MICHAEL D TYERS

Summary

Affiliation: Samuel Lunenfeld Research Institute
Country: Canada

Publications

  1. ncbi Cell cycle goes global
    Mike Tyers
    Samuel Lunenfeld Research Institute, Toronto, Canada M5G 1X5
    Curr Opin Cell Biol 16:602-13. 2004
  2. ncbi Comprehensive curation and analysis of global interaction networks in Saccharomyces cerevisiae
    Teresa Reguly
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto ON M5G 1X5, Canada
    J Biol 5:11. 2006
  3. ncbi Osprey: a network visualization system
    Bobby-Joe Breitkreutz
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University Avenue, Toronto, M5G 1X5, Canada
    Genome Biol 4:R22. 2003
  4. ncbi The GRID: the General Repository for Interaction Datasets
    Bobby-Joe Breitkreutz
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University Avenue, Toronto, M5G 1X5, Canada
    Genome Biol 4:R23. 2003
  5. ncbi AFM 4.0: a toolbox for DNA microarray analysis
    B J Breitkreutz
    Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Canada, M5G 1X5
    Genome Biol 2:SOFTWARE0001. 2001
  6. ncbi Rapid regulation of protein activity in fission yeast
    Cathrine A Bøe
    Department of Cell Biology, Rikshospitalet Radiumhospitalet Medical Centre, Montebello, 0310 Oslo, Norway
    BMC Cell Biol 9:23. 2008
  7. ncbi Broadening the horizon--level 2.5 of the HUPO-PSI format for molecular interactions
    Samuel Kerrien
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    BMC Biol 5:44. 2007
  8. ncbi From genomics to proteomics
    Mike Tyers
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, and Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Canada M5G 1X5
    Nature 422:193-7. 2003
  9. ncbi Proteolysis and the cell cycle: with this RING I do thee destroy
    M Tyers
    Programme in Molecular Biology and Cancer, Graduate Department of Molecular and Medical Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, M5G 1X5, M5S 1A8, Canada
    Curr Opin Genet Dev 10:54-64. 2000
  10. ncbi Ubiquitin junction, what's your function?
    T A Lee
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    Genome Biol 2:REPORTS4025. 2001

Research Grants

  1. MOLECULAR AND GENETIC BASIS OF CELL PROLIFERATION
    MICHAEL TYERS; Fiscal Year: 2005
  2. BioGRID: an open resource for biological interactions and network analysis
    MICHAEL TYERS; Fiscal Year: 2007

Collaborators

  • Paul Jorgensen
  • Nizar N Batada
  • Ivan Rupes
  • L D Hurst
  • Tony Pawson
  • Matthias Mann
  • Brandt L Schneider
  • Chad L Myers
  • Igor Jurisica
  • Trey Ideker
  • Ricardo Almeida
  • Alexey I Nesvizhskii
  • Thomas Preiss
  • Stephen E Kearsey
  • Erik Boye
  • Bobby-Joe Breitkreutz
  • Chris Stark
  • Ashton Breitkreutz
  • Bobby Joe Breitkreutz
  • Teresa Reguly
  • Lorrie Boucher
  • Jeffrey R Sharom
  • Jaspal Singh
  • Cathrine A Bøe
  • Mike Cook
  • Xiaojing Tang
  • Mikael Borg
  • Samuel Kerrien
  • Deborah Blake
  • Daniel Durocher
  • Robert N Woolstencroft
  • Brenda Andrews
  • Michael Costanzo
  • B J Breitkreutz
  • T A Lee
  • Matthew Dahabieh
  • Ting Cheng Su
  • Victor Neduva
  • Anne Claude Gingras
  • Ivan Sadowski
  • Jessica Ahn
  • Zhen Yuan Lin
  • Pedro Lourenco
  • Guomin Liu
  • Brett Larsen
  • Danielle Dewar-Darch
  • Zhaohui Steve Qin
  • Hyungwon Choi
  • Beáta Grallert
  • Chen Chun Pai
  • Chen-Chun Pai
  • Stuart A MacNeill
  • Henriette C Skjølberg
  • Ignacio Garcia
  • Bruno Aranda
  • Peter Woollard
  • Ioannis Xenarios
  • Ethan Cerami
  • Gary D Bader
  • Julie D Forman-Kay
  • Arnaud Ceol
  • Gianni Cesareni
  • Susan Moore
  • John Armstrong
  • Christopher Hogue
  • David Sherman
  • Matthias Oesterheld
  • Volker Stümpflen
  • Rolf Apweiler
  • Marc Vidal
  • Sandra Orchard
  • Michael E Cusick
  • Andrew Chatr-Aryamontri
  • Jerome Wojcik
  • John J Salama
  • Luisa Montecchi-Palazzi
  • David Eisenberg
  • Tanja Mittag
  • Michael Gilson
  • Henning Hermjakob
  • Nisha Vinod
  • Lukasz Salwinski
  • Antony F Quinn
  • Hue Sun Chan
  • Julie D Forman Kay
  • Jason Nerothin
  • Charles Boone
  • Kara Dolinski
  • Matthias Peter
  • Brian Luke

