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Genomes and Genes | John C MarshallSummaryAffiliation: St. Michael's Hospital Country: Canada Publications
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Publications
Sepsis research: where have we gone wrong?John C Marshall
Department of Surgery, and Interdepartmental Division of Critical Care Medicine, University of Toronto, Ontario, Canada
Crit Care Resusc 8:241-3. 2006- Principles of source control in the management of sepsisJohn C Marshall
Department of Surgery, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Ontario, Canada
Crit Care Nurs Clin North Am 23:99-114. 2011..As every intensivist learns, appropriate source-control intervention can rapidly alter the course of sepsis to a more favorable direction, and suboptimal decision-making can change a difficult clinical challenge into a nightmare... - Lipopolysaccharide: an endotoxin or an exogenous hormone?John C Marshall
Interdepartmental Division of Critical Care Medicine, Department of Surgery, University of Toronto, Toronto, Ontario, Canada
Clin Infect Dis 41:S470-80. 2005..Thus, LPS is not less an endotoxin than an exohormone, and its neutralization may potentially result in either benefit or harm... - The pathogenesis and molecular biology of sepsisJohn C Marshall
Department of Surgery, and Interdepartmental Division of Critical Care Medicine, University of Toronto, Ontario, Canada
Crit Care Resusc 8:227-9. 2006 - Principles of source control in the management of sepsisJohn C Marshall
Department of Surgery, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
Crit Care Clin 25:753-68, viii-ix. 2009..This article discusses specific approaches to source control in the abdomen, chest, and skin and soft tissues... - Critical illness is an iatrogenic disorderJohn C Marshall
Department of Surgery, St Michael s Hospital, University of Toronto, Toronto, Canada
Crit Care Med 38:S582-9. 2010.... - Sepsis: rethinking the approach to clinical researchJohn C Marshall
Department of Surgery and Critical Care Medicine, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, Canada
J Leukoc Biol 83:471-82. 2008.... - Investigator-led clinical research consortia: the Canadian Critical Care Trials GroupJohn C Marshall
Department of Surgery, Interdepartmental Division of Critical Care Medicine, University of Toronto, St Michael s Hospital, Toronto, Ontario, Canada
Crit Care Med 37:S165-72. 2009..This review summarizes the history, activities, approaches, and challenges of the CCCTG, in the conviction that investigator-led groups such as ours represent the future of intensive care unit-based research... - Transfusion in the intensive care unitJohn C Marshall
St Michael s Hospital, Toronto, Ontario, Canada
Surg Infect (Larchmt) 6:S33-9. 2005.... - Iatrogenesis, inflammation and organ injury: insights from a murine modelJohn C Marshall
University of Toronto, St Michael s Hospital, 30 Bond St Rm 4 007, Bond Wing, Toronto, Ontario, Canada M5B 1W8
Crit Care 10:173. 2006.... - The immune system in critical illnessJohn C Marshall
Interdepartmental Division of Critical Care, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, Canada M5B 1W8
Clin Chest Med 29:605-16, vii. 2008..Critical illness results in derangements of all components of the immune response, but the very complexity of the process has frustrated attempts to correct these derangements and to affect significantly the clinical course of sepsis... - Biomarkers of sepsisJohn C Marshall
Li Ka Shing Knowledge Institute, The Keenan Research Centre, Toronto, Ontario, Canada
Crit Care Med 37:2290-8. 2009..Validated biomarkers of sepsis may improve diagnosis and therapeutic decision making for these high-risk patients... - The role of the Src family of tyrosine kinases after oxidant-induced lung injury in vivoRachel G Khadaroo
Department of Surgery, University Health Network, and University of Toronto, Ontario, Canada
Surgery 136:483-8. 2004..Inhibition of the Src family kinases may be a novel approach for the treatment of lung injury after trauma... - Diagnostic and prognostic implications of endotoxemia in critical illness: results of the MEDIC studyJohn C Marshall
