Research Topics
| E J MillsSummaryAffiliation: McMaster University Country: Canada Publications
| Collaborators
|
Detail Information
Publications
The abandoned trials of pre-exposure prophylaxis for HIV: what went wrong?Jerome A Singh
Centre for the AIDS Programme of Research, South Africa
PLoS Med 2:e234. 2005
Effectiveness of smoking cessation therapies: a systematic review and meta-analysisPing Wu
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
BMC Public Health 6:300. 2006..These include Nicotine Replacement Therapy [NRT], bupropion, and varenicline. We aimed to assess their relative efficacy in smoking cessation by conducting a systematic review and meta-analysis...
EDTA chelation therapy for cardiovascular disease: a systematic reviewDugald M R Seely
Canadian College of Naturopathic Medicine, Toronto, Canada
BMC Cardiovasc Disord 5:32. 2005..To address this issue we conducted a systematic review to evaluate the best available evidence for the use of EDTA chelation therapy in the treatment of cardiovascular disease...
Barriers to participation in HIV drug trials: a systematic reviewEdward Mills
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
Lancet Infect Dis 6:32-8. 2006..The findings of this study should aid drug trialists in developing strategies to maximise participation and cooperation in HIV clinical drug trials while adequately informing and protecting prospective participants...
Tenofovir trials raise ethical issuesEdward Mills
Centre for International Human Rights Law, University of Oxford, Canada
HIV AIDS Policy Law Rev 10:31-2. 2005....
Designing research in vulnerable populations: lessons from HIV prevention trials that stopped earlyEdward J Mills
Department of Clinical Epidemiology and Biostatistics, McMaster University, HSC-2C12, 1200 Main Street West, Hamilton, ON, Canada L8N 3Z5
BMJ 331:1403-6. 2005
African herbal medicines in the treatment of HIV: Hypoxis and Sutherlandia. An overview of evidence and pharmacologyEdward Mills
Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main Street West Hamilton, L8N 3Z5, Canada
Nutr J 4:19. 2005..Efforts should also be directed at evaluating the possible benefits of natural products in HIV/AIDS treatment...
Natural health product-HIV drug interactions: a systematic reviewEdward Mills
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON L8N 3Z5, Canada
Int J STD AIDS 16:181-6. 2005..Considering patient values and the implications of these studies, further research is urgently required to determine the extent of interactions with other commonly used NHPs...
Complementary therapies for the treatment of HIV: in search of the evidenceEdward Mills
Department of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, McMaster University, HSC 2C12, 1200 Main Street West, Hamilton, ON L8N 3Z5, Canada
Int J STD AIDS 16:395-403. 2005..Vis à vis CAM's popularity, the paucity of clinical trials and their low methodological quality are concerning...
The quality of randomized trial reporting in leading medical journals since the revised CONSORT statementEdward J Mills
Department of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, McMaster University, HSC 2C12, 1200 Main Street West, Hamilton, ON, Canada, L8N 3Z5
Contemp Clin Trials 26:480-7. 2005..Although reporting of some CONSORT recommendations is high, reporting of several essential recommendations remains suboptimal. Authors need to comply with and journals need to enforce reporting of the revised CONSORT recommendations...
Natural health product-drug interactions: a systematic review of clinical trialsEdward Mills
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
Ther Drug Monit 27:549-57. 2005..With the exception of St. John wort, clinicians and the public do not have information that permits strong inferences about interactions between NHPs and conventional medications...
Melatonin in the treatment of cancer: a systematic review of randomized controlled trials and meta-analysisEdward Mills
Department of Clinical Epidemiology, McMaster University, Hamilton, ON, Canada
J Pineal Res 39:360-6. 2005..Confirming the efficacy and safety of melatonin in cancer treatment will require completion of blinded, independently conducted RCTs...
Barriers to participation in clinical trials of cancer: a meta-analysis and systematic review of patient-reported factorsEdward J Mills
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
Lancet Oncol 7:141-8. 2006..Enrolling participants onto clinical trials of cancer presents an important challenge. We aimed to identify the concerns of patients with cancer about, and the barriers to, participation in clinical trials...