Detail Information

Publications26

  1. ncbi Cell cycle goes global
    Mike Tyers
    Samuel Lunenfeld Research Institute, Toronto, Canada M5G 1X5
    Curr Opin Cell Biol 16:602-13. 2004
    ..As the interconnections between these huge datasets are beyond intuition, mathematical representation and automated analysis of functional genomic data is an urgent mandate...
  2. ncbi Comprehensive curation and analysis of global interaction networks in Saccharomyces cerevisiae
    Teresa Reguly
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto ON M5G 1X5, Canada
    J Biol 5:11. 2006
    ..Although a vast number of well substantiated interactions are recorded in the scientific literature, these data have not yet been distilled into networks that enable system-level inference...
  3. ncbi Osprey: a network visualization system
    Bobby-Joe Breitkreutz
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University Avenue, Toronto, M5G 1X5, Canada
    Genome Biol 4:R22. 2003
    ..Mouse-over functions allow rapid elaboration and organization of network diagrams in a spoke model format. User-defined large-scale datasets can be readily combined with Osprey for comparison of different methods...
  4. ncbi The GRID: the General Repository for Interaction Datasets
    Bobby-Joe Breitkreutz
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University Avenue, Toronto, M5G 1X5, Canada
    Genome Biol 4:R23. 2003
    ..Interactions parsed in The GRID can be viewed in graphical form with a versatile visualization tool called Osprey...
  5. ncbi AFM 4.0: a toolbox for DNA microarray analysis
    B J Breitkreutz
    Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Canada, M5G 1X5
    Genome Biol 2:SOFTWARE0001. 2001
    ..AFM 4.0 should be especially useful to laboratories that do not have access to specialized commercial or in-house software...
  6. ncbi Rapid regulation of protein activity in fission yeast
    Cathrine A Bøe
    Department of Cell Biology, Rikshospitalet Radiumhospitalet Medical Centre, Montebello, 0310 Oslo, Norway
    BMC Cell Biol 9:23. 2008
    ....
  7. ncbi Broadening the horizon--level 2.5 of the HUPO-PSI format for molecular interactions
    Samuel Kerrien
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    BMC Biol 5:44. 2007
    ....
  8. ncbi From genomics to proteomics
    Mike Tyers
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, and Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Canada M5G 1X5
    Nature 422:193-7. 2003
    ..But further technological improvements, organization of international proteomics projects and open access to results are needed for proteomics to fulfil its potential...
  9. ncbi Proteolysis and the cell cycle: with this RING I do thee destroy
    M Tyers
    Programme in Molecular Biology and Cancer, Graduate Department of Molecular and Medical Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, M5G 1X5, M5S 1A8, Canada
    Curr Opin Genet Dev 10:54-64. 2000
    ..The circuits that interconnect the SCF, APC/C and cyclin-dependent kinase activities form a master oscillator that coordinates the replication and segregation of the genome...
  10. ncbi Ubiquitin junction, what's your function?
    T A Lee
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    Genome Biol 2:REPORTS4025. 2001
    ..A report on the Ubiquitin and Intracellular Protein Degradation FASEB summer conference, Saxtons River, USA, 23-28 June 2001...
  11. ncbi How cells coordinate growth and division
    Paul Jorgensen
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto ON, Canada M5S 1A8
    Curr Biol 14:R1014-27. 2004
    ..Recently, genetic screens in Drosophila and functional genomics approaches in yeast have macheted into the thicket of cell size control...
  12. ncbi Ccr4 contributes to tolerance of replication stress through control of CRT1 mRNA poly(A) tail length
    Robert N Woolstencroft
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, M5G 1X5, Canada
    J Cell Sci 119:5178-92. 2006
    ..These results implicate the coordinated regulation of Crt1 via Ccr4 and Dun1 as a crucial nodal point in the response to DNA replication stress...
  13. ncbi Evolutionary and physiological importance of hub proteins
    Nizar N Batada
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    PLoS Comput Biol 2:e88. 2006
    ..We conclude that hub proteins are more important for cellular growth rate and under tight regulation but are not slow evolving...
  14. ncbi The F-box protein Dia2 overcomes replication impedance to promote genome stability in Saccharomyces cerevisiae
    Deborah Blake
    Department of Medical Genetics and Microbiology, University of Toronto, Ontario, Canada
    Genetics 174:1709-27. 2006
    ..We propose that the SCFDia2 ubiquitin ligase serves to modify or degrade protein substrates that would otherwise impede the replication fork in problematic regions of the genome...
  15. ncbi A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size
    Paul Jorgensen
