Brian Cox

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives
    Owen J Tamplin
    Program in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada
    BMC Genomics 9:511. 2008
  2. ncbi Tissue subcellular fractionation and protein extraction for use in mass-spectrometry-based proteomics
    Brian Cox
    Department of Medical Genetics, 1 King s College Circle, University of Toronto, Toronto, ON, M5S 1A8, Canada
    Nat Protoc 1:1872-8. 2006
  3. ncbi Comparative systems biology of human and mouse as a tool to guide the modeling of human placental pathology
    Brian Cox
    The Hospital for Sick Children, Program in Developmental and Stem Cell Biology, Toronto, Ontario, Canada
    Mol Syst Biol 5:279. 2009
  4. ncbi Building bridges from 'omics' to cell biology
    Brian Cox
    The Hospital for Sick Children Research Institute, Program in Stem Cell and Developmental Biology, Toronto, Ontario, Canada
    Genome Biol 10:305. 2009
  5. ncbi Translational analysis of mouse and human placental protein and mRNA reveals distinct molecular pathologies in human preeclampsia
    Brian Cox
    The Hospital for Sick Children, Program in Developmental and Stem Cell Biology, Toronto, Ontario, Canada
    Mol Cell Proteomics 10:M111.012526. 2011
  6. ncbi Global survey of organ and organelle protein expression in mouse: combined proteomic and transcriptomic profiling
    Thomas Kislinger
    Banting and Best Department of Medical Research, University of Toronto, Toronto, ON M5G 1L6, Canada
    Cell 125:173-86. 2006
  7. ncbi Integrated proteomic and transcriptomic profiling of mouse lung development and Nmyc target genes
    Brian Cox
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada
    Mol Syst Biol 3:109. 2007
  8. ncbi ?-catenin causes renal dysplasia via upregulation of Tgf?2 and Dkk1
    Darren Bridgewater
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    J Am Soc Nephrol 22:718-31. 2011
  9. ncbi Integrating gene and protein expression data: pattern analysis and profile mining
    Brian Cox
    Department of Medical and Molecular Genetics, University of Toronto, Toronto, Ont, Canada
    Methods 35:303-14. 2005
  10. ncbi PRISM, a generic large scale proteomic investigation strategy for mammals
    Thomas Kislinger
    Program in Proteomics and Bioinformatics, Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario M5G 1L6, Canada
    Mol Cell Proteomics 2:96-106. 2003

Collaborators

Detail Information

Publications12

  1. ncbi Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives
    Owen J Tamplin
    Program in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada
    BMC Genomics 9:511. 2008
    ..However, the targets of Foxa2 during embryogenesis, and the molecular impact of organizer loss on the gastrula embryo, have not been well defined...
  2. ncbi Tissue subcellular fractionation and protein extraction for use in mass-spectrometry-based proteomics
    Brian Cox
    Department of Medical Genetics, 1 King s College Circle, University of Toronto, Toronto, ON, M5S 1A8, Canada
    Nat Protoc 1:1872-8. 2006
    ..Once the fractions are isolated, they are extracted for protein and the samples can then be frozen for processing and analysis at a later date. The procedure can typically be completed in 5 h...
  3. ncbi Comparative systems biology of human and mouse as a tool to guide the modeling of human placental pathology
    Brian Cox
    The Hospital for Sick Children, Program in Developmental and Stem Cell Biology, Toronto, Ontario, Canada
    Mol Syst Biol 5:279. 2009
    ..The entire data are available as a web-accessible database to guide the informed development of mouse models to study human disease...
  4. ncbi Building bridges from 'omics' to cell biology
    Brian Cox
    The Hospital for Sick Children Research Institute, Program in Stem Cell and Developmental Biology, Toronto, Ontario, Canada
    Genome Biol 10:305. 2009
    ..A report from the Keystone Symposium on Molecular and Cellular Biology, 'Omics Meets Cell Biology', Breckenridge, Colorado, 25-30 January, 2009...
  5. ncbi Translational analysis of mouse and human placental protein and mRNA reveals distinct molecular pathologies in human preeclampsia
    Brian Cox
    The Hospital for Sick Children, Program in Developmental and Stem Cell Biology, Toronto, Ontario, Canada
    Mol Cell Proteomics 10:M111.012526. 2011
    ..We conclude that clinically similar preeclampsia patients exhibit divergent placental gene expression profiles thus implicating divergent molecular mechanisms in the origins of this disease...
  6. ncbi Global survey of organ and organelle protein expression in mouse: combined proteomic and transcriptomic profiling
    Thomas Kislinger
    Banting and Best Department of Medical Research, University of Toronto, Toronto, ON M5G 1L6, Canada
    Cell 125:173-86. 2006
    ..This molecular compendium, fully accessible via a searchable web-browser interface, serves as a reliable reference of the expressed tissue and organelle proteomes of a leading model mammal...
  7. ncbi Integrated proteomic and transcriptomic profiling of mouse lung development and Nmyc target genes
    Brian Cox
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada
    Mol Syst Biol 3:109. 2007
    ..These targets are evidence that Nmyc is a regulator of genes involved in mRNA processing and a repressor of the imprinted gene Igf2r in the developing lung...
  8. ncbi ?-catenin causes renal dysplasia via upregulation of Tgf?2 and Dkk1
    Darren Bridgewater
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    J Am Soc Nephrol 22:718-31. 2011
    ..Together, these results demonstrate that elevation of ?-catenin levels during kidney development causes dysplasia...
  9. ncbi Integrating gene and protein expression data: pattern analysis and profile mining
    Brian Cox
    Department of Medical and Molecular Genetics, University of Toronto, Toronto, Ont, Canada
    Methods 35:303-14. 2005
    ..Here, we outline several analytical approaches, methods, and tools that have proven to be helpful in the face of this important challenge...
  10. ncbi PRISM, a generic large scale proteomic investigation strategy for mammals
    Thomas Kislinger
    Program in Proteomics and Bioinformatics, Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario M5G 1L6, Canada
    Mol Cell Proteomics 2:96-106. 2003
    ..PRISM therefore offers an effective platform for in-depth investigation of complex mammalian proteomes...
  11. ncbi Canonical WNT/beta-catenin signaling is required for ureteric branching
    Darren Bridgewater
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    Dev Biol 317:83-94. 2008
    ..Together, these data demonstrate that beta-catenin performs essential functions during renal branching morphogenesis via control of a hierarchy of genes that control ureteric branching...
  12. ncbi Formation of a distinctive complex between the inducible bacterial lysine decarboxylase and a novel AAA+ ATPase
    Jamie Snider
    Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 281:1532-46. 2006
    ..Data obtained suggest that the RavA-LdcI interaction may be important for the regulation of RavA activity against its targets...