D R Kaplan

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. ncbi Signal transduction by the neurotrophin receptors
    D R Kaplan
    Brain Tumor Research Centre, Montreal Neurological Institute, 3801 University Street, Montreal, PQ, Canada, H3A 2B4
    Curr Opin Cell Biol 9:213-21. 1997
  2. ncbi Neurotrophin signal transduction in the nervous system
    D R Kaplan
    Brain Tumor Research Center, Montreal Neurological Institute, Montreal, H3A 2B4, Canada
    Curr Opin Neurobiol 10:381-91. 2000
  3. ncbi Neurotrophin signalling pathways regulating neuronal apoptosis
    F D Miller
    Center for Neuronal Survival, Montreal Neurological Institute, PQ, Canada
    Cell Mol Life Sci 58:1045-53. 2001
  4. ncbi On Trk for retrograde signaling
    F D Miller
    Center for Neuronal Survival and Brain Tumor Research Center, Montreal Neurological Institute, McGill University, 3801 rue University, H3A 2B4, Montreal, Quebec, Canada
    Neuron 32:767-70. 2001
  5. ncbi Isolation of multipotent adult stem cells from the dermis of mammalian skin
    J G Toma
    Center for Neuronal Survival, Montreal Neurological Institute, McGill University, 3801 rue University, Montreal, Quebec, Canada H3A 2B4
    Nat Cell Biol 3:778-84. 2001
  6. ncbi An anti-apoptotic role for the p53 family member, p73, during developmental neuron death
    C D Pozniak
    Center for Neuronal Survival, Brain Tumor Research Center, Montreal Neurological Institute, McGill University, Montreal, Canada H3A 2B4
    Science 289:304-6. 2000
  7. ncbi Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate
    T F Franke
    ABL Basic Research Program, National Cancer Institute Frederick Cancer Research Facility and Development Center NCI FCRFDC, Frederick, MD 21702, USA
    Science 275:665-8. 1997
  8. ncbi Autophosphorylation of activation loop tyrosines regulates signaling by the TRK nerve growth factor receptor
    M E Cunningham
    Department of Pathology and Center of Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 272:10957-67. 1997
  9. ncbi The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
    T F Franke
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cell 81:727-36. 1995
  10. ncbi A Trk nerve growth factor (NGF) receptor point mutation affecting interaction with phospholipase C-gamma 1 abolishes NGF-promoted peripherin induction but not neurite outgrowth
    D M Loeb
    Department of Pathology, Columbia University College of Physicians and Surgeons, New York, New York 10032
    J Biol Chem 269:8901-10. 1994

Collaborators

  • F D Miller
  • F McKeon
  • T F Franke
  • Lloyd Greene
  • M V Chao
  • Takao Kubo
  • P N Tsichlis
  • L C Cantley
  • J Taniguchi
  • R M Stephens
  • J G Toma
  • D Esposito
  • C D Pozniak
  • T Yamashita
  • M Endo
  • M Fujitani
  • M E Cunningham
  • B L Hempstead
  • D M Loeb
  • P Perez
  • P Patel
  • K J Fernandes
  • M Akhavan
  • A Sadikot
  • S Radinovic
  • K Datta
  • A Yang
  • B R Pflug
  • D K Morrison
  • T D Copeland
  • E A Golemis
  • D Djakiew
  • S I Yang
  • C Dionne
  • A Makris
  • T O Chan
  • J Lynch
  • T Copeland
  • T Pawson
  • U R Rapp
  • D Soppet
  • K Nikolics
  • G Sithanandam
  • L F Parada
  • L R Berkemeier
  • B R Stanton
  • T Hunter
  • T M Roberts
  • D Martin-Zanca
  • A Rosenthal
  • D S Middlemas
  • S W Reid
  • D V Goeddel
  • J W Winslow
  • J Blair
  • J Maragos
  • L T Williams
  • E Escandon
  • J A Escobedo
  • L E Burton

