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Genomes and Genes | A C GingrasSummaryAffiliation: McGill University Country: Canada Publications
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Publications
eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translationA C Gingras
Department of Biochemistry McGill University, Montreal, Quebec, Canada
Annu Rev Biochem 68:913-63. 1999..The recent determination of the structure of eIF4E at atomic resolution has provided insight about how translation is initiated and regulated. Evidence suggests that eIF4F is also implicated in malignancy and apoptosis...- Hierarchical phosphorylation of the translation inhibitor 4E-BP1A C Gingras
Department of Biochemistry and McGill Cancer Centre, McGill University, Montreal, Quebec H3G 1Y6, Canada
Genes Dev 15:2852-64. 2001..Finally, we show that phosphorylation of Ser 65 and Thr 70 alone is insufficient to block binding to eIF4E, indicating that a combination of phosphorylation events is necessary to dissociate 4E-BP1 from eIF4E... - Activation of the translational suppressor 4E-BP1 following infection with encephalomyocarditis virus and poliovirusA C Gingras
Department of Biochemistry and McGill Cancer Centre, McGill University, Montreal, Canada
Proc Natl Acad Sci U S A 93:5578-83. 1996..Dephosphorylation of 4E-BP1 by specifically inhibiting cap-dependent translation may be the major cause of the shutoff phenomenon in EMCV-infected cells... - Regulation of 4E-BP1 phosphorylation: a novel two-step mechanismA C Gingras
Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, H3G 1Y6, Canada
Genes Dev 13:1422-37. 1999..Taken together, our results suggest that 4E-BP1 phosphorylation by FRAP/mTOR on Thr-37 and Thr-46 is a priming event for subsequent phosphorylation of the carboxy-terminal serum-sensitive sites... - Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1K Tsukiyama-Kohara
Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, Canada
Nat Med 7:1128-32. 2001..These findings demonstrate that 4E-BP1 is a novel regulator of adipogenesis and metabolism in mammals... - Tissue distribution, genomic structure, and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2K Tsukiyama-Kohara
Department of Biochemistry, McGill University, Montreal, Quebec, H3G 1Y6, Canada
Genomics 38:353-63. 1996..Mouse 4E-BP1 and 4E-BP2 map to chromosomes 8 (A4-B1) and 10 (B4-B5), respectively, and human 4E-BP1 and 4E-BP2 localize to chromosomes 8p12 and 10q21-q22, respectively... - 4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein familyF Poulin
Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec H3G 1Y6, Canada
J Biol Chem 273:14002-7. 1998..The overlapping function and expression of the different 4E-BP family members imply that there is redundancy in this translational control mechanism, underscoring its importance... - Adenovirus infection inactivates the translational inhibitors 4E-BP1 and 4E-BP2A C Gingras
Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, H3G 1Y6, Canada
Virology 237:182-6. 1997..Findings similar to those described here were reported for 4E-BP1 by D. Feigenblum and R. J. Schneider (1996, Mol. Cell. Biol. 16, 5450-5457)... - Cloning and characterization of 4EHP, a novel mammalian eIF4E-related cap-binding proteinE Rom
Department of Biochemistry, McGill University, Montreal, Quebec, Canada H3G1Y6
J Biol Chem 273:13104-9. 1998..A putative function for 4EHP is discussed... - Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4ES Pyronnet
Department of Biochemistry and McGill Cancer Cancer Center, McGill University, 3655 Drummond Street, Montreal, Quebec, H3G 1Y6 Canada
EMBO J 18:270-9. 1999..We also show that Mnk1 interacts with the C-terminal region of the translational inhibitor p97, an eIF4G-related protein that does not bind eIF4E, raising the possibility that p97 can block phosphorylation of eIF4E by sequestering Mnk1... - Phosphorylation of eIF-4E on serine 209 by protein kinase C is inhibited by the translational repressors, 4E-binding proteinsS G Whalen
Department of Biochemistry and McGill Cancer Centre, McGill University, Montreal, Quebec, Canada
