Rama S Singh

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. ncbi Molecular evidence for increased regulatory conservation during metamorphosis, and against deleterious cascading effects of hybrid breakdown in Drosophila
    Carlo G Artieri
    Department of Biology, McMaster University, Hamilton, Ontario, L8S4K1, Canada
    BMC Biol 8:26. 2010
  2. ncbi Male sex drive and the maintenance of sex: evidence from Drosophila
    Rama S Singh
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    J Hered 101:S100-6. 2010
  3. ncbi Ontogeny and phylogeny: molecular signatures of selection, constraint, and temporal pleiotropy in the development of Drosophila
    Carlo G Artieri
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    BMC Biol 7:42. 2009
  4. ncbi Evolution in the fast lane: rapidly evolving sex-related genes in Drosophila
    Wilfried Haerty
    Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    Genetics 177:1321-35. 2007
  5. ncbi Darwin's legacy: why biology is not physics, or why evolution has not become a common sense
    Rama S Singh
    Department of Biology, McMaster University, Hamilton, ON, Canada
    Genome 54:868-73. 2011
  6. ncbi Male sex drive and the masculinization of the genome
    Rama S Singh
    Department of Biology, McMaster University, Hamilton, ON, Canada
    Bioessays 27:518-25. 2005
  7. ncbi Darwin to DNA, molecules to morphology: the end of classical population genetics and the road ahead
    Rama S Singh
    Department of Biology, McMaster University, Hamilton, ON, Canada
    Genome 46:938-42. 2003
  8. ncbi Sex gene pool evolution and speciation: a new paradigm
    R S Singh
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Genes Genet Syst 75:119-30. 2000
  9. ncbi Comparative analysis of function and interaction of transcription factors in nematodes: extensive conservation of orthology coupled to rapid sequence evolution
    Wilfried Haerty
    Department of Biology, McMaster University, Hamilton, ON L8S 4K1, Canada
    BMC Genomics 9:399. 2008
  10. ncbi Gene regulation divergence is a major contributor to the evolution of Dobzhansky-Muller incompatibilities between species of Drosophila
    Wilfried Haerty
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Mol Biol Evol 23:1707-14. 2006

Detail Information

Publications30

  1. ncbi Molecular evidence for increased regulatory conservation during metamorphosis, and against deleterious cascading effects of hybrid breakdown in Drosophila
    Carlo G Artieri
    Department of Biology, McMaster University, Hamilton, Ontario, L8S4K1, Canada
    BMC Biol 8:26. 2010
    ..However, this has prompted the suggestion that misexpression in adult hybrids results from the downstream cascading effects of a subset of genes improperly regulated in early development...
  2. ncbi Male sex drive and the maintenance of sex: evidence from Drosophila
    Rama S Singh
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    J Hered 101:S100-6. 2010
    ..We show that recent studies confirm that genomic masculinization, as a result of "male sex drive," has important consequences for the evolution of sexually dimorphic species...
  3. ncbi Ontogeny and phylogeny: molecular signatures of selection, constraint, and temporal pleiotropy in the development of Drosophila
    Carlo G Artieri
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    BMC Biol 7:42. 2009
    ....
  4. ncbi Evolution in the fast lane: rapidly evolving sex-related genes in Drosophila
    Wilfried Haerty
    Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    Genetics 177:1321-35. 2007
    ..SFP genes also show evidence of lineage-specific gene loss and/or gain. These results bring us closer to understanding the details of the evolutionary dynamics of SRR genes with respect to species divergence...
  5. ncbi Darwin's legacy: why biology is not physics, or why evolution has not become a common sense
    Rama S Singh
    Department of Biology, McMaster University, Hamilton, ON, Canada
    Genome 54:868-73. 2011
    ..Considering how evolution affects our lives, including health and the environment to give just two examples, a basic course in evolution should become a required component of all our college and university educational systems...
  6. ncbi Male sex drive and the masculinization of the genome
    Rama S Singh
    Department of Biology, McMaster University, Hamilton, ON, Canada
    Bioessays 27:518-25. 2005
    ..Male sex-drive theory complements the female-choice theory of sexual selection and allows for the genetic variation of costly sexual traits to be continuously replenished...
