F Labrie

Summary

Country: Canada

Publications

  1. ncbi Expression and localization of estrogenic type 12 17beta-hydroxysteroid dehydrogenase in the cynomolgus monkey
    Hong Liu
    Oncology and Molecular Endocrinology Laboratory, Laval University Hospital Research Center CRCHUL and Laval University, Quebec, GlV 4G2, Canada
    BMC Biochem 8:2. 2007
  2. ncbi Activity and safety of the antiestrogen EM-800, the orally active precursor of acolbifene, in tamoxifen-resistant breast cancer
    Fernand Labrie
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center, 2705 Laurier Blvd, T 3 67, Quebec City, Quebec, G1V 4G2, Canada
    J Clin Oncol 22:864-71. 2004
  3. ncbi Dehydroepiandrosterone, androgens and the mammary gland
    Fernand Labrie
    Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center CRCHUL and Laval University, Quebec City, Quebec, Canada
    Gynecol Endocrinol 22:118-30. 2006
  4. ncbi [Keyrole of endocrinology in the victory against prostate cancer]
    Fernand Labrie
    Centre de Recherche du Centre Hospitalier de l Universite Laval, 2705 Boulevard Laurier, Quebec, Quebec, G1V 4G2, Canada
    Bull Cancer 93:949-58. 2006
  5. ncbi Intracrinology and the skin
    F Labrie
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL, Quebec City, Canada
    Horm Res 54:218-29. 2000
  6. ncbi Endocrinology and the prostate. Preface
    Fernand Labrie
    Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center, Laval University, , Canada
    Best Pract Res Clin Endocrinol Metab 22:vii-ix. 2008
  7. ncbi Metabolism of DHEA in postmenopausal women following percutaneous administration
    Fernand Labrie
    Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center CRCHUL and Laval University, Quebec City, Canada
    J Steroid Biochem Mol Biol 103:178-88. 2007
  8. ncbi DHEA and its transformation into androgens and estrogens in peripheral target tissues: intracrinology
    F Labrie
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL, Quebec, G1V 4G2, Canada
    Front Neuroendocrinol 22:185-212. 2001
  9. ncbi Multiple intracrine hormonal targets in the prostate: opportunities and challenges
    Fernand Labrie
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center and Laval University, , Canada
    BJU Int 100:48-51. 2007
  10. ncbi Role of 17 beta-hydroxysteroid dehydrogenases in sex steroid formation in peripheral intracrine tissues
    F Labrie
    Oncology and Molecular Endocrinology Research Center, Laval University Hospital CHUL and Laval University, 2705, Laurier Boulevard, Quebec, Canada G1V 4G2
    Trends Endocrinol Metab 11:421-7. 2000

Collaborators

Detail Information

Publications145 found, 100 shown here

  1. ncbi Expression and localization of estrogenic type 12 17beta-hydroxysteroid dehydrogenase in the cynomolgus monkey
    Hong Liu
    Oncology and Molecular Endocrinology Laboratory, Laval University Hospital Research Center CRCHUL and Laval University, Quebec, GlV 4G2, Canada
    BMC Biochem 8:2. 2007
    ....
  2. ncbi Activity and safety of the antiestrogen EM-800, the orally active precursor of acolbifene, in tamoxifen-resistant breast cancer
    Fernand Labrie
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center, 2705 Laurier Blvd, T 3 67, Quebec City, Quebec, G1V 4G2, Canada
    J Clin Oncol 22:864-71. 2004
    ..To determine the efficacy and safety of EM-800 (SCH-57050), the precursor of acolbifene, a new, highly potent, orally active, pure antiestrogen in the mammary gland and endometrium, for the treatment of tamoxifen-resistant breast cancer...
  3. ncbi Dehydroepiandrosterone, androgens and the mammary gland
    Fernand Labrie
    Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center CRCHUL and Laval University, Quebec City, Quebec, Canada
    Gynecol Endocrinol 22:118-30. 2006
    ....
  4. ncbi [Keyrole of endocrinology in the victory against prostate cancer]
    Fernand Labrie
    Centre de Recherche du Centre Hospitalier de l Universite Laval, 2705 Boulevard Laurier, Quebec, Quebec, G1V 4G2, Canada
    Bull Cancer 93:949-58. 2006
    ..Using this strategy, based upon today's available diagnostic and therapeutic approaches, death from prostate cancer can be an exception, confirming that victory against prostate cancer is achieved...
  5. ncbi Intracrinology and the skin
    F Labrie
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL, Quebec City, Canada
    Horm Res 54:218-29. 2000
    ....
  6. ncbi Endocrinology and the prostate. Preface
    Fernand Labrie
    Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center, Laval University, , Canada
    Best Pract Res Clin Endocrinol Metab 22:vii-ix. 2008
  7. ncbi Metabolism of DHEA in postmenopausal women following percutaneous administration
    Fernand Labrie
    Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center CRCHUL and Laval University, Quebec City, Canada
    J Steroid Biochem Mol Biol 103:178-88. 2007
    ....
  8. ncbi DHEA and its transformation into androgens and estrogens in peripheral target tissues: intracrinology
    F Labrie
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL, Quebec, G1V 4G2, Canada
    Front Neuroendocrinol 22:185-212. 2001
    ..Such treatment, called combined androgen blockade, has led to the first demonstration of a prolongation of life in prostate cancer...
  9. ncbi Multiple intracrine hormonal targets in the prostate: opportunities and challenges
    Fernand Labrie
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center and Laval University, , Canada
    BJU Int 100:48-51. 2007
  10. ncbi Role of 17 beta-hydroxysteroid dehydrogenases in sex steroid formation in peripheral intracrine tissues
    F Labrie
    Oncology and Molecular Endocrinology Research Center, Laval University Hospital CHUL and Laval University, 2705, Laurier Boulevard, Quebec, Canada G1V 4G2
    Trends Endocrinol Metab 11:421-7. 2000
    ..To date, seven human 17 beta-HSDs have been cloned, sequenced and characterized. The 17 beta-HSDs provide each cell with the means of precisely controlling the intracellular concentration of each sex steroid according to local needs...
