Research Topics
Species | David N JuurlinkSummaryAffiliation: Institute for Clinical Evaluative Sciences Country: Canada Publications
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Detail Information
Publications
The risk of suicide with selective serotonin reuptake inhibitors in the elderlyDavid N Juurlink
Institute for Clinical Evaluative Sciences, G Wing 106, 2075 Bayview Ave, Toronto, Ont, Canada M4N 3M5
Am J Psychiatry 163:813-21. 2006..The authors explored the relationship between the initiation of therapy with selective serotonin reuptake inhibitor (SSRI) antidepressants and completed suicide in older patients...- Drug interactions with warfarin: what clinicians need to knowDavid N Juurlink
Division of General Internal Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ont
CMAJ 177:369-71. 2007 - Rates of hyperkalemia after publication of the Randomized Aldactone Evaluation StudyDavid N Juurlink
Department of Medicine University of Toronto, Toronto
N Engl J Med 351:543-51. 2004..Use of angiotensin-converting-enzyme (ACE) inhibitors is also indicated in these patients. However, life-threatening hyperkalemia can occur when these drugs are used together... - Drug-drug interactions: where do we go from here?David N Juurlink
Division of General Internal Medicine, Sunnybrook and Women's College Health Sciences Center, Toronto, Ontario, Canada
J Am Pharm Assoc (2003) 44:128, 131-2, 134. 2004 - Adverse cardiovascular events during treatment with pioglitazone and rosiglitazone: population based cohort studyDavid N Juurlink
Division of Clinical Pharmacology and Toxicology, Department of Medicine, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5
BMJ 339:b2942. 2009..To compare the risk of acute myocardial infarction, heart failure, and death in patients with type 2 diabetes treated with rosiglitazone and pioglitazone... - A population-based study of the drug interaction between proton pump inhibitors and clopidogrelDavid N Juurlink
Department of Medicine, Sunnybrook Health Sciences Centre and University of Toronto, 2075 Bayview Ave, Toronto, Ontario
CMAJ 180:713-8. 2009..Most proton pump inhibitors inhibit the bioactivation of clopidogrel to its active metabolite. The clinical significance of this drug interaction is unknown... - The safety of proton pump inhibitors and clopidogrel in patients after strokeDavid N Juurlink
Sunnybrook Research Institute, Toronto, Ontario, Canada
Stroke 42:128-32. 2011..evidence suggests that some proton pump inhibitors can attenuate the antiplatelet effect of clopidogrel. The significance of this potential drug interaction in patients with cerebrovascular disease is unknown... - Cyclo-oxygenase-2 inhibitors versus non-selective non-steroidal anti-inflammatory drugs and congestive heart failure outcomes in elderly patients: a population-based cohort studyMuhammad Mamdani
Institute for Clinical Evaluative Sciences, Toronto, ON M4N 3M5, Canada
Lancet 363:1751-6. 2004..We aimed to compare rates of admission for congestive heart failure in elderly patients who were newly dispensed COX-2 inhibitors or non-selective NSAIDs... - Risk of upper gastrointestinal hemorrhage in warfarin users treated with nonselective NSAIDs or COX-2 inhibitorsMarisa Battistella
University Health Network, University of Toronto, Toronto, Ontario, Canada
Arch Intern Med 165:189-92. 2005..We examined the association between the concomitant use of warfarin and nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) or selective COX-2 inhibitors in older adults hospitalized for upper GI hemorrhage... - Hemorrhage during warfarin therapy associated with cotrimoxazole and other urinary tract anti-infective agents: a population-based studyHadas D Fischer
Department of Health Policy Management and Evaluation, University of Toronto, Toront, Ontario, Canada
Arch Intern Med 170:617-21. 2010..We examined the risk of upper gastrointestinal (UGI) tract hemorrhage in older patients receiving warfarin in combination with antibiotics commonly used to treat urinary tract infection, with a focus on cotrimoxazole... - Effect of selective cyclooxygenase 2 inhibitors and naproxen on short-term risk of acute myocardial infarction in the elderlyMuhammad Mamdani
Institute for Clinical Evaluative Sciences, 2075 Bayview Ave G215, Toronto, Ontario, Canada M4N 3M5
