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| Jean LegaultSummaryCountry: Canada Publications
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Publications
Low-concentration methylene blue maintains energy production and strongly improves survival of Leigh syndrome French Canadian skin fibroblastsJean Legault
Department of Fundamental Sciences, Universite du Quebec a Chicoutimi, 555 boulevard de l Université, Chicoutimi, Quebec, Canada
J Pharm Pharm Sci 14:438-49. 2011..Interestingly, MB completely restores ATP content in LSFC-F1 and LSFC-F2 cells. Finally, MB strongly improves the survival of both LSFC cells...- Potentiating effect of beta-caryophyllene on anticancer activity of alpha-humulene, isocaryophyllene and paclitaxelJean Legault
Laboratoire LASEVE, Universite du Quebec a Chicoutimi, Chicoutimi, Quebec, Canada
J Pharm Pharmacol 59:1643-7. 2007..These results suggest that beta-caryophyllene facilitates the passage of paclitaxel through the membrane and thus potentiates its anticancer activity... - Antitumor activity of balsam fir oil: production of reactive oxygen species induced by alpha-humulene as possible mechanism of actionJean Legault
UMR Institut National de la Santé et de la Recherche Médicale, Clermont Ferrand, France
Planta Med 69:402-7. 2003..These results suggest that GSH depletion and ROS production may be implicated in the cytotoxicity of alpha-humulene and balsam fir oil... - Antioxidant and anti-inflammatory activities of quercetin 7-O-?-D-glucopyranoside from the leaves of Brasenia schreberiJean Legault
Laboratory for Analysis and Separation of Plant Species LASEVE, Universite du Quebec a Chicoutimi, Chicoutimi, Quebec, Canada
J Med Food 14:1127-34. 2011..7 macrophages in a dose-dependent manner. Quercetin-7-O-?-D-glucopyranoside also inhibited overexpression of cyclooxygenase-2 and granulocyte macrophage-colony-stimulating factor... - Antioxidant activity, inhibition of nitric oxide overproduction, and in vitro antiproliferative effect of maple sap and syrup from Acer saccharumJean Legault
Laboratoire d Analyse et de Séparation des Essences Végétales, Departement des Sciences Fondamentales, Universite du Quebec a Chicoutimi, Quebec, Canada
J Med Food 13:460-8. 2010..Finally, maple syrup extracts (50% inhibitory concentration = 42 +/- 6 microg/mL) and pure maple syrup possess a selective in vitro antiproliferative activity against cancer cells... - Antioxidant, anti-inflammatory and anticancer activities of methanolic extracts from Ledum groenlandicum RetziusDominic Dufour
Laboratoire LASEVE, Universite du Quebec a Chicoutimi, 555, boulevard de l Université, Chicoutimi, Quebec, Canada
J Ethnopharmacol 111:22-8. 2007..Ursolic acid was active against DLD-1 (IC(50): 9.3+/-0.3 microM) and A-549 (IC(50): 8.9+/-0.2 microM), suggesting it is, in part, responsible of the anticancer activity of the twig extract... - Isolation and identification of cytotoxic compounds from the wood of Pinus resinosaFrançois Simard
Laboratoire LASEVE, Universite du Quebec a Chicoutimi, Chicoutimi Québec, Canada
Phytother Res 22:919-22. 2008..Compound 1 exhibited the strongest cytotoxicity against both tumor cell lines and the healthy cell line with an IC50 of 25 +/- 4 microm for A549, 20 +/- 1 microm for DLD-1 and 34 +/- 3 microm for WS1... - Anticancer diarylheptanoid glycosides from the inner bark of Betula papyriferaVakhtang Mshvildadze
Laboratoire d Analyse et de Séparation des Essences Végétales, Departement des Sciences Fondamentales, Universite du Quebec a Chicoutimi, 555 boul Université, Chicoutimi, Quebec, Canada G7H 2B1
Phytochemistry 68:2531-6. 2007..Platyphylloside (4) exerted the strongest cytotoxic activity of all isolated compounds with IC(50) values ranging from 10.3 to 13.8 microM... - Synthesis and cytotoxicity of bidesmosidic betulin and betulinic acid saponinsCharles Gauthier
Laboratoire d Analyse et de Separation des Essences Vegetales LASEVE, Departement des Sciences Fondamentales, Universite du Quebec a Chicoutimi, Chicoutimi, Quebec, Canada, G7H 2B1
J Nat Prod 72:72-81. 2009..8-1.9 microM)... - A new labdane diterpene from the flowers of Solidago canadensisMarie Eve Bradette-Hébert
LASEVE, Departement des Sciences Fondamentales, Universite du Quebec a Chicoutimi, Quebec, Canada
Chem Pharm Bull (Tokyo) 56:82-4. 2008..Solicanolide (1) showed cytotoxic activity against A549 (IC(50): 13+/-2 microM), DLD-1 (IC(50): 26+/-2 microM) and WS1 (IC(50): 17+/-1 microM) cell lines... - Composition and cytotoxic activity of the leaf essential oil of Comptonia peregrina (L.) CoulterMuriel Sylvestre
Laboratoire d Analyse et de Séparation des Essences Végétales, Departement des Sciences Fondamentales, Universite du Quebec a Chicoutimi, Chicoutimi, Quebec, Canada, G7H 2B1