University Health Network, University of Toronto, Toronto, Ontario, Canada
J Infect Dis 190:527-34. 2004..Stepwise logistic regression analysis showed that elevated Acute Physiology and Chronic Health Evaluation II score, gram-negative infection, and emergency admission status were independent predictors of EA... - Oxidant-induced priming of the macrophage involves activation of p38 mitogen-activated protein kinase through an Src-dependent pathwayRachel G Khadaroo
Department of Surgery, University Health Network, and University of Toronto, Ontario, Canada
Surgery 134:242-6. 2003..Because the Src family has been shown to activate the p38 mitogen-activated protein kinase (MAPK) pathway, we hypothesize that LPS signaling after oxidant stress involves the p38 pathway and is activated by Src kinases... - Dynamic regulation of neutrophil survival through tyrosine phosphorylation or dephosphorylation of caspase-8Song Hui Jia
Department of Surgery, University of Toronto, Toronto, Ontario, Canada
J Biol Chem 283:5402-13. 2008.... - Delayed neutrophil apoptosis in sepsis is associated with maintenance of mitochondrial transmembrane potential and reduced caspase-9 activityRavi Taneja
Department of Surgery, The Toronto General Hospital, University Health Network, University of Toronto, Ontario, Canada
Crit Care Med 32:1460-9. 2004.... - Pre-B cell colony-enhancing factor (PBEF/Nampt/visfatin) primes neutrophils for augmented respiratory burst activity through partial assembly of the NADPH oxidaseZeenat Malam
Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada
J Immunol 186:6474-84. 2011..Taken together, these results demonstrate that PBEF can prime for PMN respiratory burst activity by promoting p40 and p47 translocation to the membrane, and this occurs in a MAPK-dependent fashion... - Relationship of catheter-associated urinary tract infection to mortality and length of stay in critically ill patients: a systematic review and meta-analysis of observational studiesClarence Chant
Leslie Dan Faculty of Pharmacy, University of Toronto and Pharmacy Department, St Michael s Hospital, Toronto, Canada
Crit Care Med 39:1167-73. 2011..To determine whether catheter-associated urinary tract infections are associated with increased morbidity and mortality in critically ill patients... - Twenty-five percent albumin prevents lung injury following shock/resuscitationKinga A Powers
Department of Surgery, University Health Network, Toronto, Canada
Crit Care Med 31:2355-63. 2003..These studies suggest a novel role for 25% albumin as an anti-inflammatory agent in neutrophil-mediated diseases, such as acute respiratory distress syndrome... - Oxidative stress generated by hemorrhagic shock recruits Toll-like receptor 4 to the plasma membrane in macrophagesKinga A Powers
Department of Surgery, St Michael s Hospital and University Health Network, Toronto, Ontario, Canada
J Exp Med 203:1951-61. 2006..Collectively, these studies suggest a novel mechanism whereby oxidative stress might prime the responsiveness of cells of the innate immune system... - Hypertonic saline resuscitation from hemorrhagic shock does not impair the neutrophil response to intraabdominal infectionGiuseppe Papia
Department of Surgery, St Michael s Hospital and University of Toronto, and the Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
Surgery 144:814-21. 2008.... - Empiric antimicrobial therapy in critical illness: results of a surgical infection society surveyMary Anne W Aarts
Department of Surgery, University of Toronto, Toronto, Ontario, Canada
Surg Infect (Larchmt) 8:329-36. 2007..Often, therapy is initiated empirically; practice patterns are not well characterized. We documented approaches to empiric antibiotic therapy among members of the Surgical Infection Society (SIS)... - Altered inhibitory ?B? expression in LPS-stimulated alveolar macrophages following resuscitated hemorrhagic shockGuiseppe Papia
Li Ka Shing Knowledge Institute and the Keenan Research Centre, St Michael s Hospital, Toronto, Ontario, Canada
