Research Topics
| J AntoniouSummaryAffiliation: McGill University Country: Canada Publications
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Detail Information
Publications
Effect of nitrogen-rich cell culture surfaces on type X collagen expression by bovine growth plate chondrocytesAlain Petit
Lady Davis Institute for Medical Research, SMBD Jewish General Hospital, Montreal, QC, Canada
Biomed Eng Online 10:4. 2011..of n...- The effect of novel nitrogen-rich plasma polymer coatings on the phenotypic profile of notochordal cellsFackson Mwale
Division of Orthopaedic Surgery, McGill University, and Lady Davis Institute for Medical Research, 3755, Chemin de la Cote Ste Catherine, Montreal, QC H3T 1E2, Canada
Biomed Eng Online 6:33. 2007..Furthermore, little is known about the influence of the substratum on the molecular markers of notochordal cells... - The efficacy of Link N as a mediator of repair in a rabbit model of intervertebral disc degenerationFackson Mwale
Division of Orthopaedic Surgery, McGill University, 1650 Cedar Avenue, Montreal, QC, Canada, H3G 1A4
Arthritis Res Ther 13:R120. 2011..The purpose of the present study was to evaluate the effect of Link N in vivo in a rabbit model of IVD degeneration... - Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte hypertElena V Tchetina
Shriners Hospitals for Children, Department of Surgery, McGill University, 1529 Cedar Avenue, Montreal, Quebec H3G 1A6, Canada
Arthritis Res Ther 9:R75. 2007..Together these initial observations reveal the importance of very low concentrations of PGE2 in maintaining a more normal chondrocyte phenotype... - Quantitative magnetic resonance imaging of enzymatically induced degradation of the nucleus pulposus of intervertebral discsJohn Antoniou
Lady Davis Institute and Department of Surgery, McGill University, Montreal, Quebec, Canada
Spine (Phila Pa 1976) 31:1547-54. 2006..The structural integrity of the nucleus pulposus (NP) of intervertebral discs was targeted by enzyme-specific degradations to correlate their effects to the magnetic resonance (MR) signal... - Apparent diffusion coefficient of intervertebral discs related to matrix composition and integrityJohn Antoniou
Lady Davis Institute for Medical Research, SMBD Jewish General Hospital, Division of Orthopedic Surgery, McGill University, Montreal, Quebec H3T 1E2, Canada
Magn Reson Imaging 22:963-72. 2004.... - Metal ion levels in the blood of patients after hip resurfacing: a comparison between twenty-eight and thirty-six-millimeter-head metal-on-metal prosthesesJohn Antoniou
Lady Davis Institute for Medical Research, SMBD Jewish General Hospital, 3755, Chemin de la Cote Ste Catherine, Montreal, QC H3T 1E2, Canada
J Bone Joint Surg Am 90:142-8. 2008..Thus, understanding the biological fate of metal ions, and consequently their long-term systemic effects, is of great interest to patients and surgeons alike... - Elevated synthetic activity in the convex side of scoliotic intervertebral discs and endplates compared with normal tissuesJ Antoniou
Orthopaedic Research Laboratory, Royal Victoria Hospital and Division of Orthopaedic Surgery, McGill University, Montreal, Quebec, Canada
Spine (Phila Pa 1976) 26:E198-206. 2001..We measured concentrations of specific molecules reflecting matrix synthesis and degradation in normal and scoliotic intervertebral discs and endplates... - Capsulolabral augmentation for the the management of posteroinferior instability of the shoulderJ Antoniou
Department of Orthopaedics, University of Washington, Seattle, USA
J Bone Joint Surg Am 82:1220-30. 2000.... - Collagen crosslinked N-telopeptides as markers for evaluating particulate osteolysis: a preliminary studyJ Antoniou
Division of Orthopaedics, Royal Victoria Hospital, Montreal, Quebec, Canada