J Biol Chem 271:11831-7. 1996..This suggests a two-step model for the phosphorylation (and activation) of eIF4E by growth factors and hormones: first, dissociation of eIF4E from 4E-BPs, followed by eIF4E phosphorylation... - The eIF4E-binding proteins 1 and 2 are negative regulators of cell growthD Rousseau
Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, Canada
Oncogene 13:2415-20. 1996..Thus, we demonstrate that the eIF4E-binding proteins act as negative regulators of cell growth. We propose that 4E-BPs are members of a class of negative regulators of cell growth acting on the translation machinery of the cell... - The mRNA 5' cap-binding protein eIF4E and control of cell growthN Sonenberg
Department of Biochemistry, McGill University, Montreal, Quebec, Canada
Curr Opin Cell Biol 10:268-75. 1998..A major unresolved question is how the changes in translation modulate cell growth rate, and a working model will be discussed... - Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap functionA Pause
Department of Biochemistry, McGill University, Montreal, Quebec, Canada
Nature 371:762-7. 1994..The action of this new regulator of protein synthesis is therefore modulated by insulin, which acts to stimulate the overall rate of translation and promote cell growth... - Regulation of the rapamycin and FKBP-target 1/mammalian target of rapamycin and cap-dependent initiation of translation by the c-Abl protein-tyrosine kinaseV Kumar
Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 275:10779-87. 2000..These findings with the c-Abl tyrosine kinase represent the first demonstration of a negative physiologic regulator of RAFT1-mediated 5' cap-dependent translation... - Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4GJ Marcotrigiano
Laboratories of Molecular Biophysics, Rockefeller University, New York, New York 10021, USA
Mol Cell 3:707-16. 1999..The implications of our results for translation initiation are discussed in detail, and a molecular mechanism for relief of translation inhibition following phosphorylation of the 4E-BPs is proposed... - Insulin regulation of protein translation repressor 4E-BP1, an eIF4E-binding protein, in renal epithelial cellsB K Bhandari
Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78299-3900, USA
Kidney Int 59:866-75. 2001..The requirement for Erk-1/-2 MAP kinase activation for 4E-BP1 phosphorylation by insulin suggests a cross-talk between PI 3-kinase and Erk-1/-2-type MAP kinase pathways... - Regulation of translation initiation by FRAP/mTORA C Gingras
Department of Biochemistry, McGill University, , , Canada
Genes Dev 15:807-26. 2001 - Differential regulation of translation and eIF4E phosphorylation during human thymocyte maturationL Beretta
INSERM U 365, Institut Curie, Paris, France
J Immunol 160:3269-73. 1998..These data provide evidence for differential regulation of the translational machinery during T cell development... - Requirement for Akt (protein kinase B) in insulin-induced activation of glycogen synthase and phosphorylation of 4E-BP1 (PHAS-1)M Takata
Second Department of Internal Medicine, Kobe University School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
J Biol Chem 274:20611-8. 1999..These data suggest that Akt, but not PKClambda, is required for insulin activation of glycogen synthase and for insulin-induced phosphorylation of 4E-BP1... - The target of rapamycin (TOR) proteinsB Raught
Department of Biochemistry and McGill Cancer Centre, McGill University, 3655 Promenade Sir-William-Osler, , QC H3G 1Y6 Canada
Proc Natl Acad Sci U S A 98:7037-44. 2001..Intriguingly, recent studies have also suggested that TOR signaling plays a critical role in brain development, learning, and memory formation... - mTOR signaling to translationA C Gingras
Department of Biochemistry, McGill Cancer Centre, McGill University, 3655 Promenade Sir-William-Osler, , , H3G 1Y6, Canada
Curr Top Microbiol Immunol 279:169-97. 2004..We then describe how the TOR pathway can modulate translation in yeast and in mammals, through the modulation of the phosphorylation of key translation components, and the regulation of the abundance of ribosomes and translation factors...