Charles Ramassamy

Summary

Country: Canada

Publications

  1. ncbi Challenges for research on polyphenols from foods in Alzheimer's disease: bioavailability, metabolism, and cellular and molecular mechanisms
    Manjeet Singh
    INRS Institut Armand Frappier, 531 Boulevard des Prairies, Laval, Quebec H7V 1B7, Canada
    J Agric Food Chem 56:4855-73. 2008
  2. ncbi Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: a review of their intracellular targets
    Charles Ramassamy
    INRS Institut Armand Frappier, 245 Hymus Boulevard, Pointe Claire, Quebec, H9R 1G6 INAF, Univ Laval Québec, QC, Canada
    Eur J Pharmacol 545:51-64. 2006
  3. ncbi Ginkgo biloba extract (EGb 761) in Alzheimer's disease: is there any evidence?
    Charles Ramassamy
    Institut National de la Recherche Scientifique, Institut Armand Frappier, Pointe Claire, Quebec, Canada
    Curr Alzheimer Res 4:253-62. 2007
  4. ncbi Molecular regulations induced by acrolein in neuroblastoma SK-N-SH cells: relevance to Alzheimer's disease
    Thanh Nam Dang
    INRS Institut Armand Frappier, Quebec, Canada
    J Alzheimers Dis 21:1197-216. 2010
  5. ncbi Role of by-products of lipid oxidation in Alzheimer's disease brain: a focus on acrolein
    Manjeet Singh
    INRS Institut Armand Frappier, Laval, PQ, Canada
    J Alzheimers Dis 21:741-56. 2010
  6. ncbi Challenges associated with curcumin therapy in Alzheimer disease
    Abdenour Belkacemi
    INRS Institut Armand Frappier, Laval, Quebec, Canada
    Expert Rev Mol Med 13:e34. 2011
  7. ncbi Modulation of hydrogen peroxide and acrolein-induced oxidative stress, mitochondrial dysfunctions and redox regulated pathways by the Bacopa monniera extract: potential implication in Alzheimer's disease
    Manjeet Singh
    INRS Institut Armand Frappier, Laval, PQ, Canada
    J Alzheimers Dis 21:229-47. 2010
  8. ncbi Regulation of redox-sensitive signaling pathways in rat primary astrocytes following acrolein exposure
    Dang Thanh Nam
    INRS Institut Armand Frappier, Laval, QC, Canada
    J Alzheimers Dis 25:263-77. 2011
  9. ncbi Scientific basis for the use of Indian ayurvedic medicinal plants in the treatment of neurodegenerative disorders: ashwagandha
    M R Ven Murthy
    Department of Medical Biology, Faculty of Medicine, Laval University, Laval, Quebec, Canada G1K 7P4, Canada
    Cent Nerv Syst Agents Med Chem 10:238-46. 2010
  10. ncbi Neurotherapeutic applications of nanoparticles in Alzheimer's disease
    Jasjeet Kaur Sahni
    INRS Institut Armand Frappier, 531, boul des Prairies, H7V 1B7 Laval, Quebec, Canada
    J Control Release 152:208-31. 2011

Collaborators

  • Neven Zarkovic
  • Yves Christen
  • Sanjula Baboota
  • Javed Ali
  • Manjeet Singh
  • Madeleine Arseneault
  • Thanh Nam Dang
  • Abdenour Belkacemi
  • Dang Thanh Nam
  • Ven Murthy
  • Le Dao
  • Sihem Doggui
  • Jasjeet Kaur Sahni
  • C St-Laurent-Thibault
  • M R Ven Murthy
  • Georg Waeg
  • Tri Vuong
  • M Arseneault
  • F Longpre
  • Manasi Deshpande
  • Prabhakar K Ranjekar
  • Thomas Sanderson
  • Louis C Martineau
  • Pierre S Haddad
  • Chantal Matar

