Research Topics
| J G PfausSummaryAffiliation: Concordia University Country: Canada Publications
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Publications
What can animal models tell us about human sexual response?James G Pfaus
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 7141 Sherbrooke St W Montréal, QC H4B 1R6, Canada
Annu Rev Sex Res 14:1-63. 2003....- Effects of pelvic, pudendal, or hypogastric nerve cuts on Fos induction in the rat brain following vaginocervical stimulationJames G Pfaus
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 7141 Sherbrooke W, Montreal, QC, Canada H4B 1R6
Physiol Behav 89:627-36. 2006..These data confirm that the pelvic nerve is largely responsible for the neural and behavioral effects of VCS, and support a separate function for the hypogastric nerve... - Naloxone, but not flupenthixol, disrupts the development of conditioned ejaculatory preference in the male ratNafissa Ismail
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, QC H4B 1R6 Canada
Behav Neurosci 123:992-9. 2009..These findings suggest that activation of opioid, but not dopamine, systems during sexual interaction are necessary for conditioned ejaculatory preference in male rats... - Differential induction of Fos in the female rat brain following different amounts of vaginocervical stimulation: modulation by steroid hormonesJ G Pfaus
Department of Psychology, Concordia University, Montreal, Que Canada
Brain Res 741:314-30. 1996..Different brain regions may participate in gating the sensory information of VCS into different behavioral and neuroendocrine events... - Selective facilitation of sexual solicitation in the female rat by a melanocortin receptor agonistJames G Pfaus
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, QC, Canada H4B 1R6
Proc Natl Acad Sci U S A 101:10201-4. 2004..Accordingly, PT-141 may be the first identified pharmacological agent with the capability to treat female sexual desire disorders... - Conditioning and sexual behavior: a reviewJ G Pfaus
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 1455 deMaisonneuve Bldg W, Montreal, Quebec, H3G 1M8 Canada
Horm Behav 40:291-321. 2001.... - Appetitive and consummatory sexual behaviors of female rats in bilevel chambers. II. Patterns of estrus termination following vaginocervical stimulationJ G Pfaus
Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, H3G 1M8, Canada
Horm Behav 37:96-107. 2000..However, the effects of VCS are dependent on the frequency of hormone priming, suggesting that hormone treatment may block some of the long-term inhibitory effects of VCS on female sexual behavior... - Neurobiology of sexual behaviorJ G Pfaus
Department of Psychology, Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, H3G 1M8, Canada
Curr Opin Neurobiol 9:751-8. 1999..Brain imaging of visually evoked sexual arousal in humans has also been examined... - Appetitive and consummatory sexual behaviors of female rats in bilevel chambers. I. A correlational and factor analysis and the effects of ovarian hormonesJ G Pfaus
Department of Psychology, Concordia University, Montreal, Quebec, H3G 1M8, Canada
Horm Behav 35:224-40. 1999.... - Vaginocervical stimulation induces Fos in glutamate neurons in the ventromedial hypothalamus: attenuation by estrogen and progesteroneMichaela Georgescu
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, QC, Canada
Horm Behav 56:450-6. 2009..In turn, this may allow females to receive a sufficient number of intromissions for the activation of sexual reward and the facilitation of pregnancy... - Neuronal activation by stimuli that predict sexual reward in female ratsG A Coria Avila
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 7141 Sherbrooke W, Montreal, QC, Canada H4B 1R6
Neuroscience 148:623-32. 2007..The significance of the brain areas activated is discussed with regard to their role in sexual and other motivated behaviors... - The development of olfactory conditioned ejaculatory preferences in the male rat. II. Parametric manipulation of conditioning session number and durationT E Kippin
Department of Psychology, Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada
Physiol Behav 73:471-85. 2001.... - Olfactory conditioned partner preference in the female ratGenaro A Coria-Avila
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Quebec, Canada
Behav Neurosci 119:716-25. 2005..Females in the paired group solicited the scented male more frequently, and most chose the scented male for their 1st ejaculation. Thus, an odor paired with paced copulation elicits conditioned partner preference in female rats... - The nature of the conditioned response mediating olfactory conditioned ejaculatory preference in the male ratT E Kippin
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Quebec, Montreal, Canada
Behav Brain Res 122:11-24. 2001..These findings suggest that the paired-trained males attend to the scented female near the point of ejaculation, and are consistent with the hypothesis that CEP is mediated by selective ejaculation... - The development of olfactory conditioned ejaculatory preferences in the male rat. I. Nature of the unconditioned stimulusT E Kippin
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Quebec, Canada