Arch Intern Med 163:481-6. 2003..We compared the rates of acute myocardial infarction (AMI) among elderly patients dispensed selective cyclooxygenase 2 inhibitors, naproxen, and nonselective nonnaproxen nonsteroidal anti-inflammatory drugs (NSAIDs)... - Antipsychotic drugs and the risk of hyperglycemia in older adults without diabetes: a population-based observational studyLorraine L Lipscombe
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
Am J Geriatr Psychiatry 19:1026-33. 2011..To determine whether current antipsychotic use among older persons without diabetes is associated with a higher risk of hospital visits for hyperglycemia, as previous studies in this population have yielded conflicting results... - Trimethoprim-sulfamethoxazole induced hyperkalaemia in elderly patients receiving spironolactone: nested case-control studyTony Antoniou
University of Toronto, Toronto, ON, Canada
BMJ 343:d5228. 2011..To characterise the risk of admission to hospital for hyperkalaemia in elderly patients treated with trimethoprim-sulfamethoxazole in combination with spironolactone... - Drug-induced lithium toxicity in the elderly: a population-based studyDavid N Juurlink
Clinical Epidemiology and Healthcare Research Program, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
J Am Geriatr Soc 52:794-8. 2004..To study the association between hospital admission for lithium toxicity and the use of diuretics, angiotensin-converting enzyme (ACE) inhibitors, and nonsteroidal antiinflammatory drugs (NSAIDs) in the elderly... - Trends in opioid use and dosing among socio-economically disadvantaged patientsTara Gomes
Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5
Open Med 5:e13-22. 2011..The objective of this study was to examine trends in opioid utilization for nonmalignant pain among recipients of social assistance and to explore the relation between dose of analgesic and mortality... - Risk-treatment mismatch in the pharmacotherapy of heart failureDouglas S Lee
Institute for Clinical Evaluative Sciences, Department of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada
JAMA 294:1240-7. 2005..Understanding the reasons underlying this mismatch may facilitate improvements in care and outcomes for patients with heart failure... - Gastrointestinal bleeding after the introduction of COX 2 inhibitors: ecological studyMuhammad Mamdani
Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue G106, Toronto, ON, Canada M4N 3M5
BMJ 328:1415-6. 2004 - A risk quantification instrument for acute acetaminophen overdose patients treated with N-acetylcysteineMarco L A Sivilotti
Department of Emergency Medicine, Queen s University, Kingston, Ontario, Canada
Ann Emerg Med 46:263-71. 2005..We quantitatively estimate the risk of hepatotoxicity based on the degree and duration of pretreatment exposure to supratherapeutic concentrations of acetaminophen... - Clinical and demographic characteristics of patients receiving different oral hypoglycemic agentsTara Gomes
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
Pharmacoepidemiol Drug Saf 18:756-60. 2009.... - Trimethoprim-sulfamethoxazole-induced hyperkalemia in patients receiving inhibitors of the renin-angiotensin system: a population-based studyTony Antoniou
Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
Arch Intern Med 170:1045-9. 2010..The objective of this study was to characterize the risk of hyperkalemia-associated hospitalization in elderly patients who were being treated with trimethoprim-sulfamethoxazole along with either an ACEI or an ARB... - Antidepressants, warfarin, and the risk of hemorrhagePaul A Kurdyak
The Health Systems Research and Consulting Unit, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
J Clin Psychopharmacol 25:561-4. 2005..We speculated that, among patients receiving warfarin, initiation of selective serotonin reuptake inhibitor treatment would be associated with an increased risk of hospitalization for upper gastrointestinal tract bleeding (UGIB)... - Comparative adherence to oxybutynin or tolterodine among older patientsTara Gomes
The Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
Eur J Clin Pharmacol 68:97-9. 2012..To compare persistence of oxybutynin or tolterodine therapy among older patients newly prescribed one of these drugs... - Impaired renal function modifies the risk of severe hypoglycaemia among users of insulin but not glyburide: a population-based nested case-control studyMatthew A Weir