Milk thistle and indinavir: a randomized controlled pharmacokinetics study and meta-analysisEdward Mills
Faculty of Health Sciences, Clinical Epidemiology and Biostatistics, McMaster University, HSC 2C12, 1200 Main Street West, Hamilton, ON, L8N 3Z5, Canada
Eur J Clin Pharmacol 61:1-7. 2005..To determine whether ingestion of milk thistle affects the pharmacokinetics of indinavir...
Systematically reviewing qualitative studies complements survey design: an exploratory study of barriers to paediatric immunisationsEdward J Mills
Department of Clinical Epidemiology and Biostatistics, McMaster University, Health Science Centre, Hamilton, Ontario, Canada
J Clin Epidemiol 58:1101-8. 2005..We examined surveys addressing parental barriers to vaccinating children to determine if they comprehensively included themes identified in published qualitative studies...
Design, analysis, and presentation of crossover trialsEdward J Mills
Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada
Trials 10:27. 2009..Although crossover trials enjoy wide use, standards for analysis and reporting have not been established. We reviewed methodological aspects and quality of reporting in a representative sample of published crossover trials...
Metastatic renal cell cancer treatments: an indirect comparison meta-analysisEdward J Mills
Faculty of Health Sciences, Simon Fraser University, Vancouver, Canada
BMC Cancer 9:34. 2009..New treatment options may provide improved progression-free survival (PFS). We aimed to determine the relative effectiveness of new therapies in this field...
Primary prevention of cardiovascular mortality and events with statin treatments: a network meta-analysis involving more than 65,000 patientsEdward J Mills
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
J Am Coll Cardiol 52:1769-81. 2008..This study aimed to evaluate the effectiveness of 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitors (statins) in primary prevention of cardiovascular events...
Antiretroviral effects on HIV-1 RNA, CD4 cell count and progression to AIDS or death: a meta-regression analysisE J Mills
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
HIV Med 9:849-57. 2008..We aimed to determine the strength of the association between the magnitude of the effect of changes in CD4 cell count and HIV-1 RNA and progression to AIDS or death in the highly active antiretroviral therapy (HAART) era...
A randomized trial of Pegaptanib sodium for age-related macular degeneration used an innovative design to explore disease-modifying effectsEdward Mills
Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
J Clin Epidemiol 60:456-60. 2007..We aimed to determine if this design would permit inferences regarding disease modification in a trial evaluating Pegaptanib sodium, an intra-ocular injection, for the treatment of age-related macular degeneration...
Participation in HIV vaccine trials: listening to participant & community concernsEdward J Mills
B.C. Centre for Excellence in HIV/AIDS, St. Paul's Hospital Vancouver BC
Indian J Med Res 124:608-10. 2006
The challenges of involving traditional healers in HIV/AIDS careE Mills
Department of Clinical Epidemiology and Biostatistics, McMaster University, Ontario, Canada, and Department of Medicine, University of Calabar Teaching Hospital, Nigeria
Int J STD AIDS 17:360-3. 2006..Collaboration is essential, given the changing epidemic of HIV and the dynamic relationship between the two health sectors...
Determining the reporting quality of RCTs in clinical pharmacologyEdward Mills
University of Oxford, Oxford, UK
Br J Clin Pharmacol 58:61-5. 2004..The Consolidated Standards for Reporting Trials (CONSORT) are recommendations for improving the quality of reports of randomized controlled trials (RCTs)...
Interaction of St John's wort with conventional drugs: systematic review of clinical trialsEdward Mills
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada L8N 3Z5
BMJ 329:27-30. 2004..To determine the methodological quality of clinical trials that examined possible interactions of St John's wort with conventional drugs, and to examine the results of these trials...
Epidemiology and reporting of randomized trials employing re-randomization of patient groups: a systematic surveyEdward J Mills
Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada
Contemp Clin Trials 28:268-75. 2007....
Adverse events associated with individual statin treatments for cardiovascular disease: an indirect comparison meta-analysisM Alberton
Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada
QJM 105:145-57. 2012..Statins are the most widely prescribed drug available. Due to this reason, it is important to understand the risks involved with the drug class and individual statins...
