Research Topics
| L C LandsSummaryAffiliation: McGill University Country: Canada Publications
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Detail Information
Publications
Applying physiology to conventional mechanical ventilationLarry C Lands
Respiratory Medicine, Montreal Children s Hospital McGill University Health Centre
Paediatr Respir Rev 7:S33-6. 2006..This article reviews the physiological principles that underpin decision making about support for patients with respiratory difficulties, whether they are related to inadequate oxygenation or ventilation...- Nutrition in pediatric lung diseaseLarry C Lands
McGill University and Pediatric Respiratory Medicine, Montreal Children s Hospital McGill University Health Centre, Montreal, Canada
Paediatr Respir Rev 8:305-11; quiz 312. 2007..The challenge to both clinicians and investigators is to understand how defenses are integrated and coordinated so that enhanced protection can be delivered... - Asthma and chronic sickle cell lung disease: a dynamic relationshipN R Shilo
Division of Pediatric Respiratory Medicine, Montreal Children s Hospital McGill University Health Centre, Montreal, Quebec, Canada
Paediatr Respir Rev 12:78-82. 2011..This review will explore what we know about asthma and airway hyper-reactivity in sickle cell disease and whether currently available asthma therapies may be beneficial in delaying or averting the progression of sickle cell lung disease... - High-dose ibuprofen in cystic fibrosis: Canadian safety and effectiveness trialLarry C Lands
Department of Pediatrics, Montreal Children s Hospital McGill University Health Center, Montreal, Quebec, Canada
J Pediatr 151:249-54. 2007..To assess the effectiveness and safety of high-dose ibuprofen when used as part of routine therapy in patients with cystic fibrosis (CF)... - Dietary supplementation with pressurized whey in patients with cystic fibrosisL C Lands
Division of Pediatric Respiratory Medicine, Montreal Children s Hospital McGill University Health Centre, Montreal, Quebec, Canada
J Med Food 13:77-82. 2010..Whole blood glutathione levels did not change. Thus, oral supplementation with pressurized whey improves nutritional status and can have additional beneficial effects on inflammation in patients with CF... - Total plasma antioxidant capacity in cystic fibrosisL C Lands
Division of Respiratory Medicine, McGill University Medical Centre Montreal Children s Hospital, Montreal, Quebec, Canada
Pediatr Pulmonol 29:81-7. 2000..While being responsive to oxidative stress, the mechanism of the response may differ between clinical situations, such that the clinical significance of changes in plasma TEAC remains to be defined... - Effect of supplementation with a cysteine donor on muscular performanceL C Lands
Division of Respiratory Medicine, McGill University Health Centre Montreal Children s Hospital, Montreal, Quebec, Canada H3H 1P3
J Appl Physiol 87:1381-5. 1999..02), with no change in the placebo group (-0.9 +/- 9.6%). This is the first study to demonstrate that prolonged supplementation with a product designed to augment antioxidant defenses resulted in improved volitional performance... - Accounting for radioactivity before and after nebulization of tobramycin to insure accuracy of quantification of lung depositionA L Coates
Division of Respiratory Medicine, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
J Aerosol Med 13:169-78. 2000..This technique could be adapted to accurately quantify the amount of deposition on any inhaled therapeutic agent, but caution must be used when extrapolating performance of a nebulizer on the bench to expected deposition in patients... - Lymphocyte glutathione levels in children with cystic fibrosisL C Lands
Department of Pediatrics, McGill University Medical Centre Montreal Children s Hospital, Quebec, Canada
Chest 116:201-5. 1999..Evidence suggests that lymphocyte GSH reflects lung GSH concentrations, and so could potentially serve as a peripheral marker of lung inflammation... - Do sinusoidal models of respiration accurately reflect the respiratory events of patients breathing on nebulizers?A L Coates
Division of Respiratory Medicine, Hospital for Sick Children, University of Toronto, Ontario, Canada
J Aerosol Med 12:265-73. 1999..These results suggest that there are both systematic and random errors arising from the use of a sinusoidal waveform to mimic respiratory events in patients... - Effect of whey protein to modulate immune response in children with atopic asthmaJames B Lothian
The Department of Respiratory Medicine, McGill University Medical Centre, Montreal Children's Hospital, Montreal, Quebec, Canada