J Orthop Res 18:64-7. 2000..These insights have potential value in the understanding and clinical management of aseptic loosening... - The human lumbar endplate. Evidence of changes in biosynthesis and denaturation of the extracellular matrix with growth, maturation, aging, and degenerationJ Antoniou
Orthopaedic Research Laboratory, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada
Spine (Phila Pa 1976) 21:1153-61. 1996..Phase III (degenerative) is illustrated by an increase in Type II collagen denaturation and Type I procollagen synthesis, both related to grade of tissue degeneration... - Amifostine and dexrazoxane enhance the rapid loss of bone mass and further deterioration of vertebrae architecture in female ratsF Mwale
Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, 3755 Chemin de la Cote St Catherine, Montreal, QC H3T 1E2, Canada
Calcif Tissue Int 77:175-9. 2005..This information will be useful in designing better cancer combination therapies that do not lead to bone deterioration... - The involvement of aggrecan polymorphism in degeneration of human intervertebral disc and articular cartilageP Roughley
Shriners Hospital for Children, Department of Surgery, McGill University, Montreal, Quebec, Canada
Eur Cell Mater 11:1-7; discussion 7. 2006.... - Distinction between the extracellular matrix of the nucleus pulposus and hyaline cartilage: a requisite for tissue engineering of intervertebral discF Mwale
Lady Davis Institute for Medical Research and Department of Surgery, SMBD Jewish General Hospital, Montreal, QC, Canada
Eur Cell Mater 8:58-63; discussion 63-4. 2004.... - The role of proteoglycans in aging, degeneration and repair of the intervertebral discP J Roughley
Genetics Unit, Shriners Hospital for Children, 1529 Cedar Avenue, Montreal, Quebec, H3G 1A6, Canada
Biochem Soc Trans 30:869-74. 2002..Such cells can be supported in a biomolecular scaffold, but it is essential that the scaffold is compatible with high aggrecan retention if a functional tissue is to be attained... - [Chemonucleolysis. Its effectiveness in the treatment of lumbar diskopathies caused by compressive or rotational injuries]A Hadjipavlou
Jewish General Hospital, Montreal, Quebec, Canada
Int Orthop 17:148-53. 1993..The result was excellent or very good in 60% of patients, while in 40% the procedure failed. The rate of success at the L.5/S.1 level was 70%, at the L.4/5 level it was 63% and 37% were successful when multiple levels were treated... - Endoglin differentially regulates TGF-?-induced Smad2/3 and Smad1/5 signalling and its expression correlates with extracellular matrix production and cellular differentiation state in human chondrocytesK W Finnson
Division of Plastic Surgery, Department of Surgery, McGill University, Montreal, Quebec, Canada
Osteoarthritis Cartilage 18:1518-27. 2010..Our objective was to determine whether endoglin regulates TGF-?/Smad signalling and extracellular matrix (ECM) production in human chondrocytes and whether its expression varies with chondrocyte differentiation state... - A new technique for measuring lumbar segmental motion in vivo. Method, accuracy, and preliminary resultsT Steffen
Orthopaedic Research Laboratory, McGill University, Montreal, Canada
Spine (Phila Pa 1976) 22:156-66. 1997..Repetitive ranging experiments are highly reproducible. The range of motion for axial rotation seems overestimated in previous cadaveric studies. Coupling patterns show large variations between individuals... - Posterior instabilityJ Antoniou
Department of Orthopaedic Surgery, McGill University, Jewish General Hospital, Montreal, Quebec, Canada
Orthop Clin North Am 32:463-73, ix. 2001..This technique is effective in treating posteroinferior instability... - Concussions among university football and soccer players: a pilot studyJ S Delaney
McGill Sport Medicine Clinic, Department of Emergency Medicine, McGill University Health Center, McGill University, Montreal, Quebec, Canada