  11. ncbi Drug insight: breast cancer prevention and tissue-targeted hormone replacement therapy
    Fernand Labrie
    Molecular Endocrinology and Oncology Research Center, Laval University Hospital Research Center CRCHUL, Quebec City, Quebec, Canada
    Nat Clin Pract Endocrinol Metab 3:584-93. 2007
    ....
  12. ncbi Evaluation of prostatic specific antigen and digital rectal examination as screening tests for prostate cancer
    B Candas
    Prostate Cancer Clinical Research Unit, Department of Medicine and Laboratory of Molecular Endocrinology, Laval University Medical Center CHUL and Laval University, Quebec, Canada
    Prostate 45:19-35. 2000
    ..The 11,811 first visits and 46,751 annual follow-up visits performed since 1988 were analyzed in order to assess the efficacy of serum prostatic specific antigen (PSA) and digital rectal examination (DRE) for diagnosis of prostate cancer...
  13. ncbi Intracrinology: role of the family of 17 beta-hydroxysteroid dehydrogenases in human physiology and disease
    F Labrie
    Oncology and Molecular Endocrinology Research Center, Laval University Hospital CHUL and Laval University, Quebec, Canada G1V 4G2
    J Mol Endocrinol 25:1-16. 2000
    ..To date, seven human 17 beta-HSDs have been cloned, sequenced and characterized. The 17 beta-HSDs provide each cell with the means of precisely controlling the intracellular concentration of each sex steroid according to local needs...
  14. ncbi EM-652 (SCH57068), a pure SERM having complete antiestrogenic activity in the mammary gland and endometrium
    F Labrie
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL, 2705 Laurier Boulevard, Que, G1V 4G2, Quebec City, Canada
    J Steroid Biochem Mol Biol 79:213-25. 2001
    ..The above-summarized preclinical and clinical data clearly suggest the interest of studying this compounds in the neoadjuvant and adjuvant settings and, most importantly, for the prevention of breast and uterine cancer...
  15. ncbi Dehydroepiandrosterone (DHEA) is an anabolic steroid like dihydrotestosterone (DHT), the most potent natural androgen, and tetrahydrogestrinone (THG)
    Fernand Labrie
    Molecular Endocrinology and Oncology Laboratory, Laval University Hospital Research Center CRCHUL and Laval University, Quebec City, Canada G1V 4G2
    J Steroid Biochem Mol Biol 100:52-8. 2006
    ..The present microarray approach to identify anabolic compounds is applicable to all potential androgenic/anabolic compounds...
  16. ncbi Future perspectives of selective estrogen receptor modulators used alone and in combination with DHEA
    F Labrie
    Molecular Endocrinology and Oncology Research Center, Laval University Hospital Research Center CRCHUL and Laval University, 2705, Laurier Boulevard, Quebec City, Quebec G1V 4G2, Canada
    Endocr Relat Cancer 13:335-55. 2006
    ..DHEA could thus compensate for the important loss of androgens that accompanies aging and could also permit sex steroid formation and action in the brain while breast cancer prevention would be achieved by the SERM...
  17. ncbi Screening decreases prostate cancer mortality: 11-year follow-up of the 1988 Quebec prospective randomized controlled trial
    Fernand Labrie
    Oncology and Molecular Endocrinology Research Center and Departments of Medicine and Radiology, Laval University Medical Center CHUL, and Laval University, Quebec, Canada
    Prostate 59:311-8. 2004
    ..This clinical trial is aimed at evaluating the impact of prostate cancer screening on cancer-specific mortality...
  18. ncbi Medical castration with LHRH agonists: 25 years later with major benefits achieved on survival in prostate cancer
    Fernand Labrie
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center (CHUL) and Laval University, , , Canada
    J Androl 25:305-13. 2004
  19. ncbi [From the gene to the clinic: prostate cancer death can now be an exception?]
    Fernand Labrie
    Centre de recherche en endocrinologie moléculaire et oncologique, Centre de Recherche du CHUL, Centre Hospitalier de l Université Laval et Université Laval, Sainte Foy, Quebec, G1V 4G2 Canada
    Med Sci (Paris) 19:910-9. 2003
    ..Today's data show that with the simple application of the available diagnostic and therapeutic tools, death from prostate cancer should be an exception...
  20. ncbi The combination of a novel selective estrogen receptor modulator with an estrogen protects the mammary gland and uterus in a rodent model: the future of postmenopausal women's health?
    Fernand Labrie
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center and Laval University, 2705 Laurier Boulevard, Quebec City, Quebec, Canada G1V 4G2
    Endocrinology 144:4700-6. 2003
    ....
  21. ncbi Tetrahydrogestrinone induces a genomic signature typical of a potent anabolic steroid
    Fernand Labrie
    Molecular Endocrinology and Oncology Laboratory, Laval University Medical Research Center CRCHUL and Laval University, Quebec City, G1V 4G2, Canada
    J Endocrinol 184:427-33. 2005
    ..The present microarray data provide an extremely precise and unquestionable signature of the androgenic/anabolic activity of THG, an approach which should apply to the analysis of the activity of any anabolic steroid...
  22. ncbi Major impact of hormonal therapy in localized prostate cancer--death can already be an exception
    Fernand Labrie
    Oncology and Molecular Endocrinology Research Center, Le Centre Hospitalier de l Université Laval CHUL and Laval University, 2705 Laurier Boulevard, Quebec City, Quebec, Canada G1V 4G2
    J Steroid Biochem Mol Biol 92:327-44. 2004
    ..Most importantly, recent data show that the addition of a pure antiandrogen to an LHRH agonist in order to block the androgens made locally in the prostate leads to a 90% long-term control or probable cure of prostate cancer...
