Research Topics
| Jean Pierre ChanoineSummaryAffiliation: University of British Columbia Country: Canada Publications
| Collaborators
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Detail Information
Publications
Selenium decreases thyroglobulin concentrations but does not affect the increased thyroxine-to-triiodothyronine ratio in children with congenital hypothyroidismJ P Chanoine
Children s Hospital Reine Fabiola, B 1020 Brussels, Belgium
J Clin Endocrinol Metab 86:1160-3. 2001....- Ghrelin and the growth hormone secretagogue receptor in growth and developmentJ P Chanoine
Endocrinology and Diabetes Unit, Department of Pediatrics, British Columbia s Children s Hospital, University of British Columbia, 4480 Oak Street, Vancouver, British Columbia, Canada
Int J Obes (Lond) 33:S48-52. 2009..These data point toward a physiological role for ghrelin and GHSR in growth and/or in the maturation of hormonal systems involved in the regulation of energy balance... - GLP-1 and appetite responses to a meal in lean and overweight adolescents following exerciseJean Pierre Chanoine
Endocrinology and Diabetes Unit, British Columbia s Children s Hospital, University of British Columbia, Vancouver, Canada
Obesity (Silver Spring) 16:202-4. 2008..Increased physical activity is an integral part of weight loss programs in adolescents. We prospectively investigated the effects of exercise on glucagon-like peptide-1 (GLP-1) concentrations and on appetite markers... - Obestatin, acylated and total ghrelin concentrations in the perinatal rat pancreasJean Pierre Chanoine
Endocrinology and Diabetes Unit, British Columbia s Children s Hospital, University of British Columbia, Vancouver, Canada
Horm Res 66:81-8. 2006..Acylated ghrelin inhibits insulin secretion. We investigated the plasma and tissue ontogeny of ghrelin and obestatin in the rat... - Effect of orlistat on weight and body composition in obese adolescents: a randomized controlled trialJean Pierre Chanoine
Endocrinology and Diabetes Unit, British Columbia Children s Hospital, Vancouver, Canada
JAMA 293:2873-83. 2005..In this population, behavioral therapy alone has had limited success in providing meaningful, sustained weight reduction, and pharmacological treatment has not been extensively studied... - Ghrelin in growth and developmentJ P Chanoine
Endocrinology and Diabetes Unit, British Columbia s Children s Hospital, University of British Columbia, Vancouver, B C, Canada
Horm Res 63:129-38. 2005..These data raise a number of fascinating questions on the potential physiologic role of this hormone during growth and development... - Early weight loss and outcome at one year in obese adolescents treated with orlistat or placeboJean Pierre Chanoine
Endocrinology and Diabetes Unit, British Columbia Children s Hospital, University of British Columbia, Vancouver, Canada
Int J Pediatr Obes 6:95-101. 2011..Pharmacotherapy, associated with a comprehensive weight loss intervention, has emerged as a promising therapeutic approach in adolescents. Identification of subjects who best respond to a pharmacological intervention remains difficult... - Selenium deficiency impairs corticosterone and leptin responses to adrenocorticotropin in the ratJean Pierre Chanoine
Endocrinology and Diabetes Unit, British Columbia s Children s Hospital, University of British Columbia, Vancouver, BC, Canada
Biofactors 20:109-18. 2004..Our results suggest that oxidative stress causes a decrease in circulating corticosterone in response to ACTH, and, as a consequence, a decrease in plasma leptin concentrations... - Ghrelin gene expression is markedly higher in fetal pancreas compared with fetal stomach: effect of maternal fastingJean Pierre Chanoine
Endocrinology and Diabetes Unit, British Columbia s Children s Hospital, University of British Columbia, Vancouver, British Columbia, Canada V6H 3V4
Endocrinology 145:3813-20. 2004..Furthermore, the presence of a strong ghrelin gene expression and of ghrelin receptor mRNA in the fetal pancreas is intriguing and suggests that ghrelin may play an important role in beta-cell development... - Modulation of steroidogenesis by selenium in a novel adrenal cell line developed using targeted tumorigenesisJ P Chanoine
Department of Pediatrics, Endocrine and Diabetes Unit, University of British Columbia, Vancouver V5Z 4H4, BC, Canada
