Tamas Fulop

Summary

Country: Canada

Publications

  1. ncbi The role of lipid rafts in T lymphocyte signal transduction with aging
    Tamas Fulop
    , Center on Aging Research, Faculty of Medicine, , Sherbrooke, QC, J1H, 4C4 Canada
    Ann N Y Acad Sci 973:302-4. 2002
  2. ncbi Cytokine receptor signalling and aging
    T Fulop
    Centre de recherche sur le vieillissement, Service de Geriatrie, Departement de Medecine, Universite de Sherbrooke, Sherbrooke, Que, Canada
    Mech Ageing Dev 127:526-37. 2006
  3. ncbi The metabolic syndrome
    T Fulop
    Research Centre on Aging, Immunology Graduate Programme, Faculty of Medicine, University of Sherbrooke, 1036, rue Belvedere Sud, Sherbrooke, Que, Canada J1H 4C4
    Pathol Biol (Paris) 54:375-86. 2006
  4. ncbi The role of elastin peptides in modulating the immune response in aging and age-related diseases
    T Fulop
    Research Center on Aging, University of Sherbrooke, 1036, rue Belvedere Sud, Sherbrooke, QC, J1H 4C4, Canada
    Pathol Biol (Paris) 60:28-33. 2012
  5. ncbi Elastin peptides induced oxidation of LDL by phagocytic cells
    Tamas Fulop
    Centre de recherche sur le vieillissement, Faculte de Medecine, Universite de Sherbrooke, Que, Canada
    Pathol Biol (Paris) 53:416-23. 2005
  6. ncbi Dysregulation of T-cell function in the elderly : scientific basis and clinical implications
    Tamas Fulop
    Immunology Program, Geriatric Division, Research Center on Aging, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada
    Drugs Aging 22:589-603. 2005
  7. ncbi Potential role of immunosenescence in cancer development
    Tamas Fulop
    Research Center on Aging, Department of Medicine, University of Sherbrooke, Sherbrooke, Canada
    Ann N Y Acad Sci 1197:158-65. 2010
  8. ncbi Ageing, autoimmunity and arthritis: Perturbations of TCR signal transduction pathways with ageing - a biochemical paradigm for the ageing immune system
    Tamas Fulop
    Research Center on Ageing, Sherbrooke Geriatric University Institute, University of Sherbrooke, Quebec, Canada
    Arthritis Res Ther 5:290-302. 2003
  9. ncbi Insulin receptor and ageing
    Tamas Fulop
    Centre de recherche sur le vieillissement, Institut Universitaire de Gériatrie, Service de Geriatrie, Departement de Medecine, Faculte de Medecine, Universite de Sherbrooke, Sherbrooke, Que, Canada J1H 4C4
    Pathol Biol (Paris) 51:574-80. 2003
  10. ncbi Aging, frailty and age-related diseases
    T Fulop
    Research Center on Aging, Immunology Program, Geriatric Division, Faculty of Medicine, University of Sherbrooke, Sherbrooke, QC, Canada
    Biogerontology 11:547-63. 2010

Collaborators

Detail Information

Publications42

  1. ncbi The role of lipid rafts in T lymphocyte signal transduction with aging
    Tamas Fulop
    , Center on Aging Research, Faculty of Medicine, , Sherbrooke, QC, J1H, 4C4 Canada
    Ann N Y Acad Sci 973:302-4. 2002
  2. ncbi Cytokine receptor signalling and aging
    T Fulop
    Centre de recherche sur le vieillissement, Service de Geriatrie, Departement de Medecine, Universite de Sherbrooke, Sherbrooke, Que, Canada
    Mech Ageing Dev 127:526-37. 2006
    ..In this review we summarise our present knowledge on cytokine signalling with ageing, mainly focusing on IL-2 and IL-6 receptors signalling...
  3. ncbi The metabolic syndrome
    T Fulop
    Research Centre on Aging, Immunology Graduate Programme, Faculty of Medicine, University of Sherbrooke, 1036, rue Belvedere Sud, Sherbrooke, Que, Canada J1H 4C4
    Pathol Biol (Paris) 54:375-86. 2006
    ..More research is needed to bring new therapies to be able to decrease the incidence and prevalence of the MS among the population and thus increasing their quality of life...