Detail Information

Publications21

  1. ncbi Signal transduction by the neurotrophin receptors
    D R Kaplan
    Brain Tumor Research Centre, Montreal Neurological Institute, 3801 University Street, Montreal, PQ, Canada, H3A 2B4
    Curr Opin Cell Biol 9:213-21. 1997
    ..These differing responses point to a complex interplay between neurotrophin-stimulated survival, differentiation, and apoptosis pathways...
  2. ncbi Neurotrophin signal transduction in the nervous system
    D R Kaplan
    Brain Tumor Research Center, Montreal Neurological Institute, Montreal, H3A 2B4, Canada
    Curr Opin Neurobiol 10:381-91. 2000
    ..In addition, a number of novel p75NTR-interacting proteins have been identified that transmit growth, survival, and apoptotic signals...
  3. ncbi Neurotrophin signalling pathways regulating neuronal apoptosis
    F D Miller
    Center for Neuronal Survival, Montreal Neurological Institute, PQ, Canada
    Cell Mol Life Sci 58:1045-53. 2001
    ..In this review, we focus on the proapoptotic actions of the p75 neurotrophin receptor (p75NTR), and on the interplay between Trk and p75NTR that determines neuronal survival...
  4. ncbi On Trk for retrograde signaling
    F D Miller
    Center for Neuronal Survival and Brain Tumor Research Center, Montreal Neurological Institute, McGill University, 3801 rue University, H3A 2B4, Montreal, Quebec, Canada
    Neuron 32:767-70. 2001
    ....
  5. ncbi Isolation of multipotent adult stem cells from the dermis of mammalian skin
    J G Toma
    Center for Neuronal Survival, Montreal Neurological Institute, McGill University, 3801 rue University, Montreal, Quebec, Canada H3A 2B4
    Nat Cell Biol 3:778-84. 2001
    ....
  6. ncbi An anti-apoptotic role for the p53 family member, p73, during developmental neuron death
    C D Pozniak
    Center for Neuronal Survival, Brain Tumor Research Center, Montreal Neurological Institute, McGill University, Montreal, Canada H3A 2B4
    Science 289:304-6. 2000
    ..Thus, truncated p73 is an essential anti-apoptotic protein in neurons, serving to counteract the pro-apoptotic function of p53...
  7. ncbi Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate
    T F Franke
    ABL Basic Research Program, National Cancer Institute Frederick Cancer Research Facility and Development Center NCI FCRFDC, Frederick, MD 21702, USA
    Science 275:665-8. 1997
    ..Thus, Akt is apparently regulated by the direct interaction of PtdIns-3,4-P2 with the Akt PH domain...
  8. ncbi Autophosphorylation of activation loop tyrosines regulates signaling by the TRK nerve growth factor receptor
    M E Cunningham
    Department of Pathology and Center of Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 272:10957-67. 1997
    ....
  9. ncbi The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
    T F Franke
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cell 81:727-36. 1995
    ..These results identify Akt as a novel target of PI 3-kinase and suggest that the Akt PH domain may be a mediator of PI 3-kinase signaling...
  10. ncbi A Trk nerve growth factor (NGF) receptor point mutation affecting interaction with phospholipase C-gamma 1 abolishes NGF-promoted peripherin induction but not neurite outgrowth
    D M Loeb
    Department of Pathology, Columbia University College of Physicians and Surgeons, New York, New York 10032
    J Biol Chem 269:8901-10. 1994
    ..This supports the presence of multiple and separable signaling pathways in the NGF mechanism of action...
  11. ncbi High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor
    B L Hempstead
    Department of Medicine, Cornell University Medical College, New York, New York 10021
    Nature 350:678-83. 1991
    ..These studies reveal a new growth factor receptor-mediated mechanism of cellular differentiation involving trk and the low-affinity NGF receptor...
  12. ncbi The cytoplasmic and transmembrane domains of the p75 and Trk A receptors regulate high affinity binding to nerve growth factor
    D Esposito
    Division of Hematology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Biol Chem 276:32687-95. 2001
    ..These results indicate that the transmembrane and cytoplasmic domains of Trk A and p75 are responsible for high affinity site formation and suggest that p75 alters the conformation of Trk A to generate high affinity NGF binding...
  13. ncbi 95-kilodalton B-Raf serine/threonine kinase: identification of the protein and its major autophosphorylation site
    R M Stephens
    Molecular Mechanisms of Carcinogenesis Laboratory, National Cancer Institute Frederick Cancer Research and Development Center, Maryland
    Mol Cell Biol 12:3733-42. 1992
    ..A threonine residue is present at similar positions in all three mammalian Raf family members and may represent a regulatory site for these proteins...
  14. ncbi Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses
    R M Stephens
    ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Maryland 21702
    Neuron 12:691-705. 1994
    ..These results suggest a model whereby Trk receptors utilize at least partially redundant signal transduction pathways to mediate NGF responses...
  15. ncbi AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation
    K Datta
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111
    Mol Cell Biol 15:2304-10. 1995
    ..Addition of maltose-binding protein-AH/PH fusion recombinant protein, which is expected to bind Akt, to the immunoprecipitates from serum-starved cells induced the activation of the Akt kinase...
  16. ncbi Expression of a Trk high affinity nerve growth factor receptor in the human prostate
    B R Pflug
    Department of Cell Biology, Georgetown University Medical Center, Washington, D C 20007
    Endocrinology 136:262-8. 1995
    ....
  17. ncbi Direct activation of the serine/threonine kinase activity of Raf-1 through tyrosine phosphorylation by the PDGF beta-receptor
    D K Morrison
    Department of Medicine, Howard Hughes Medical Institute, University of California, San Francisco 94143
    Cell 58:649-57. 1989
    ..This is the first demonstration of the direct modulation of a protein activity by a growth factor receptor tyrosine kinase...
  18. ncbi Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB
    L R Berkemeier
    Department of Molecular Biology, Genentech, Inc, South San Francisco, California 94080
    Neuron 7:857-66. 1991
    ..Receptor sharing could enable neurotrophic factors emanating from distinct targets to cooperate in regulating neurons with multiple connections...
  19. ncbi Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF
    D R Kaplan
    Eukaryotic Signal Transduction Group, NCI Frederick Cancer Research and Development Center, Maryland 21701
    Nature 350:158-60. 1991
    ..Activation of the trk tyrosine kinase receptor provides a possible mechanism for signal transduction by NGF...
  20. ncbi The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor
    D Soppet
    Molecular Embryology Section, NCI Frederick Cancer Research and Development Center, Maryland 21702
    Cell 65:895-903. 1991
    ..Thus, the trk family of receptors are likely to be important signal transducers of NGF-related trophic signals in the formation and maintenance of neuronal circuits...
  21. ncbi Rap1 is involved in the signal transduction of myelin-associated glycoprotein
    J Taniguchi
    Department of Neurobiology, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba, Japan
    Cell Death Differ 15:408-19. 2008
    ..Rap1 activity is required for survival of the DRG neurons as well as CGNs when treated with MAG. The transport of the signaling complex containing the p75 receptor and Rap1 may play a role in the effect of MAG...