Br J Neurosurg 23:431-6. 2009..Tumor size may not be a major risk factor for haemorrhage. Good outcomes can be achieved with microsurgical management. The histological features presented here differ clearly from findings in previously published case reports... - Surgical management of cervical spine manifestations of neurofibromatosis Type 1: long-term clinical and radiological follow-up in 22 casesFaisal S Taleb
Neuroscience Center, Toronto Western Hospital, Spinal Program, West Wing 4th Floor, 399 Bathurst Street, Toronto, Ontario, Canada
J Neurosurg Spine 14:356-66. 2011..Iatrogenic instability following resection of tumors is underappreciated in the literature. The focus of this study was to understand the indications for stabilization in this specific group of patients... - Fiber density index correlates with reduced fractional anisotropy in white matter of patients with glioblastomaTim P L Roberts
Department of Medical Imaging, University of Toronto, Toronto, Canada
AJNR Am J Neuroradiol 26:2183-6. 2005..In this report, FDi is computed in 10 patients with glioblastoma multiforme, in white matter that is peritumoral and contralateral. FDi is shown to correlate significantly with fractional anisotropy... - Lipoma compressing the brachial plexus in a patient with sarcoidosis: case reportDaipayan Guha
Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Br J Neurosurg 25:530-1. 2011..We document a unique case of a sarcoidosis patient with an extraneural lipoma compressing the brachial plexus, and present a review of the current literature... - Three-dimensional in vivo modeling of vestibular schwannomas and surrounding cranial nerves with diffusion imaging tractographyDavid Qixiang Chen
Division of Neurosurgery, Toronto Western Hospital and University of Toronto, Toronto, Ontario, Canada
Neurosurgery 68:1077-83. 2011..However, imaging of the CN fibers surrounding vestibular schwannomas has been limited with 2-dimensional imaging alone... - Aberrant G protein signaling in nervous system tumorsStacey A Woods
Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada
J Neurosurg 97:627-42. 2002.... - Metaplastic bone formation in a low grade conus glioma: case report and review of the literatureVitaly Siomin
Division of Neurosurgery Western Hospital, University Health Network, University of Toronto, Ontario, Canada
J Neurooncol 62:275-80. 2003..We present a case of bony metaplasia in the conus medullaris associated with a low grade astrocytoma. Radiological, pathological and clinical features of this unique case are discussed... - Contrasting in vivo and in vitro fates of glioblastoma cell subpopulations with amplified EGFRAjay Pandita
The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, University of Toronto, Toronto, Ontario
Genes Chromosomes Cancer 39:29-36. 2004.... - Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healingSophia S Cheon
Program in Developmental Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
FASEB J 20:692-701. 2006..These results demonstrate a crucial role for beta-catenin in regulating cutaneous wound size. Furthermore, these data implicate mesenchymal cells as playing a critical role regulating wound size... - Oligodendrogliomas result from the expression of an activated mutant epidermal growth factor receptor in a RAS transgenic mouse astrocytoma modelHao Ding
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, USA
Cancer Res 63:1106-13. 2003.... - Suppression of glioblastoma tumorigenicity by the Kruppel-like transcription factor KLF6Alec C Kimmelman
The Derald H Ruttenberg Cancer Center, The Mount Sinai School of Medicine, New York, NY 10029, USA
Oncogene 23:5077-83. 2004..Our results provide the first evidence of functional tumor suppression by KFL6, and its loss may contribute to glial tumor progression... - Intermittent atlantoaxial subluxation caused by a prolapsing neurofibroma. Case reportMichael O Kelleher
Spinal Program, Krembil Neuroscience Centre, Toronto Western Hospital, University Health Network, Ontario, Canada
J Neurosurg Spine 8:288-91. 2008..The authors discuss this unusual lesion and describe the associated operative findings and surgical management... - Mouse glioma gene expression profiling identifies novel human glioma-associated genesDavid H Gutmann
Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
Ann Neurol 51:393-405. 2002..The use of this transgenic mouse model to identify novel genetic changes that might underlie the pathogenesis of human high-grade astrocytomas provides a unique opportunity to discover future targets for brain tumor therapy... - Expression of GATA6 in the human and mouse central nervous systemDeepak Kamnasaran
The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada M5G 1X8
Brain Res Dev Brain Res 160:90-5. 2005..2 kb transcript in the adult mouse brain and several regions of the adult human brain. Furthermore, cellular characterization demonstrates GATA6 nuclear expression in neurons, astrocytes, choroids plexus epithelium, and endothelial cells... - Proteolytic cleavage of the CD44 adhesion molecule in multiple human tumorsIsamu Okamoto
Department of Microbiology and Immunology, Kimmel Cancer Institute, BLSB 2002, Thomas Jefferson University, 233 S 10th St, Philadelphia, PA 19107, USA
Am J Pathol 160:441-7. 2002..Tumors expressing a CD44 splice variant showed a significantly higher incidence of enhanced CD44 cleavage. The wide prevalence of CD44 cleavage suggests that it plays an important role in the pathogenesis of human tumors... - Proteomic identification of biomarkers in the cerebrospinal fluid (CSF) of astrocytoma patientsFatima W Khwaja
Laboratory of Molecular Neuro Oncology, Department of Neurosurgery and Winship Cancer Institute, Emory University School of Medicine, 1365C Clifton Road NE, Atlanta, GA 30322, USA
J Proteome Res 6:559-70. 2007....