  4. ncbi The role of elastin peptides in modulating the immune response in aging and age-related diseases
    T Fulop
    Research Center on Aging, University of Sherbrooke, 1036, rue Belvedere Sud, Sherbrooke, QC, J1H 4C4, Canada
    Pathol Biol (Paris) 60:28-33. 2012
    ..This review will describe the putative contribution of elastin peptides to inflamm-aging and extend on their role on immunosenescence, as well as on age-associated chronic inflammatory diseases...
  5. ncbi Elastin peptides induced oxidation of LDL by phagocytic cells
    Tamas Fulop
    Centre de recherche sur le vieillissement, Faculte de Medecine, Universite de Sherbrooke, Que, Canada
    Pathol Biol (Paris) 53:416-23. 2005
    ..In our present study, the HDL was able to decrease the LDL oxidation by KE. This is a new mechanism by which elastin peptides might participate in the initiation and progression of the atherosclerotic process...
  6. ncbi Dysregulation of T-cell function in the elderly : scientific basis and clinical implications
    Tamas Fulop
    Immunology Program, Geriatric Division, Research Center on Aging, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada
    Drugs Aging 22:589-603. 2005
    ..Considering the public health consequences of decreased immune competence in old age, strategies for immune response modulation are desirable to decrease the health burden for the elderly and improve their quality of life...
  7. ncbi Potential role of immunosenescence in cancer development
    Tamas Fulop
    Research Center on Aging, Department of Medicine, University of Sherbrooke, Sherbrooke, Canada
    Ann N Y Acad Sci 1197:158-65. 2010
    ..Understanding the contribution of immunosenescence to cancer development and progression may lead to better interventions for the elderly...
  8. ncbi Ageing, autoimmunity and arthritis: Perturbations of TCR signal transduction pathways with ageing - a biochemical paradigm for the ageing immune system
    Tamas Fulop
    Research Center on Ageing, Sherbrooke Geriatric University Institute, University of Sherbrooke, Quebec, Canada
    Arthritis Res Ther 5:290-302. 2003
    ..The putative contribution of altered T-cell signalling with ageing in the development of autoimmune diseases will be also discussed...
  9. ncbi Insulin receptor and ageing
    Tamas Fulop
    Centre de recherche sur le vieillissement, Institut Universitaire de Gériatrie, Service de Geriatrie, Departement de Medecine, Faculte de Medecine, Universite de Sherbrooke, Sherbrooke, Que, Canada J1H 4C4
    Pathol Biol (Paris) 51:574-80. 2003
    ..The understanding of the IR physiology with ageing will help to develop more adequate preventive and therapeutic strategies in order to decrease the burden of the complications related to insulin resistance...
  10. ncbi Aging, frailty and age-related diseases
    T Fulop
    Research Center on Aging, Immunology Program, Geriatric Division, Faculty of Medicine, University of Sherbrooke, Sherbrooke, QC, Canada
    Biogerontology 11:547-63. 2010
    ..This review will focus on the relationship between aging, frailty and age-related diseases, and will highlight possible interventions to reduce the occurrence and effects of frailty in elderly people...
  11. ncbi Immunosupportive therapies in aging
    Tamas Fulop
    Research Center on Aging, Immunology Program, Geriatric Division, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada
    Clin Interv Aging 2:33-54. 2007
    ..We will then discuss possible interventions that might one day become applicable in an appropriate ethical environment...
  12. ncbi Impairment of SHP-1 down-regulation in the lipid rafts of human neutrophils under GM-CSF stimulation contributes to their age-related, altered functions
    Carl F Fortin
    Laboratory for Immunology, Research Center on Aging, Clinical Research Center, and Department of Medicine, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada
    J Leukoc Biol 79:1061-72. 2006
    ..Our results suggest an alteration of the SHP-1 modulation by GM-CSF in lipid rafts of PMN with aging. These alterations could contribute to the decreased GM-CSF effects on PMN...