Prevalence of mental disorders and torture among Bhutanese refugees in Nepal: a systemic review and its policy implicationsEdward Mills
Faculty of Health Sciences, Simon Fraser University, Vancouver, British Columbia, Canada
Med Confl Surviv 24:5-15. 2008..The international community must resolve this protracted crisis...
An analysis of general medical and specialist journals that endorse CONSORT found that reporting was not enforced consistentlyEdward Mills
Department of Clinical Epidemiology and Biostatistics, HSC 2C12, Faculty of Health Sciences, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
J Clin Epidemiol 58:662-7. 2005..We aimed to determine if specialist journals implement specific Consolidated Standards for Reporting Trials (CONSORT) recommendations to the same extent as general medical journals...
Impact of African herbal medicines on antiretroviral metabolismEdward Mills
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
AIDS 19:95-7. 2005..Initiating policies to provide herbal medicines with antiretroviral agents may put patients at risk of treatment failure, viral resistance or drug toxicity...
In the era of systematic reviews, does the size of an individual trial still matterGordon H Guyatt
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
PLoS Med 5:e4. 2008..Others point out that small trials can still be potentially misleading...
Adherence to HAART: a systematic review of developed and developing nation patient-reported barriers and facilitatorsEdward J Mills
Centre for International Health and Human Rights Studies, Toronto, Ontario, Canada
PLoS Med 3:e438. 2006..We systematically reviewed the literature to determine patient-reported barriers and facilitators to adhering to antiretroviral therapy...
Adherence to antiretroviral therapy in sub-Saharan Africa and North America: a meta-analysisEdward J Mills
Centre for International Health and Human Rights Studies, Toronto, Ontario, Canada
JAMA 296:679-90. 2006..Concerns about incomplete adherence among patients living in poverty have been an important consideration in expanding the access to antiretroviral therapy in sub-Saharan Africa...
Safety and efficacy of ginkgo (Ginkgo biloba) during pregnancy and lactationJean Jacques Dugoua
Department of Clinical Epidemiology, Canadian College of Naturopathic Medicine, Toronto, Canada
Can J Clin Pharmacol 13:e277-84. 2006..This is one article in a series that systematically reviews the evidence for commonly used herbs during pregnancy and lactation...
Safety and efficacy of St. John's wort (hypericum) during pregnancy and lactationJean Jacques Dugoua
Department of Clinical Epidemiology, Canadian College of Naturopathic Medicine, Toronto, Canada
Can J Clin Pharmacol 13:e268-76. 2006..This is one article in a series that systematically reviews the evidence for commonly used herbs during pregnancy and lactation...
Randomized controlled trials in long-term care residents with dementia: a systematic reviewEdward J Mills
The University of Oxford
J Am Med Dir Assoc 4:302-7. 2003..The reporting quality is highly variable in the trials reviewed, and concerns exist surrounding the conduct of several trials...
Efficacy and safety of statin treatment for cardiovascular disease: a network meta-analysis of 170,255 patients from 76 randomized trialsE J Mills
Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
QJM 104:109-24. 2011..Statins represent the largest selling class of cardiovascular drug in the world. Previous randomized trials (RCTs) have demonstrated important clinical benefits with statin therapy...
Health food store recommendations: implications for breast cancer patientsEdward Mills
Department of Research, Canadian College of Naturopathic Medicine, North York, Ontario, Canada
Breast Cancer Res 5:R170-4. 2003..Many breast cancer patients use complementary and alternative medicine (CAM). We aimed to determine what advice health food store employees present to individuals seeking treatment options for breast cancer...
Randomized trials stopped early for harm in HIV/AIDS: a systematic surveyEdward Mills
Centre for International Health and Human Rights Studies, North York, Ontario, Canada
HIV Clin Trials 7:24-33. 2006..We assessed the prevalence of randomized clinical trials (RCTs) stopped early for harm in HIV/AIDS and determined the quality of reporting of methods to inform the decision to stop the trial...
Safety and efficacy of black cohosh (Cimicifuga racemosa) during pregnancy and lactationJean Jacques Dugoua
Department of Clinical Epidemiology, Canadian College of Naturopathic Medicine, Toronto, Canada
Can J Clin Pharmacol 13:e257-61. 2006..This is one article in a series that systematically reviews the evidence for commonly used herbs during pregnancy and lactation...