Int J Food Sci Nutr 57:204-11. 2006..Supplementation for longer periods, or with more potent whey-based supplements, currently under development, may prove more beneficial... - Effect of size and disease on estimated deposition of drugs administered using jet nebulization in children with cystic fibrosisA L Coates
Division of Respiratory Medicine, Hospital for Sick Children, University of Toronto, Toronto, Canada
Chest 119:1123-30. 2001.... - Evaluation of a school-based tuberculosis-screening program and associate investigation targeting recently immigrated children in a low-burden countryPaul Brassard
Department of Medicine, McGill University, Montreal, Quebec, Canada
Pediatrics 117:e148-56. 2006.... - An open-label dose-response study of lymphocyte glutathione levels in healthy men and women receiving pressurized whey protein isolate supplementsGerald S Zavorsky
Department of Anesthesia, McGill University Health Center, Montreal, Quebec, Canada
Int J Food Sci Nutr 58:429-36. 2007.... - Efficacy of high dose phylloquinone in correcting vitamin K deficiency in cystic fibrosisDonna Drury
Montreal Children s Hospital, McGill University Health Center, 2300 Tupper Avenue, Montreal, Canada H3H 1P3
J Cyst Fibros 7:457-9. 2008..The aim of this study is determine if a supplemental dose of 1 mg/day or 5 mg/day vitamin K1 per day would normalize vitamin K status in a population of children with cystic fibrosis... - Comparison of fingertip to arterial blood samples at rest and during exerciseGerald S Zavorsky
Department of Anesthesia, McGill University Health Center, Montreal, Quebec, Canada
Clin J Sport Med 15:263-70. 2005..The purpose was to determine whether arterialized fingertip blood-gas samples are comparable to arterial samples at rest and at exercise... - Lung diffusion capacity for nitric oxide and carbon monoxide is impaired similarly following short-term graded exerciseGerald S Zavorsky
Department of Anesthesia, McGill University Health Center, 1650 Cedar Avenue, Room D10 144, Montreal, Que, Canada H3G 1A4
Nitric Oxide 12:31-8. 2005.... - The relationship between single-breath diffusion capacity of the lung for nitric oxide and carbon monoxide during various exercise intensitiesGerald S Zavorsky
Department of Exercise Science, Concordia University, Montreal, QC, Canada
Chest 125:1019-27. 2004.... - Cardiorespiratory status after treatment for acute lymphoblastic leukemiaS O Turner-Gomes
Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
Med Pediatr Oncol 26:160-5. 1996..Longitudinal studies will identify if further abnormalities or overt morbidity develop. In later years, continuing obesity and a sedentary state may contribute to clinically relevant heart disease... - Sex differences in habitual physical activity and lung function decline in children with cystic fibrosisJ Schneiderman-Walker
Division of Respiratory Medicine, Hospital for Sick Children, Research Institute, Toronto, Ontario, Canada
J Pediatr 147:321-6. 2005..This research suggests that an inactive lifestyle may partially explain the poorer survival of female patients with CF. The HAES is a feasible tool for routine follow-up of HPA in our CF clinic... - Laboratory 20-km cycle time trial reproducibilityG S Zavorsky
Department of Anesthesia, McGill University, Montreal, Canada
Int J Sports Med 28:743-8. 2007..This study demonstrated that (1) a familiarization session improves the reliability of the measurements (i.e., average PO, time to completion and speed), and (2) the CV was much smaller for the best performers... - Combined effect of dietary supplementation with pressurized whey and exercise training in chronic obstructive pulmonary disease: a randomized, controlled, double-blind pilot studyLouis Laviolette
Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, Canada
J Med Food 13:589-98. 2010..Thus dietary supplementation with pressurized whey may potentiate the effects of exercise training on exercise tolerance and quality of life in patients with COPD... - Ibuprofen modulates NF-kB activity but not IL-8 production in cystic fibrosis respiratory epithelial cellsNurlan Dauletbaev
Research Institute, McGill University Health Centre, Montreal Children s Hospital, Montreal, Que, Canada
Respiration 79:234-42. 2010..High-dose ibuprofen is clinically effective in cystic fibrosis (CF); however, its molecular mechanisms are poorly understood... - Oxidative stress and cystic fibrosis-related diabetes: a pilot study in childrenThierry Ntimbane
Department of Nutrition, University of Montreal, Montreal, Canada
J Cyst Fibros 7:373-84. 2008..Cystic fibrosis (CF) is characterized by chronic inflammation with increased oxidative stress. We evaluated the relationship between glucose tolerance and oxidative stress in CF children... - Sweat collection for testing in Canadian Cystic Fibrosis Centers, is it optimal?M Beauchamp