Clin J Sport Med 11:234-40. 2001..A pilot study to examine the incidence and characteristics of concussions for one season of university football and soccer... - A biological approach to treating disc degeneration: not for today, but maybe for tomorrowM Alini
Orthopaedic Research Laboratory, Division of Orthopaedic Surgery, McGill University, Montreal, Canada
Eur Spine J 11:S215-20. 2002.... - Effect of a Type II Collagen Fragment on the Expression of Genes of the Extracellular Matrix in Cells of the Intervertebral DiscF Mwale
Division of Orthopaedic Surgery, McGill University, Lady Davis Institute for Medical Research, SMBD Jewish General Hospital, 3755, Chemin de la Cote Ste Catherine, Montreal, QC H3T 1E2, Canada
Open Orthop J 2:1-9. 2008.... - Effect of dexrazoxane and amifostine on the vertebral bone quality of Doxorubicin treated male ratsF Mwale
Lady Davis Institute for Medical Research, SMBD Jewish General Hospital
Open Orthop J 2:115-20. 2008..04). The trabecular number (Tb.N) decreased with DXR and DOX+DXR and increased with DOX+AMF treatments. This information will be useful in designing better cancer combination therapies that do not lead to vertebrae deterioration... - Gender-dependent reductions in vertebrae length, bone mineral density and content by doxorubicin are not reduced by dexrazoxane in young rats: effect on growth plate and intervertebral discsF Mwale
Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, 3755 Chemin Cote Ste Catherine, Montreal, Quebec, Canada H3T 1E2
Calcif Tissue Int 76:214-21. 2005..DOX-treated rats also exhibited growth plate and intervertebral disc defects. This information will be useful in the design of interventions to promote bone growth or retard bone loss during DOX treatment... - Deviations between intra-operative navigation data and post-operative weight-bearing X-raysI Livshetz
Department of Orthopaedic Surgery, Jewish General Hospital, McGill University, Montreal, Quebec, Canada
Comput Aided Surg 15:56-62. 2010..4% of patients, and in the HKA angle of 29% of patients. Our results indicate that the use of navigation alone is insufficient to prevent outliers beyond an acceptable range of 3 degrees ... - Effect of bisphosphonates on the stimulation of macrophages by alumina ceramic particles: a comparison with ultra-high-molecular-weight polyethyleneAlain Petit
Division of Orthopaedic Surgery, McGill University, Lady Davis Institute for Medical Research, The Sir Mortimer B. Davis--Jewish General Hospital, 3755 Chemin de la Cote Ste-Catherine, Montreal, QC, H3 T 1 E2, Canada
J Mater Sci Mater Med 17:667-73. 2006..In conclusion, our results suggest that the effect of BPs on particle-stimulated macrophages is, at least in part, particle composition dependent... - TNF-alpha secretion and macrophage mortality induced by cobalt and chromium ions in vitro-qualitative analysis of apoptosisIsabelle Catelas
Department of Biomedical Engineering, McGill University, Duff Medical Building, 3775 University Street, Montreal, Quebec, Canada H3A 2B4
Biomaterials 24:383-91. 2003..The relative importance of apoptosis and necrosis in the induction of macrophage mortality by these metal ions remains to be investigated... - Limitations of using aggrecan and type X collagen as markers of chondrogenesis in mesenchymal stem cell differentiationFackson Mwale
Lady Davis Institute for Medical Research and Department of Surgery, SMBD Jewish General Hospital, McGill University, Montreal, Quebec, Canada
J Orthop Res 24:1791-8. 2006..Thus, caution must be exercised when using aggrecan and type X collagen as markers for chondrogenesis and chondrocyte hypertrophy, respectively, in association with stem cell differentiation from this source... - Cobalt and chromium ions induce nitration of proteins in human U937 macrophages in vitroAlain Petit
Division of Orthopaedic Surgery, McGill University, Lady Davis Institute for Medical Research, The SMBD-Jewish General Hospital, 3755 Ch. Cote Ste-Catherine, Montreal, Quebec, Canada, H3T 1E2
