Jonathan P Wong

Summary

Affiliation: Defence Research and Development Canada
Country: Canada

Publications

  1. ncbi Nucleic acid-based antiviral drugs against seasonal and avian influenza viruses
    J P Wong
    Defence R and D Canada Suffield, Ralston, AB, Canada
    Vaccine 25:3175-8. 2007
  2. ncbi Immunoprophylactic strategies against respiratory influenza virus infection
    E G Saravolac
    Chemical and Biological Defence Section, Defence Research Establishment Suffield, Box 4000 Station Main, Alberta, T1A 8K6, Medicine Hat, Canada
    Vaccine 19:2227-32. 2001
  3. ncbi Aerosol and nasal delivery of vaccines and antiviral drugs against seasonal and pandemic influenza
    Jonathan P Wong
    Defence R and D Canada Suffield, Box 4000 Station Main, Medicine Hat, Alberta T1A8K6, Canada
    Expert Rev Respir Med 4:171-7. 2010
  4. ncbi Prophylaxis of acute respiratory virus infections using nucleic acid-based drugs
    Jonathan P Wong
    Defence R and D Canada Suffield, Alberta, Canada
    Vaccine 23:2266-8. 2005
  5. ncbi Liposome delivery of ciprofloxacin against intracellular Francisella tularensis infection
    Jonathan P Wong
    Chemical and Biological Defence Section, Defence R and D Canada Suffield, Box 4000 Station Main, Medicine Hat, Alberta, Canada T1A 8K6
    J Control Release 92:265-73. 2003
  6. ncbi Activation of toll-like receptor signaling pathway for protection against influenza virus infection
    J P Wong
    Biotechnology Section, Defence R and D Canada Suffield, Ralston, Alberta, Canada
    Vaccine 27:3481-3. 2009
  7. ncbi Broad-spectrum drugs against viral agents
    Mary E Christopher
    Defence Research and Development Canada Suffield, Box 4000, Station Main, Medicine Hat, AB, Canada T1A 8K6 E Mail J W
    Int J Mol Sci 9:1561-94. 2008
  8. ncbi Antiviral role of toll-like receptor-3 agonists against seasonal and avian influenza viruses
    J P Wong
    Molecular Biology Group, Biotechnology Section, Defence R and D Canada Suffield, Ralston, Alberta, Canada
    Curr Pharm Des 15:1269-74. 2009
  9. ncbi Broad-spectrum and virus-specific nucleic acid-based antivirals against influenza
    Jonathan P Wong
    Molecular Biology Group, Biotechnology Section, Defence Research and Development Canada Suffield, Ralston, Alberta, Canada
    Front Biosci (Schol Ed) 2:791-800. 2010
  10. ncbi Infectivity variation and genetic diversity among strains of Western equine encephalitis virus
    Les P Nagata
    Chemical and Biological Defence Section, Defence Research and Development Canada Suffield, Station Main, Medicine Hat, AB T1A 8K6, Canada
    J Gen Virol 87:2353-61. 2006

Collaborators

  • M Wang
  • Wei Gang Hu
  • Murray J Cairns
  • Carlos F Lange
  • George G Brownlee
  • W H Finlay
  • Les P Nagata
  • Mary E Christopher
  • Edward G Saravolac
  • M E Christopher
  • Fay L Schmaltz
  • George A Rayner
  • Lyle G Sweeney
  • Daqing Wang
  • Roderic M K Dale
  • Tejas R Desai
  • E G Saravolac
  • M C Long
  • Damon Chau
  • Michael Parker
  • Christine Chan
  • Dipankar Das
  • Mavanur R Suresh
  • Saad A Masri
  • David Proll
  • Scott Jager
  • Raimar Loebenberg
  • Josh Wu
  • Melissa C Long
  • Lellean Jebailey
  • Zhaolin Wang
  • John Samuel
  • Monika A Zabielski
  • Hongduo Li
  • Glen Schnell
  • Robert E W Hancock
  • C Crist
  • G V Ludwig
  • K Blasetti
  • L P Nagata
  • M Kende
  • H Yang
  • K E Marshall
  • B J Kearney
  • H B Levy
  • G Schnell
  • D Sabuda

