Research Topics
Species | Premysl BercikSummaryAffiliation: McMaster University Country: Canada Publications
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Detail Information
Publications
Lactobacillus paracasei normalizes muscle hypercontractility in a murine model of postinfective gut dysfunctionElena F Verdu
McMaster University, 1200 Main Street West, HSC 3N5C, Hamilton, Ontario, Canada
Gastroenterology 127:826-37. 2004..We tested whether probiotics influence persistent muscle hypercontractility in mice after recovery from infection with Trichinella spiralis and analyzed the underlying mechanisms...- The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in micePremysl Bercik
The Farncombe Family Digestive Health Institute, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
Gastroenterology 141:599-609, 609.e1-3. 2011..We examined whether the intestinal microbiota affects behavior and brain biochemistry in mice... - Immune-mediated neural dysfunction in a murine model of chronic Helicobacter pylori infectionPremysl Bercik
Intestinal Diseases Research Programme, McMaster University, Hamilton, Ontario, Canada
Gastroenterology 123:1205-15. 2002..Neuromuscular changes producing dysmotility and hyperalgesia may underlie symptom generation in functional gastrointestinal disorders. We investigated whether chronic Helicobacter pylori-induced gastritis causes neuromuscular dysfunction... - Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in micePremysl Bercik
Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Gastroenterology 139:2102-2112.e1. 2010..Clinical and preclinical studies have associated gastrointestinal inflammation and infection with altered behavior. We investigated whether chronic gut inflammation alters behavior and brain biochemistry and examined underlying mechanisms... - Microbial-gut interactions in health and disease. Irritable bowel syndromeElena F Verdu
Intestinal Research Programme, McMaster University, Hamilton, Ont, Canada
Best Pract Res Clin Gastroenterol 18:315-21. 2004..This chapter concentrates on the experimental evidence for a role of intestinal microbiota and the potential therapeutic value of probiotics in functional diseases such as irritable bowel syndrome... - Visceral hyperalgesia and intestinal dysmotility in a mouse model of postinfective gut dysfunctionPremysl Bercik
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Gastroenterology 127:179-87. 2004..The present study determined whether gut dysfunction in this model involves motor and sensory changes reminiscent of changes found in patients with postinfective irritable bowel syndrome (PI-IBS) and investigated underlying mechanisms... - Role of gut-brain axis in persistent abnormal feeding behavior in mice following eradication of Helicobacter pylori infectionPremysl Bercik
Intestinal Diseases Research Program, McMaster Univ, MUMC 4W8, Hamilton, Ontario L8N 3Z5
Am J Physiol Regul Integr Comp Physiol 296:R587-94. 2009..pylori eradication and is accompanied by increased TNF-alpha in the brain. The results support a role for altered gut-brain pathways in the maintenance of postinfective gut dysfunction... - Is irritable bowel syndrome a low-grade inflammatory bowel disease?Premysl Bercik
Intestinal Disease Research Program and Division of Gastroenterology, McMaster University, 1200 Main Street West, HSC 3N49C, Hamilton, Ontario L8N 3Z5, Canada
Gastroenterol Clin North Am 34:235-45, vi-vii. 2005..This article examines these relation-ships using immune activation and inflammation as a common pathogenic process to IBD and a subset of IBS patients... - The role of luminal factors in the recovery of gastric function and behavioral changes after chronic Helicobacter pylori infectionElena F Verdu
McMaster Univ HSC 3N49C, 1200 Main St West, Hamilton, Ontario, Canada
Am J Physiol Gastrointest Liver Physiol 295:G664-70. 2008..These changes do not seem to occur in association with modulation of intestinal permeability... - Antidepressants attenuate increased susceptibility to colitis in a murine model of depressionAshwin K Varghese
Intestinal Diseases Research Program, McMaster University, Hamilton, Ontario, Canada
Gastroenterology 130:1743-53. 2006..This vulnerability is reversed by antidepressant therapy. Depression increases vulnerability to intestinal inflammation. We speculate that pre-existing depression may facilitate the expression of inflammatory bowel diseases... - CD4+ T-cell modulation of visceral nociception in miceMonica Verma-Gandhu
Intestinal Disease Research Programme, McMaster University Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Gastroenterology 130:1721-8. 2006..We hypothesized that a component of the immune system exerts an antinociceptive influence, thus enabling the gut to function in the absence of undue pain or discomfort... - Visceral pain perception is determined by the duration of colitis and associated neuropeptide expression in the mouseMonica Verma-Gandhu
Intestinal Disease Research Programme, McMaster University, Health Sciences Bldg, Hamilton, ON, Canada
Gut 56:358-64. 2007..This suggests that the nature of the inflammatory infiltrate influences visceral perception... - Proton pump inhibitors exacerbate NSAID-induced small intestinal injury by inducing dysbiosisJohn L Wallace
Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada
Gastroenterology 141:1314-22, 1322.e1-5. 2011..However, suppression of gastric acid secretion by PPIs is unlikely to provide any protection against the damage caused by NSAIDs in the more distal small intestine... - Adenoviral transfer of the murine oncostatin M gene suppresses dextran-sodium sulfate-induced colitisAna L Sanchez
Intestinal Disease Research Programme, McMaster University, Hamilton, Ontario, Canada
J Interferon Cytokine Res 23:193-201. 2003..Thus, systemic administration of AdMuOSM given as a cotreatment and to a lesser extent as a therapy was found to be of benefit in DSS-induced colitis, a murine model of inflammatory bowel disease (IBD)... - Pathology of interstitial cells of Cajal in relation to inflammation revealed by ultrastructure but not immunohistochemistryXuan-Yu Wang
Intestinal Disease Research Program and Department ofMedicine, McMaster University, Hamilton, Ontario, Canada
Am J Pathol 160:1529-40. 2002..From day 23 onward, immune cells withdrew from the musculature except macrophages, resulting in a markedly increased population of macrophages in the AP area at day 60 after infection... - Lack of pyloric interstitial cells of Cajal explains distinct peristaltic motor patterns in stomach and small intestineXuan-Yu Wang
Intestinal Disease Research Program and Department of Medicine, McMaster Univ, HSC-3N5C, 1200 Main St. West, Hamilton, Ontario, Canada L8N 3Z5
Am J Physiol Gastrointest Liver Physiol 289:G539-49. 2005..Throughout this coordinated motor activity, the pacemaker systems in antrum and duodenum remain independent... - Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualismEmma Slack
Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON L8S 4L8, Canada
Science 325:617-20. 2009..Spontaneous hyper-activation of adaptive immunity against the intestinal microbiota, secondary to innate immune deficiency, may clarify the underlying mechanisms of inflammatory diseases where immune dysfunction is implicated... - Pathogenic factors involved in the development of irritable bowel syndrome: focus on a microbial roleCarolina M Bolino
Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
Infect Dis Clin North Am 24:961-75, ix. 2010.... - Effect of probiotics on gastrointestinal function: evidence from animal modelsElena F Verdu
Department of Medicine, McMaster University, Hamilton, Canada
Therap Adv Gastroenterol 2:31-5. 2009..This article focuses on lessons learned from animal models of gut dysfunction...