Ghislaine Fontes

Summary

Country: Canada

Publications

  1. ncbi Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells
    Ghislaine Fontes
    Montreal Diabetes Research Center, CRCHUM, University of Montreal, Quebec, Canada
    Diabetes 58:2048-58. 2009
  2. ncbi Lack of preservation of insulin gene expression by a glucagon-like peptide 1 agonist or a dipeptidyl peptidase 4 inhibitor in an in vivo model of glucolipotoxicity
    Ghislaine Fontes
    Montreal Diabetes Research Center, CRCHUM, University of Montreal, QC, Canada
    Diabetes Res Clin Pract 87:322-8. 2010
  3. ncbi Binding of activating transcription factor 6 to the A5/Core of the rat insulin II gene promoter does not mediate its transcriptional repression
    Julie Amyot
    Montreal Diabetes Research Center, Centre de recherche du Centre hospitalier de l Université de Montréal CRCHUM, Technopole Angus, 2901 Rachel Est, Montreal, Quebec H1W 4A4, Canada
    J Mol Endocrinol 47:273-83. 2011
  4. ncbi Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets
    Derek K Hagman
    DVM, Montreal Diabetes Research Center, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Technopole Angus, 2901 Rachel Est, Montreal, QC, H1W 4A4, Canada
    Diabetes 57:424-31. 2008
  5. ncbi Lipopolysaccharides Impair Insulin Gene Expression in Isolated Islets of Langerhans via Toll-Like Receptor-4 and NF-?B Signalling
    Julie Amyot
    Montreal Diabetes Research Center, Centre de recherche du Centre hospitalier de l Université de Montréal CRCHUM, Montreal, Quebec, Canada
    PLoS ONE 7:e36200. 2012
  6. ncbi Glucolipotoxicity of the pancreatic beta cell
    Vincent Poitout
    Montreal Diabetes Research Center, CRCHUM, Department of Medicine, University of Montreal, Montreal, QC, Canada
    Biochim Biophys Acta 1801:289-98. 2010

Collaborators

Detail Information

Publications6

  1. ncbi Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells
    Ghislaine Fontes
    Montreal Diabetes Research Center, CRCHUM, University of Montreal, Quebec, Canada
    Diabetes 58:2048-58. 2009
    ..This study aimed to ascertain the role of extracellular-regulated kinases (ERKs)1/2, protein kinase B (PKB), and Per-Arnt-Sim kinase (PASK) in palmitate inhibition of insulin gene expression in pancreatic beta-cells...
  2. ncbi Lack of preservation of insulin gene expression by a glucagon-like peptide 1 agonist or a dipeptidyl peptidase 4 inhibitor in an in vivo model of glucolipotoxicity
    Ghislaine Fontes
    Montreal Diabetes Research Center, CRCHUM, University of Montreal, QC, Canada
    Diabetes Res Clin Pract 87:322-8. 2010
    ..Prolonged exposure of pancreatic beta-cells to elevated levels of glucose and fatty acids adversely affects insulin secretion and gene expression...
  3. ncbi Binding of activating transcription factor 6 to the A5/Core of the rat insulin II gene promoter does not mediate its transcriptional repression
    Julie Amyot
    Montreal Diabetes Research Center, Centre de recherche du Centre hospitalier de l Université de Montréal CRCHUM, Technopole Angus, 2901 Rachel Est, Montreal, Quebec H1W 4A4, Canada
    J Mol Endocrinol 47:273-83. 2011
    ..Therefore, although ATF6 binds directly to the A5/Core of the rat insulin II gene promoter, this direct binding does not appear to contribute to its repressive activity...
  4. ncbi Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets
    Derek K Hagman
    DVM, Montreal Diabetes Research Center, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Technopole Angus, 2901 Rachel Est, Montreal, QC, H1W 4A4, Canada
    Diabetes 57:424-31. 2008
    ..Whether such a phenomenon also occurs in vivo is unknown. Our objective was therefore to ascertain whether chronic nutrient oversupply inhibits insulin gene expression in vivo...
  5. ncbi Lipopolysaccharides Impair Insulin Gene Expression in Isolated Islets of Langerhans via Toll-Like Receptor-4 and NF-?B Signalling
    Julie Amyot
    Montreal Diabetes Research Center, Centre de recherche du Centre hospitalier de l Université de Montréal CRCHUM, Montreal, Quebec, Canada
    PLoS ONE 7:e36200. 2012
    ..In this study, we tested the hypothesis that LPS alters insulin gene expression via TLR4 and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-?B) in islets...
  6. ncbi Glucolipotoxicity of the pancreatic beta cell
    Vincent Poitout
    Montreal Diabetes Research Center, CRCHUM, Department of Medicine, University of Montreal, Montreal, QC, Canada
    Biochim Biophys Acta 1801:289-98. 2010
    ..It is therefore likely that glucolipotoxicity contributes to beta-cell failure in type 2 diabetes as well as to the decline in beta-cell function observed after the onset of the disease...