Mitigation of antiretroviral-induced hyperlipidemia by hepatitis C virus co-infectionCurtis L Cooper
Division of Infectious Diseases, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada
AIDS 21:71-6. 2007..Hyperlipidemia is a recognized complication of HIV antiretroviral therapy. The interactions between HIV, hepatitis C virus (HCV), antiretroviral agents and lipids are not well understood...
HIV/AIDS in African militaries: an ecological analysisOumar Ba
Faculty of Health Sciences, Simon Fraser University, Vancouver, Canada
Med Confl Surviv 24:88-100. 2008..4). Population levels predicted military prevalence rates (P < or = 0.001). HIV/AIDS prevalence rates in most African militaries are significantly elevated compared to their host communities...
Changing attitudes towards polio vaccination: a randomized trial of an evidence-based presentation versus a presentation from a polio survivorKumanan Wilson
Department of Medicine, University of Toronto, Canada
Vaccine 23:3010-5. 2005..These findings suggest that confronting deeply held beliefs regarding vaccination may paradoxically strengthen these belief systems...
Teaching evidence-based complementary and alternative medicine: 2. A conceptual approach to causation-part 2Kumanan Wilson
Department of Medicine, University of Toronto, Ontario, Canada
J Altern Complement Med 8:385-9. 2002..more likely to lead to disease? Is there evidence from several different studies showing the same association? Does withdrawal of the cause result in loss of the effect? Is there a biologic model that can explain the causal relationship?..
Closing comment: Evidence-based complementary and alternative medicine: is it a viable concept?Kumanan Wilson
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
J Altern Complement Med 8:875-6. 2002
Enrolling women into HIV preventive vaccine trials: an ethical imperative but a logistical challengeEdward Mills
Centre for International Health and Human Rights Studies, Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
PLoS Med 3:e94. 2006
Problems with use of composite end points in cardiovascular trials: systematic review of randomised controlled trialsIgnacio Ferreira Gonzalez
Departament de Medicina, Universitat Autonoma de Barcelona, and Hospital Vall d Hebron, Barcelona 08035, Spain
BMJ 334:786. 2007....
Teaching evidence-based complementary and alternative medicine: 2. A conceptual approach to causation-part 1Kumanan Wilson
Department of Medicine, University of Toronto, Ontario, Canada
J Altern Complement Med 8:379-83. 2002....
A wake-up call for global access to salvage HIV drug regimensEdward J Mills
British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada
Lancet 370:1885-7. 2007
In vitro evaluation of human cytochrome P450 and P-glycoprotein-mediated metabolism of some phytochemicals in extracts and formulations of African potatoVipin D P Nair
Division of Pharmaceutics, Faculty of Pharmacy, Rhodes University, Grahamstown, South Africa
Phytomedicine 14:498-507. 2007..Appropriate measures are therefore necessary to explore the possibility of such in vitro-in vivo correlations...
The impact of conflict on HIV/AIDS in sub-Saharan AfricaEdward J Mills
Centre for International Health and Human Rights Studies, Toronto, Canada
Int J STD AIDS 17:713-7. 2006..We examine the complexity of monitoring HIV/AIDS in conflict settings. We argue that increased efforts are needed to protect vulnerable populations and design health-delivery systems that are sustainable in settings of conflict...
The effects of green tea consumption on incidence of breast cancer and recurrence of breast cancer: a systematic review and meta-analysisDugald Seely
Department of Clinical Epidemiology, Canadian College of Naturopathic Medicine, Toronto, Ontario, Canada
Integr Cancer Ther 4:144-55. 2005..Green tea is widely used by women for the prevention and treatment of breast cancer. The authors aimed to determine the efficacy of green tea ingestion on the risk of breast cancer development and the risk of breast cancer recurrence...
Teaching evidence-based complementary and alternative medicine: 1. A learning structure for clinical decision changesEdward J Mills
Department of Research, The Canadian College of Naturopathic Medicine, North York, Ontario
J Altern Complement Med 8:207-14. 2002..In order to create communication effectively, an evidence-based approach may provide the common ground required for all schools of thought...