  23. ncbi Extragonadal synthesis of sex steroids: intracrinology
    F Labrie
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL, and Laval University, 2705 Boulevard Laurier, Quebec
    Ann Endocrinol (Paris) 64:95-107. 2003
    ....
  24. ncbi Current status of endocrine therapy in localized prostate cancer: cure has become a strong possibility
    Fernand Labrie
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL, Quebec City, Quebec, Canada
    Int Braz J Urol 30:3-11. 2004
    ..This paper presents and discusses the current knowledge available on the use and results of endocrine therapy in localized prostate cancer...
  25. ncbi Gonadotropin-releasing hormone agonists in the treatment of prostate cancer
    Fernand Labrie
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center Centre Hospitalier de l Université Laval, 2705 Laurier Boulevard, Quebec City, Quebec, Canada
    Endocr Rev 26:361-79. 2005
    ....
  26. ncbi Androgen blockade in prostate cancer in 2002: major benefits on survival in localized disease
    Fernand Labrie
    Molecular Endocrinology and Oncology Research Center, Laval University Medical Center CHUL, Laval University, 2705 Laurier Boulevard, Quebec City, Quebec, Canada G1V 4G2
    Mol Cell Endocrinol 198:77-87. 2002
    ..On the other hand, data already available show that long term and continuous (not intermittent) androgen blockade is highly efficient and can achieve long term control or possible cure of localized prostate cancer...
  27. ncbi Is dehydroepiandrosterone a hormone?
    F Labrie
    Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center CRCHUL and Laval University, Quebec City, Quebec G1V4G2, Canada
    J Endocrinol 187:169-96. 2005
    ....
  28. ncbi Androgen glucuronides, instead of testosterone, as the new markers of androgenic activity in women
    Fernand Labrie
    Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center CRCHUL and Laval University, Quebec City, Que, Canada
    J Steroid Biochem Mol Biol 99:182-8. 2006
    ..Measuring ADT-G and 3alpha-diol-G might identify cases of true androgen deficiency and provide an opportunity to offer appropriate androgen therapy...
  29. ncbi Screening and early hormonal treatment of prostate cancer are accumulating strong evidence and support
    F Labrie
    Oncology and Molecular Endocrinology Research Center, Department of Medicine, CHUL Research Center, Centre Hospitalier Universitaire de Quebec and Laval University, Quebec City, Quebec, Canada
    Prostate 43:215-22. 2000
    ..I review the data published during the last 5 years on the effects of early treatment of prostate cancer on survival...
  30. ncbi Changes in serum DHEA and eleven of its metabolites during 12-month percutaneous administration of DHEA
    Fernand Labrie
    Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center CRCHUL and Laval University, Quebec City, Quebec G1V 4G2, Canada
    J Steroid Biochem Mol Biol 110:1-9. 2008
    ..On the other hand, the pharmacokinetics of the steroids are stable over the 12-month period with no significant induction or decrease of activity of the enzymatic systems transforming DHEA predominantly into androgens...
  31. ncbi Comparable amounts of sex steroids are made outside the gonads in men and women: strong lesson for hormone therapy of prostate and breast cancer
    Fernand Labrie
    Molecular Endocrinology and Oncology Research Center, Laval University Hospital Research Center CRCHUL 2705, Laurier Boulevard, Quebec City, Quebec, Canada G1V 4G2
    J Steroid Biochem Mol Biol 113:52-6. 2009
    ..Not adding an antiandrogen to castration in men treated for prostate cancer is equivalent to not prescribing a blocker of estrogens in women suffering from breast cancer because they are postmenopausal and have low circulating estradiol...
  32. ncbi Effect of intravaginal DHEA on serum DHEA and eleven of its metabolites in postmenopausal women
    Fernand Labrie
    Oncology and Molecular Endocrinology Research Center, Laval University Hospital Research Center CRCHUL and Laval University, 2705 Laurier Boulevard, Quebec City, Quebec G1V 4G2, Canada
    J Steroid Biochem Mol Biol 111:178-94. 2008
    ..In addition, the recent observation that DHEA is transformed into both androgens and estrogens in the vagina permits to exert benefits on all the three layers of the vaginal wall...
  33. ncbi EM-652 (SCH 57068), a third generation SERM acting as pure antiestrogen in the mammary gland and endometrium
    F Labrie
    Oncology and Molecular Endocrinology Research Center, Centre Hospitalier Universitaire de Quebec, Department of Medicine, Laval University, Canada
    J Steroid Biochem Mol Biol 69:51-84. 1999
    ..EM-652 was also the most potent inhibitor of the percentage of cycling cancer cells. (ABSTRACT TRUNCATED)..
  34. ncbi Effect of one-week treatment with vaginal estrogen preparations on serum estrogen levels in postmenopausal women
    Fernand Labrie
    Oncology and Molecular Endocrinology Research Center, Laval University Hospital Research Center CRCHUL and Laval University, Quebec, Canada
    Menopause 16:30-6. 2009
    ....
  35. ncbi Screening decreases prostate cancer death: first analysis of the 1988 Quebec prospective randomized controlled trial
    F Labrie
    Department of Medicine, Laval University Medical Research Center CHUL, Quebec, Canada
    Prostate 38:83-91. 1999
    ....
  36. ncbi Adrenal androgens and intracrinology
    Fernand Labrie
    Oncology and Molecular Endocrinology Research Center, Laval University Hospital Research Center, Quebec City, Canada
    Semin Reprod Med 22:299-309. 2004
    ..The benefits of DHEA include increased bone mineral density, muscle mass, well-being, and libido, as well as beneficial effects against skin atrophy, type 2 diabetes, and obesity...