Division of Nephrology, Department of Medicine, University of Western Ontario, London, Canada
Nephrol Dial Transplant 26:1888-94. 2011..Little evidence justifies the avoidance of glyburide in patients with impaired renal function. We aimed to determine if renal function modifies the risk of hypoglycaemia among patients using glyburide... - Bisphosphonate use and the risk of subtrochanteric or femoral shaft fractures in older womenLaura Y Park-Wyllie
Institute for Clinical Evaluative Sciences, and Li Ka Shing Knowledge Institute of St Michael s Hospital, 30 Bond St, Toronto, Ontario, M5B 1W8
JAMA 305:783-9. 2011..Oral bisphosphonates have become a mainstay of treatment, but concerns have emerged that long-term use of these drugs may suppress bone remodeling, leading to unusual fractures... - A population-based assessment of the potential interaction between serotonin-specific reuptake inhibitors and digoxinDavid N Juurlink
Clinical Epidemiology and Healthcare Research Program, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Br J Clin Pharmacol 59:102-7. 2005..We sought to determine if some SSRIs cause digoxin toxicity in the clinical setting... - Drug-drug interactions among elderly patients hospitalized for drug toxicityDavid N Juurlink
Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
JAMA 289:1652-8. 2003..Drug-drug interactions are a preventable cause of morbidity and mortality, yet their consequences in the community are not well characterized... - Beta-blockers, trimethoprim-sulfamethoxazole, and the risk of hyperkalemia requiring hospitalization in the elderly: a nested case-control studyMatthew A Weir
University of Western Ontario, London, Ontario, Canada
Clin J Am Soc Nephrol 5:1544-51. 2010..The simultaneous use of beta adrenergic receptor blockers (beta-blockers) and trimethoprim-sulfamethoxazole (TMP-SMX) may confer a high risk of hyperkalemia... - Missed opportunities in the secondary prevention of myocardial infarction: an assessment of the effects of statin underprescribing on mortalityPeter C Austin
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
Am Heart J 151:969-75. 2006..We explored the potential reduction in mortality at the population level that could result from improving statin prescribing among patients least likely to be prescribed a statin after acute myocardial infarction (AMI)... - Antipsychotic drugs and hyperglycemia in older patients with diabetesLorraine L Lipscombe
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
Arch Intern Med 169:1282-9. 2009..Evidence suggests that there is an association between antipsychotic drugs and new-onset diabetes, but little is known about the risk of hyperglycemia among persons with preexisting diabetes... - Medical illness and the risk of suicide in the elderlyDavid N Juurlink
Clinical Epidemiology and Healthcare Research Program, University of Toronto, and the Institute for Clinical Evaluative Sciences, Toronto, Ontario
Arch Intern Med 164:1179-84. 2004..We explored the relationship between treatment for several illnesses and the risk of suicide in elderly patients using a population-based approach... - How many "Me-Too" drugs are enough? The case of physician preferences for specific statinsPeter C Austin
Institute for Clinical Evaluative Sciences, Toronto, Canada
Ann Pharmacother 40:1047-51. 2006..The increasing availability of "Me-Too" drugs has provided considerable treatment options for clinicians. However, the number of such drugs within a class that are actually used by clinicians has not been well studied... - Thiazolidinediones and cardiovascular outcomes in older patients with diabetesLorraine L Lipscombe
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
JAMA 298:2634-43. 2007..However, the association between TZD use and cardiovascular events has not been adequately evaluated on a population level... - Inequitable distribution of implantable cardioverter defibrillators in OntarioJacob A Udell
Institute for Clinical Evaluative Sciences, University of Toronto, Ontario, and Department of Medicine, Vancouver Hospital and Health Sciences Centre, Vancouver, British Columbia, Canada