Shock 35:171-7. 2011..Together, these effects on the important regulatory molecule I?B in the macrophage may contribute to the heightened inflammatory response observed after S/R... - Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsisSong Hui Jia
Department of Surgery, University of Toronto, Toronto General Hospital, Toronto, Ontario, Canada
J Clin Invest 113:1318-27. 2004..These data identify PBEF as a novel inflammatory cytokine that plays a requisite role in the delayed neutrophil apoptosis of clinical and experimental sepsis... - Endotoxin in the pathogenesis of sepsisJohn C Marshall
Department of Surgery, University of Toronto, and the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, ON M5B 1W8, Canada
Contrib Nephrol 167:1-13. 2010..Future studies of antiendotoxin strategies in acute illness are more likely to succeed if they recruit patients with endotoxemia, and titrate therapy to an optimal level... - Daily variation in endotoxin levels is associated with increased organ failure in critically ill patientsDavid J Klein
St Michael s Hospital, University of Toronto, Ontario, Canada
Shock 28:524-9. 2007..Further studies are warranted to assess the role of daily variation in endotoxin levels in the pathogenesis and potential therapy of organ failure in the critically ill... - Pre-B cell colony-enhancing factor (PBEF)/visfatin: a novel mediator of innate immunityTracy Luk
Department of Surgery and the Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Ontario, Canada
J Leukoc Biol 83:804-16. 2008..This review summarizes the admittedly incomplete body of emerging knowledge about a remarkable new mediator of innate immunity... - Outcome measures for clinical research in sepsis: a report of the 2nd Cambridge Colloquium of the International Sepsis ForumJohn C Marshall
Department of Surgery, Interdepartmental Division of Critical Care Medicine, University of Toronto, St Michael s Hospital, Canada
Crit Care Med 33:1708-16. 2005..We sought to evaluate existing approaches and to draw on insights from other disciplines to propose a comprehensive approach to outcome evaluation in sepsis clinical trials... - Oxidative stress reprograms lipopolysaccharide signaling via Src kinase-dependent pathway in RAW 264.7 macrophage cell lineRachel G Khadaroo
Department of Surgery, University of Toronto and University Health Network, Toronto, Ontario M5G 2C4, Canada
J Biol Chem 278:47834-41. 2003.... - Antibiotic management of suspected nosocomial ICU-acquired infection: does prolonged empiric therapy improve outcome?Mary Anne W Aarts
University of Toronto, Interdepartmental Division of Critical Care Medicine and the Department of Surgery, Toronto, Canada
Intensive Care Med 33:1369-78. 2007..To characterize empiric antibiotic use in patients with suspected nosocomial ICU-acquired infections (NI), and determine the impact of prolonged therapy in the absence of infection... - Hypertonic preconditioning prevents hepatocellular injury following ischemia/reperfusion in mice: a role for interleukin 10George D Oreopoulos
Department of Surgery, University Health Network and University of Toronto, Toronto, Ontario, Canada
Hepatology 40:211-20. 2004.... - Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndromeYumiko Imai
Department of Critical Care, St Michael's Hospital, University of Toronto, Toronto, Ontario
JAMA 289:2104-12. 2003..This may partially explain the high rate of MODS observed in patients with ARDS and the decrease in morbidity and mortality in patients treated with a lung protective strategy... - Empiric antibiotic therapy for suspected ventilator-associated pneumonia: a systematic review and meta-analysis of randomized trialsMary Anne W Aarts
Department of Surgery, University of Toronto, Toronto, Ontario
Crit Care Med 36:108-17. 2008..To compare specific antibiotic regimens, and monotherapy vs. combination therapy, for the empirical treatment of ventilator-associated pneumonia (VAP)... - Interleukin-1beta mediates LPS-induced inhibition of apoptosis in retinoic acid-differentiated HL-60 cellsJohn C Marshall
Department of Surgery, St Michael s Hospital, University of Toronto, 4th Floor Bond Wing, Room 4 007, 30 Bond Street, Toronto, Ont, Canada