Biofactors 14:229-38. 2001..Glutathione peroxidase (GPx-1) is a selenoenzyme that metabolizes H(2)O(2), a source of potentially toxic free radicals. Steroidogenesis is markedly inhibited by H(2)O(2) in vitro... - Selenium and thyroid function in infants, children and adolescentsJean Pierre Chanoine
Department of Pediatrics, Endocrinology and Diabetes Unit, University of British Columbia, Vancouver V6H 3V4, BC, Canada
Biofactors 19:137-43. 2003.... - Immunoreactive ghrelin in human cord blood: relation to anthropometry, leptin, and growth hormoneJean Pierre Chanoine
Endocrinology and Diabetes Unit, Room K4212, British Columbia Children s Hospital, 4480 Oak Street, Vancouver, BC V6H 3V4, Canada
J Pediatr Gastroenterol Nutr 35:282-6. 2002..Leptin and ghrelin central effects are mediated, at least partly, through the neuropeptide Y/Y1 receptor pathway in the hypothalamus... - Umbilical cord ghrelin concentrations in Asian and Caucasian neonatesJean Pierre Chanoine
Endocrinology and Diabetes Unit, British Columbia s Children s Hospital, Vancouver, Canada
Horm Res 60:116-20. 2003..To compare the relationship between cord plasma ghrelin and growth hormone (GH) concentrations and birth weight in Asian and Caucasian neonates... - Regulation of appetite in lean and obese adolescents after exercise: role of acylated and desacyl ghrelinKerry J MacKelvie
Endocrinology and Diabetes Unit, Room K4 212, British Columbia s Children s Hospital, 4480 Oak Street, Vancouver, British Columbia, Canada V6H 3V4
J Clin Endocrinol Metab 92:648-54. 2007..We hypothesized that exercise could affect appetite-regulating hormones and the subjective desire to eat, which could partly explain the poor success rate of the existing interventions... - In vitro and in vivo effect of acylated and unacylated ghrelin on neonatal glucose homeostasisHehong Ni
Endocrinology and Diabetes Unit, British Columbia Children s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
Pediatr Res 67:609-13. 2010..In summary, AG has insulinostatic effects in vitro as early as during the perinatal period. These effects could not be confirmed in vivo, possibly due to the short half-life of AG in rat neonates... - Long-acting octreotide treatment causes a sustained decrease in ghrelin concentrations but does not affect weight, behaviour and appetite in subjects with Prader-Willi syndromeKathleen De Waele
Endocrinology and Diabetes Unit, British Columbia s Children s Hospital, University of British Columbia, 4480 Oak Street, Vancouver, Canada
Eur J Endocrinol 159:381-8. 2008..We evaluated whether long-acting octreotide (Oct) decreases acylated and desacyl ghrelin concentrations, body mass, appetite and compulsive behaviour towards food in adolescents with PWS... - Effects of glucose and insulin on acyl ghrelin and desacyl ghrelin, leptin, and adiponectin in pregnant women with diabetesWilliam Gibson
Department of Medical Genetics, University of British Columbia, Vancouver, Canada V6H 3N1
Metabolism 59:841-7. 2010..Glucose and insulin regulate desacyl ghrelin concentrations in pregnant women with diabetes. Impaired desacyl ghrelin regulation may affect energy metabolism in pregnant women with poorly controlled diabetes... - Ghrelin is suppressed by glucagon and does not mediate glucagon-related growth hormone releaseDenton Hirsh
Endocrinology and Diabetes Unit, British Columbia s Children s Hospital, University of British Columbia, Vancouver, Canada
Horm Res 63:111-8. 2005..Because glucagon stimulates the promoter of the ghrelin gene in vitro as well as ghrelin secretion by the perfused rat stomach, we sought to determine whether ghrelin mediates glucagon-induced GH secretion... - Ontogeny of acylated ghrelin degradation in the ratHehong Ni
Endocrinology and Diabetes Unit, British Columbia Children s Hospital, University of British Columbia, Vancouver V6H 3V4, Canada
Peptides 31:301-6. 2010..We speculate that this process allows for fine tuning of the physiological effects of both AG and UAG... - Elevated umbilical cord ghrelin concentrations in small for gestational age neonatesJuliet Farquhar
Special Care Nursery, British Columbia's Children's Hospital, Vancouver, British Columbia, Canada V6H 3V4
J Clin Endocrinol Metab 88:4324-7. 2003..In conclusion, SGA neonates present with higher umbilical cord ghrelin plasma concentrations than AGA/LGA neonates. Ghrelin may play a physiological role in fetal adaptation to intrauterine malnutrition... - Healthy Buddies: a novel, peer-led health promotion program for the prevention of obesity and eating disorders in children in elementary schoolSuzanne Stock