Int J Technol Assess Health Care 23:354-61. 2007..The objective of this study was to examine the influence of age, gender, place of residence, and socioeconomic status on rates of ICD implantation for the primary prevention of death... - The risk of postpartum hemorrhage with selective serotonin reuptake inhibitors and other antidepressantsErin Salkeld
Department of Public Health Sciences, Faculty of Medicine, University of Toronto, Ontario, Canada
J Clin Psychopharmacol 28:230-4. 2008.... - Outpatient gatifloxacin therapy and dysglycemia in older adultsLaura Y Park-Wyllie
Institute for Clinical Evaluative Sciences, St. Michael's Hospital, Toronto
N Engl J Med 354:1352-61. 2006.... - Appropriateness of spironolactone prescribing in heart failure patients: a population-based studyDennis T Ko
Division of Cardiology, Shulich Heart Centre, Department of Medicine, Sunnybrook and Women's Health Sciences Centre, Toronto, Ontario, Canada
J Card Fail 12:205-10. 2006..These findings highlight the need for more careful patient selection when prescribing spironolactone to minimize potential life-threatening hyperkalemia... - Colchicine poisoning: the dark side of an ancient drugYaron Finkelstein
Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
Clin Toxicol (Phila) 48:407-14. 2010..Although colchicine poisoning is sometimes intentional, unintentional toxicity is common and often associated with a poor outcome... - Proton pump inhibitors and hospitalization for Clostridium difficile-associated disease: a population-based studyDonna O Lowe
Department of Pharmacy Services, University Health Network, University of Toronto, ON, M5G 2C4, Canada
Clin Infect Dis 43:1272-6. 2006..Whether outpatient PPI use influences the risk of hospital admission for CDAD among older patients who have recently been treated with antibiotics is unknown... - Selective serotonin reuptake inhibitors and breast cancer mortality in women receiving tamoxifen: a population based cohort studyCatherine M Kelly
Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Canada
BMJ 340:c693. 2010..To characterise whether some selective serotonin reuptake inhibitor (SSRI) antidepressants reduce tamoxifen's effectiveness by inhibiting its bioactivation by cytochrome P450 2D6 (CYP2D6)... - Testing multiple statistical hypotheses resulted in spurious associations: a study of astrological signs and healthPeter C Austin
Institute for Clinical Evaluative Sciences, G1 06, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5 Canada
J Clin Epidemiol 59:964-9. 2006..To illustrate how multiple hypotheses testing can produce associations with no clinical plausibility... - Prescribing of opioid analgesics and related mortality before and after the introduction of long-acting oxycodoneIrfan A Dhalla
Department of Medicine, University of Toronto, and the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario
CMAJ 181:891-6. 2009..Opioid-related mortality appears to be increasing in Canada. We examined the true extent of the problem and the impact of the introduction of long-acting oxycodone... - Long-term analgesic use after low-risk surgery: a retrospective cohort studyAsim Alam
Department of Anesthesiology, University of Toronto, Ontario, Canada
Arch Intern Med 172:425-30. 2012..This study evaluated the risk of long-term analgesic use after low-risk surgery in older adults not previously prescribed analgesics... - Blood glucose test strips: options to reduce usageTara Gomes
Institute for Clinical Evaluative Sciences, Toronto, Ont
CMAJ 182:35-8. 2010..The impact of more focused public-payer policies for the use of blood glucose test strips may be substantial... - Antenatal use of selective serotonin-reuptake inhibitors and QT interval prolongation in newbornsGal Dubnov-Raz
Hospital for Sick Children, Motherisk Program, Divisions of Clinical Pharmacology and Toxicology and Emergency Medicine, Department of Pediatrics, 555 University Avenue Toronto, Ontario, Canada
Pediatrics 122:e710-5. 2008..The aim of this study was to determine the effect of maternal use of selective serotonin-reuptake inhibitor antidepressants during pregnancy on the QTc interval of the offspring... - Trimethoprim/sulfamethoxazole-induced phenytoin toxicity in the elderly: a population-based studyTony Antoniou
University of Toronto, Toronto, Department of Family and Community Medicine, St Michael s Hospital, Toronto, Ontario, Canada