  13. ncbi Effects of aging on triggering receptor expressed on myeloid cells (TREM)-1-induced PMN functions
    Carl F Fortin
    Immunology Graduate Program, Clinical Research Center, University of Sherbrooke, 3001, 12eme Avenue Nord, Sherbrooke, Que, Canada J1H 5N4
    FEBS Lett 581:1173-8. 2007
    ..The observed alterations in TREM-1 response are possibly an important contributing factor in the higher incidence of sepsis-related deaths in the elderly population...
  14. ncbi Antioxidant-rich food intakes and their association with blood total antioxidant status and vitamin C and E levels in community-dwelling seniors from the Quebec longitudinal study NuAge
    Abdelouahed Khalil
    Research Centre on Aging, Department of Medicine, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Canada
    Exp Gerontol 46:475-81. 2011
    ..25, P<0.025). These results highlight associations between ARF consumption and circulating levels of antioxidants in the elderly and suggest benefits from antioxidant-rich foods during aging...
  15. ncbi Do membrane rafts contribute to human immunosenescence?
    Andru Tomoiu
    Research Center on Aging, Immunology Program, Geriatric Division, Faculty of Medicine, University of Sherbrooke, 1036 rue Belvedere sud, Sherbrooke J1H 4C4, Quebec, Canada
    Ann N Y Acad Sci 1100:98-110. 2007
    ..The alterations in membrane rafts composition and function can underline this altered activation of T cells with aging and then contribute to human immunosenescence. The experimental data in favor of this hypothesis will be reviewed...
  16. ncbi GM-CSF activates the Jak/STAT pathway to rescue polymorphonuclear neutrophils from spontaneous apoptosis in young but not elderly individuals
    Carl F Fortin
    Department of Medicine, Research Center on Aging, Laboratory of Biogerontology, Sherbrooke Geriatric University Institute, 1036, rue Belvedere Sud, J1H 4C4 Sherbrooke, QC, Canada
    Biogerontology 8:173-87. 2007
    ....
  17. ncbi Presence and active synthesis of the 67 kDa elastin-receptor in human circulating white blood cells
    Anis Larbi
    Laboratoire de Bio gérontologie, Centre de recherche sur le vieillissement, Institut Universitaire de Gériatrie, Departement de Medecine, Universite de Sherbrooke, Sherbrooke, Que, Canada
    Biochem Biophys Res Commun 332:787-92. 2005
    ..The presence of El-R is very important for the interaction of circulating cell with the matrix as these cells intervene during atherosclerosis and in host defence...
  18. ncbi Signal transduction and functional changes in neutrophils with aging
    Tamas Fulop
    Centre de recherche sur le vieillissement, Institut Universitaire de Gériatrie, Programme d Immunologie, Universite de Sherbrooke, Sherbrooke, Quebec J1H 4C4, Canada
    Aging Cell 3:217-26. 2004
    ..Alterations were also found in the neutrophil membrane lipid rafts. These alterations in neutrophil functions and signal transduction that occur during aging might contribute to the significant increase in infections in old age...
  19. ncbi Effects of TREM-1 activation in human neutrophils: activation of signaling pathways, recruitment into lipid rafts and association with TLR4
    Carl F Fortin
    Immunology Graduate Program, Clinical Research Center, Faculty of Medicine, University of Sherbrooke, Quebec J1H 4C4, Canada
    Int Immunol 19:41-50. 2007
    ..These data shed a new light on how various receptors implicated in the innate immune response could interact to insure an efficient inflammatory response upon pathogens-associated aggression...
  20. ncbi Sepsis, leukocytes, and nitric oxide (NO): an intricate affair
    Carl F Fortin
    Pulmonary Division and Groupe de Physiopathologie Respiratoire, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Shock 33:344-52. 2010
    ..Consequently, the manipulation of NO distribution in septic patients, used in conjunction with conventional treatments aimed at restoring normal immune functions, may represent a valuable therapeutic strategy...
