Research Topics
| Brent M McGrathSummaryAffiliation: Dalhousie University Country: Canada Publications
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Publications
Unlike lithium, anticonvulsants and antidepressants do not alter rat brain myo-inositolBrent M McGrath
Department of Psychiatry, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
Neuroreport 18:1595-8. 2007..This suggests that these agents might work via a mechanism that is not centered on changes in myo-inositol concentration...- Acute dextro-amphetamine administration does not alter brain myo-inositol levels in humans and animals: MRS investigations at 3 and 18.8 TBrent M McGrath
Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada T6G 2B7
Neurosci Res 61:351-9. 2008.... - Palmaria palmata (Dulse) as an unusual maritime aetiology of hyperkalemia in a patient with chronic renal failure: a case reportBrent M McGrath
Department of Medicine General Internal Medicine, Dalhousie University, and Saint John Regional Hospital, Department of Medical Education, 3DS, 400 University Avenue, PO Box 2100, Saint John, NB, E2L 4L2, Canada
J Med Case Reports 4:301. 2010..Palmaria palmata (dulse) is an edible seaweed known to be very rich in potassium. We report a case of hyperkalemia precipitated by the consumption of dulse by a patient with known renal disease... - Lithium and valproate and their possible effects on themyo-inositol second messenger system in healthy volunteers and bipolar patientsPeter H Silverstone
Department of Psychiatry, University of Alberta, Edmonton, AB, Canada T6G 2B7
Int Rev Psychiatry 21:414-23. 2009..Nonetheless, given the current technical and clinical limitations of the literature to date, this conclusion cannot be considered completely definitive... - Valproate attenuates dextroamphetamine-induced subjective changes more than lithiumMorgan C Willson
Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada
Eur Neuropsychopharmacol 15:633-9. 2005..These results suggest that lithium and valproate do not have the same mechanism of action on dextroamphetamine-induced changes, and this finding may relate to differences in their mechanism of action in mood disorders... - Lithium alters regional rat brain myo-inositol at 2 and 4 weeks: an ex-vivo magnetic resonance spectroscopy study at 18.8 TBrent M McGrath
Department of Psychiatry, National High Field Magnetic Resonance Centre, University of Alberta, Edmonton, Alberta, Canada
Neuroreport 17:1323-6. 2006..Studies suggest brain region-specific alterations in myo-inositol concentrations among bipolar patients. Our findings suggest that lithium-induced reduction of myo-inositol is more global... - Bipolar disorder and myo-inositol: a review of the magnetic resonance spectroscopy findingsPeter H Silverstone
Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada
Bipolar Disord 7:1-10. 2005..myo-Inositol concentrations can be measured in vivo with magnetic resonance spectroscopy (MRS)... - A review of the possible relevance of inositol and the phosphatidylinositol second messenger system (PI-cycle) to psychiatric disorders--focus on magnetic resonance spectroscopy (MRS) studiesHyeonjin Kim
Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada
Hum Psychopharmacol 20:309-26. 2005..More definitive investigation is required before PI-cycle dysfunction can be considered specific to bipolar disorder... - Neurobiological findings in bipolar II disorder compared with findings in bipolar I disorderBrent M McGrath
Department of Psychiatry, University of Alberta, Edmonton
Can J Psychiatry 49:794-801. 2004..Given the importance of understanding whether there are neurochemical differences between these groups, further research in this area is clearly needed...