Br J Clin Pharmacol 71:544-9. 2011..We studied the risk of phenytoin toxicity following the prescription of trimethoprim/sulfamethoxazole (TMP/SMX), a commonly used antibiotic, among elderly patients receiving phenytoin... - Dihydropyridine calcium channel blockers and cardiovascular outcomes in elderly patients: a population-based studyClaudia Bucci
Department of Pharmacie, Sunnybook Health Sciences Centre, University of Toronto, Ontario, Canada
Can J Cardiol 24:629-32. 2008..Despite safety concerns associated with short-acting agents, increasing evidence supports the safety of long-acting dihydropyridines. Although amlodipine is the best studied of these, there are few studies comparing it with nifedipine... - Suboptimal use of statin therapy in elderly patients with atherosclerosis: a population-based studyMohammed Al-Omran
Division of Vascular Surgery, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
J Vasc Surg 48:607-12. 2008..However, limited population-based data are available on use of statin therapy in these patients in Canada. We sought to study trends in statin use to treat these patients in Ontario during a 10-year period... - The risk of hypotension following co-prescription of macrolide antibiotics and calcium-channel blockersAlissa J Wright
Department of Medicine, University of Toronto, Ont, Canada
CMAJ 183:303-7. 2011..We explored the risk of hypotension or shock requiring hospital admission following the simultaneous use of calcium-channel blockers and macrolide antibiotics... - Cholinesterase inhibitors and hospitalization for bradycardia: a population-based studyLaura Y Park-Wyllie
Department of Family and Community Medicine, St Michael s Hospital, Ontario, Canada
PLoS Med 6:e1000157. 2009..These drugs enhance the effects of acetylcholine, and reports suggest they may precipitate bradycardia in some patients. We aimed to examine the association between use of cholinesterase inhibitors and hospitalization for bradycardia... - Are broad-spectrum fluoroquinolones more likely to cause Clostridium difficile-associated disease?Irfan A Dhalla
Department of Medicine, Unversity of Toronto, Ontario M4E 3E9, Canada
Antimicrob Agents Chemother 50:3216-9. 2006..difficile-associated disease requiring hospitalization among patients prescribed gatifloxacin or moxifloxacin compared to levofloxacin... - Observational study of upper gastrointestinal haemorrhage in elderly patients given selective cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugsMuhammad Mamdani
Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue G215, Toronto, Ontario, Canada
BMJ 325:624. 2002..To compare rates of upper gastrointestinal haemorrhage among elderly patients given selective cyclo-oxygenase-2 (COX 2) inhibitors and non-selective non-steroidal anti-inflammatory drugs (NSAIDs)... - Sex-and age-based differences in the delivery and outcomes of critical careRobert A Fowler
Interdepartmental Division of Critical Care Medicine and Department of Medicine, University of Toronto and Sunnybrook Health Sciences Centre, Toronto, Ont
CMAJ 177:1513-9. 2007..Our objective was to determine whether sex and age are associated with differences in admission practices, processes of care and clinical outcomes for critically ill patients... - Clustering of opioid prescribing and opioid-related mortality among family physicians in OntarioIrfan A Dhalla
Department of Medicine, University of Toronto, Toronto, Ont
Can Fam Physician 57:e92-6. 2011..To examine whether variation in prescribing at the level of the individual physician is associated with opioid-related mortality... - The effect of antidepressant warnings on prescribing trends in Ontario, CanadaPaul A Kurdyak
Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Am J Public Health 97:750-4. 2007..We studied whether 5 regulatory agency advisories concerning the possible increased risk of suicidal behavior during antidepressant therapy had an effect on antidepressant prescription trends in Ontario... - Guillain-Barré syndrome after influenza vaccination in adults: a population-based studyDavid N Juurlink
Institute of Clinical Evaluative Sciences, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario
Arch Intern Med 166:2217-21. 2006..CONCLUSION: Influenza vaccination is associated with a small but significantly increased risk for hospitalization because of GBS... - New fibrate use and acute renal outcomes in elderly adults: a population-based studyYing Y Zhao