  21. ncbi T cell response in aging: influence of cellular cholesterol modulation
    Tamas Fulop
    Research Center on Aging, University of Sherbrooke, Sherbrooke, J1H 4C4, , Canada
    Adv Exp Med Biol 584:157-69. 2006
  22. ncbi Aging, immunity, and cancer
    Tamas Fulop
    Research Center on Aging, University of Sherbrooke, Quebec, Canada
    Discov Med 11:537-50. 2011
    ..Future research will unravel new aspects of the immune response against tumors which will be modulable to decrease the burden of cancer in elderly individuals...
  23. ncbi Aging and neutrophils: there is still much to do
    Carl F Fortin
    Pulmonary Division, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada
    Rejuvenation Res 11:873-82. 2008
    ..Furthermore, we discuss how aging potentially affects the production and release of mediators by human neutrophils in ways that may contribute to the development of these pathologies...
  24. ncbi MT6-MMP is present in lipid rafts and faces inward in living human PMNs but translocates to the cell surface during neutrophil apoptosis
    Carl F Fortin
    Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
    Int Immunol 22:637-49. 2010
    ..Collectively, these results provide new insights on the role of MT6-MMP in the physiology of human PMNs...
  25. ncbi The role of Mcl-1 and Bax expression alteration in the decreased rescue of human neutrophils from apoptosis by GM-CSF with aging
    Tamas Fulop
    , Center on Aging Research, Department of Medicine, , Faculty of Medicine, , Sherbrooke, Quebec J1H 4C4, Canada
    Ann N Y Acad Sci 973:305-8. 2002
  26. ncbi Frailty in the elderly is associated with insulin resistance of glucose metabolism in the postabsorptive state only in the presence of increased abdominal fat
    Eric D B Goulet
    McGill Nutrition and Food Science Centre, MUHC Royal Victoria Hospital, Montreal, Que, Canada
    Exp Gerontol 44:740-4. 2009
    ..5% and 8.5% of the variance in IS. Increased abdominal obesity is associated with IR in frail elderly. Non-obese frail persons are not more IR than their healthy counterparts...
  27. ncbi Musical structural determinants of emotional judgments in dementia of the Alzheimer type
    Lise Gagnon
    Research Center on Aging, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Neuropsychology 23:90-7. 2009
    ..These results constitute a preliminary empirical demonstration that, in early DAT, musical emotional judgments appear to be based on normal structural analysis of musical input...
  28. ncbi Impairment of the ABCA1 and SR-BI-mediated cholesterol efflux pathways and HDL anti-inflammatory activity in Alzheimer's disease
    Abdelouahed Khalil
    Research Centre on Aging, University of Sherbrooke, Sherbrooke, Quebec, Canada
    Mech Ageing Dev 133:20-9. 2012
    ..In conclusion, our study provides evidence for the first time that the functionality of HDL is impaired in AD and that this alteration might be caused by AD-associated oxidative stress and inflammation...
  29. ncbi Effects of vitamin C supplementation on antioxidants and lipid peroxidation markers in elderly subjects with type 2 diabetes
    Daniel M Tessier
    Biogerontology Laboratory, Research Center on Aging, Sherbrooke Geriatric University Institute, 375 Rue Argyll, Sherbrooke, QC J1J 3H5, Canada
    Arch Gerontol Geriatr 48:67-72. 2009
    ..These changes are not sufficient to decrease the LDL susceptibility to peroxidation...
  30. ncbi Modulation of T-cell signalling by non-esterified fatty acids
    Pascal Brassard
    Department of Medicine and Centre de recherche Clinique Etienne Le Bel, Faculty of Medicine, Universite de Sherbrooke, QC, Canada
    Prostaglandins Leukot Essent Fatty Acids 77:337-43. 2007
    ..Further mechanistic studies and randomized controlled clinical trials are needed to assess more accurately their effects in healthy and pathological states...
  31. ncbi Age-related decrease in high-density lipoproteins antioxidant activity is due to an alteration in the PON1's free sulfhydryl groups
    Leila Jaouad
    Centre de recherche sur le vieillissement, , Sherbrooke, Que, Canada J1H4C4
    Atherosclerosis 185:191-200. 2006
    ..There was a significant decrease in the number of free sulfhydryls between Y-PON1 and E-PON1 with respect to cysteine-284 amino acid residues (p<0.0092)...
