Research Topics
| Nancy M HeddleSummaryAffiliation: McMaster University Country: Canada Publications
| Collaborators
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Detail Information
Publications
Utilization of platelet transfusions in the intensive care unit: indications, transfusion triggers, and platelet count responsesDonald M Arnold
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Transfusion 46:1286-91. 2006..A description of current platelet (PLT) transfusion practice in the intensive care unit (ICU) is needed...- The research questionNancy M Heddle
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Transfusion 47:15-7. 2007 - Do expert assessments converge? An exploratory case study of evaluating and managing a blood supply riskJohn Eyles
School of Geography and Earth Sciences, McMaster University, 1280 Main St West, Hamilton, Ontario, Canada
BMC Public Health 11:666. 2011..It also describes the context of publicly funded blood transfusion in Canada and the withdrawal event that is the basis of this study... - A randomized controlled trial comparing the frequency of acute reactions to plasma-removed platelets and prestorage WBC-reduced plateletsNancy M Heddle
Department of Pathology, McMaster University, Hamilton, Ontario, Canada
Transfusion 42:556-66. 2002..This study evaluates the effectiveness of plasma removal and two methods of prestorage WBC reduction for preventing acute reactions to platelets... - Evidence-based decision making in transfusion medicineN M Heddle
McMaster Transfusion Research Program, McMaster Uiversity, Canadian Blood Services, Hamilton, Ontario, Canada
Vox Sang 91:214-20. 2006.... - Comparing the efficacy and safety of apheresis and whole blood-derived platelet transfusions: a systematic reviewNancy M Heddle
The Department of Medicine and the Department of Molecular Medicine and Pathology, McMaster University, Hamilton, Ontario, Canada
Transfusion 48:1447-58. 2008.... - A descriptive analysis of international transfusion practice and bleeding outcomes in patients with acute leukemiaNancy M Heddle
Department of Medicine, McMaster University, Canadian Blood Services, Hamilton, Ontario, Canada, and the Transfusion and Transplant Immunology Center IRCCS, Maggiore Hospital, Milan, Italy
Transfusion 46:903-11. 2006..The purpose of this study was to provide a descriptive summary of data from PLT studies conducted in four countries and exploratory analyses to determine the relationship between bleeding and PLT count... - In vitro evaluation of prestorage pooled leukoreduced whole blood-derived platelets stored for up to 7 daysN M Heddle
Department of Medicine, McMaster University, Canadian Blood Services, Hamilton, Ontario, Canada
Transfusion 45:904-10. 2005..The in vitro quality of pre-storage pooled PLTs stored for up to 7 days was assessed... - Assessing the effectiveness of whole blood-derived platelets stored as a pool: a randomized block noninferiority trialN M Heddle
Department of Medicine and Pathology and Molecular Medicine, McMaster University, and the Canadian Blood Services, Hamilton, Ontario, Canada
Transfusion 45:896-903. 2005..This study evaluated the in vivo effect of the prestorage pooling of PLTs stored for up to 5 days, by assessing the corrected count increment (CCI) 18 to 24 hours after transfusion of the product... - A policy informing qualitative study to improve the process of blood product recalls and withdrawalsNancy M Heddle
Departments of Medicine and the School of Geography, and Earth Science, McMaster University, Hamilton, Ontario, Canada
Transfusion 48:2585-95. 2008..With the use of qualitative techniques and a modified grounded theory approach, the current process was mapped, issues were identified, and recommendations to improve the system were developed... - A randomized controlled trial comparing standard- and low-dose strategies for transfusion of platelets (SToP) to patients with thrombocytopeniaNancy M Heddle
Department of Medicine, McMaster University, Hamilton, ON, Canada
Blood 113:1564-73. 2009..Whether this finding was due to chance or represents a real difference requires further investigation. These clinical studies are registered on (http://www.clinicaltrials.gov) as NCT00420914... - Factors affecting the frequency of red blood cell outdates: an approach to establish benchmarking targetsNancy M Heddle
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Transfusion 49:219-26. 2009..In this study, a provincial database of red blood cell (RBC) product inventory/disposition in hospitals was analyzed to identify factors that affected RBC outdates and to systematically establish optimal target levels for RBC outdates... - Clinical research designs: quantitative studiesNancy M Heddle
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Vox Sang 83:247-50. 2002 - Methodologic issues in the use of bleeding as an outcome in transfusion medicine studiesNancy M Heddle
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Transfusion 43:742-52. 2003.... - Adjudicating bleeding events in a platelet dose study: impact on outcome results and challengesNancy M Heddle