J Biomed Mater Res A 79:599-605. 2006.... - Suppression of genes related to hypertrophy and osteogenesis in committed human mesenchymal stem cells cultured on novel nitrogen-rich plasma polymer coatingsFackson Mwale
Division of Orthopaedic Surgery, McGill University, Montreal, Quebec, Canada
Tissue Eng 12:2639-47. 2006.... - Sites of collagenase cleavage and denaturation of type II collagen in aging and osteoarthritic articular cartilage and their relationship to the distribution of matrix metalloproteinase 1 and matrix metalloproteinase 13William Wu
Shriners Hospitals for Children, Montreal, Quebec, Canada
Arthritis Rheum 46:2087-94. 2002..There was no evidence that the damage to CII is ordinarily initiated in sites other than at and near the articular surface and around chondrocytes... - Evaluation of quantitative magnetic resonance imaging, biochemical and mechanical properties of trypsin-treated intervertebral discs under physiological compression loadingFackson Mwale
Lady Davis Institute for Medical Research, SMBD Jewish General Hospital, McGill University, Montreal, Quebec, Canada
J Magn Reson Imaging 27:563-73. 2008..To investigate the influence of targeted trypsin digestion and 16 hours compression loading on MR parameters and the mechanical and biochemical properties of bovine disc segments... - Cleavage of type II collagen by cathepsin K in human osteoarthritic cartilageValeria M Dejica
Joint Diseases Laboratory, Shriners Hospitals for Children, 1529 Cedar Ave, Montreal, Quebec, H3G1A6, Canada
Am J Pathol 173:161-9. 2008..These data suggest that cathepsin K is involved in the cleavage of type II collagen in human articular cartilage in certain OA patients and that it may play a role in both OA pathophysiology and the aging process... - Transforming growth factor-beta2 suppresses collagen cleavage in cultured human osteoarthritic cartilage, reduces expression of genes associated with chondrocyte hypertrophy and degradation, and increases prostaglandin E(2) productionElena V Tchetina
Joint Diseases Laboratory, Shriners Hospitals for Children, 1529 Cedar Ave, Quebec H3G 1A6, Canada
Am J Pathol 168:131-40. 2006..Therefore TGF-beta2 could provide therapeutic control of type II collagen degeneration in OA... - Differential apoptotic response of J774 macrophages to alumina and ultra-high-molecular-weight polyethylene particlesAlain Petit
Division of Orthopaedic Surgery, McGill University, Lady Davis Institute for Medical Research, The Sir Mortimer B. Davis-Jewish General Hospital, , Montreal, Que, Canada
J Orthop Res 20:9-15. 2002..The identification of an apoptosis-related pathway in the macrophage response to ceramic particles provides crucial data for a rational approach in the treatment and/or prevention of periprosthetic osteolysis... - Prostaglandin E2 stimulates p53 transactivational activity through specific serine 15 phosphorylation in human synovial fibroblasts. Role in suppression of c/EBP/NF-kappaB-mediated MEKK1-induced MMP-1 expressionWissam H Faour
Ottawa Health Research Institute, University of Ottawa, Ontario, Canada
J Biol Chem 281:19849-60. 2006..PGE(2)-stimulated [phospho-Ser(15)]p53 abrogated the DNA binding of c/EBPbeta dimers and c/EBPbeta/NF-kappaB p65 heterodimers. Our data suggest that COX-2 prostaglandins may be implicated in p53 function and p53 target gene expression... - Effect of cobalt and chromium ions on human MG-63 osteoblasts in vitro: morphology, cytotoxicity, and oxidative stressCyrille Fleury
Division of Orthopaedic Surgery, McGill University, Lady Davis Institute for Medical Research, The Sir Mortimer B. Davis-Jewish General Hospital, , Montreal, Que, Canada H3 T 1E2