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Genes Dev 18:2491-505. 2004
    ..These findings suggest that nutrient signals set the critical cell-size threshold via Sfp1 and Sch9-mediated control of ribosome biosynthetic rates...
  16. ncbi CDK activity antagonizes Whi5, an inhibitor of G1/S transcription in yeast
    Michael Costanzo
    Department of Medical Genetics and Microbiology, University of Toronto, 1 King s College Circle, Toronto, M5S 1A8, Canada
    Cell 117:899-913. 2004
    ..Elimination of CDK activity at the end of mitosis allows Whi5 to reenter the nucleus to again repress G1/S transcription. These findings harmonize G1/S control in eukaryotes...
  17. ncbi Systematic identification of pathways that couple cell growth and division in yeast
    Paul Jorgensen
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Science 297:395-400. 2002
    ..Cell growth and division appear to be coupled by multiple conserved mechanisms...
  18. ncbi PhosphoGRID: a database of experimentally verified in vivo protein phosphorylation sites from the budding yeast Saccharomyces cerevisiae
    Chris Stark
    Centre for Systems Biology, Samuel Lunenfeld Research Institute, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Database (Oxford) 2010:bap026. 2010
    ..Database URL: http://phosphogrid.org/..
  19. ncbi A Rab escort protein integrates the secretion system with TOR signaling and ribosome biogenesis
    Jaspal Singh
    Department of Molecular Genetics, University of Toronto, Ontario, Canada
    Genes Dev 23:1944-58. 2009
    ..The Sfp1-Mrs6 interaction is a nexus for growth regulation that links the secretory system and TOR-dependent nutrient signaling to ribosome biogenesis...
  20. ncbi Osprey: a network visualization system
    Bobby-Joe Breitkreutz
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto M5G 1X5, Canada
    Genome Biol 3:PREPRINT0012. 2002
    ..Mouse-over functions allow rapid elaboration and organization of network diagrams in a spoke model format. User-defined large-scale data sets can be readily combined with Osprey for comparison of different methods...
  21. ncbi Size control goes global
    Mike Cook
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada M5G 1X5
    Curr Opin Biotechnol 18:341-50. 2007
    ..While the plethora of genes that alter size phenotypes at present defies a unified model, systems-level analysis suggests many new inroads into the longstanding enigma of size control...
  22. ncbi The size of the nucleus increases as yeast cells grow
    Paul Jorgensen
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, ON M5S 1A8, Canada
    Mol Biol Cell 18:3523-32. 2007
    ..Nuclear expansion must now be factored into conceptual and mathematical models of budding yeast growth and division. These results raise questions as to the unknown force(s) that expand the nucleus as yeast cells grow...
  23. ncbi Polyelectrostatic interactions of disordered ligands suggest a physical basis for ultrasensitivity
    Mikael Borg
    Department of Biochemistry, Faculty of Medicine, University of Toronto, Toronto, ON, Canada M5S 1A8
    Proc Natl Acad Sci U S A 104:9650-5. 2007
    ..Thus, polyelectrostatic interactions may provide a simple yet powerful framework for understanding the modulation of protein interactions by multiple phosphorylation sites in disordered protein regions...
  24. ncbi Phenotypic and transcriptional plasticity directed by a yeast mitogen-activated protein kinase network
    Ashton Breitkreutz
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    Genetics 165:997-1015. 2003
    ..This systems-level robustness may also account for the observed diversity of signals that trigger invasive growth...
  25. ncbi Stratus not altocumulus: a new view of the yeast protein interaction network
    Nizar N Batada
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    PLoS Biol 4:e317. 2006
    ..In turn, control of the activity of the most highly connected proteins may be vital. Indeed, we find that a fluctuation in steady-state levels of the most connected proteins is minimized...
  26. ncbi A global protein kinase and phosphatase interaction network in yeast
    Ashton Breitkreutz
    Centre for Systems Biology, Samuel Lunenfeld Research Institute, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada
    Science 328:1043-6. 2010
    ..An extensive backbone of kinase-kinase interactions cross-connects the proteome and may serve to coordinate diverse cellular responses...

Research Grants2

  1. MOLECULAR AND GENETIC BASIS OF CELL PROLIFERATION
    MICHAEL TYERS; Fiscal Year: 2005
    ..The Gordon Conferences format provides a unique environment that encourages informal and open discussion among the participants and this in turn fosters initiation of collaborative efforts and stimulates future research directions. ..
  2. BioGRID: an open resource for biological interactions and network analysis
    MICHAEL TYERS; Fiscal Year: 2007
    ..The BioGRID and Osprey software platforms serve this function for the international research community. ..