Biochem Biophys Res Commun 369:532-8. 2008..These studies provide further evidence of a complex regulatory pathway that modulates the expression of granulocyte apoptosis during inflammation, and point to a specific role for IL-1beta as an autocrine survival factor... - Source control in the management of severe sepsis and septic shock: an evidence-based reviewJohn C Marshall
From the Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
Crit Care Med 32:S513-26. 2004..Appropriate source control should be part of the systematic checklist we have to keep in mind in setting up the therapeutic strategy in sepsis... - A Canadian Critical Care Trials Group project in collaboration with the international forum for acute care trialists - Collaborative H1N1 Adjuvant Treatment pilot trial (CHAT): study protocol and design of a randomized controlled trialKaren E A Burns
Interdepartmental Division of Critical Care Medicine and Departments of Pharmacy, University of Toronto, Toronto, Ontario, Canada
Trials 12:70. 2011.... - Measures, markers, and mediators: toward a staging system for clinical sepsis. A report of the Fifth Toronto Sepsis Roundtable, Toronto, Ontario, Canada, October 25-26, 2000John C Marshall
Department of Surgery and Interdepartmental, Division of Critical Care, University of Toronto, Canada
Crit Care Med 31:1560-7. 2003..The evaluation of effective therapies has been hampered by limitations in our ability to characterize the process and to stratify patients into more homogeneous groups with respect to pathogenesis... - Intensive care unit management of intra-abdominal infectionJohn C Marshall
Department of Surgery, University of Toronto and Toronto General Hospital, University Health Network, Ontario, Canada
Crit Care Med 31:2228-37. 2003..To review the biologic characteristics of, and management approaches to, intra-abdominal infection in the critically ill patient... - The staging of sepsis: understanding heterogeneity in treatment efficacyJohn C Marshall
Department of Surgery, University of Toronto, Toronto, Ontario, Canada
Crit Care 9:626-8. 2005..They will be no less important in the optimal management of sepsis... - Preclinical models of shock and sepsis: what can they tell us?John C Marshall
St Michael s Hospital, Toronto, Ontario, Canada
Shock 24:1-6. 2005..Hence, greater model standardization would aid in interpreting data and in pooling results into systematic data syntheses: such efforts should be promoted and undertaken... - Discordance between perception and treatment practices associated with intensive care unit-acquired bacteriuria and funguria: a Canadian physician surveyClarence Chant
Pharmacy Department, St Michael s Hospital, Toronto, Ontario, Canada
Crit Care Med 36:1158-67. 2008..To determine physician practice and perception about the management of intensive care unit (ICU)-acquired bacteriuria and funguria... - Such stuff as dreams are made on: mediator-directed therapy in sepsisJohn C Marshall
Department of Surgery and the Interdepartmental Division of Critical Care Medicine, University of Toronto, Eaton North 9 234, Toronto General Hospital, University Health Network, 200 Elizabeth Street, Toronto, Ontario, Canada
Nat Rev Drug Discov 2:391-405. 2003.... - Neutrophils in the pathogenesis of sepsisJohn C Marshall
St. Michael's Hospital, Toronto, Ontario, Canada
Crit Care Med 33:S502-5. 2005 - Transfusion trigger: when to transfuse?John C Marshall
University of Toronto, Toronto, Ontario, Canada
Crit Care 8:S31-3. 2004..Arbitrary numeric hemoglobin triggers, however, cannot supercede intervention based on individual physiologic need and clinical circumstances... - Challenges in evaluating surgical innovationPatrick L Ergina
Department of Surgery, McGill University Health Centre, Montreal, QC, Canada
Lancet 374:1097-104. 2009..Although difficult, surgical evaluation is achievable and necessary. Solutions tailored to surgical research and a framework for generating evidence on which to base surgical practice are essential... - Sepsis: current status, future prospectsJohn C Marshall
Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
