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Genomes and Genes | Haibo ZhangSummaryAffiliation: St. Michael's Hospital Country: Canada Publications
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Publications
Year in review 2008: Critical Care--respirologyHaibo Zhang
Keenan Research Centre at the Li Ka Shing Knowledge Institute of St Michael s Hospital, Bond Street, Toronto, ON, Canada
Crit Care 13:225. 2009....- Neurally adjusted ventilatory assist decreases ventilator-induced lung injury and non-pulmonary organ dysfunction in rabbits with acute lung injuryLukas Brander
Interdepartmental Division of Critical Care Medicine, Department of Critical Care Medicine, University of Toronto, St Michael s Hospital, Toronto, ON M5B 1W8, Canada
Intensive Care Med 35:1979-89. 2009.... - Activating transcription factor 3 confers protection against ventilator-induced lung injuryAli Akram
Keenan Research Centre at the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
Am J Respir Crit Care Med 182:489-500. 2010..Understanding the molecular basis for response to cyclic stretch (CS) and its derangement during high-volume ventilation is of high priority... - Ischemia and reperfusion increases susceptibility to ventilator-induced lung injury in ratsEttore Crimi
Division of Respiratory Medicine, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Am J Respir Crit Care Med 174:178-86. 2006..CONCLUSIONS: HSR priming renders the lung and kidney more susceptible to mechanical ventilation-induced organ injury... - Role of human neutrophil peptides in the initial interaction between lung epithelial cells and CD4+ lymphocytesRosanna Vaschetto
Department of Anaesthesia, University of Toronto, St Michael s Hospital, Room 7 007, Queen Wing, 30 Bond St, Toronto, ON M5B 1W8, Canada
J Leukoc Biol 81:1022-31. 2007..We conclude that HNP play an important role in linking innate to acquired immunity by activation of costimulatory molecules in lung epithelial cells and CD4+ lymphocytes... - Long pentraxin PTX3 deficiency worsens LPS-induced acute lung injuryBing Han
Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, Toronto, ON, Canada
Intensive Care Med 37:334-42. 2011..However, the role of PTX3 in the pathogenesis of ALI is not fully understood. We hypothesized that PTX3, as an important immune modulator, may determine the severity of ALI... - Inhibition of poly(adenosine diphosphate-ribose) polymerase attenuates ventilator-induced lung injuryRosanna Vaschetto
The Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
Anesthesiology 108:261-8. 2008..Therefore, the authors hypothesized that the pharmacologic inhibition of poly(adenosine diphosphate-ribose) polymerase by PJ-34 would attenuate ventilator-induced lung injury... - Differential signaling mechanisms of HNP-induced IL-8 production in human lung epithelial cells and monocytesFarisa Syeda
The Keenan Research Centre, Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ont, Canada
J Cell Physiol 214:820-7. 2008..We conclude that the activation of ERK1/2 and PI3K/Akt pathways is required for HNP-induced IL-8 release which occurs in a Src-independent manner in lung epithelial cells, while is Src-dependent in monocytes... - Cerebral cortical gene expression in acutely anemic rats: a microarray analysisFrancoise Briet
Department of Anaesthesia, Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, ON, Canada
Can J Anaesth 56:921-34. 2009..This study assesses whether hemodilutional anemia up-regulated inflammatory cerebral gene expression (microarray) to help define the mechanism... - Human neutrophil peptides: a novel potential mediator of inflammatory cardiovascular diseasesKieran Quinn
The Keenan Research Centre in the Li Ka Shing Knowledge Institute of Saint Michael s Hospital, Toronto, ON, Canada
Am J Physiol Heart Circ Physiol 295:H1817-24. 2008.... - Human neutrophil peptides induce interleukin-8 production through the P2Y6 signaling pathwayAye Aye Khine
Department of Anaesthesia, St Michael s Hospital, Rm 7 007, Queen Wing, 30 Bond St, Toronto, Ontario M5B 1W8, Canada
Blood 107:2936-42. 2006..Transfection of lung epithelial cells with antisense oligonucleotides targeting specific purinergic P2Y receptors revealed that the P2Y6 (ligand of UDP) signaling pathway plays a predominant role in mediating HNP-induced IL-8 production... - Human neutrophil peptides and phagocytic deficiency in bronchiectatic lungsStefanos Voglis
The Keenan Research Centre, Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
Am J Respir Crit Care Med 180:159-66. 2009..The mechanisms remain unknown... - Bench-to-bedside review: Biotrauma and modulation of the innate immune responseClaudia C dos Santos
Department of Medicine, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada
Crit Care 9:280-6. 2005..In this paper, we explore the pertinent evidence implicating biotrauma caused by cyclic MV and its effect on innate immune responses... - Conventional mechanical ventilation is associated with bronchoalveolar lavage-induced activation of polymorphonuclear leukocytes: a possible mechanism to explain the systemic consequences of ventilator-induced lung injury in patients with ARDSHaibo Zhang
Department of Anaesthesia and Critical Care Program, Interdepartmental Division of Critical Care Medicine, St. Michael's Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada
Anesthesiology 97:1426-33. 2002..This result may possibly explain the decreased mortality in acute respiratory distress syndrome patients treated with a lung-protective strategy... - Human neutrophil peptides mediate endothelial-monocyte interaction, foam cell formation, and platelet activationKieran L Quinn
Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
Arterioscler Thromb Vasc Biol 31:2070-9. 2011..Human neutrophil peptides (HNPs) released from activated neutrophils exert immune modulating properties. We hypothesized that HNPs play an important role in neutrophil-mediated inflammatory cardiovascular responses in atherosclerosis... - XB130, a novel adaptor protein for signal transductionJing Xu
Division of Cellular and Molecular Biology, University Health Network Toronto General Research Institute, and Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada
J Biol Chem 282:16401-12. 2007..These data suggest that XB130 as an adaptor may play an important role in the regulation of signal transduction and cellular functions... - Differential gene profiling in acute lung injury identifies injury-specific gene expressionClaudia C dos Santos
Thoracic Surgery Research Laboratory, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
Crit Care Med 36:855-65. 2008..Physiologic and morphologic manifestations of disparate forms of injury are often indistinguishable. We sought to demonstrate that acute lung injury resulting from distinct insults may lead to different gene expression profiles... - Enhanced adaptive immunity in mice lacking the immunoinhibitory adaptor Hacs1Dingyan Wang
St Michael s Hospital, 30 Bond St, Queen Wing, Rm 8 019, Toronto, ON, Canada M5B 1W8
FASEB J 24:947-56. 2010..Wang, D., Stewart, A. K., Zhuang, L., Zhu, Y., Wang, Y., Shi, C., Keating, A., Slutsky, A., Zhang, H., Wen, X.-Y. Enhanced adaptive immunity in mice lacking the immunoinhibitory adaptor Hacs1... - Pulmonary coagulopathy as a new target in therapeutic studies of acute lung injury or pneumonia--a reviewMarcus J Schultz
Department of Intensive Care Medicine, University of Amsterdam, Netherlands, and the Interdepartmental Division of Critical Care, St. Michael's Hospital, Toronto, ON, Canada
Crit Care Med 34:871-7. 2006.... - Adiponectin deficiency promotes endothelial activation and profoundly exacerbates sepsis-related mortalityHwee Teoh
Div of Cardiovascular and Thoracic Surgery, St Michael s Hospital, Toronto, ON, Canada M5B 1W8
Am J Physiol Endocrinol Metab 295:E658-64. 2008..These data suggest a critical role of adiponectin as a modulator of survival and endothelial inflammation in experimental sepsis and a potential mechanistic link between adiposity and increased sepsis... - Acute lung injury: a yellow card for engineered nanoparticles?Mingyao Liu
Toronto General Research Institute, University Health Network, Toronto, ON, Canada
J Mol Cell Biol 1:6-7. 2009..To translate nanotechnology into nanomedicine, it is important to understand any potential mechanisms of toxicity caused by nanomaterials, and to design approaches to mitigate any detrimental effects... - A potential role for inducible nitric oxide synthase in the cerebral response to acute hemodilutionAnya T McLaren
Department of Anesthesia, Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, ON, M5B 1W8, Canada
Can J Anaesth 56:502-9. 2009..This study assessed the effects of acute hemodilution on inducible NOS (iNOS) and systemic inflammatory cytokines... - GABA exerts protective and regenerative effects on islet beta cells and reverses diabetesNepton Soltani
Division of Endocrinology and Metabolism, The Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, ON, Canada M5B 1W8
Proc Natl Acad Sci U S A 108:11692-7. 2011..The ?-cell regenerative and immunoinhibitory effects of GABA provide insights into the role of GABA in regulating islet cell function and glucose homeostasis, which may find clinical application... - Modulation of bacterial growth by tumor necrosis factor-alpha in vitro and in vivoJin-Hwa Lee
Department of Anaesthesia, St. Michael's Hospital, Toronto, ON, M5B 1W8 Canada
Am J Respir Crit Care Med 168:1462-70. 2003..coli growth in vitro and in vivo. However, in vivo, this effect becomes only apparent in neutropenic animals. The relevance of these findings for immune compromised patients remains to be investigated... - Effect of ventilator-induced lung injury on the development of reperfusion injury in a rat lung transplant modelMarc de Perrot
Thoracic Surgery Research Laboratory, Toronto General Hospital, Toronto, Ontario, Canada
J Thorac Cardiovasc Surg 124:1137-44. 2002.... - Pressure and volume limited ventilation for the ventilatory management of patients with acute lung injury: a systematic review and meta-analysisKaren E A Burns
Interdepartmental Division of Critical Care, University of Toronto, Toronto, Canada
PLoS ONE 6:e14623. 2011..We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing pressure and volume-limited (PVL) ventilation strategies with more traditional mechanical ventilation in adults with ALI and ARDS... - Cytokines and their relationship to the symptoms and outcome of cancerBostjan Seruga
Division of Medical Oncology, Princess Margaret Hospital, St Michael s Hospital, University of Toronto, Toronto, Canada
Nat Rev Cancer 8:887-99. 2008..However, physical activity might modify cytokine levels and decrease fatigue in patients with cancer, and might also improve their prognosis... - Ventilation with negative airway pressure induces a cytokine response in isolated mouse lungKuo-Chen Cheng
Departments of Anaesthesia and Critical Care Medicine, St. Michael's Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada
Anesth Analg 94:1577-82, table of contents. 2002..This finding may have clinical relevance in certain patients who are prone to atelectasis during mechanical ventilation...