  37. ncbi DHEA and the intracrine formation of androgens and estrogens in peripheral target tissues: its role during aging
    F Labrie
    Laboratory of Molecular Endocrinology, CHUL Le Centre Hospitalier de l Université Laval Research Center, Quebec, Canada
    Steroids 63:322-8. 1998
    ..Furthermore, the inhibitory effect of DHEA on the growth of human breast cancer xenografts in vivo in nude mice supports the beneficial use of DHEA as hormone replacement therapy in women...
  38. ncbi Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells
    Y Lachance
    Medical Research Council Group in Molecular Endocrinology, CHUL Research Centre, Quebec, Canada
    J Biol Chem 265:20469-75. 1990
    ....
  39. ncbi Analysis of the androgenic activity of synthetic "progestins" currently used for the treatment of prostate cancer
    C Labrie
    Medical Research Council Group in Molecular Endocrinology, Laval University Medical Center, Quebec, Canada
    J Steroid Biochem 28:379-84. 1987
    ..As shown by the present data, the synthetic "progestins" so-far available all possess variable levels of androgenic activity and are thus not recommended for the treatment of prostate cancer...
  40. ncbi Structure and tissue-specific expression of a novel member of the rat 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) family. The exclusive 3 beta-HSD gene expression in the skin
    J Simard
    Medical Research Council Group in Molecular Endocrinology, CHUL Research Center, Quebec, Canada
    J Biol Chem 268:19659-68. 1993
    ....
  41. ncbi Structure and expression of a new complementary DNA encoding the almost exclusive 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase in human adrenals and gonads
    E Rheaume
    Medical Research Council Group in Molecular Endocrinology, CHUL Research Center, Quebec, Canada
    Mol Endocrinol 5:1147-57. 1991
    ..The present data show for the first time that adrenals and gonads express a type of 3 beta HSD isoenzyme that is distinct from the type expressed in the placenta.(ABSTRACT TRUNCATED AT 400 WORDS)..
  42. ncbi Localization of type 7 17beta-hydroxysteroid dehydrogenase in mouse tissues. In situ hybridization studies
    G Pelletier
    Oncology and Molecular Endocrinology Research Center, Centre de Recherche du Centre Hospitalier de l Universite Laval, Quebec, Canada GIV 4G2
    J Steroid Biochem Mol Biol 93:49-57. 2005
    ....
  43. ncbi Heterogeneity of rat type I 5 alpha-reductase cDNA: cloning, expression and regulation by pituitary implants and dihydrotestosterone
    I Lopez-Solache
    Medical Research Council Group in Molecular Endocrinology, CHUL Research Center, Quebec, Canada
    Biochim Biophys Acta 1305:139-44. 1996
    ..The results demonstrated that rat type I 5 alpha-reductase mRNA is stimulated by pituitary hormones and castration but is decreased by DHT and hypophysectomy...
  44. ncbi Functional characterization of the novel L108W and P186L mutations detected in the type II 3 beta-hydroxysteroid dehydrogenase gene of a male pseudohermaphrodite with congenital adrenal hyperplasia
    R Sanchez
    Medical Research Council Group in Molecular Endocrinology, CHUL Research Center, Quebec, Canada
    Hum Mol Genet 3:1639-45. 1994
    ..3% and 0.2% for the L108W and P186L enzymes, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)..
  45. ncbi Localization of oestrogen receptor alpha, oestrogen receptor beta and androgen receptors in the rat reproductive organs
    G Pelletier
    Molecular Endrocrinology Laboratory, CHUL Research Center of Laval University, Quebec G1V 4G2, Canada
    J Endocrinol 165:359-70. 2000
    ..By establishing the precise sites of action of oestrogens and androgens they contribute to a better understanding of the respective role of these steroids in reproduction function...
  46. ncbi Characterization of two mRNA species encoding human estradiol 17 beta-dehydrogenase and assignment of the gene to chromosome 17
    F Labrie
    Department of Molecular Endocrinology, Laval University Medical Centre, Quebec, Canada
    J Steroid Biochem 34:189-97. 1989
    ..Using hp E2DH-36 cDNA as a probe for in situ hybridization of translocated chromosomes, the human E2DH gene was localized to the q11-q12 region of chromosome 17...
  47. ncbi Human types 1 and 3 3 alpha-hydroxysteroid dehydrogenases: differential lability and tissue distribution
    I Dufort
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL and Laval University, Quebec G1V 4G2, Canada
    J Clin Endocrinol Metab 86:841-6. 2001
    ....
  48. ncbi Molecular biology and genetics of the 3 beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase gene family
    J Simard
    Medical Research Council Group in Molecular Endocrinology, CHUI Research Center, , Canada
    J Endocrinol 150:S189-207. 1996
  49. ncbi Localization of type 5 17beta-hydroxysteroid dehydrogenase mRNA in mouse tissues as studied by in situ hybridization
    G Pelletier
    Oncology and Molecular Endocrinology Research Center, Le Centre Hospitalier de l Université Laval CHUL, 2705, Laurier Boulevard, Quebec, G1V 4G2, Canada
    Cell Tissue Res 320:393-8. 2005
    ..The data indicate that androgens and estrogens are formed via the action of type 5 17beta-HSD in specific cell types in the liver, ovary, adrenal cortex, and kidney...
  50. ncbi Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta
    G B Tremblay
    Molecular Oncology Group, Boyal Victoria Hospital Montréal, Quebec, Canada
    Mol Endocrinol 11:353-65. 1997
    ..Our results demonstrate that while ER beta shares many of the functional characteristics of ER alpha, the molecular mechanisms regulating the transcriptional activity of mER beta may be distinct from those of ER alpha...