Physiol Behav 73:457-69. 2001..These findings indicate that events during the PEI are the critical components of the UCS for CEP development... - Sensory mediation of female-male mounting in the rat: II. Role of tactile and conspecific cuesVeronica M Afonso
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 7141 Sherbrooke St. W, , QC, Canada H4B 1R6
Physiol Behav 87:863-9. 2006..A positive linear relationship was found between male activity level and FMM. These data indicate that both tactile cues and cues associated with locomotor activity of the stimulus male modulate FMM... - Neurochemical basis of conditioned partner preference in the female rat: II. Disruption by flupenthixolGenaro A Coria-Avila
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Quebec, Canada
Behav Neurosci 122:396-406. 2008..The role of dopamine in conditioned partner preference depends on the type of stimuli to be learned... - Context-dependent acquisition of copulatory behavior in the male rat: role of female availabilityNafissa Ismail
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Quebec, Canada
Behav Neurosci 122:991-7. 2008..Males ejaculated preferentially with females associated with the 4-hole pacing condition. Copulatory behavior in male rats is sensitive to female availability, and females associated with greater availability are preferred... - Sensory mediation of female-male mounting in the rat: I. Role of olfactory cuesVeronica M Afonso
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 7141 Sherbrooke St. W, , QC, Canada H4B 1R6
Physiol Behav 87:857-62. 2006..These data indicate that the olfactory sense is a prime mediator of FMM, and that prior mounting experience does not offset the disruption of FMM caused by the elimination of olfactory cues... - Estrogen and the neural mediation of female-male mounting in the ratVeronica M Afonso
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Quebec, Canada H4B 1R6
Behav Neurosci 123:369-81. 2009..These data indicate that the ventromedial hypothalamus is a critical area of convergence of hormonal, olfactory, and somatosensory inputs for FMM... - Dopamine: helping males copulate for at least 200 million years: theoretical comment on Kleitz-Nelson et al. (2010)James G Pfaus
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, QC, Canada
Behav Neurosci 124:877-80; discussion 881-3. 2010..Those data suggest that the steroid-dependent role of hypothalamic DA in male sexual behavior has been conserved through evolutionary time... - Conditioned ejaculatory preference in male rats paired with haloperidol-treated femalesNafissa Ismail
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, QC, Canada H4B 1R6
Physiol Behav 100:116-21. 2010..We conclude that copulation to ejaculation at a male's preferred rate is essential for the development of CEP, as it is for the development of a sexually-conditioned place preference... - Pathways of sexual desireJames G Pfaus
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Canada
J Sex Med 6:1506-33. 2009..Sexual desire is controlled by brain systems involved in sexual excitation and inhibition. Hypoactive sexual desire disorder (HSDD) may result from hypofunctional excitation, hyperfunctional inhibition, or some mix of the two... - Inhibitory and disinhibitory effects of psychomotor stimulants and depressants on the sexual behavior of male and female ratsJames G Pfaus
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 7141 Sherbrooke W, Montreal, QC, Canada H4B 1R6
Horm Behav 58:163-76. 2010.... - Clitoral stimulation induces conditioned place preference and Fos activation in the ratMayte Parada
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, QC Canada
Horm Behav 57:112-8. 2010..These data indicate that CLS induces a reward state in the rat and a pattern of Fos activation in regions of the brain that process genitosensory input, incentive salience, and reward... - Enhanced synaptic responses in the piriform cortex associated with sexual stimulation in the male ratJ G Pfaus
Department of Psychology, Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC, H4B 1R6 Canada
Neuroscience 164:1422-30. 2009..These data indicate that short-term alterations in synaptic responsiveness occur in piriform cortex as a function of sexual stimulation in the male rat, but that responses are not significantly altered by a conditioned odor... - Neurochemical basis of conditioned partner preference in the female rat: I. Disruption by naloxoneGenaro A Coria-Avila
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Quebec
Behav Neurosci 122:385-95. 2008..The authors concluded that opioids mediated the conditioned partner preference induced by paced copulation... - Pacing conditions contribute to the conditioned ejaculatory preference for a familiar female in the male ratNafissa Ismail
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, QC, Canada H4B 1R6
Physiol Behav 96:201-8. 2009..These findings indicate that pacing conditions in which males have restricted access to the female contribute to the conditioned ejaculatory preference for familiar females bearing a neutral odor... - Estrous odors and sexually conditioned neutral odors activate separate neural pathways in the male ratT E Kippin