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Transfusion 51:2304-10. 2011..This study describes the challenges associated with adjudicating bleeding events and compares the adjudicated and bedside results for bleeding grade... - A pilot randomized trial of adjuvant rituximab or placebo for nonsplenectomized patients with immune thrombocytopeniaDonald M Arnold
Department of Medicine, Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
Blood 119:1356-62. 2012..No difference in the frequency of the composite outcome was observed in this pilot trial (registered at www.clinicaltrials.gov NCT00372892)... - A multicenter pilot-randomized controlled trial of the feasibility of an augmented red blood cell transfusion strategy for patients treated with induction chemotherapy for acute leukemia or stem cell transplantationKathryn E Webert
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Transfusion 48:81-91. 2008..Anemia may be an important factor contributing to an increased risk of bleeding, particularly in patients with thrombocytopenia... - An evaluation of methods for determining reference intervals for light transmission platelet aggregation tests on samples with normal or reduced platelet countsCatherine P M Hayward
McMaster University and the Hamilton Regional Laboratory Medicine Program, Hamilton, Ontario, Canada, L8N 3Z5
Thromb Haemost 100:134-45. 2008..The derived limits for thrombocytopenic samples provide guidance for evaluating thrombocytopenic platelet function disorders, including which agonists to test, based on the sample platelet count... - In vivo recovery and survival of apheresis and whole blood-derived platelets: a paired comparison in healthy volunteersDonald M Arnold
Canadian Blood Services, Hamilton, Ontario, Canada
Transfusion 46:257-64. 2006..The reasons for this effect are not clear. These results may not apply to all apheresis and PRP methods of platelet preparation... - Platelet transfusions in children: results of a randomized, prospective, crossover trial of plasma removal and a prospective audit of WBC reductionStephen Couban
Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
Transfusion 42:753-8. 2002..The effectiveness of plasma reduction after storage and WBC reduction of platelet concentrates before storage was studied in pediatric recipients of platelet transfusions... - Misleading hepatitis B test results due to intravenous immunoglobulin administration: implications for a clinical trial of rituximab in immune thrombocytopeniaDonald M Arnold
Department of Medicine, Michael deGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
Transfusion 50:2577-81. 2010..A high seroprevalence of anti-HBc observed among patients screened for the trial prompted this substudy to investigate for an association between anti-HBc seropositivity and exposure to intravenous immunoglobulin (IVIG)... - Transfusion premedication to prevent acute transfusion reactions: a retrospective observational study to assess current practicesJessica L Fry
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
Transfusion 50:1722-30. 2010.... - A review of randomized controlled trials comparing the effectiveness of hand held computers with paper methods for data collectionShannon J Lane
Department of Medicine, McMaster University, Hamilton, Canada
BMC Med Inform Decis Mak 6:23. 2006..CONCLUSION: Handhelds are an effective alternative to paper and pencil modes of data collection; they are faster and were preferred by most users... - A study of the agreement between patient self-assessment and study personnel assessment of bleeding symptomsKathryn E Webert
McMaster University, Hamilton, Ontario, Canada
Transfusion 46:1926-33. 2006..These assessments are commonly performed by study personnel and can be time-consuming. The purpose of this study was to assess whether patients were able to reliably assess their bleeding status on a daily basis... - The risk of bleeding in thrombocytopenic patients with acute myeloid leukemiaKathryn Webert
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Haematologica 91:1530-7. 2006..Patients with acute myeloid leukemia are at risk of bleeding. The risk factors for different severities of bleeding are poorly studied... - Duration of red cell storage before transfusion and in-hospital mortalityJohn W Eikelboom
Department of Medicine, McMaster University, Ontario, Canada
Am Heart J 159:737-743.e1. 2010..The objective of the study was to examine the association between duration of pretransfusion storage of red cells and in-hospital mortality... - Hypotensive transfusion reactions can occur with blood products that are leukoreduced before storageDonald M Arnold
Canadian Blood Services, Ontario, Canada
Transfusion 44:1361-6. 2004..CONCLUSION: Hypotensive reactions can occur with blood products that are LR before storage and non-LR ANH. An inherent defect in the metabolism of kinins may be a risk factor for the development of hypotensive transfusion reactions... - Posttransfusion platelet count increments after ABO-compatible versus ABO-incompatible platelet transfusions in noncancer patients: an observational studyKaterina Pavenski
Department of Medicine, McMaster University, and Canadian Blood Services, Hamilton, Ontario, Canada