  51. ncbi Structure of the human type II 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) gene: adrenal and gonadal specificity
    Y Lachance
    CHUL Research Center, Quebec, Canada
    DNA Cell Biol 10:701-11. 1991
    ..The present findings should provide the tools required for detailed analysis of the molecular basis of 3 beta-HSD deficiency as well as of normal sex steroid biosynthesis...
  52. ncbi Molecular cloning, cDNA structure and predicted amino acid sequence of bovine 3 beta-hydroxy-5-ene steroid dehydrogenase/delta 5-delta 4 isomerase
    H F Zhao
    Medical Research Council Group in Molecular Endocrinology, Laval University Medical Centre, Quebec, Canada
    FEBS Lett 259:153-7. 1989
    ..Hybridization of cloned cDNAs to bovine ovary poly(A)+ RNA shows the presence of an approximately 1.7 kb mRNA species...
  53. ncbi Expression of 17beta-hydroxysteroid dehydrogenase type 2 and type 5 in breast cancer and adjacent non-malignant tissue: a correlation to clinicopathological parameters
    B Han
    Molecular Endocrinology and Oncology Research Center, Laval University Hospital Research Center, 2705 Laurier Blvd, Quebec City, QC, G1V 4G2, Canada
    J Steroid Biochem Mol Biol 112:194-200. 2008
    ..The decrease in 17beta-HSD type 2 and 17beta-HSD type 5 expressions in breast cancer may play a predominant role in the development and/or progression of the cancer by modifying the intratumoral levels of estrogens and androgens...
  54. ncbi Localization of 17beta-hydroxysteroid dehydrogenase type 1 mRNA in mouse tissues
    G Pelletier
    Oncology and Molecular Endocrinology Research Center, Centre de recherche du Centre Hospitalier de l Université Laval CRCHUL, 2705, Laurier Boulevard, Quebec, Québec GIV 4G2, Canada
    J Mol Endocrinol 33:459-65. 2004
    ..In the testes and peripheral tissues, the action of E2 is probably limited to the cells involved in its formation in an intracrine fashion...
  55. ncbi Characterization of macaque 3 beta-hydroxy-5-ene steroid dehydrogenase/delta 5-delta 4 isomerase: structure and expression in steroidogenic and peripheral tissues in primate
    J Simard
    Medical Research Council Group in Molecular Endocrinology, CHUL Research Centre, Quebec, Canada
    Mol Cell Endocrinol 75:101-10. 1991
    ....
  56. ncbi Identification and characterization of the G15D mutation found in a male patient with 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD) deficiency: alteration of the putative NAD-binding domain of type II 3 beta-HSD
    E Rheaume
    MRC Group in Molecular Endocrinology, CHUL Research Center, Quebec, Canada
    Biochemistry 34:2893-900. 1995
    ..Moreover, the expressed G15D and G15A proteins had decreased affinities for NAD+ with Km values of 113 microM and 148 microM, respectively, compared with 22 microM for normal type II 3 beta-HSD.(ABSTRACT TRUNCATED AT 250 WORDS)..
  57. ncbi Isolation and characterization of a stereospecific 3beta-hydroxysteriod sulfotransferase (pregnenolone sulfotransferase) cDNA
    I Dufort
    Medical Research Council Group in Molecular Endocrinology, CHUL Research Center and Laval University, Quebec, Canada
    DNA Cell Biol 15:481-7. 1996
    ..3 kb is expressed in liver, intestine, and kidney. Guinea pig 3beta-hydroxysteroid sulfotransferase is thus different from that in humans, who possess two mRNA species of 1.3 and 1.8 kb...
  58. ncbi Effects of dihydrotestosterone on adipose tissue measured by serial analysis of gene expression
    C Bolduc
    Molecular Endocrinology and Oncology Research Center, Laval University Medical Center, Department of Anatomy and Physiology, , , Canada
    J Mol Endocrinol 33:429-44. 2004
    ..The novel transcripts regulated by DHT may contribute to identify new mechanisms involved in the action of sex hormones and their potential role in obesity...
  59. ncbi The human type II 17 beta-hydroxysteroid dehydrogenase gene encodes two alternatively spliced mRNA species
    Y Labrie
    CHUL Research Center, Quebec, Canada
    DNA Cell Biol 14:849-61. 1995
    ..Cloning of the 17 beta-HSD type II gene provides us with the tools to study its transcriptional expression...
  60. ncbi Type 5 17beta-hydroxysteroid dehydrogenase: its role in the formation of androgens in women
    V Luu-The
    Medical Research Council Group in Molecular Endocrinology, Oncology and Molecular Endocrinology Research Center, Laval University Hospital CHUL and Laval University, 2705 Laurier Boulevard, G1V 4G2, Quebec, Canada
    Mol Cell Endocrinol 171:77-82. 2001
    ..The double activity of type 5 17beta-HSD in the female reproductive tissues is probably necessary to the control of the optimal level of progesterone and sex steroids...
  61. ncbi Cloning and expression of cDNA encoding human placental estrogen sulfotransferase
    F Bernier
    Medical Research Council Group in Molecular Endocrinology, CHUL Research Center, Quebec, Canada
    Mol Cell Endocrinol 99:R11-5. 1994
    ....
  62. ncbi Structure of two in tandem human 17 beta-hydroxysteroid dehydrogenase genes
    V Luu-The
    Medical Research Council Group in Molecular Endocrinology, Laval University Medical Centre, Quebec, Canada
    Mol Endocrinol 4:268-75. 1990
    ..These new findings provide the basis for a better understanding of the molecular mechanisms involved in 17 beta-HSD deficiency and peripheral sex steroid metabolism...
  63. ncbi Molecular basis of congenital adrenal hyperplasia in two siblings with classical nonsalt-losing 3 beta-hydroxysteroid dehydrogenase deficiency
    E Rheaume
    Medical Research Council Group in Molecular Endocrinology, CHUL Research Center, Quebec, Canada
    J Clin Endocrinol Metab 79:1012-8. 1994
    ....