  32. ncbi Putative role of 67 kDa elastin-laminin receptor in tumor invasion
    Tamas Fulop
    Departement de Medecine, Center de recherché sur le vieillissement, Service de Geriatrie, Institut Universitaire de Geriatrie de Sherbrooke, 1036 rue Belvedere sud, Sherbrooke, Que, Canada J1H 4C4
    Semin Cancer Biol 12:219-29. 2002
    ..In this review we will concentrate on the putative role of the 67 kDa ELR subunit in tumor invasion...
  33. ncbi Immunosenescence and vaccination in nursing home residents
    Tamas Fulop
    Research Center on Aging, Immunology Program, Geriatric Division, Faculty of Medicine, University of Sherbrooke, Quebec, Canada
    Clin Infect Dis 48:443-8. 2009
    ..Research efforts should continue attempts to elucidate the immunological basis of impaired immunity in nursing home residents to design improved prevention strategies for this vulnerable group...
  34. ncbi Brain fuel metabolism, aging, and Alzheimer's disease
    Stephen Cunnane
    Research Center on Aging, Health and Social Services Center Sherbrooke University Geriatrics Institute, Universite de Sherbrooke, Sherbrooke, QC, Canada
    Nutrition 27:3-20. 2011
    ....
  35. ncbi Study of factors influencing the decreased HDL associated PON1 activity with aging
    Ildiko Seres
    First Department of Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
    Exp Gerontol 39:59-66. 2004
    ..Altogether our results suggest that the decrease in PON1 activity may be related to the development of oxidative stress conditions with aging and the increased HDL susceptibility to oxidation in elderly subjects...
  36. ncbi Zinc status, psychological and nutritional assessment in old people recruited in five European countries: Zincage study
    Fiorella Marcellini
    Social Gerontology Unit, Res Dept, INRCA Italian National Research Centres on Ageing, Via S Margherita 5, 60100, Ancona, Italy
    Biogerontology 7:339-45. 2006
    ....
  37. ncbi Mediterranean diet and plasma concentration of inflammatory markers in old and very old subjects in the ZINCAGE population study
    George V Dedoussis
    Department of Nutrition Science and Dietetics, Harokopio University of Athens, Athens, Greece
    Clin Chem Lab Med 46:990-6. 2008
    ..The Mediterranean diet has been suggested as a determinant of longevity. In the current study, we investigated the impact of the Mediterranean diet on inflammatory status in old subjects...
  38. ncbi Host resistance and immune responses in advanced age
    Steven C Castle
    Geriatric Research Education and Clinical Center GRECC mail code 11G, VA Greater Los Angeles Healthcare System, UCLA School of Medicine, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Clin Geriatr Med 23:463-79, v. 2007
    ....
  39. ncbi Zinc, metallothioneins, and longevity--effect of zinc supplementation: zincage study
    Eugenio Mocchegiani
    Immunology Center Section Nutrigenomic and Immunosenescence, Research Department, Italian National Research Center on Ageing, Ancona, Italy
    Ann N Y Acad Sci 1119:129-46. 2007
    ....
  40. ncbi NF-kappaB, AP-1, Zinc-deficiency and aging
    Georges Herbein
    Department of Virology, IFR 133, EA 3186, Franche Comte University, F 25030, Besancon, France
    Biogerontology 7:409-19. 2006
    ..In this review we summarize our present knowledge on NF-kappaB and AP-1 activation and underline the role of Zn in this process, especially in the context of Zn deficiency observed in aged persons leading to immunosenescence...
  41. ncbi Nef and TNFalpha are coplayers that favor HIV-1 replication in monocytic cells and primary macrophages
    Georges Herbein
    Department of Virology, University of Franche Comte, Besancon, France
    Curr HIV Res 6:117-29. 2008
    ....
  42. ncbi Engineering anticancer T cells for extended functional longevity
    Graham Pawelec
    Center for Medical Research, ZMF, University of Tubingen Medical School, Waldhornlestrasse 22, D 72072 Tuebingen, Germany
    Ann N Y Acad Sci 1019:178-85. 2004
    ....