Montreal Children's Hospital-McGill University Medical Centre, 2300 Tupper St, Room D-380, Montreal, QC, Canada, H3H 1P3
Clin Biochem 38:934-7. 2005..This will decrease the need for repeat testing and delay in diagnosis... - Voriconazole inhibition of vitamin A metabolism: are adverse events increased in cystic fibrosis patients?Matthew Pellan Cheng
Department of Pediatrics, The Montreal Children s Hospital, McGill University, Montreal, Canada
Pediatr Pulmonol 45:661-6. 2010..As Voriconazole is being used more frequently in cystic fibrosis (CF) patients, we aimed to describe the adverse events associated with voriconazole treatment in this population... - Reliability and validity of the habitual activity estimation scale (HAES) in patients with cystic fibrosisGreg D Wells
Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada
Pediatr Pulmonol 43:345-53. 2008..The Habitual Activity Estimation Scale (HAES) questionnaire has been shown to be a feasible tool to measure physical activity however the reliability and validity have yet to be determined in the CF population... - High hydrostatic pressure enhances whey protein digestibility to generate whey peptides that improve glutathione status in CFTR-deficient lung epithelial cellsRegina Maria Vilela
School of Dietetics and Human Nutrition, Macdonald Campus of McGill University, Ste. Anne de Bellevue, Quebec, Canada
Mol Nutr Food Res 50:1013-29. 2006..Hydrostatic pressure processing of whey proteins appears to enhance their impact on cellular GSH status in cells with the mutant CFTR condition... - Isokinetic muscle function in COPDCharles Haccoun
Montreal Children's Hospital-McGill University Health Centre, Montreal, PQ, Canada
Chest 121:1079-84. 2002..CONCLUSIONS: Both ventilatory function and leg muscle function contribute to exercise limitation, and a 20-s isokinetic test can be utilized to assess leg function in patients with COPD... - Sweat-testing: a review of current technical requirementsM Beauchamp
Montreal Children's Hospital, McGill University Medical Centre, Montreal, Quebec, Canada
Pediatr Pulmonol 39:507-11. 2005..However, it is technically challenging, especially in young children. This review covers technical aspects related to the devices and protocols associated with conducting successful tests... - Induced sputum in cystic fibrosis: within-week reproducibility of inflammatory markersArgyrios A Smountas
Department of Respiratory Medicine, McGill University Medical Centre, Montreal Children's Hospital, Montreal, 2300 Tupper Street, Montreal, Quebec, Canada H3H 1P3
Clin Biochem 37:1031-6. 2004..76, 0.82, 0.93, 0.82, 0.74, respectively). CONCLUSIONS: The method developed here for the analysis of CF sputum shows good reproducibility and can be used to evaluate therapeutic interventions in patients with cystic fibrosis... - Improved glutathione status in young adult patients with cystic fibrosis supplemented with whey proteinVijaylaxmi Grey
The Department of Pathology and Molecular Medicine, McMaster Division, Hamilton Health Sciences, Hamilton, Ontario, Canada
J Cyst Fibros 2:195-8. 2003..This nutritional approach may be useful in maintaining optimal levels of GSH and counteract the deleterious effects of oxidative stress in the lung in cystic fibrosis... - Inhibition of IL-8 release from CFTR-deficient lung epithelial cells following pre-treatment with fenretinideRegina Maria Vilela
School of Dietetics and Human Nutrition, Macdonald Campus of McGill University, 21, 111 Lakeshore, Ste. Anne de Bellevue, Quebec, Canada H9X 3V9
Int Immunopharmacol 6:1651-64. 2006..The fenretinide mediated decrease in IL-8 release in CF cells under TNF-alpha stimulated conditions presents the possibility that the lung inflammation in CF could be attenuated via low dose fenretinide treatment... - Role of heme oxygenases in sepsis-induced diaphragmatic contractile dysfunction and oxidative stressEsther Barreiro
Department of Respiratory Medicine, Hospital del Mar Municipal Institute of Medical Research, Pompeu Fabra University, 08003 Barcelona, Spain
Am J Physiol Lung Cell Mol Physiol 283:L476-84. 2002..We conclude that both HO-1 and HO-2 proteins play an important role in the regulation of muscle contractility and in the defense against sepsis-induced oxidative stress... - Fenretinide corrects newly found ceramide deficiency in cystic fibrosisClaudine Guilbault
McGill University Health Center, Montreal General Hospital Research Institute, 1650 Cedar Avenue, Room L11 218, Montreal, PQ, H3G 1A4 Canada
Am J Respir Cell Mol Biol 38:47-56. 2008..Our data provide a strong rationale for clinical intervention that may benefit patients with CF suffering from CF lung disease...