  7. ncbi Darwin to DNA, molecules to morphology: the end of classical population genetics and the road ahead
    Rama S Singh
    Department of Biology, McMaster University, Hamilton, ON, Canada
    Genome 46:938-42. 2003
    ....
  8. ncbi Sex gene pool evolution and speciation: a new paradigm
    R S Singh
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Genes Genet Syst 75:119-30. 2000
    ..It is proposed that the evolutionary study of genes affecting viability versus fertility is the key to understanding the genetic basis of speciation...
  9. ncbi Comparative analysis of function and interaction of transcription factors in nematodes: extensive conservation of orthology coupled to rapid sequence evolution
    Wilfried Haerty
    Department of Biology, McMaster University, Hamilton, ON L8S 4K1, Canada
    BMC Genomics 9:399. 2008
    ....
  10. ncbi Gene regulation divergence is a major contributor to the evolution of Dobzhansky-Muller incompatibilities between species of Drosophila
    Wilfried Haerty
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Mol Biol Evol 23:1707-14. 2006
    ..These results suggest that gene regulation divergence of sex- and reproduction-related genes is a major contributor to the evolution of Dobzhansky-Muller incompatibilities between species of Drosophila...
  11. ncbi Rapidly evolving genes of Drosophila: differing levels of selective pressure in testis, ovary, and head tissues between sibling species
    Santosh Jagadeeshan
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Mol Biol Evol 22:1793-801. 2005
    ....
  12. ncbi Rapid evolution of outer egg membrane proteins in the Drosophila melanogaster subgroup: a case of ecologically driven evolution of female reproductive traits
    Santosh Jagadeeshan
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Mol Biol Evol 24:929-38. 2007
    ..At this point, however, our results support previous suggestions that divergences in ecology, particularly, ovipositional substrate divergences may be a strong force driving the evolution of eggshell proteins...
  13. ncbi Association between levels of coding sequence divergence and gene misregulation in Drosophila male hybrids
    Carlo G Artieri
    Department of Biology, McMaster University, Life Science Building 540, 1280 Main Street West, L8S 4K1 Hamilton, Ontario, Canada
    J Mol Evol 65:697-704. 2007
    ....
  14. ncbi Sexual selection and maintenance of sex: evidence from comparisons of rates of genomic accumulation of mutations and divergence of sex-related genes in sexual and hermaphroditic species of Caenorhabditis
    Carlo G Artieri
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Mol Biol Evol 25:972-9. 2008
    ..Our results provide empirical evidence of increased sexual selection pressure in dioecious animals, supporting the possibility that sexual selection may play an important role in the maintenance of sexual reproduction...
  15. ncbi A reanalysis of protein polymorphism in Drosophila melanogaster, D. simulans, D. sechellia and D. mauritiana: effects of population size and selection
    Richard A Morton
    Department of Biology, McMaster University, 1280 Main Street West Hamilton, Ont, Canada L8S 4K1
    Genetica 120:101-14. 2004
    ..melanogaster, and of possibly ancient population structure and recent worldwide migration in D. simulans. Population size differences alone are insufficient as an explanation for the patterns of variation between these two species...
  16. ncbi Rapid evolution through gene duplication and subfunctionalization of the testes-specific alpha4 proteasome subunits in Drosophila
    Dara G Torgerson
    Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    Genetics 168:1421-32. 2004
    ..Newly duplicated genes that are freer from selective constraints may provide a mechanism for developing new interactions and a pathway for the evolution of new genes...
  17. ncbi Sex-specific functional specialization and the evolutionary rates of essential fertility genes
    Dara G Torgerson
    Department of Biology, McMaster University, Hamilton, Ontario L8S 1J4, Canada
    J Mol Evol 61:650-8. 2005
    ....
  18. ncbi A genomic comparison of faster-sex, faster-X, and faster-male evolution between Drosophila melanogaster and Drosophila pseudoobscura
    Heidi Musters
    Department of Biology, McMaster University, 1280 Main Street W, Hamilton, Ontario, L8S 4K1, Canada
    J Mol Evol 62:693-700. 2006
    ..pseudoobscura orthologue. These results, from widely separated taxa, bolster the thesis that sexual system genes experience accelerated rates of change in comparison to nonsexual genes in evolution and speciation...
