Rachel A Hanna

Summary

Affiliation: Queen's University
Country: Canada

Publications

  1. ncbi Calpastatin simultaneously binds four calpains with different kinetic constants
    Rachel A Hanna
    Department of Biochemistry, Queen s University, Kingston, Ontario, Canada
    FEBS Lett 581:2894-8. 2007
  2. ncbi Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin
    Rachel A Hanna
    Department of Biochemistry, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Nature 456:409-12. 2008
  3. ncbi Limb-girdle muscular dystrophy type 2A can result from accelerated autoproteolytic inactivation of calpain 3
    Christopher P Garnham
    Department of Biochemistry, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Biochemistry 48:3457-67. 2009

Collaborators

Detail Information

Publications3

  1. ncbi Calpastatin simultaneously binds four calpains with different kinetic constants
    Rachel A Hanna
    Department of Biochemistry, Queen s University, Kingston, Ontario, Canada
    FEBS Lett 581:2894-8. 2007
    ..Their K(d) values ranged from picomolar to nanomolar in the order CAST1>4>3>2. They have similar k(on) values but the k(off) values ranged over three orders of magnitude and can account for the differences in affinity...
  2. ncbi Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin
    Rachel A Hanna
    Department of Biochemistry, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Nature 456:409-12. 2008
    ....
  3. ncbi Limb-girdle muscular dystrophy type 2A can result from accelerated autoproteolytic inactivation of calpain 3
    Christopher P Garnham
    Department of Biochemistry, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Biochemistry 48:3457-67. 2009
    ..The putative in vivo effects of these mutations on calpain 3 activity are discussed with respect to their ability to cause LGMD2A...