The Yale University School of Medicine, New Haven, Connecticut University of Western Ontario, London, Ontario, Canada Institute for Clinical Evaluative Sciences, University of Toronto, and Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada and McMaster University, Hamilton, Ontario, Canada
Ann Intern Med 156:560-9. 2012..The mechanism and clinical significance of the increase in serum creatinine level with fibrates is unclear. Primary Funding Source: Ontario Ministry of Health and Long-Term Care Drug Innovation Fund... - Selective serotonin reuptake inhibitors and pulmonary arterial hypertension: a case-control studyIrfan A Dhalla
Department of Medicine, St Michael s Hospital, 30 Bond St, Toronto, ON, M5B 1W8, Canada
Chest 141:348-53. 2012..Animal and human studies suggest that selective serotonin reuptake inhibitors (SSRIs) might be useful for the prevention or treatment of pulmonary arterial hypertension... - Polymorphism of the MDR1/ABCB1 C3435T drug-transporter and resistance to anticonvulsant drugs: a meta-analysisFacundo Garcia Bournissen
Divisions of Clinical Pharmacology and Toxicology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
Epilepsia 50:898-903. 2009.... - Opioid dose and drug-related mortality in patients with nonmalignant painTara Gomes
Institute for Clinical Evaluative Sciences, G Wing 106, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada
Arch Intern Med 171:686-91. 2011..However, the risk-benefit ratio of high-dose opioid therapy is not well characterized. The objective of this study was to characterize the relationship between opioid dose and opioid-related mortality... - Does the treatment of dyslipidemia affect the risk of depression or suicidal behaviour?David N Juurlink
Division of General Internal Medicine, Sunnybrook and Women's Health Sciences Centre, Toronto, Ont
CMAJ 170:192. 2004 - Safety of influenza vaccination in patients with myasthenia gravis: a population-based studyLorne Zinman
Department of Medicine, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
Muscle Nerve 40:947-51. 2009..Vaccination of patients with MG against influenza was not found to be associated with exacerbations of the disease. Our findings do not support the practice of withholding influenza vaccination in patients with MG... - Use of other opioids during methadone therapy: a population-based studyPaul Kurdyak
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
Addiction 107:776-80. 2012..To determine the extent to which other opioids are prescribed to patients receiving methadone in Ontario, Canada... - Iron poisoning in young children: association with the birth of a siblingDavid N Juurlink
Department of Medicine, University of Toronto, Toronto, Ont
CMAJ 168:1539-42. 2003..We explored the association between iron poisoning in young children and the birth of a sibling... - Ciprofloxacin-induced theophylline toxicity: a population-based studyTony Antoniou
University of Toronto, Toronto, ON, Canada
Eur J Clin Pharmacol 67:521-6. 2011..We studied the risk of theophylline toxicity associated with the co-prescription of ciprofloxacin and theophylline... - Discrepant advice from poison centres and their medical directorsDavid N Juurlink
Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
Can J Clin Pharmacol 9:101-5. 2002.... - Risk of serious falls associated with oxybutynin and tolterodine: a population based studyTara Gomes
Institute for Clinical Evaluative Sciences, University of Toronto, Toronto, Ontario, Canada
J Urol 186:1340-4. 2011..We compared the short-term risk of falls among recipients of oxybutynin or tolterodine to treat urinary incontinence... - Is morphine exposure associated with acute chest syndrome in children with vaso-occlusive crisis of sickle cell disease? A 6-year case-crossover studyYaron Finkelstein
Department of Pediatrics, The Hospital for Sick Children, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Clin Ther 29:2738-43. 2007..However, the belief that these drugs can promote development of the acute chest syndrome (ACS) may lead to undertreatment of pain... - A substantial and confusing variation exists in handling of baseline covariates in randomized controlled trials: a review of trials published in leading medical journalsPeter C Austin
Institute for Clinical Evaluative Sciences, G1 06, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