Transfusion 50:1552-60. 2010..However, most studies to date have been small and involved hematology/oncology patients... - A retrospective 11-year analysis of obstetric patients with idiopathic thrombocytopenic purpuraKathryn E Webert
Department of Medicine, McMaster University, Rm HSC 3N43, 1200 Main St W, Hamilton, ON, Canada L8N 3Z5
Blood 102:4306-11. 2003..6%) required treatment for hemostatic impairment. Two fetal deaths occurred. One was caused by hemorrhage. ITP in pregnancy carries a low risk, but mothers and infants may require therapy to raise their platelet counts... - Understanding the meaning of permanent deferral for blood donorsSusan Whittaker
Department of Medicine and the Department of Nursing, McMaster University, Hamilton, Ontario, Canada
Transfusion 48:64-72. 2008..The purpose of this study was to explore the permanent deferral experience from the donor's perspective... - Combination immunosuppressant therapy for patients with chronic refractory immune thrombocytopenic purpuraDonald M Arnold
Department of Medicine, Michael G DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada
Blood 115:29-31. 2010..Severe adverse events did not occur. Combination immunosuppressant therapy can produce a rise in the platelet count that is sometimes sustained in refractory ITP patients... - Developing a tracking system for coagulation factor concentrates in southern OntarioIrwin R Walker
McMaster University Medical Center, 1200 Main St West, Hamilton, Ontario, Canada, L8N 3Z5, USA
Transfusion 43:556-62. 2003..This study describes the development of a verifiable and comprehensive regional tracking system for coagulation factor concentrates... - Diagnostic utility of light transmission platelet aggregometry: results from a prospective study of individuals referred for bleeding disorder assessmentsC P M Hayward
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
J Thromb Haemost 7:676-84. 2009..Light transmission aggregometry (LTA) is commonly performed to assess individuals for bleeding disorders... - Designing laboratory-based research studies: is it time for a change?Richard J Cook
Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada
Transfusion 47:2336-7. 2007 - Geographical variations in the correlates of blood donor turnout rates: an investigation of Canadian metropolitan areasP J Saberton
School of Geography and Earth Sciences, McMaster University, Hamilton Ontario, Canada
Int J Health Geogr 8:56. 2009..Analysis of donor data will help to identify systematic patterns of donation and its correlates... - Bleeding risks associated with inheritance of the Quebec platelet disorderHeather McKay
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
Blood 104:159-65. 2004..These data illustrate that QPD is associated with increased risks of bleeding that can be modified by fibrinolytic inhibitors... - Individual and contextual determinants of blood donation frequency with a focus on clinic accessibility: A case study of Toronto, CanadaKristina Cimaroli
School of Geography and Earth Sciences, McMaster University, 1280 Main St West, Hamilton, Ontario, Canada L8S 4K1
Health Place 18:424-33. 2012..The results indicate that higher levels of accessibility increase the probability of donor return and more frequent donations... - Laboratory diagnosis of immune heparin-induced thrombocytopeniaTheodore E Warkentin
Hamilton Regional Laboratory Medicine Program, Hamilton Health Sciences, Hamilton General Site, 237 Baron Street East, Hamilton, ON L8L 2X2, Canada
Curr Hematol Rep 2:148-57. 2003..quot; However, optimal diagnostic information requires that laboratory test results be interpreted in the appropriate clinical context... - Clinical and laboratory practices in investigation of suspected transfusion-transmitted bacterial infection: a survey of Canadian hospitalsA N Traore
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Vox Sang 96:157-9. 2009..If there is no residual product in the component bag, 36% of respondents would use a segment to perform testing. Guidelines could be helpful in improving and standardizing these practices... - Methods for the analysis of bleeding outcomes in randomized trials of PLT transfusion triggersR J Cook
Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada
Transfusion 44:1135-42. 2004..The analysis strategy should be selected based on the clinical question being addressed... - Universal leukoreduction and acute transfusion reactions: putting the puzzle togetherNancy M Heddle
Transfusion 44:1-4. 2004 - Intravenous (IV) anti-D and IV immunoglobulin achieve acute platelet increases by different mechanisms: modulation of cytokine and platelet responses to IV anti-D by FcgammaRIIa and FcgammaRIIIa polymorphismsNichola Cooper
Division of Hematology Oncology, Department of Pediatrics, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, NY 10021, USA
Br J Haematol 124:511-8. 2004.... - Clinical research design and reporting: always room for improvement!Nancy M Heddle
Transfusion 47:2-3. 2007 - Evidence-based clinical reporting: a need for improvementNancy M Heddle
Transfusion 42:1106-10. 2002