  64. ncbi Effects of intravaginal dehydroepiandrosterone on vaginal histomorphology, sex steroid receptor expression and cell proliferation in the rat
    Louise Berger
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL and Laval University, Quebec G1V 4G2, Canada
    J Steroid Biochem Mol Biol 109:67-80. 2008
    ..Moreover, intravaginal estrogen-containing pills, creams and rings lead to significant systemic exposure to estrogen, thus indicating the need for a completely novel approach to alleviate vaginal atrophy in postmenopausal women...
  65. ncbi DHEA, important source of sex steroids in men and even more in women
    Fernand Labrie
    Research Center in Molecular Endocrinology, Oncology and Human Genomics, Laval University and Laval University Hospital Research Center CRCHUL, Quebec, Canada
    Prog Brain Res 182:97-148. 2010
    ....
  66. ncbi Hormonal therapy of prostate cancer
    Fernand Labrie
    Research Center in Molecular Endocrinology, Oncology and Human Genomics, Laval University and Laval University Hospital Research Center CRCHUL, Quebec, Canada
    Prog Brain Res 182:321-41. 2010
    ....
  67. ncbi Isolation and characterization of a cDNA encoding mouse 3alpha-hydroxysteroid dehydrogenase: an androgen-inactivating enzyme selectively expressed in female tissues
    Véronique Bellemare
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL, 2705 Laurier Boulevard, Que, Canada G1V 4G2
    J Steroid Biochem Mol Biol 98:18-24. 2006
    ..This role could be related to the inactivation of excess of androgen and progesterone that are more severely regulated than in man...
  68. ncbi Serum steroid levels during 12-week intravaginal dehydroepiandrosterone administration
    Fernand Labrie
    Laval University Hospital Research Center and Laval University, Quebec, Canada
    Menopause 16:897-906. 2009
    ..8% (23.4 mg) intravaginal DHEA, the objective of the present study was to investigate the serum steroid levels during a 12-week daily intravaginal administration of 0%, 0.25%, 0.5%, and 1.0% DHEA (Prasterone) 1.3 mL ovules...
  69. ncbi Atlas of dihydrotestosterone actions on the transcriptome of prostate in vivo
    Ci Ma
    Department of Anatomy and Physiology, Molecular Endocrinology and Oncology Research Center, Laval University Medical Center, Laval University, Quebec, Canada
    Prostate 69:293-316. 2009
    ..Using serial analysis of gene expression (SAGE), we studied the transcriptomic changes in vivo by dihydrotestosterone (DHT) treatment in mice to better understand androgen effects in the prostate...
  70. ncbi Plasma lipoprotein profile in the male cynomolgus monkey under normal, hypogonadal, and combined androgen blockade conditions
    Mathias Leblanc
    Molecular Endocrinology and Oncology Research Center, Laval University Medical Center and Laval University, , Canada, G1V 4G2
    J Clin Endocrinol Metab 89:1849-57. 2004
    ..Such data support the suggestion that androgens and estrogens produced from adrenal precursors in peripheral intracrine tissues could have important, but so-far unsuspected, effects on the homeostasis of lipid and lipoprotein metabolism...
  71. ncbi Gender differences and effects of sex steroids and dehydroepiandrosterone on androgen and oestrogen alpha receptors in mouse sebaceous glands
    L Azzi
    Oncology and Molecular Endocrinology Research Center, CHUL Research Center and Laval University, 2705 Laurier Boulevard, Quebec City, Quebec G1V 4G2, Canada
    Br J Dermatol 154:21-7. 2006
    ..CONCLUSIONS: The present data show gender differences and demonstrate that DHT, E2 and DHEA exert specific effects on the expression of AR and ERalpha in mouse sebocytes...
  72. ncbi Estrogen receptor alpha-mediated adiposity-lowering and hypocholesterolemic actions of the selective estrogen receptor modulator acolbifene
    C Lemieux
    Department of Anatomy and Physiology, Faculty of Medicine, Laval Hospital Research Center, Laval University, Quebec City, Quebec, Canada
    Int J Obes (Lond) 29:1236-44. 2005
    ..CONCLUSION: The beneficial metabolic actions of the SERM ACOL on adiposity and on plasma and liver lipids are entirely due to its interaction with the ERalpha...
  73. ncbi Can combined androgen blockade provide long-term control or possible cure of localized prostate cancer?
    Fernand Labrie
    Prostate Cancer Clinical Research Unit, Department of Medicine, Laval University Medical Center (CHUL) and Laval University, Quebec City, Quebec, Canada
    Urology 60:115-9. 2002
    ..CONCLUSIONS: The present data suggest that long-term and continuous CAB offers the possibility of long-term control or possible cure of localized prostate cancer...
  74. ncbi Chemical synthesis and biological activities of 16alpha-derivatives of 5alpha-androstane-3alpha,17beta-diol as antiandrogens
    Jenny Roy
    Medicinal Chemistry Division, Oncology and Molecular Endocrinology Research Center, Centre Hospitalier Universitaire de Quebec CHUQ, Pavillon CHUL and Université Laval, Que, Canada G1V 4G2
    Bioorg Med Chem 15:3003-18. 2007
    ..1 microM). The new steroidal compound, 15, thus constitutes a good starting point for development of future antiandrogens with a therapeutic potential against prostate cancer...
  75. ncbi Gender differences in mouse skin morphology and specific effects of sex steroids and dehydroepiandrosterone
    Lamia Azzi
    Oncology and Molecular Endocrinology Research Center, CHUL Research Center and Laval University, Quebec City, QC, Canada
    J Invest Dermatol 124:22-7. 2005
    ..GDX triggers a rapid hair growth from telogen to anagen with a thicker hair shaft diameter in females. This data shows that DHT, E2, and DHEA exert specific effects on the different skin layers and appendages...