Disclosure of natural product use to primary care physicians: a cross-sectional survey of naturopathic clinic attendeesJason W Busse
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
Mayo Clin Proc 80:616-23. 2005..Our findings suggest that disclosure rates could be improved by physicians taking a more active role in asking their patients about natural product use...
Simple, effective interventions are key to improving adherence in marginalized populationsEdward J Mills
Clin Infect Dis 45:916-7. 2007
Reporting of informed consent, standard of care and post-trial obligations in global randomized intervention trials: a systematic survey of registered trialsEmma R M Cohen
Simon Fraser University, Burnaby, British Columbia, Canada
Dev World Bioeth 9:74-80. 2009....
An in vivo analysis of the herbal compound essiacBlair J N Leonard
Faculty of Medicine, University of Toronto, Toronto, ON, Canada
Anticancer Res 26:3057-63. 2006..CONCLUSION: Essiac, administered in established in vivo experimental models, did not significantly demonstrate its purported physiological modifying effects...
Prevalence of mental disorders among children exposed to war: a systematic review of 7,920 childrenVindya Attanayake
Faculty of Health Sciences, Simon Fraser University, Vancouver, BC, Canada
Med Confl Surviv 25:4-19. 2009..Given the number of current conflicts, there is a paucity of information regarding mental disorders among children affected by war...
Diagnostic accuracy among the allied health professions: commentary on Grace et AlDugald Seely
Department of Clinical Epidemiology, The Canadian College of Naturopathic Medicine, North York, Ontario, Canada
J Altern Complement Med 12:701-2. 2006
In vitro analysis of the herbal compound EssiacDugald Seely
Department of Research and Clinical Epidemiology, The Canadian College of Naturopathic Medicine, Toronto, ON, Canada
Anticancer Res 27:3875-82. 2007..We aimed to address this deficiency by conducting a series of assays to determine some of the purported activities of Essiac in vitro...
Randomized trials stopped early for benefit: a systematic reviewVictor M Montori
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
JAMA 294:2203-9. 2005..These findings suggest clinicians should view the results of such trials with skepticism...
Characteristics of pediatric and adolescent patients attending a naturopathic college clinic in CanadaKumanan Wilson
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Pediatrics 115:e338-43. 2005..We also determined factors associated with the use of CAM products and vaccination status...
Teaching evidence-based complementary and alternative medicine: 3. Asking the questions and identifying the informationKumanan Wilson
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
J Altern Complement Med 8:499-506. 2002..This paper suggests practical strategies for successful database searches in support of EBCAM...
Should active recruitment of health workers from sub-Saharan Africa be viewed as a crime?Edward J Mills
British Columbia Centre for Excellence in HIV/AIDS, University of British Columbia, Canada
Lancet 371:685-8. 2008
Neglected diseases, civil conflicts, and the right to healthChris Beyrer
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Lancet 370:619-27. 2007..We also discuss the role of researchers in advocating for and researching within oppressed populations...
Teaching evidence-based complementary and alternative medicine: 4. Appraising the evidence for papers on therapyKumanan Wilson
Department of Medicine, University of Toronto, Ontario, Canada
J Altern Complement Med 8:673-9. 2002....
Teaching evidence-based complementary and alternative medicine: 5. Interpreting the results of a study on therapy and applying them to a patientKumanan Wilson
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
J Altern Complement Med 8:867-73. 2002....
HIV infection as a weapon of warEdward J Mills
Lancet Infect Dis 6:752-3. 2006
Introducing evidence-based complementary and alternative medicine: answering the challengeKumanan Wilson
J Altern Complement Med 8:103-5. 2002
Dangerous journey: documenting the experience of Tibetan refugeesSonam Dolma
Department of Political Science, York University, Toronto, Ontario
Am J Public Health 96:2061-4. 2006..International pressure is needed to prevent human rights violations and reduce potential long-term physical and mental health effects associated with this dangerous crossing...
Migration and transmission of blood-borne infections among injection drug users: understanding the epidemiologic bridgeBeth Rachlis
BC Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, British Columbia, Canada
Drug Alcohol Depend 90:107-19. 2007..We also discuss the potential policy implications of addressing prevention and care issues in mobile drug using populations...