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, QC, Montreal, Canada
Neuroscience 117:971-9. 2003.... - Amphetamine pretreatment facilitates appetitive sexual behaviors in the female ratVeronica M Afonso
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 7141 Sherbrooke Street West, Montreal, QC, Canada
Psychopharmacology (Berl) 205:35-43. 2009..This sensitization involves an increase in mesolimbic and nigrostriatal dopamine release, and in male rats, facilitates sexual behavior... - Sexual behavior in lactating rats: role of estrogen-induced progesterone receptorsErica Barbosa-Vargas
CSBN GRNC, Concordia University, Montreal H4B 1R6, Canada
Horm Behav 56:246-53. 2009.... - Role of glutamate receptors in the ventromedial hypothalamus in the regulation of female rat sexual behaviors I. Behavioral effects of glutamate and its selective receptor agonists AMPA, NMDA and kainateMichaela Georgescu
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, , QC, Canada H4B 1R2
Pharmacol Biochem Behav 83:322-32. 2006..These data indicate that the activation of glutamate receptors in the VMH is inhibitory for both appetitive and consummatory aspects of sexual behavior in the female rat... - Conditioned partner preference in female rats for strain of maleGenaro A Coria-Avila
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 7141 Sherbrooke W, Montreal, QC, Canada H4B 1R6
Physiol Behav 88:529-37. 2006.... - Role of glutamate receptors in the ventromedial hypothalamus in the regulation of female rat sexual behaviors. II. Behavioral effects of selective glutamate receptor antagonists AP-5, CNQX, and DNQXMichaela Georgescu
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, , QC, Canada H4B 1R2
Pharmacol Biochem Behav 83:333-41. 2006..These data support the notion that glutamate receptors in the VMH contribute a strong inhibitory influence in the control of female sexual behavior... - Fecal bulking in a frequently mated female rat. Colonic obstruction due to severe vaginal distensionGenaro A Coria-Avila
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 7141 Sherbrooke West, , Quebec H4B 1R6, Canada
Lab Anim (NY) 35:20-3. 2006 - Hormonal and experiential control of female-male mounting in the female ratVeronica M Afonso
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, QC, Canada
Horm Behav 49:30-7. 2006..These data suggest that FMM occurs naturally in rats as a "super-solicitational" behavior that is modified by hormone treatment and prior heterosexual experience... - Opposing roles of the nucleus accumbens and anterior lateral hypothalamic area in the control of sexual behaviour in the male ratTod E Kippin
Center for Studies in Behavioural Neurobiology, Department of Psychology, Concordia University, Montreal, QC, H3G 1M8, Canada
Eur J Neurosci 19:698-704. 2004..These findings indicate that the aLHA plays an inhibitory role in the regulation of sexual arousal and an excitatory role in the regulation of ejaculation. Conversely, the NAc plays an excitatory role in the regulation in sexual arousal... - Timing between ejaculations changes paternity successGenaro A Coria-Avila
Center for Studies in Behavioural Neurobiology, Department of Psychology, Concordia University, 7141 Sherbrooke W, Montreal, QC, H4B 1R6, Canada
Physiol Behav 80:733-7. 2004..After 5 min, a second male has no advantage in fathering pups... - Cecum location in rats and the implications for intraperitoneal injectionsGenaro A Coria-Avila
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 7141 Sherbrooke West, Montreal, QC H4B 1R6, Canada
Lab Anim (NY) 36:25-30. 2007..Of the rats they investigated, 71.8% had ceca on the left side of the abdomen. The authors also found that injections on the left side were more likely to result in punctured ceca... - Sudden bladder distention in a female ratGenaro A Coria-Avila
Center for Studies in Behavioral Neurobiology, Psychology Department, Concordia University, Montreal, Quebec, Canada
Lab Anim (NY) 34:22-3, 24-5. 2005 - Scrotal enlargement and constipation in a male rat. Scrotal fecal (or rectoscrotal) fistulaGenaro A Coria-Avila
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 7141 Sherbrooke West, , QC H4B 1R6, Canada
Lab Anim (NY) 36:17, 18-9. 2007 - High-dose methadone maintenance in rats: effects on cocaine self-administration and behavioral side effectsFrancesco Leri
Department of Psychology, University of Guelph, Guelph, ON, Canada NIG 2WI
Neuropsychopharmacology 32:2290-300. 2007..Taken together, these results from studies in rats support the usefulness of larger doses of methadone to reduce severe cocaine abuse in opioid-dependent individuals and possibly in the management of pure-cocaine addiction... - A sexually dimorphic hypothalamic nucleus in a macaque species with frequent female-female mounting and same-sex sexual partner preferencePaul L Vasey
Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, Alta, Canada T1K 3M4
Behav Brain Res 157:265-72. 2005..This study is the first to examine the relationship between sex-atypical sexual activity and the cytoarchitecture of a hypothalamic nucleus in hormonally unmanipulated females...