Endocrinology and Diabetes Unit, Department of Psychology, British Columbia s Children s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
Pediatrics 120:e1059-68. 2007..We designed and tested a novel health promotion program for elementary schools that was based on peer teaching from older to younger schoolchildren ("Healthy Buddies")... - Ontogeny of ghrelin, obestatin, preproghrelin, and prohormone convertases in rat pancreas and stomachPallavi Walia
Endocrinology and Diabetes Unit, British Columbia Children s Hospital, Vancouver, British Columbia, V6H 3V4, Canada
Pediatr Res 65:39-44. 2009..In pancreas, the colocalization of PC1/3 or PC2 in ghrelin positive cells points to a role for both PCs in preproghrelin processing... - Acylated ghrelin concentrations are markedly decreased during pregnancy in mothers with and without gestational diabetes: relationship with cholinesteraseElaine Tham
British Columbia s Children s Hospital, Vancouver, BC, Canada V6H 3V4
Am J Physiol Endocrinol Metab 296:E1093-100. 2009..Desacyl ghrelin increases in gestational diabetes, possibly reflecting resistance to the inhibitory effect of insulin on ghrelin secretion... - Pharmacotherapy and weight-loss supplements for treatment of paediatric obesityAlexander L Rogovik
Pediatric Research in Emergency Therapeutics Program, BC Children s Hospital, Vancouver, British Columbia, and The Hospital for Sick Children, Toronto, Ontario, Canada
Drugs 70:335-46. 2010..No single approach will successfully treat obesity, and lifestyle modification presently remains the main pillar of any intervention aiming at decreasing bodyweight... - Different relationship between anthropometric markers and umbilical cord plasma leptin in Asian and Caucasian neonatesLouisa P K Yeung
Endocrinology and Diabetes Unit, British Columbia's Children's Hospital, Vancouver BC V6H 3V4, Canada
Pediatr Res 53:1019-24. 2003..This may represent the first clinical evidence of a difference in leptin regulation between these two ethnic groups... - Ghrelin, peptide YY, glucose-dependent insulinotropic polypeptide, and hunger responses to a mixed meal in anorexic, obese, and control female adolescentsSue Stock
Endocrinology and Diabetes Unit, Room K4-212, British Columbia's Children's Hospital, 4480 Oak Street, Vancouver, British Columbia V6H 3V4, Canada
J Clin Endocrinol Metab 90:2161-8. 2005..Ghrelin is unlikely to play a causal role in anorexia nervosa or obesity. The lower GIP observed in AN subjects despite a similar caloric intake may appropriately prevent an excessive insulin response in these patients... - Obesity and physical activity in childrenMia Pradinuk
BC Children s Hospital, Department of Pediatrics, Room K4 226, Ambulatory Care Bldg, 4480 Oak St, Vancouver, BC V6H 3V4
Can Fam Physician 57:779-82. 2011..Addressing physical inactivity and its contribution to childhood obesity requires a comprehensive and holistic approach... - Skewed X-chromosome inactivation is associated with primary but not secondary ovarian failureKarla L Bretherick
Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
Am J Med Genet A 143:945-51. 2007..X-chromosome abnormalities undetectable by array, or reduced follicular pool due to an early trisomic rescue event, may explain the skewed XCI observed in POF patients presenting with primary amenorrhea... - Transcriptome, methylome and genomic variations analysis of ectopic thyroid glandsRasha Abu-Khudir
Department of Pediatrics, Endocrinology Service and Research Center, CHU Sainte Justine, University of Montreal, Montreal, Canada
PLoS ONE 5:e13420. 2010..Moreover, a survey of monozygotic twins yielded a discordance rate of 92%, suggesting that somatic events, genetic or epigenetic, probably play an important role in the etiology of CHTD... - Iodine overload and severe hypothyroidism in a premature neonateMinesh Khashu
Division of Neonatology, Department of Pediatrics, British Columbia Children's Hospital and University of British Columbia, Vancouver BC V6H 3V4, Canada
J Pediatr Surg 40:E1-4. 2005.... - Editorial: Individual differences in the hormonal control of appetite: a step toward a (more) successful treatment of childhood overweight?Jean-Pierre Chanoine
J Clin Endocrinol Metab 91:2864-6. 2006