Detail Information

Publications18

  1. ncbi Challenges for research on polyphenols from foods in Alzheimer's disease: bioavailability, metabolism, and cellular and molecular mechanisms
    Manjeet Singh
    INRS Institut Armand Frappier, 531 Boulevard des Prairies, Laval, Quebec H7V 1B7, Canada
    J Agric Food Chem 56:4855-73. 2008
    ..The focus of this review is aimed at presenting the role of some polyphenols from fruits, vegetables, and beverages in neuroprotection and particularly in Alzheimer's disease and the research challenges in this area...
  2. ncbi Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: a review of their intracellular targets
    Charles Ramassamy
    INRS Institut Armand Frappier, 245 Hymus Boulevard, Pointe Claire, Quebec, H9R 1G6 INAF, Univ Laval Québec, QC, Canada
    Eur J Pharmacol 545:51-64. 2006
    ..We will review some of these mechanisms and particular emphasis will be given to polyphenolic compounds from green tea, the Ginkgo biloba extract EGb 761, blueberries extracts, wine components and curcumin...
  3. ncbi Ginkgo biloba extract (EGb 761) in Alzheimer's disease: is there any evidence?
    Charles Ramassamy
    Institut National de la Recherche Scientifique, Institut Armand Frappier, Pointe Claire, Quebec, Canada
    Curr Alzheimer Res 4:253-62. 2007
    ..Moreover we will discuss the complexity of the cellular and molecular mechanisms of EGb 761 and the significance of the synergic effect of different constituents of EGb 761...
  4. ncbi Molecular regulations induced by acrolein in neuroblastoma SK-N-SH cells: relevance to Alzheimer's disease
    Thanh Nam Dang
    INRS Institut Armand Frappier, Quebec, Canada
    J Alzheimers Dis 21:1197-216. 2010
    ..Collectively, these data strengthen the contribution of acrolein in the induction of oxidative stress as observed in mild cognitive impairment and in AD brain...
  5. ncbi Role of by-products of lipid oxidation in Alzheimer's disease brain: a focus on acrolein
    Manjeet Singh
    INRS Institut Armand Frappier, Laval, PQ, Canada
    J Alzheimers Dis 21:741-56. 2010
    ..In this review, we will summarize some mechanisms implicated in the toxicity of by-products of lipid peroxidation such as IsoPs, HNE, and acrolein and their implication in AD...
  6. ncbi Challenges associated with curcumin therapy in Alzheimer disease
    Abdenour Belkacemi
    INRS Institut Armand Frappier, Laval, Quebec, Canada
    Expert Rev Mol Med 13:e34. 2011
    ..To be effective as a drug therapy, curcumin must be combined with other drugs, or new delivery strategies need to be developed...
  7. ncbi Modulation of hydrogen peroxide and acrolein-induced oxidative stress, mitochondrial dysfunctions and redox regulated pathways by the Bacopa monniera extract: potential implication in Alzheimer's disease
    Manjeet Singh
    INRS Institut Armand Frappier, Laval, PQ, Canada
    J Alzheimers Dis 21:229-47. 2010
    ..Thus, our findings demonstrate that BM can protect human neuroblastoma cells against H2O2 and acrolein through different mechanisms involved in the pathophysiology of AD and could have a therapeutic application in the prevention of AD...
  8. ncbi Regulation of redox-sensitive signaling pathways in rat primary astrocytes following acrolein exposure
    Dang Thanh Nam
    INRS Institut Armand Frappier, Laval, QC, Canada
    J Alzheimers Dis 25:263-77. 2011
    ..Considering the crucial role of astrocytes in the brain, these results demonstrated that acrolein could disrupt neuronal functions and synaptic homeostasis by provoking dysfunctional or loss of astrocytes...
  9. ncbi Scientific basis for the use of Indian ayurvedic medicinal plants in the treatment of neurodegenerative disorders: ashwagandha
    M R Ven Murthy
    Department of Medical Biology, Faculty of Medicine, Laval University, Laval, Quebec, Canada G1K 7P4, Canada
    Cent Nerv Syst Agents Med Chem 10:238-46. 2010
    ..Some of the major points on its use in the treatment of neurodegenerative disorders are described below...
  10. ncbi Neurotherapeutic applications of nanoparticles in Alzheimer's disease
    Jasjeet Kaur Sahni
    INRS Institut Armand Frappier, 531, boul des Prairies, H7V 1B7 Laval, Quebec, Canada
    J Control Release 152:208-31. 2011
    ..Some of them have been shown to cross the BBB and have been tested either for diagnosis or treatment of AD. Finally, the route of NPs administration and the future prospects will be discussed...
  11. ncbi Potential role of acrolein in neurodegeneration and in Alzheimer's disease
    Thanh Nam Dang
    INRS Institut Armand Frappier, 531, boul des Prairies, H7V 1B7 Laval, Quebec, Canada
    Curr Mol Pharmacol 3:66-78. 2010
    ..In this review, we will summarize some mechanisms implicated in the toxicity of this by-product of lipid peroxidation in brain and their implication in AD...
  12. ncbi Standardized extracts of Bacopa monniera protect against MPP+- and paraquat-induced toxicity by modulating mitochondrial activities, proteasomal functions, and redox pathways
    Manjeet Singh
    INRS Institut Armand Frappier, Laval, Quebec, Canada
    Toxicol Sci 125:219-32. 2012
    ..By preserving the cellular redox homeostasis and mitochondrial activities and by promoting cell survival pathways, BM extract may have therapeutic uses in various age-related neurodegenerative diseases such as PD...
  13. ncbi Time sequence of oxidative stress in the brain from transgenic mouse models of Alzheimer's disease related to the amyloid-? cascade
    Abdenour Belkacemi
    INRS Institut Armand Frappier, H7V 1B7 Laval, QC, Canada
    Free Radic Biol Med 52:593-600. 2012
    ..Here we review the evidence for increased free radical-mediated damage to the brain with particular attention to the stage of the disease in various transgenic models of AD related to the amyloid-? cascade...
  14. ncbi Molecular Regulations Induced by Acrolein in Neuroblastoma SK-N-SH Cells: Relevance to Alzheimer's Disease
    Dang Thanh Nam
    INRS Institut Armand Frappier, Quebec, Canada
    J Alzheimers Dis 21:1197-216. 2010
    ..Collectively, these data strengthen the contribution of acrolein in the induction of oxidative stress as observed in mild cognitive impairment and in AD brain...
  15. ncbi Tyrosol and hydroxytyrosol, two main components of olive oil, protect N2a cells against amyloid-?-induced toxicity. Involvement of the NF-?B signaling
    C St-Laurent-Thibault
    INRS Institut Armand Frappier, 531, boul des Prairies, Laval, Quebec, H7V 1B7, Canada
    Curr Alzheimer Res 8:543-51. 2011
    ..These results identified two individual food components of the MeDi as neuroprotective agent against A? and their potential involvement in the beneficial effect of the MeDi for the prevention of AD...
  16. ncbi Fermented Canadian lowbush blueberry juice stimulates glucose uptake and AMP-activated protein kinase in insulin-sensitive cultured muscle cells and adipocytes
    Tri Vuong
    Department of Pharmacology, Universite de Montreal, P O Box 6128, Downtown Station, Montreal, QC H3C3J7, Canada
    Can J Physiol Pharmacol 85:956-65. 2007
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