Biomaterials 27:3351-60. 2006..In conclusion, this study demonstrated that Cr(3+) and Co(2+) have a cytotoxic effect on MG-63 osteoblasts and have the potential to modify their redox state... - Adhesion of human U937 macrophages to phosphorylcholine-coated surfacesYong-Kuan Gong
Department of Chemistry and Faculty of Pharmacy, University of Montreal, CP 6128, Succursale Centre Ville, Montreal, Quebec, H3C 3J7, Canada
J Biomed Mater Res A 72:1-9. 2005.... - Induction of apoptosis and necrosis by metal ions in vitroOlga L Huk
Division of Orthopaedic Surgery, McGill University, Lady Davis Institute for Medical Research, The Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec, Canada
J Arthroplasty 19:84-7. 2004..Indeed, at short incubation times (24 h), the noninflammatory process of apoptosis was predominant. At longer incubation times (48 h), however, necrosis was predominant at higher ion concentrations... - Quantitative analysis of macrophage apoptosis vs. necrosis induced by cobalt and chromium ions in vitroIsabelle Catelas
Department of Biomedical Engineering, McGill University, Duff Medical Building, 3775 University Street, Montreal, QC, Canada H3A 2B4
Biomaterials 26:2441-53. 2005..These results point to the potential for these ions of inducing tissue damage by necrosis if present in large concentrations in vivo... - Value and limitations of using the bovine tail as a model for the human lumbar spineCaroline N Demers
Division of Orthopaedic Surgery, Lady Davis Institute for Medical Research, SMBD-Jewish General Hospital, McGill University, Montreal, Quebec, Canada
Spine 29:2793-9. 2004..CONCLUSION: Differences in matrix contents exist between the bovine coccygeal discs and the human lumbar spine. Thus, caution must be exercised when using the bovine tail as a model for the human lumbar spine in biochemical studies... - Effect of cobalt and chromium ions on bcl-2, bax, caspase-3, and caspase-8 expression in human U937 macrophagesAlain Petit
Division of Orthopaedic Surgery, Lady Davis Institute for Medical Research, McGill University, The SMBD-Jewish General Hospital, 3755 Ch Cote Ste-Catherine, Que, Montreal, Canada H3T 1E2
Biomaterials 25:2013-8. 2004..In conclusion, our results suggest that the modulation of the expression of proteins from the bcl-2 and the caspase families of proteins are implicated in the induction of macrophage apoptosis by Co(2+) and Cr(3+) ions... - Role of interleukin-1 and tumor necrosis factor alpha in matrix degradation of human osteoarthritic cartilageMasahiko Kobayashi
Joint Diseases Laboratory, Departments of Surgery and Medicine, Shriners Hospital for Children, McGill University, 1529 Cedar Avenue, Montreal, Quebec H3G 1A6, Canada
Arthritis Rheum 52:128-35. 2005..To determine whether interleukin-1 (IL-1) or tumor necrosis factor alpha (TNFalpha), or both, plays a role in the excessive degradation that is observed in cultured osteoarthritic (OA) articular cartilage... - Induction of protein oxidation by cobalt and chromium ions in human U937 macrophagesAlain Petit
Division of Orthopaedic Surgery, Lady Davis Institute for Medical Research, McGill University, The SMBD-Jewish General Hospital, 3755 Ch. Cote Ste-Catherine, Montreal, Quebec, Canada H3T 1E2
Biomaterials 26:4416-22. 2005..The long term effect of these ions on protein oxidation in vivo remains to be investigated... - Biological evaluation of chitosan salts cross-linked to genipin as a cell scaffold for disk tissue engineeringFackson Mwale
Division of Orthopaedic Surgery, McGill University, Lady Davis Institute for Medical Research, Montreal, QC, Canada
Tissue Eng 11:130-40. 2005..This study demonstrates that 2.5% Protasan UP G213 cross-linked to 5% genipin might be a promising scaffold for disk tissue engineering... - A synthetic peptide of link protein stimulates the biosynthesis of collagens II, IX and proteoglycan by cells of the intervertebral discFackson Mwale
Lady Davis Institute and Department of Surgery, McGill University, 3755, Chemin de la Cote Ste Catherine, Montreal, Quebec H3T 1E2, Canada