Detail Information

Publications20

  1. ncbi Nucleic acid-based antiviral drugs against seasonal and avian influenza viruses
    J P Wong
    Defence R and D Canada Suffield, Ralston, AB, Canada
    Vaccine 25:3175-8. 2007
    ..The versatility and potency of nucleic acid-based drugs make them potential drug candidates for used in seasonal or pandemic influenza situations...
  2. ncbi Immunoprophylactic strategies against respiratory influenza virus infection
    E G Saravolac
    Chemical and Biological Defence Section, Defence Research Establishment Suffield, Box 4000 Station Main, Alberta, T1A 8K6, Medicine Hat, Canada
    Vaccine 19:2227-32. 2001
    ..These results suggest liposome-mediated immunoprophylactic approaches are effective in the prevention of respiratory influenza virus infection...
  3. ncbi Aerosol and nasal delivery of vaccines and antiviral drugs against seasonal and pandemic influenza
    Jonathan P Wong
    Defence R and D Canada Suffield, Box 4000 Station Main, Medicine Hat, Alberta T1A8K6, Canada
    Expert Rev Respir Med 4:171-7. 2010
    ..Since influenza is a disease with respiratory clinical manifestations, specific delivery of antiviral drugs or vaccines to the respiratory tract may represent a safe and effective approach to combat influenza...
  4. ncbi Prophylaxis of acute respiratory virus infections using nucleic acid-based drugs
    Jonathan P Wong
    Defence R and D Canada Suffield, Alberta, Canada
    Vaccine 23:2266-8. 2005
    ..Together, these studies suggest nucleic acid-based immunomodulators are promising antiviral agents which can offer effective and non-specific protection against acute respiratory virus infections...
  5. ncbi Liposome delivery of ciprofloxacin against intracellular Francisella tularensis infection
    Jonathan P Wong
    Chemical and Biological Defence Section, Defence R and D Canada Suffield, Box 4000 Station Main, Medicine Hat, Alberta, Canada T1A 8K6
    J Control Release 92:265-73. 2003
    ..These results suggest that liposome encapsulation of ciprofloxacin enhances drug delivery to the primary site of infection and results in increasing therapeutic efficacy against F. tularensis...
  6. ncbi Activation of toll-like receptor signaling pathway for protection against influenza virus infection
    J P Wong
    Biotechnology Section, Defence R and D Canada Suffield, Ralston, Alberta, Canada
    Vaccine 27:3481-3. 2009
    ..Taken together, these results do support the potential role of TLR-3 and TLR-9 agonists such as Poly ICLC and LE Poly ICLC in protection against lethal seasonal and HPAI virus infection...
  7. ncbi Broad-spectrum drugs against viral agents
    Mary E Christopher
    Defence Research and Development Canada Suffield, Box 4000, Station Main, Medicine Hat, AB, Canada T1A 8K6 E Mail J W
    Int J Mol Sci 9:1561-94. 2008
    ..These may offer protection against various bacterial and viral pathogens regardless of their genetic makeup, zoonotic origin or drug resistance...
  8. ncbi Antiviral role of toll-like receptor-3 agonists against seasonal and avian influenza viruses
    J P Wong
    Molecular Biology Group, Biotechnology Section, Defence R and D Canada Suffield, Ralston, Alberta, Canada
    Curr Pharm Des 15:1269-74. 2009
    ....
  9. ncbi Broad-spectrum and virus-specific nucleic acid-based antivirals against influenza
    Jonathan P Wong
    Molecular Biology Group, Biotechnology Section, Defence Research and Development Canada Suffield, Ralston, Alberta, Canada
    Front Biosci (Schol Ed) 2:791-800. 2010
    ..In summary, nucleic acid-based antiviral agents are versatile, diverse and could complement existing antiviral drugs in combating influenza...
  10. ncbi Infectivity variation and genetic diversity among strains of Western equine encephalitis virus
    Les P Nagata
    Chemical and Biological Defence Section, Defence Research and Development Canada Suffield, Station Main, Medicine Hat, AB T1A 8K6, Canada
    J Gen Virol 87:2353-61. 2006
    ..Furthermore, potential amino acid differences in some positions between the two groups were identified, suggesting that these amino acid variations contributed to the observed differences in virulence...
