Vladimir I Titorenko

Summary

Affiliation: Concordia University
Country: Canada

Publications

  1. ncbi The peroxisome: orchestrating important developmental decisions from inside the cell
    Vladimir I Titorenko
    Department of Biology, Concordia University, 7141 Sherbrooke St, West SP Building, Room SP 501 9, Montreal, Quebec H4B 1R6, Canada
    J Cell Biol 164:641-5. 2004
  2. ncbi Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes
    Alexander A Goldberg
    Department of Biology, Concordia University, Montreal, Quebec, Canada
    Aging (Albany NY) 2:393-414. 2010
  3. ncbi A novel function of lipid droplets in regulating longevity
    Alexander A Goldberg
    Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Room 501 9, Montreal, QC, Canada
    Biochem Soc Trans 37:1050-5. 2009
  4. ncbi A signal from inside the peroxisome initiates its division by promoting the remodeling of the peroxisomal membrane
    Tong Guo
    Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada
    J Cell Biol 177:289-303. 2007
  5. ncbi Spatiotemporal dynamics of the ER-derived peroxisomal endomembrane system
    Vladimir I Titorenko
    Department of Biology, Concordia University, Montreal, Quebec, Canada
    Int Rev Cell Mol Biol 272:191-244. 2009
  6. ncbi Xenohormetic, hormetic and cytostatic selective forces driving longevity at the ecosystemic level
    Alexander A Goldberg
    Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada
    Aging (Albany NY) 2:461-70. 2010
  7. ncbi Dynamic ergosterol- and ceramide-rich domains in the peroxisomal membrane serve as an organizing platform for peroxisome fusion
    Tatiana Boukh-Viner
    Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada
    J Cell Biol 168:761-73. 2005
  8. ncbi Lipids and lipid domains in the peroxisomal membrane of the yeast Yarrowia lipolytica
    Tatiana Boukh-Viner
    Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Room 501-9, Montreal, Quebec, Canada H4B 1R6
    Biochim Biophys Acta 1763:1688-96. 2006
  9. ncbi Peroxisome biogenesis: the peroxisomal endomembrane system and the role of the ER
    Vladimir I Titorenko
    Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada
    J Cell Biol 174:11-7. 2006
  10. ncbi Peroxisome metabolism and cellular aging
    Vladimir I Titorenko
    Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Office SP 501 9, Montreal, Quebec H4B1R6, Canada
    Traffic 12:252-9. 2011

Collaborators

  • Jan A K W Kiel
  • Troy A A Harkness
  • Stanley R Terlecky
  • M Veenhuis
  • Alexander A Goldberg
  • Tatiana Boukh-Viner
  • Pavlo Kyryakov
  • Christopher Gregg
  • Adam Beach
  • Simon D Bourque
  • Tong Guo
  • Michelle T Burstein
  • Richard A Rachubinski
  • Oleh I Petriv
  • Svetlana Milijevic
  • Gayane Machkalyan
  • Vincent Richard
  • Sonia Rampersad
  • Ann M English
  • Vivianne Wong
  • Sandra Haile
  • Jonathan Solomon
  • Jean-Marc Nicaud
  • Andrea LeBlanc
  • Gerald F Davies
  • David Y Thomas
  • Mylène Juneau
  • Anastasia Glebov
  • Vincent R Richard
  • Olivia Koupaki
  • David Cyr
  • Karen Hung Yeung San
  • Tatiana Boukh Viner
  • Simon Bourque
  • Farhana Banu
  • Alexander Goldberg
  • Robert Kyskan
  • Alex Alexandrian
  • Daniel Oren
  • Ling Tang
  • Yuriy Y Kit
  • Marie-Therese Le Dall
  • Honey Chan
  • Hojatollah Vali
  • S Kelly Sears
  • David B Pilgrim