Curr Opin Crit Care 10:250-64. 2004 - Measurement of endotoxin activity in critically ill patients using whole blood neutrophil dependent chemiluminescenceJohn C Marshall
Medical Surgical Intensive Care Unit, University Health Network, Toronto, Ontario, Canada
Crit Care 6:342-8. 2002..The relationship between endotoxaemia, Gram-negative infection and the clinical syndrome of sepsis has been difficult to establish, in part because of the limitations of available endotoxin assays... - The Surviving Sepsis Campaign: a history and a perspectiveJohn C Marshall
Department of Surgery and Critical Care Medicine and Keenan Research Centre of Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
Surg Infect (Larchmt) 11:275-81. 2010.... - Saturday night fever: finding and controlling the source of sepsis in critical illnessSandro B Rizoli
Department of Surgery, Interdepartmental Division of Critical Care, Sepsis Research Laboratories, Toronto General Hospital, University of Toronto, Ontario, Canada
Lancet Infect Dis 2:137-44. 2002.... - Measurements in the intensive care unit: what do they mean?John C Marshall
Department of Surgery and the Interdepartmental Division of Critical Care Medicine, University of Toronto, and the Toronto General Hospital, University Health Network, Toronto, Canada
Crit Care 7:415-6. 2003 - Gastrointestinal dysfunction in the critically ill: can we measure it?Rachel G Khadaroo
Department of Surgery, and Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada, M5B 1W8
Crit Care 12:180. 2008..Nonetheless, and even with its shortcomings, their effort is a welcome contribution to the surprisingly complex process of describing the morbidity of critical illness... - Surgical decision-making: integrating evidence, inference, and experienceJohn C Marshall
Departments of Surgery and Critical Care Medicine, University of Toronto, St Michael s Hospital, 4th Floor Bond Wing, Room 4 007, 30 Bond Street, Toronto, Ontario, Canada M5B 1W8
Surg Clin North Am 86:201-15, xii. 2006.... - The International Sepsis Forum's controversies in sepsis: how will sepsis be treated in 2051?John C Marshall
University of Toronto, General and Critical Care Surgery, Toronto General Hospital, Toronto, Ontario, Canada
Crit Care 6:465-7. 2002 - Modulating neutrophil apoptosisJohn C Marshall
Department of Surgery, Interdepartmental Division of Critical Care Medicine, St Michael s Hospital, University of Toronto, Toronto, Canada
Novartis Found Symp 280:53-66; discussion 67-72, 160-4. 2007..A complex series of interactions between the neutrophil and microorganisms or their products regulates the duration and intensity of an inflammatory response, and so provides an attractive target for therapeutic manipulation... - Monocyte adhesion and transmigration induce tissue factor expression: role of the mitogen-activated protein kinasesIan D McGilvray
Department of Surgery, University of Toronto and University Health Network, Ontario, Canada
Shock 18:51-7. 2002..The selective inhibition of the mitogen-activated protein kinases may offer a novel therapeutic means of modulating this inflammatory sequence... - Regulation of Toll-like receptor 4 expression in the lung following hemorrhagic shock and lipopolysaccharideJie Fan
Department of Surgery, University Health Network, St Michael s Hospital and University of Toronto, Toronto, Ontario, Canada
J Immunol 168:5252-9. 2002.... - The effects of granulocyte colony-stimulating factor in preclinical models of infection and acute inflammationJohn C Marshall
Department of Surgery and the Interdepartmental Division of Critical Care, Toronto General Hospital, University of Toronto, Ontario, Canada
Shock 24:120-9. 2005..Significant variability in the design and reporting of studies of preclinical models of acute illness precludes more sophisticated data synthesis... - Up-regulation of functional CXCR4 expression on human lymphocytes in sepsisZiqiang Ding
Division of Thoracic Surgery, Department of Surgery, Toronto General Research Institute of the University Health Network, University of Toronto, Toronto, ON, Canada
Crit Care Med 34:3011-7. 2006..CONCLUSIONS: Blocking CXCR4 and CXCL12 function may provide a novel therapeutic method for controlling systemic inflammation and tissue injury in sepsis... - Coming of ageJohn C Marshall