  76. ncbi Bioavailability and pharmacokinetics of dehydroepiandrosterone in the cynomolgus monkey
    Mathias Leblanc
    Molecular Endocrinology and Oncology Research Center, Laval University Medical Center, , , Canada G1V 4G2
    J Clin Endocrinol Metab 88:4293-302. 2003
    ..Furthermore, the present study supports the importance of measuring circulating androgen glucuronide derivatives to assess hormonal exposure of peripheral tissues to androgens after DHEA administration...
  77. ncbi Pharmacokinetics of oral dehydroepiandrosterone (DHEA) in the ovariectomised cynomolgus monkey
    Mathias Leblanc
    Laboratory of Molecular Endocrinology and Oncology, Laval University Medical Center (CHUL, Laval University, Que, Canada
    J Steroid Biochem Mol Biol 81:159-64. 2002
    ....
  78. ncbi Steroidal lactones as inhibitors of 17beta-hydroxysteroid dehydrogenase type 5: chemical synthesis, enzyme inhibitory activity, and assessment of estrogenic and androgenic activities
    Patrick Bydal
    Medicinal Chemistry Division, Oncology and Molecular Endocrinology Research Center, CHUL Research Center and University Laval, 2705 Laurier Boulevard, Quebec, Quebec G1V 4G2, Canada
    Eur J Med Chem 44:632-44. 2009
    ..03 microM. Interestingly, no significant proliferative effect was detected on Shionogi (AR+) cells in culture in the presence of 0.1 and 1 microM of lactone 26...
  79. ncbi Adrenal precursor C19 steroids are potent stimulators of growth of androgen-sensitive mouse mammary carcinoma Shionogi cells in vitro
    D Begin
    MRC Group in Molecular Endocrinology, Laval University Medical Center, Quebec, Canada
    Mol Cell Endocrinol 58:213-9. 1988
    ..The present data show that the four main adrenal steroids present in the serum of adult men can exert potent stimulatory effects on the growth of an androgen-sensitive cancer cell line through an androgen receptor-mediated mechanism...
  80. ncbi Structural characterization of the human androgen receptor ligand-binding domain complexed with EM5744, a rationally designed steroidal ligand bearing a bulky chain directed toward helix 12
    Line Cantin
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL and Laval University, Quebec G1V 4G2, Canada
    J Biol Chem 282:30910-9. 2007
    ..This structural information will be helpful to refine the structure of the chains placed on the C18 atom to obtain efficient H12-directed steroidal antiandrogens...
  81. ncbi Intravaginal dehydroepiandrosterone (Prasterone), a physiological and highly efficient treatment of vaginal atrophy
    Fernand Labrie
    Laval University Hospital Research Center and Laval University, Quebec, Canada
    Menopause 16:907-22. 2009
    ....
  82. ncbi Fine temporal analysis of DHT transcriptional modulation of the ATM/Gadd45g signaling pathways in the mouse uterus
    Mahine Ivanga
    Oncology and Molecular Endocrinology Research Center, CHUL Research Center, CHUQ, Department of Anatomy and Physiology, Laval University, Quebec, Canada
    Mol Reprod Dev 76:278-88. 2009
    ....
  83. ncbi Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity
    Karine Pereira de Jésus-Tran
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL and Laval University, Quebec, QC G1V 4G2, Canada
    Protein Sci 15:987-99. 2006
    ..Our crystallographic data combined with those obtained by modeling will be helpful in the design of novel molecules with stronger affinity for the AR...
  84. ncbi Comparison of the effects of EM-652 (SCH57068), tamoxifen, toremifene, droloxifene, idoxifene, GW-5638 and raloxifene on the growth of human ZR-75-1 breast tumors in nude mice
    Matthieu Gutman
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center and Laval University, Quebec, Canada
    Int J Cancer 99:273-8. 2002
    ....
  85. ncbi Oestrogenic regulation of pro-opiomelanocortin, neuropeptide Y and corticotrophin-releasing hormone mRNAs in mouse hypothalamus
    G Pelletier
    Oncology and Molecular Endocrinology Research Center, Centre de recherche du Centre Hospitalier de l Université Laval CRCHUL, Quebec, Quebec, Canada
    J Neuroendocrinol 19:426-31. 2007
    ..The present data suggest that oestrogen might exert an anorexigenic action by stimulating POMC and CRH mRNA expression and decreasing NPY mRNA expression in the hypothalamus...
  86. ncbi Molecular cloning of human type 3 3 alpha-hydroxysteroid dehydrogenase that differs from 20 alpha-hydroxysteroid dehydrogenase by seven amino acids
    I Dufort
    Medical Research Council Group in Molecular Endocrinology, CHUL Research Center, Quebec, Canada
    Biochem Biophys Res Commun 228:474-9. 1996
    ..1, 78.3, and 67.4% identity with rat 3 alpha-HSD and rabbit and rat 20 alpha-HSD, respectively. 3 alpha-HSD3 belongs to the aldo-keto reductase family and like almost all the members of this family preferred NADPH as cofactor...
  87. ncbi Localization of type 5 17beta-hydroxysteroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase, and androgen receptor in the human prostate by in situ hybridization and immunocytochemistry
    M El-Alfy
    Medical Research Council Group in Molecular Endocrinology, CHUL Research Center and Laval University, Quebec, Canada
    Endocrinology 140:1481-91. 1999
    ..The potential role of androgen formation and action in blood vessels is unknown and opens new avenues of investigation for a better understanding of the multiple roles of androgens...