J Clin Epidemiol 63:142-53. 2010..Furthermore, some have advocated for the use of regression adjustment to estimate the effect of treatment after adjusting for potential imbalances in prognostically important baseline covariates between treatment groups... - Unintended medication discrepancies at the time of hospital admissionPatricia L Cornish
Department of Pharmacy, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
Arch Intern Med 165:424-9. 2005..These errors are particularly worthy of attention because they are not likely to be detected by computerized physician order entry systems... - A new predictor of toxicity following acetaminophen overdose based on pretreatment exposureMarco L A Sivilotti
Department of Emergency Medicine, Queen s University, Kingston, Ontario, Canada
Clin Toxicol (Phila) 43:229-34. 2005..We set out to parameterize both the degree and duration of pretreatment exposure into a single, continuous measure of exposure, which will serve as the x-axis of an eventual dose-response curve... - Recurrent ibuprofen-induced aseptic meningitisHuy T V Nguyen
Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario, Canada
Ann Pharmacother 38:408-10. 2004..A detailed drug history is invaluable in the assessment of such patients, with particular attention to nonprescription medications such as ibuprofen... - N-acetylcysteine for the treatment of clove oil-induced fulminant hepatic failureJeffrey S Eisen
Department of Emergency Medicine, Queen s University, Kingston, Ontario, Canada
J Toxicol Clin Toxicol 42:89-92. 2004..Over the next 72 h her liver synthetic function and clinical status improved, and she made a complete recovery. Previous reported cases of clove oil toxicity and the potential role of N-AC therapy are reviewed... - Drugs and the QT interval - caveat doctorBarbara A Liu
Department of Medicine, University of Toronto
N Engl J Med 351:1053-6. 2004 - A case of recurrent meningitisErin B Norris
Department of Medicine, University of Toronto and Sunnybrook and Women's College Health Sciences Centre, Toronto, Ont
CMAJ 174:1093-4. 2006 - Drug safety in patients with heart failureDavid N Juurlink
Arch Intern Med 165:118. 2005 - Are selective COX 2 inhibitors superior to traditional NSAIDs? Little is known about COX 2 inhibitorsMuhammad Mamdani
BMJ 325:161; author reply 161. 2002 - Clinical consequences of generic warfarin substitution: an ecological studyJ Michael Paterson
JAMA 296:1969-72. 2006 - Do Ontario patients with heart failure have equal access to life-saving technology?Douglas S Lee
Canadian Institutes of Health Research, Canada
Healthc Q 11:20-1. 2008 - The effect of publication on Internet-based solicitation of personal-injury litigantsDavid N Juurlink
CMAJ 177:1369-70. 2007..We found that early online release and print publication were associated with an immediate and sustained increase in the number of websites soliciting plaintiffs for legal action... - Drug-induced hepatotoxicityDavid N Juurlink
N Engl J Med 349:1974-6; author reply 1974-6. 2003 - Deliberate self-poisoning in Ontario following the terrorist attacks of September 11, 2001Michael E Detsky
JAMA 294:1900-1. 2005 - Hyperbaric oxygen for carbon monoxide poisoning : a systematic review and critical analysis of the evidenceNicholas A Buckley
Department of Clinical Pharmacology and Toxicology, Australian National University Medical School, Canberra, Australian Capital Territory
Toxicol Rev 24:75-92. 2005..Such research should not exclude patients with severe poisoning, have a primary outcome that is clinically meaningful and have oversight from an independent data monitoring and ethics committee... - Kappa statisticDavid N Juurlink
CMAJ 173:16; author reply 17. 2005 - Pseudoephedrine-induced toxic epidermal necrolysisJeffrey J Nagge
Arch Dermatol 141:907-8. 2005 - Identifying individuals with a reduced GFR using ambulatory laboratory database surveillanceAmit X Garg
Division of Nephrology, University of Western Ontario, London Kidney Clinical Research Unit, Room A01, Westminster Tower, London Health Sciences Centre, 800 Commissioners Road East, London, Ontario N6A 4G5, Canada
J Am Soc Nephrol 16:1433-9. 2005..Whether such identification leads to improved health outcomes warrants further study... - Withholding 4-methylpyrazole pretreatment in suspected toxic alcohol ingestionsMarco L A Sivilotti
Acad Emerg Med 12:574-5. 2005