Department of Surgery and the Interdepartmental Division of Critical Care Medicine, University of Toronto, and the Sepsis Research Laboratory, Li Ka Shing Knowledge Institute, St. Michaels' Hospital, Toronto, Ontario, Canada
Surg Infect (Larchmt) 9:111-20. 2008 - Early observational research and registries during the 2009-2010 influenza A pandemicRobert A Fowler
Canadian Critical Care Trials Group, Toronto, Ontario, Canada
Crit Care Med 38:e120-32. 2010.... - ARDS and the multiple organ dysfunction syndrome. Common mechanisms of a common systemic processRachel G Khadaroo
Department of Surgery, Interdepartmental Division of Critical Care, Sepsis Research Laboratories, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
Crit Care Clin 18:127-41. 2002..The growing recognition that iatrogenic factors contribute to the expression of MODS has highlighted the need for the clinician to be aware of the potential for harm inherent with every intervention... - Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levelsEdward A Panacek
Department of Medicine, University of California-Davis Medical Center, Sacramento, CA, USA
Crit Care Med 32:2173-82. 2004..CONCLUSIONS: Afelimomab is safe, biologically active, and well tolerated in patients with severe sepsis, reduces 28-day all-cause mortality, and attenuates the severity of organ dysfunction in patients with elevated interleukin-6 levels... - Intra-abdominal infectionsJohn C Marshall
Department of Surgery and the Interdepartmental Division of Critical Care Medicine, University of Toronto and the Toronto General Hospital, University Health Network, Toronto, Ont, Canada M5G 2C4
Microbes Infect 6:1015-25. 2004..Successful management depends on aggressive resuscitation and hemodynamic support, administration of adequate antimicrobial therapy, and the timely use of source control measures appropriate to the clinical situation... - DNR directives are established early in mechanically ventilated intensive care unit patientsTasnim Sinuff
Department of Medicine, McMaster University Health Sciences Center, Room 2C11, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
Can J Anaesth 51:1034-41. 2004..The strongest predictors of DNR directives were physician prediction of low probability of survival, physician perception of patient preference to limit life support, organ dysfunction, medical diagnosis and age... - In defense of evidence: the continuing saga of selective decontamination of the digestive tractMary-Anne Aarts
Am J Respir Crit Care Med 166:1014-5. 2002 - 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions ConferenceMitchell M Levy
Rhode Island Hospital, Brown University School of Medicine, 593 Eddy Street, Providence, RI 02903, USA
Crit Care Med 31:1250-6. 2003..This lack of evidence serves to underscore the challenge still present in diagnosing sepsis in 2003 for clinicians and researchers and also provides the basis for introducing PIRO as a hypothesis-generating model for future research... - 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions ConferenceMitchell M Levy
Rhode Island Hospital, 593 Eddy Street, MICU Main 7, Providence RI 02903, USA
Intensive Care Med 29:530-8. 2003..Nevertheless, there has been an impetus from experts in the field to modify these definitions to reflect our current understanding of the pathophysiology of these syndromes... - Dissociations: double or quits?Jennifer M Gurd
Neuropsychology Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
Cortex 39:192-5. 2003 - The PIRO concept: O is for organ dysfunctionJean-Louis Vincent
Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
Crit Care 7:260-4. 2003 - Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shockR Phillip Dellinger
Section of Critical Care Medicine, Cooper University Hospital, One Cooper Plaza, 393 Dorrance, Camden, NJ 08103, USA
Intensive Care Med 30:536-55. 2004..The impact of these guidelines will be formally tested and guidelines updated annually, and even more rapidly when some important new knowledge becomes available... - Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shockR Phillip Dellinger