  88. ncbi Effect of long-term treatment with the antiestrogen EM-652.HCl on pituitary estrogen receptor alpha and prolactin mRNA expression in intact, ovariectomized and gonadotropin-releasing hormone-treated female rats
    G Pelletier
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL, and Laval University, Quebec, Canada
    Neuroendocrinology 74:367-74. 2001
    ..It is suggested that estrogens can positively regulate pituitary ERalpha gene transcription and that the antiestrogen EM-652.HCl can downregulate by itself pituitary ERalpha gene transcription...
  89. ncbi Immunoelectron microscopic localization of three key steroidogenic enzymes (cytochrome P450(scc), 3 beta-hydroxysteroid dehydrogenase and cytochrome P450(c17)) in rat adrenal cortex and gonads
    G Pelletier
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL, and Laval University, Quebec, Canada G1V 4G2
    J Endocrinol 171:373-83. 2001
    ....
  90. ncbi Chronic administration of dehydroepiandrosterone (DHEA) to female monkey and rat has no effect on mammary gland histology
    G Pelletier
    Laboratory of Molecular Endocrinology and Oncology, CHUL Research Center and Laval University, 2705 Laurier Boulevard, Quebec City, Quebec, Canada
    J Steroid Biochem Mol Biol 108:102-8. 2008
    ..As in the monkey, the histology of the female rat mammary gland remained unchanged following long-term treatment with any of the two doses of DHEA...
  91. ncbi Expression of sulfotransferase 1E1 in human prostate as studied by in situ hybridization and immunocytochemistry
    Y Takase
    Oncology and Molecular Endocrinology Laboratory, CHUL Research Center, Quebec, Canada
    Prostate 67:405-9. 2007
    ..We have recently shown that EST 1E1 is highly expressed in male mouse reproductive organs, including prostate. It appeared of interest to study the expression of EST 1E1 in human prostate...
  92. ncbi Localization and glucocorticoid regulation of 11beta-hydroxysteroid dehydrogenase type 1 mRNA in the male mouse forebrain
    G Pelletier
    Oncology and Molecular Endocrinology Research Center, Centre de Recherche du Centre Hospitalier de l Universite Laval, 2705 Laurier Boulevard, Quebec, Quebec, Canada G1V 4G2
    Neuroscience 145:110-5. 2007
    ..This downregulation might contribute to maintain low intracellular corticosterone levels in central regions and then prevent the deleterious effects induced by high glucocorticoid levels...
  93. ncbi Immunoelectron microscopic localization of 3beta-hydroxysteroid dehydrogenase and type 5 17beta-hydroxysteroid dehydrogenase in the human prostate and mammary gland
    G Pelletier
    Oncology and Molecular Endocrinology Research Center, Laval University Hospital CHUL, Quebec, G1V 4G2, Canada
    J Mol Endocrinol 26:11-9. 2001
    ..The absence of any association of the enzymes with membrane-bound organelles appears as a common finding in the reactive cell types of two peripheral tissues...
  94. ncbi Unique features of the basal cells of human prostate epithelium
    M El-Alfy
    Oncology and Molecular Endocrinology Research Center, Laval University Hospital CHUL, and Laval University, Quebec, G1V 4G2, Canada
    Microsc Res Tech 51:436-46. 2000
    ..Human basal cells could thus regulate functions of the luminal cells by being part of a two-cell mechanism somewhat analogous to thecal and granulosa cells in the ovary...
  95. ncbi Cellular localization of estrogen receptor beta messenger ribonucleic acid in cynomolgus monkey reproductive organs
    G Pelletier
    Laboratory of Molecular Endocrinology, Laval University Medical Research Center and Laval University, Quebec, Canada G1V 4G2
    Biol Reprod 61:1249-55. 1999
    ..In the male testis and prostate, ER-beta has been found in cells that contain very little or no ER-alpha. The role of circulating or locally produced estrogens in the male reproductive system remains to be clarified...
  96. ncbi Role of extra-ovarian oestrogens in the regulation of gonadotropin releasing hormone mRNA expression in the rat brain
    G Pelletier
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL and Laval University, Quebec, Canada
    J Neuroendocrinol 13:678-82. 2001
    ....
  97. ncbi Androgenic down-regulation of urotensin II precursor, urotensin II-related peptide precursor and androgen receptor mRNA in the mouse spinal cord
    G Pelletier
    Oncology and Molecular Endocrinology Research Center, Centre de Recherche du Centre Hospitalier de l Universite Laval, 2705 Laurier Boulevard, Quebec, Canada GIV 4G2
    Neuroscience 132:689-96. 2005
    ....
  98. ncbi Prostate cancer susceptibility genes: lessons learned and challenges posed
    J Simard
    Cancer Genomics Laboratory, Oncology and Molecular Endocrinology Research Center, CHUL Research Center and Laval University, Quebec City, Canada G1V 4G2
    Endocr Relat Cancer 10:225-59. 2003
    ....
  99. ncbi Cellular localization of mRNA expression of enzymes involved in the formation and inactivation of hormonal steroids in the mouse prostate
    G Pelletier
    Oncology and Molecular Endocrinology Research Center, Laval University Hospital CHUL, 2705, Laurier Boulevard, Quebec, G1V 4G2, Canada
    J Histochem Cytochem 52:1351-6. 2004
    ..The present results indicate that both epithelial and stromal cells in the mouse prostate play a role in local formation and inactivation of hormonal steroids...
  100. ncbi Localization of 20alpha-hydroxysteroid dehydrogenase mRNA in mouse brain by in situ hybridization
    G Pelletier
    Oncology and Molecular Endocrinology Research Center, Centre de Recherche du Centre Hospitalier de l Universite Laval, Quebec, 2705, Laurier Boulevard, Canada G1V 4G2
    Brain Res Mol Brain Res 125:143-6. 2004
    ..In the hippocampus, the labelling was mostly located over pyramidal cells of the CA1 layer. These results suggest that progesterone can be inactivated by 20alpha-HSD in some specific brain areas...