John I Toohey

Summary

Affiliation: Cytoregulation Research
Country: Canada

Publications

  1. ncbi Mercaptopropionaldehyde from homocysteine: implications for Alzheimer's disease
    John I Toohey
    Cytoregulation Research, Elgin, Ontario, Canada
    J Alzheimers Dis 12:241-3. 2007
  2. ncbi Dehydroascorbic acid as an anti-cancer agent
    John I Toohey
    Cytoregulation Research, 2305 Opinicon Road, Elgin, Ont, Canada KOG 1EO
    Cancer Lett 263:164-9. 2008
  3. ncbi Sulfur metabolism in AIDS: cystamine as an anti-HIV agent
    John I Toohey
    Cytoregulation Research, Elgin, Ontario, Canada
    AIDS Res Hum Retroviruses 25:1057-60. 2009
  4. ncbi Homocysteine toxicity in connective tissue: theories, old and new
    John I Toohey
    Cytoregulation Research, Elgin, Ontario, Canada
    Connect Tissue Res 49:57-61. 2008
  5. ncbi Vitamin B12 and methionine synthesis: a critical review. Is nature's most beautiful cofactor misunderstood?
    John I Toohey
    Cytoregulation Research, Elgin, Ontario, Canada KOG 1EO
    Biofactors 26:45-57. 2006

Detail Information

Publications5

  1. ncbi Mercaptopropionaldehyde from homocysteine: implications for Alzheimer's disease
    John I Toohey
    Cytoregulation Research, Elgin, Ontario, Canada
    J Alzheimers Dis 12:241-3. 2007
    ..The two reactions are extremely facile and appear to be physiologically compatible suggesting a mechanism by which homocysteine may promote the deposition of proteins in nerve cells as amyloid plaques and fibrillary tangles...
  2. ncbi Dehydroascorbic acid as an anti-cancer agent
    John I Toohey
    Cytoregulation Research, 2305 Opinicon Road, Elgin, Ont, Canada KOG 1EO
    Cancer Lett 263:164-9. 2008
    ..The effectiveness of dehydroascorbic acid might be further increased by combining it with methionine and/or methotrexate to increase the homocysteine concentration in cancer cells...
  3. ncbi Sulfur metabolism in AIDS: cystamine as an anti-HIV agent
    John I Toohey
    Cytoregulation Research, Elgin, Ontario, Canada
    AIDS Res Hum Retroviruses 25:1057-60. 2009
    ..Sulfane sulfur could have two beneficial effects: (1) it could increase the vigor and resistance of the lymphocytes and (2) it could interfere with the HIV replication process. A clinical trial of cystamine in AIDS is indicated...
  4. ncbi Homocysteine toxicity in connective tissue: theories, old and new
    John I Toohey
    Cytoregulation Research, Elgin, Ontario, Canada
    Connect Tissue Res 49:57-61. 2008
    ....
  5. ncbi Vitamin B12 and methionine synthesis: a critical review. Is nature's most beautiful cofactor misunderstood?
    John I Toohey
    Cytoregulation Research, Elgin, Ontario, Canada KOG 1EO
    Biofactors 26:45-57. 2006
    ..The rearranged product is readily degraded to CH3-SH, providing a mechanism for removing toxic homocysteine...