  11. ncbi Spray-freeze-dried liposomal ciprofloxacin powder for inhaled aerosol drug delivery
    Lyle G Sweeney
    Department of Mechanical Engineering, University of Alberta, Aerosol Research Laboratory of Alberta, Edmonton, AB, Canada
    Int J Pharm 305:180-5. 2005
    ..5% in isotonic saline, 80% in bovine mucin, 75% in porcine mucus and 73% in five-fold-diluted ex vivo human cystic fibrosis patient sputum...
  12. ncbi Liposome-mediated immunotherapy against respiratory influenza virus infection using double-stranded RNA poly ICLC
    J P Wong
    Medical Countermeasures Section, Defence Research Establishment Suffield, Medicine Hat, Ralston, Alta, Canada
    Vaccine 17:1788-95. 1999
    ....
  13. ncbi A novel approach to the pulmonary delivery of liposomes in dry powder form to eliminate the deleterious effects of milling
    Tejas R Desai
    Aerosol Research Laboratory of Alberta, Department of Mechanical Engineering, University of Alberta, Edmonton, Alberta, Canada, T6G 2G8
    J Pharm Sci 91:482-91. 2002
    ..2 +/- 1.4% for ciprofloxacin, 100% for CM3 peptide, and 45.3 +/- 3.1% for salbutamol sulfate compared with a high amount of leakage (> 50%) observed due to jet-milling of lyophilized liposome formulations encapsulating ciprofloxacin...
  14. ncbi Efficacy of DNA vaccination against western equine encephalitis virus infection
    Les P Nagata
    Chemical Biological Defence Section, Defence R and D Canada Suffield, Box 4000, Station Main, Medicine Hat, Alta, Canada T1A 8K6
    Vaccine 23:2280-3. 2005
    ..The efficacy results suggest a DNA vaccine may be a promising approach against WEE infection...
  15. ncbi DNA vaccination against respiratory influenza virus infection
    J P Wong
    Chemical and Biological Defence Section, Defence Research Establishment Suffield, Box 4000 Station Main, Alta, T1A 8K6, Medicine Hat, Canada
    Vaccine 19:2461-7. 2001
    ..These results suggest DNA vaccines encapsulated in liposomes are efficacious in inducing complete protective immunity against respiratory influenza virus infection...
  16. ncbi Recent developments in delivery of nucleic acid-based antiviral agents
    M E Christopher
    Chemical and Biological Defence Section, Defence R and D Canada - Suffield, Ralston, Alberta, Canada
    Curr Pharm Des 12:1995-2006. 2006
    ..Research is ongoing to increase drug delivery to the desired target cells while eliminating adverse side effects...
  17. ncbi Pharmacokinetics study of a novel chimeric single-chain variable fragment antibody against western equine encephalitis virus
    M C Long
    Chemical and Biological Defence Section, Defence Research Establishment Suffield, Medicine Hat, Alberta, Canada
    Hybridoma 20:1-10. 2001
    ..In contrast, when administered intramuscularly to mice, the RS10B5huFc antibody was not detected in the lungs and only found in the liver and kidneys...
  18. ncbi Intranasal immunization with liposome-encapsulated plasmid DNA encoding influenza virus hemagglutinin elicits mucosal, cellular and humoral immune responses
    Daqing Wang
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada T6G 2N8
    J Clin Virol 31:S99-106. 2004
    ..Mice immunized i.n. were able to withstand a lethal challenge of influenza virus, confirming that the immune responses mediated by the vaccine were protective...
  19. ncbi Therapeutic efficacy of "nubiotics" against burn wound infection by Pseudomonas aeruginosa
    Roderic M K Dale
    Oligos Etc, Inc, Wilsonville, Oregon, USA
    Antimicrob Agents Chemother 48:2918-23. 2004
    ..These results suggest that nubiotics may be a promising and effective approach for the treatment of burn wound infection caused by P. aeruginosa...
  20. ncbi Recent Patents on development of nucleic acid-based antiviral drugs against seasonal and pandemic influenza virus infections
    Edward G Saravolac
    Acrux Ltd West Melbourne, Victoria, Australia 3003
    Recent Pat Antiinfect Drug Discov 2:140-7. 2007
    ..The review will assess the recent patents, research and development of antisense oligonucleotides, small interfering RNA, immunomodulating RNA for the prevention and treatment of influenza infection...