Research Topics
| S VasdevSummaryAffiliation: Memorial University of Newfoundland Country: Canada Publications
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Publications
Fructose and moderately high dietary salt-induced hypertension: prevention by a combination of N-acetylcysteine and L-arginineSudesh Vasdev
Department of Medicine, Health Sciences Centre, Memorial University, St John s, NL, Canada
Mol Cell Biochem 337:9-16. 2010..Plasma methylglyoxal and MGH may not represent tissue modification or, alternatively, other tissue AGEs, derived from methylglyoxal or other aldehydes, may be involved in hypertension in this model...
Fructose-induced hypertension in Wistar-Kyoto rats: interaction with moderately high dietary saltSudesh Vasdev
Department of Medicine and Laboratory Medicine Health Sciences Centre, Memorial University of Newfoundland, St John s, NL A1B 3V6, Canada
Can J Physiol Pharmacol 85:413-21. 2007..However, the SBP and tissue changes persisted even after discontinuation of treatment. The fructose and salt combination may result in long-lasting vascular alterations leading to hypertension...
Low ethanol intake prevents salt-induced hypertension in WKY ratsSudesh Vasdev
Discipline of Medicine, Faculty of Medicine Memorial University of Newfoundland St John s, Newfoundland, A1B 3V6, Canada
Mol Cell Biochem 287:53-60. 2006..These results suggest that chronic low ethanol intake prevents salt-induced hypertension and attenuates renal vascular changes in WKY rats by preventing an increase in tissue aldehyde conjugates and cytosolic [Ca2+]i...
Dietary lipoic acid supplementation attenuates hypertension in Dahl salt sensitive ratsSudesh Vasdev
Department of Medicine, Room H 4310, Health Sciences Centre, Memorial University of Newfoundland, St John s, Newfoundland, Canada
Mol Cell Biochem 275:135-41. 2005..Dietary lipoic acid supplementation attenuated the increase in systolic blood pressure and associated biochemical and histopathological changes...
Role of advanced glycation end products in hypertension and atherosclerosis: therapeutic implicationsSudesh Vasdev
Discipline of Medicine, Faculty of Medicine, Room H 4310, Health Sciences Centre, Memorial University of Newfoundland, St John s, NF, A1B 3V6, Canada
Cell Biochem Biophys 49:48-63. 2007....
Dietary vitamin e supplementation attenuates hypertension in Dahl salt-sensitive ratsSudesh Vasdev
Department of Medicine and Laboratory Medicine, Health Sciences Centre, Memorial University of Newfoundland, St John s, Newfoundland, Canada
J Cardiovasc Pharmacol Ther 10:103-11. 2005..Dietary vitamin E supplementation significantly attenuated the increase in systolic blood pressure and associated biochemical and histopathologic changes...
Beneficial effect of low ethanol intake on the cardiovascular system: possible biochemical mechanismsSudesh Vasdev
Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, Health Sciences Centre, St John s, Newfoundland, Canada
Vasc Health Risk Manag 2:263-76. 2006..In conclusion, we suggest that chronic low ethanol intake confers its beneficial effect mainly through its ability to increase antioxidant capacity and lower AGEs...
Prevention of fructose-induced hypertension by dietary vitaminsSudesh Vasdev
Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada
Clin Biochem 37:1-9. 2004..Dietary management through lower sucrose or fructose intake and increased consumption of vitamins improves glucose metabolism, lowers tissue aldehydes, increases anti-oxidant capacity and may also prevent hypertension...
Salt-induced hypertension in WKY rats: prevention by alpha-lipoic acid supplementationSudesh Vasdev
Department of Medicine and Laboratory Medicine, Health Sciences Centre, Memorial University of Newfoundland, St John s Newfoundland, Canada
Mol Cell Biochem 254:319-26. 2003..Kidney aldehydes and renal vascular changes were attenuated, but not normalized...
Dietary vitamin E and C supplementation prevents fructose induced hypertension in ratsS Vasdev
Department of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada
Mol Cell Biochem 241:107-14. 2002....
Dietary alpha-lipoic acid supplementation lowers blood pressure in spontaneously hypertensive ratsS Vasdev
Department of Medicine, Health Sciences Centre, Memorial University of Newfoundland, St John s, Canada
J Hypertens 18:567-73. 2000....
Dietary vitamin E supplementation lowers blood pressure in spontaneously hypertensive ratsS Vasdev
Department of Medicine, Health Sciences Centre, Memorial University of Newfoundland, St John s, Canada
Mol Cell Biochem 238:111-7. 2002..Dietary vitamin E supplementation in SHRs lowered the systolic blood pressure, cytosolic [Ca2+], tissue aldehyde conjugates and attenuated adverse renal vascular changes...
Dietary vitamin C supplementation lowers blood pressure in spontaneously hypertensive ratsS Vasdev
Department of Medicine, Health Sciences Centre, Memorial University of Newfoundland, St. John's, Canada
Mol Cell Biochem 218:97-103. 2001..Dietary vitamin C supplementation in SHRs lowered the systolic blood pressure, tissue aldehyde conjugates and attenuated adverse renal vascular changes...
Measurement of methylglyoxal in rat tissues by electrospray ionization mass spectrometry and liquid chromatographyE W Randell
Department of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland, Canada
J Pharmacol Toxicol Methods 51:153-7. 2005..The high selectivity of this method offers an advantage over other methods based on fluorescence. This method will allow the evaluation of methylglyoxal in essential hypertension and type-2 diabetes...
Effect of poststroke captopril treatment on mortality associated with hemorrhagic stroke in stroke-prone ratsJ Smeda
Division of Basic Medical Sciences, Health Sciences Centre, Memorial University of Newfoundland, St John s, Newfoundland, Canada
J Pharmacol Exp Ther 291:569-75. 1999..The observation that spironolactone treatment couldn't duplicate the effects of captopril suggests that aldosterone may facilitate stroke through nongenomic receptor mechanisms...
Serum visfatin concentrations are positively correlated with serum triacylglycerols and down-regulated by overfeeding in healthy young menGuang Sun
Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St John s, NL, Canada
Am J Clin Nutr 85:399-404. 2007..Visfatin is an insulin-mimicking adipokine. Visfatin is elevated in obesity and type 2 diabetes. However, its role in glucose and lipid metabolism in healthy humans is unclear...
Altered calcium homeostasis is correlated with abnormalities of fasting serum glucose, insulin resistance, and beta-cell function in the Newfoundland populationGuang Sun
Discipline of Genetics, Memorial University of Newfoundland, St John s, Newfoundland and Labrador, Canada
Diabetes 54:3336-9. 2005..Our results suggest that alteration of serum calcium homeostasis is significantly correlated with the abnormality of glucose level, insulin resistance, and beta-cell function...
Serum retinol-binding protein 4 concentrations in response to short-term overfeeding in normal-weight, overweight, and obese menJennifer Shea
Discipline of Genetics and Medicine, Faculty of Medicine, Memorial University of Newfoundland, St John s, Canada
Am J Clin Nutr 86:1310-5. 2007..Studies in humans have shown a correlation between serum RBP4 and insulin resistance in obese subjects and in subjects with type 2 diabetes. Few data are available regarding the nutritional regulation of RBP4...
Plasma advanced glycation endproduct, methylglyoxal-derived hydroimidazolone is elevated in young, complication-free patients with Type 1 diabetesYingchun Han
Division of Biochemical Pathology, Memorial University of Newfoundland, St John s, Newfoundland and Labrador, Canada
Clin Biochem 42:562-9. 2009..The relationship of plasma free MG-H to hemoglobin A1C (A1C) and plasma methylglyoxal levels was also determined...