  19. ncbi Sex-linked mammalian sperm proteins evolve faster than autosomal ones
    Dara G Torgerson
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Mol Biol Evol 20:1705-9. 2003
    ....
  20. ncbi The nature of genetic variation in sex and reproduction-related genes among sibling species of the Drosophila melanogaster complex
    Rob J Kulathinal
    Department of Biology, McMaster University, Hamilton, Ont, Canada L8S 4K1
    Genetica 120:245-52. 2004
    ..These results follow a general trend observed in other taxa and demonstrate the preferential involvement of SRR genes in reproductive isolation and species formation...
  21. ncbi Variation and evolution of male sex combs in Drosophila: nature of selection response and theories of genetic variation for sexual traits
    Abha Ahuja
    Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    Genetics 179:503-9. 2008
    ..We discuss the implications of these results for theories of genetic variation in display and nondisplay male sex traits...
  22. ncbi Demystifying phenotypes: The comparative genomics of evo-devo
    Carlo G Artieri
    Department of Biology, McMaster University, Hamilton, ON, Canada
    Fly (Austin) 4:18-20. 2010
    ....
  23. ncbi A biogeographic genetic approach for testing the role of reinforcement: the case of Drosophila pseudoobscura and D. persimilis
    R J Kulathinal
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Evolution 54:210-7. 2000
    ..We suggest more parsimonious explanations such as reinforcement without genetic exchange (model II) and ecological differentiation, which require high levels of preexisting reproductive isolation between populations...
  24. ncbi Rapid evolution of the sex-determining gene, transformer: structural diversity and rate heterogeneity among sibling species of Drosophila
    Rob J Kulathinal
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Mol Biol Evol 20:441-52. 2003
    ..A comparison of tra orthologs across the genus Drosophila suggest that TRA maintains an assortment of RS domains for proper sex determining function while much of the protein evolves relatively unconstrained...
  25. ncbi Condition dependence and the nature of genetic variation for male sex comb bristle number in Drosophila melanogaster
    Abha Ahuja
    Department of Biology, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada
    Genetica 139:505-10. 2011
    ..The nature of genetic variation for male sex traits continues to be an important unresolved issue in evolutionary biology...
  26. ncbi Is speciation accompanied by rapid evolution? Insights from comparing reproductive and nonreproductive transcriptomes in Drosophila
    Santosh Jagadeeshan
    Department of Biology, McMaster University, Hamilton, ON, Canada L8S 4KI
    Int J Evol Biol 2011:595121. 2011
    ..The identification of loci associated with accelerated evolution allows us to address the mechanisms of rapid evolution and speciation, which in our study appears to be a combination of both selection and rapid demographical changes...
  27. ncbi Mammalian sperm proteins are rapidly evolving: evidence of positive selection in functionally diverse genes
    Dara G Torgerson
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Mol Biol Evol 19:1973-80. 2002
    ..These results demonstrate the rapid evolution of sperm-specific genes and highlight the molecular action of sexual selection on a variety of characters involved in mammalian sperm function...
  28. ncbi Sex-related genes, directional sexual selection, and speciation
    A Civetta
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Mol Biol Evol 15:901-9. 1998
    ..g., D. melanogaster and D. pseudoobscura). However, a saturation in the number of nucleotide substitutions since the time of species separation may mask any sign of directional selection between more distantly related species...
  29. ncbi A time-sequence functional analysis of mating behaviour and genital coupling in Drosophila: role of cryptic female choice and male sex-drive in the evolution of male genitalia
    S Jagadeeshan
    Department of Biology, McMaster University, Hamilton, ON, Canada
    J Evol Biol 19:1058-70. 2006
    ..We propose that variation in male usage of novel genitalic structures and shifts in copulatory behaviour have played an important role in the diversification of genitalia in species of the Drosophila subgroup...
  30. ncbi Evolution of genes and genomes on the Drosophila phylogeny
    Andrew G Clark
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Nature 450:203-18. 2007
    ..These may prove to underlie differences in the ecology and behaviour of these diverse species...