J Cell Biochem 88:1202-13. 2003..Link N may have value in stimulating the growth and regeneration of the damaged IVD... - Effect of cobalt and chromium ions on MMP-1, TIMP-1, and TNF-alpha gene expression in human U937 macrophages: a role for tyrosine kinasesLi Luo
Division of Orthopaedic Surgery, McGill University, Lady Davis Institute for Medical Research, SMBD-Jewish General Hospital, , , , Canada H3T 1E2
Biomaterials 26:5587-93. 2005..Together, these findings indicate that activation of MMP-1, TIMP-1, and TNF-alpha by Co2+ and Cr3+ ions is regulated by tyrosine kinases... - Selective inhibition of type X collagen expression in human mesenchymal stem cell differentiation on polymer substrates surface-modified by glow discharge plasmaValentin Nelea
Department of Engineering Physics, Ecole Polytechnique, 2900 Edouard-Montpetit, , , Canada
J Biomed Mater Res A 75:216-23. 2005..These results indicate that plasma-treated polypropylene or nylon-6 may be a suitable surface for inducing MSCs to a disc-like phenotype for tissue engineering of intervertebral discs in which hypertrophy is suppressed... - The potential of chitosan-based gels containing intervertebral disc cells for nucleus pulposus supplementationPeter Roughley
Genetics Unit, Shriners Hospital for Children, and Department of Surgery, McGill University, Montreal, Canada
Biomaterials 27:388-96. 2006..The results support the concept that chitosan may be a suitable scaffold for cell-based supplementation to help restore the function of the NP during the early stages of IVD degeneration... - Effect of pamidronate on the stimulation of macrophage TNF-alpha release by ultra-high-molecular-weight polyethylene particles: a role for apoptosisOlga L Huk
Division of Orthopaedic Surgery, McGill University, Lady Davis Institute for Medical Research, The Sir Mortimer B Davis Jewish General Hospital, 3755 Ch Cote Ste Catherine, Que, Montreal, Canada H3T 1E2
J Orthop Res 21:81-7. 2003..The demonstration that drugs such as pamidronate induce specific apoptosis-related pathways in macrophages contributes data for a rational approach in the treatment and/or prevention of periprosthetic osteolysis... - The effect of glow discharge plasma surface modification of polymers on the osteogenic differentiation of committed human mesenchymal stem cellsFackson Mwale
Division of Orthopaedic Surgery, McGill University, Montreal, QC, Canada
Biomaterials 27:2258-64. 2006..Thus, the nature of the surface can directly influence MSCs differentiation, ultimately affecting the quality of new tissue formation with BOPP-t suppressing osteogenic differentiation... - Risk of periprosthetic femoral neck fracture after hip resurfacing arthroplasty: valgus compared with anatomic alignment. A biomechanical and clinical analysisCorey J Richards
Department of Orthopaedics, Montreal General Hospital, 1650 Cedar Avenue, Montreal, QC H3G 1A4, Canada
J Bone Joint Surg Am 90:96-101. 2008..A biomechanical analysis was completed in order to determine if the achieved valgus orientation of the femoral component reduced the risk of periprosthetic fracture... - Production of prostaglandin D(2) by human osteoblasts and modulation of osteoprotegerin, RANKL, and cellular migration by DP and CRTH2 receptorsMaxime A Gallant
Division of Rheumatology, , , Sherbrooke, , Canada
J Bone Miner Res 20:672-81. 2005..As an autacoid, PGD(2) can act on DP and CRTH2 receptors, both present on these cells. Specific activation of CRTH2 could lead directly and indirectly to an anabolic response in bone... - In-hospital cost of total hip arthroplasty in Canada and the United StatesJohn Antoniou
Division of Orthopaedic Surgery, Jewish General Hospital, McGill University Montreal, 3755 Cote Ste. Catherine Road, Suite E-003, Montreal, Quebec H3T 1E2, Canada
J Bone Joint Surg Am 86:2435-9. 2004....