Crit Care Med 32:858-73. 2004..The impact of these guidelines will be formally tested and guidelines updated annually and even more rapidly as some important new knowledge becomes as available... - The PIRO concept: R is for responseHerwig Gerlach
Department of Anaesthesiology and Intensive Care Medicine, Vivantes-Klinikum Neukoelln, Germany
Crit Care 7:256-9. 2003 - Progesterone acutely increases LH pulse amplitude but does not acutely influence nocturnal LH pulse frequency slowing during the late follicular phase in womenChristopher R McCartney
Center for Research in Reproduction, Box 800391, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
Am J Physiol Endocrinol Metab 292:E900-6. 2007.... - Obesity and sex steroid changes across puberty: evidence for marked hyperandrogenemia in pre- and early pubertal obese girlsChristopher R McCartney
Center for Research in Reproduction, Box 800391, University of Virginia Health System, Charlottesville, Virginia 22908, USA
J Clin Endocrinol Metab 92:430-6. 2007..Peripubertal obesity is associated with abnormal sex steroid concentrations, but the timing of onset and degree of these abnormalities remain unclear... - Effect of a liberal versus restrictive transfusion strategy on mortality in patients with moderate to severe head injuryLauralyn A McIntyre
Centre for Transfusion and Critical Care Research, Clinical Epidemiology Unit, Critical Care Program, University of Ottawa and Ottawa Health Research Institute, Ottawa, Ontario
Neurocrit Care 5:4-9. 2006..To compare a restrictive versus a liberal transfusion strategy in patients with moderate to severe closed head injury following multiple trauma in 13 Canadian intensive care units (ICUs)... - The surviving sepsis campaignJohn C Marshall
Crit Care Resusc 8:181-2. 2006 - Controversies in sepsis clinical trials: proceedings of a meeting of the International Sepsis Forum, Lausanne, Switzerland, September 29, 2001R Phillip Dellinger
Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08854, USA
J Crit Care 21:38-47. 2006..Once a therapy is approved, adopting less stringent but still appropriate criteria for the use of that therapy in clinical practice may be appropriate... - Category-specificity: what is the question?John C Marshall
University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
Cortex 41:861-2; discussion 869-72. 2005 - Surviving sepsis: a guide to the guidelinesJean Louis Vincent
Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, B 1070 Brussels, Belgium
Crit Care 12:162. 2008..The revised guidelines are far from perfect, but they represent the best available synthesis of contemporary knowledge in this area and as such should be promoted... - Burden of illness in venous thromboembolism in critical care: a multicenter observational studyRakesh Patel
Department of Medicine, University of Ottawa, Canada K1Y 4E9
J Crit Care 20:341-7. 2005..Findings suggest the need for increased suspicion among clinicians, renewed efforts at thromboprophylaxis, and evaluation of superior prevention strategies... - Intraabdominal infections in infants and children: descriptions and definitionsAnn E Thompson
Critical Care Medicine and Pediatrics, University of Pittsburgh School of Medicine, PA, USA
Pediatr Crit Care Med 6:S30-5. 2005..CONCLUSIONS: Criteria defining intraabdominal infection are proposed based on reports in the pediatric literature and expert opinion. Additional study of individual disorders, diagnostic criteria, and approach to management is warranted... - Modeling MODS: what can be learned from animal models of the multiple-organ dysfunction syndrome?John C Marshall
Intensive Care Med 31:605-8. 2005 - Measuring organ dysfunction in the intensive care unit: why and how?John C Marshall
Can J Anaesth 52:224-30. 2005 - The safety of targeted antibiotic therapy for ventilator-associated pneumonia: a multicenter observational studyAri R Joffe
Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada T6G 2B7
J Crit Care 23:82-90. 2008..The aim of this study was to determine the safety of targeted antibiotic therapy (TT) in ventilator-associated pneumonia (VAP)...