Jorge Filmus

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi Glypicans
    Jorge Filmus
    Department of Medical Biophysics, Division of Molecular and Cellular Biology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario M4N 3M5, Canada
    Genome Biol 9:224. 2008
  2. ncbi The role of glypican-3 in the regulation of body size and cancer
    Jorge Filmus
    Division of Molecular and Cell Biology, Sunnybrook Research Institute and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Cell Cycle 7:2787-90. 2008
  3. ncbi Mammalian Notum induces the release of glypicans and other GPI-anchored proteins from the cell surface
    Alexandra Traister
    Division of Molecular and Cell Biology, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, University of Toronto, S 220 Toronto, ON, Canada M4N 3M5, and Department ofMedical Biophysics, University of Toronto, Toronto, ON, Canada
    Biochem J 410:503-11. 2008
  4. ncbi The contribution of in vivo manipulation of gene expression to the understanding of the function of glypicans
    Jorge Filmus
    Sunnybrook and Women s College Health Sciences Centre, and Department of Medical Biophysics, University of Toronto, Canada
    Glycoconj J 19:319-23. 2002
  5. ncbi Overgrowth of a mouse model of Simpson-Golabi-Behmel syndrome is partly mediated by Indian hedgehog
    Mariana I Capurro
    Division of Molecular and Cell Biology, University of Toronto, Toronto, Ontario, Canada
    EMBO Rep 10:901-7. 2009
  6. ncbi Soluble glypican 3 inhibits the growth of hepatocellular carcinoma in vitro and in vivo
    Sandra I Zittermann
    Division of Molecular and Cellular Biology, Sunnybrook Research Institute and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
    Int J Cancer 126:1291-301. 2010

Collaborators

  • Mariana I Capurro
  • Sandra I Zittermann
  • Wen Shi
  • Alexandra Traister
  • Fuchuan Li

Detail Information

Publications6

  1. ncbi Glypicans
    Jorge Filmus
    Department of Medical Biophysics, Division of Molecular and Cellular Biology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario M4N 3M5, Canada
    Genome Biol 9:224. 2008
    ..Surprisingly, the regulatory activity of glypicans in the Wnt, Hedgehog and BMP signaling pathways is only partially dependent on the heparan sulfate chains...
  2. ncbi The role of glypican-3 in the regulation of body size and cancer
    Jorge Filmus
    Division of Molecular and Cell Biology, Sunnybrook Research Institute and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Cell Cycle 7:2787-90. 2008
    ..Finally, we propose an explanation for the tissue-specific function of GPC3...
  3. ncbi Mammalian Notum induces the release of glypicans and other GPI-anchored proteins from the cell surface
    Alexandra Traister
    Division of Molecular and Cell Biology, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, University of Toronto, S 220 Toronto, ON, Canada M4N 3M5, and Department ofMedical Biophysics, University of Toronto, Toronto, ON, Canada
    Biochem J 410:503-11. 2008
    ..Finally, by using a cellular system in which GPC3 (glypican-3) stimulates Wnt signalling, we show that Notum can act as a negative regulator of this growth factor...
  4. ncbi The contribution of in vivo manipulation of gene expression to the understanding of the function of glypicans
    Jorge Filmus
    Sunnybrook and Women s College Health Sciences Centre, and Department of Medical Biophysics, University of Toronto, Canada
    Glycoconj J 19:319-23. 2002
    ..Future studies should investigate whether the phenotype of GPC-3-deficient individuals is also due to altered modulation of cellular responses to these factors...
  5. ncbi Overgrowth of a mouse model of Simpson-Golabi-Behmel syndrome is partly mediated by Indian hedgehog
    Mariana I Capurro
    Division of Molecular and Cell Biology, University of Toronto, Toronto, Ontario, Canada
    EMBO Rep 10:901-7. 2009
    ..8% bigger than the Ihh-null mice. Consistent with the role of GPC3 in Hh endocytosis and degradation, the Gpc3-null mice show increased levels of Ihh protein and signalling, but similar levels of Ihh messenger RNA...
  6. ncbi Soluble glypican 3 inhibits the growth of hepatocellular carcinoma in vitro and in vivo
    Sandra I Zittermann
    Division of Molecular and Cellular Biology, Sunnybrook Research Institute and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
    Int J Cancer 126:1291-301. 2010
    ..An anti-angiogenic effect in Huh7 and HepG2-derived tumors was also observed. We conclude that sGPC3 can inhibit HCC tumorigenicity by blocking the activity of several pro-tumorigenic growth factors...