Phytother Res 21:536-40. 2007..Two sesquiterpenes present in the oil, alpha-humulene and (E)-nerolidol, have been found to be cytotoxic against both tumor cell lines... - Synthesis and structure-activity relationship study of cytotoxic germanicane- and lupane-type 3beta-O-monodesmosidic saponins starting from betulinDominic Thibeault
Laboratoire d Analyse et de Séparation des Essences Végétales, Departement des Sciences Fondamentales, Universite du Quebec a Chicoutimi, 555 boul de l Université, Chicoutimi, Quebec, Canada
Bioorg Med Chem 15:6144-57. 2007.... - Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponinsCharles Gauthier
Laboratoire LASEVE, Chaire de Recherche sur les Agents Anticancéreux d Origine Naturelle, Universite du Quebec a Chicoutimi, Chicoutimi, Quebec, Canada
Bioorg Med Chem 17:2002-8. 2009.... - Synthesis and cytotoxicity evaluation of natural alpha-bisabolol beta-D-fucopyranoside and analoguesMarianne Piochon
Laboratoire d Analyse et de Separation des Essences Vegetales LASEVE, Departement des Sciences Fondamentales, Université du Québec à Chicoutimi UQAC, 555 boul de l Université, Chicoutimi, Quebec, Canada G7H 2B1
Phytochemistry 70:228-36. 2009..According to ADME in silico predictions, this glycoside closely respects physicochemical parameters necessary to cross the blood-brain barrier passively... - Synthesis, cytotoxicity, and haemolytic activity of chacotrioside lupane-type neosaponins and their germanicane-type rearrangement productsCharles Gauthier
Laboratoire LASEVE, Chaire de Recherche sur les Agents Anticancéreux d Origine Naturelle, Universite du Quebec a Chicoutimi, Chicoutimi, Quebec, Canada
Bioorg Med Chem Lett 19:2310-4. 2009..One important result was that only chacotriosides featuring non-polar functions at the C-28 position (6, 9 and 10) exerted a haemolytic activity against red blood cells... - Abibalsamins A and B, two new tetraterpenoids from Abies balsamea oleoresinSerge Lavoie
Universite du Quebec a Chicoutimi, Laboratoire d Analyse et de Separation des Essences Vegetales LASEVE, Departement des Sciences Fondamentales, 555 boul de l Université, Chicoutimi Québec, Canada, G7H 2B1
Org Lett 14:1504-7. 2012..The absolute configuration of 1 was determined by single-crystal X-ray diffraction. Both compounds exhibited significant cytotoxic activity against cancer cell lines... - Cytotoxic steroidal saponins from the flowers of Allium leucanthumLasha Mskhiladze
Tbilisi State Medical University, Departement of Pharmacognosy, 33, Vazha Pshavela Ave, Tbilisi, 0177, Georgia
Molecules 13:2925-34. 2008..Compounds 1-3 and 5 were found to be the most active, with relatively similar IC50 values ranging from 3.7 to 5.8 microM for a lung cancer cell line (A549) and 5.6 to 8.2 microM for a colon cancer cell line (DLD-1)... - Glycosidation of lupane-type triterpenoids as potent in vitro cytotoxic agentsCharles Gauthier
Laboratoire LASEVE, , UQAC, Chicoutimi, , Canada G7H 2B1
Bioorg Med Chem 14:6713-25. 2006..6-3.9 microM, 22) than the healthy cells (IC50 31 microM). Thus, this study indicates that 3-O-glycosides of lupane-type triterpenoids represent an interesting class of potent in vitro cytotoxic agents... - Antiangiogenic and antitumoral activity of phenyl-3-(2-chloroethyl)ureas: a class of soft alkylating agents disrupting microtubules that are unaffected by cell adhesion-mediated drug resistanceEric Petitclerc
Centre de Recherche, , CHUQ, , , Canada
Cancer Res 64:4654-63. 2004.... - Essential oil analysis and anticancer activity of leaf essential oil of Croton flavens L. from GuadeloupeMuriel Sylvestre
, , , Qu, Canada
J Ethnopharmacol 103:99-102. 2006..Three compounds identified in the leaf essential oil, alpha-cadinol (3.97%), beta-elemene (1.53%) and alpha-humulene (1.06%) are cytotoxic against tumor cell lines... - Antineoplastic potency of arylchloroethylurea derivatives in murine colon carcinomaElisabeth Miot-Noirault
, Rue Montalembert BP 184, 63005 Clermont-Ferrand, France
Invest New Drugs 22:369-78. 2004..These results make CEU-98 a candidate for further investigations with a view to developing an efficacious treatment of colorectal cancer... - A new generation of N-aryl-N'-(1-alkyl-2-chloroethyl)ureas as microtubule disrupters: synthesis, antiproliferative activity, and beta-tubulin alkylation kineticsEmmanuelle Mounetou
Centre de Recherche, CHUQ, Hopital Saint Francois d Assise, 10, Rue de l Espinay, Québec G1L3L5, Canada
J Med Chem 46:5055-63. 2003..In this new series, CEUs 16a and 18a displayed particularly enhanced antiproliferative activity related to a faster reaction with beta-tubulin and merit further investigation as potential antitumor agents... - Sanguinarine-induced apoptosis is associated with an early and severe cellular glutathione depletionEric Debiton
UMR-INSERM U-484, rue Montalembert, BP 184, 63005, Clermont-Ferrand, France
Cancer Chemother Pharmacol 51:474-82. 2003..They also suggest that the clinical usefulness of this alkaloid as an anticancer drug is limited...