Detail Information

Publications17

  1. ncbi The peroxisome: orchestrating important developmental decisions from inside the cell
    Vladimir I Titorenko
    Department of Biology, Concordia University, 7141 Sherbrooke St, West SP Building, Room SP 501 9, Montreal, Quebec H4B 1R6, Canada
    J Cell Biol 164:641-5. 2004
    ....
  2. ncbi Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes
    Alexander A Goldberg
    Department of Biology, Concordia University, Montreal, Quebec, Canada
    Aging (Albany NY) 2:393-414. 2010
    ....
  3. ncbi A novel function of lipid droplets in regulating longevity
    Alexander A Goldberg
    Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Room 501 9, Montreal, QC, Canada
    Biochem Soc Trans 37:1050-5. 2009
    ....
  4. ncbi A signal from inside the peroxisome initiates its division by promoting the remodeling of the peroxisomal membrane
    Tong Guo
    Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada
    J Cell Biol 177:289-303. 2007
    ..This protein team promotes membrane fission, thereby executing the terminal step of peroxisome division...
  5. ncbi Spatiotemporal dynamics of the ER-derived peroxisomal endomembrane system
    Vladimir I Titorenko
    Department of Biology, Concordia University, Montreal, Quebec, Canada
    Int Rev Cell Mol Biol 272:191-244. 2009
    ..We also critically evaluate the molecular and cellular mechanisms governing these processes, outline the most important unanswered questions, and suggest directions for future research...
  6. ncbi Xenohormetic, hormetic and cytostatic selective forces driving longevity at the ecosystemic level
    Alexander A Goldberg
    Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada
    Aging (Albany NY) 2:461-70. 2010
    ..We therefore propose that bile acids released into the environment by mammals may act as interspecies chemical signals providing longevity benefits to yeast and, perhaps, other species within an ecosystem...
  7. ncbi Dynamic ergosterol- and ceramide-rich domains in the peroxisomal membrane serve as an organizing platform for peroxisome fusion
    Tatiana Boukh-Viner
    Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada
    J Cell Biol 168:761-73. 2005
    ..Our data suggest a model for the multistep reorganization of the multicomponent peroxisome fusion machinery that transiently associates with ECR domains...
  8. ncbi Lipids and lipid domains in the peroxisomal membrane of the yeast Yarrowia lipolytica
    Tatiana Boukh-Viner
    Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Room 501-9, Montreal, Quebec, Canada H4B 1R6
    Biochim Biophys Acta 1763:1688-96. 2006
    ..We critically evaluate the molecular mechanisms through which lipid constituents of the peroxisomal membrane control these multistep processes and outline directions for future research in this field...
  9. ncbi Peroxisome biogenesis: the peroxisomal endomembrane system and the role of the ER
    Vladimir I Titorenko
    Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada
    J Cell Biol 174:11-7. 2006
    ....
  10. ncbi Peroxisome metabolism and cellular aging
    Vladimir I Titorenko
    Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Office SP 501 9, Montreal, Quebec H4B1R6, Canada
    Traffic 12:252-9. 2011
    ..At low levels, peroxisomal ROS activate an anti-aging program in the cell; at concentrations beyond a specific threshold, a pro-aging course is triggered...
  11. ncbi Effect of calorie restriction on the metabolic history of chronologically aging yeast
    Alexander A Goldberg
    Department of Biology, Concordia University, Montreal, Quebec, Canada
    Exp Gerontol 44:555-71. 2009
    ..Thus, our data suggest that longevity in chronologically aging yeast is programmed by the level of metabolic capacity and organelle organization they developed, in a diet-specific fashion, prior to entry into a non-proliferative state...
  12. ncbi Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells
    Alexander A Goldberg
    Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada
    Oncotarget 2:761-82. 2011
    ..Moreover, our finding that LCA kills cultured human breast cancer and rat glioma cells implies that it has a broad anti-tumor effect on cancer cells derived from different tissues and organisms...
  13. ncbi Peroxisome division in the yeast Yarrowia lipolytica is regulated by a signal from inside the peroxisome
    Tong Guo
    Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada
    J Cell Biol 162:1255-66. 2003
    ..This interaction inhibits the negative action of Pex16p, thereby allowing mature peroxisomes to divide...
  14. ncbi Overproduction of translation elongation factor 1-alpha (eEF1A) suppresses the peroxisome biogenesis defect in a Hansenula polymorpha pex3 mutant via translational read-through
    Jan A K W Kiel
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, The Netherlands
    FEMS Yeast Res 7:1114-25. 2007
    ..Subsequent co-overexpression of TEF2 in this strain fully restored its peroxisome biogenesis defect and resulted in the formation of major amounts of full-length Pex3p, presumably via translational read-through...
  15. ncbi A new definition for the consensus sequence of the peroxisome targeting signal type 2
    Oleh I Petriv
    Department of Cell Biology, University of Alberta, Medical Sciences Building 5-14, Edmonton, Alta, Canada T6G 2H7
    J Mol Biol 341:119-34. 2004
    ..These redefined PTS2 consensus sequences will facilitate the identification of proteins of unknown cellular localization as possible peroxisomal proteins...
  16. ncbi RNA interference of peroxisome-related genes in C. elegans: a new model for human peroxisomal disorders
    Oleh I Petriv
    Department of Cell Biology, University of Alberta, Edmonton T6G 2H7, Canada
    Physiol Genomics 10:79-91. 2002
    ..elegans as a valuable model system with which to study the molecular and physiological defects underlying the human peroxisomal disorders...
  17. ncbi Acyl-CoA oxidase is imported as a heteropentameric, cofactor-containing complex into peroxisomes of Yarrowia lipolytica
    Vladimir I Titorenko
    Department of Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    J Cell Biol 156:481-94. 2002
    ..We provide evidence that the Aox2p- and Aox3p-assisted assembly of the Aox complex in the cytosol is mandatory for its import into peroxisomes and that no component of the complex can penetrate the peroxisomal matrix as a monomer...