R E J Mitchel

Summary

Affiliation: Chalk River
Country: Canada

Publications

  1. ncbi Depleted uranium dust from fired munitions: physical, chemical and biological properties
    R E J Mitchel
    Atomic Energy of Canada Limited, Chalk River Laboratories, Chalk River Ontario, K0J 1J0, Canada
    Health Phys 87:57-67. 2004
  2. ncbi Low-dose radiation exposure and atherosclerosis in ApoE?/? mice
    R E J Mitchel
    Radiological Protection Research and Instrumentation Branch, Atomic Energy of Canada, Chalk River, Ontario, Canada
    Radiat Res 175:665-76. 2011
  3. ncbi A lower dose threshold for the in vivo protective adaptive response to radiation. Tumorigenesis in chronically exposed normal and Trp53 heterozygous C57BL/6 mice
    R E J Mitchel
    Radiation Biology and Health Physics Branch, Atomic Energy of Canada, Ontario, Canada
    Radiat Res 170:765-75. 2008
  4. ncbi Fractionated, low-dose-rate ionizing radiation exposure and chronic ulcerative dermatitis in normal and Trp53 heterozygous C57BL/6 mice
    R E J Mitchel
    Radiation Biology and Health Physics Branch, Atomic Energy of Canada, Chalk River Ontario, K0J 1J0, Canada
    Radiat Res 168:716-24. 2007
  5. ncbi Upper dose thresholds for radiation-induced adaptive response against cancer in high-dose-exposed, cancer-prone, radiation-sensitive Trp53 heterozygous mice
    R E J Mitchel
    Radiation Biology and Health Physics Branch, Atomic Energy of Canada Limited, Chalk River Laboratories, Chalk River, Ontario, K0J 1J0 Canada
    Radiat Res 162:20-30. 2004
  6. ncbi Skin tumor promotion by Vitamin E in mice: amplification by ionizing radiation and Vitamin C
    R E J Mitchel
    Chalk River Laboratories, Radiation Biology and Health Physics Branch, Atomic Energy of Canada Limited, Chalk River, Ont, Canada KOJ 1JO
    Cancer Detect Prev 27:102-8. 2003
  7. ncbi Low doses of radiation increase the latency of spontaneous lymphomas and spinal osteosarcomas in cancer-prone, radiation-sensitive Trp53 heterozygous mice
    R E J Mitchel
    Radiation Biology and Health Physics Branch, Atomic Energy of Canada Limited, Chalk River Laboratories, Chalk River, Ontario, K0J 1J0 Canada
    Radiat Res 159:320-7. 2003
  8. ncbi Influence of prior exposure to low-dose adapting radiation on radiation-induced teratogenic effects in fetal mice with varying Trp53 function
    R E J Mitchel
    Radiation Biology and Health Physics Branch, Atomic Energy of Canada Limited, Chalk River Laboratories, Ontario, K0J 1J0 Canada
    Radiat Res 158:458-63. 2002
  9. ncbi Cancer and non-cancer risks in normal and cancer-prone Trp53 heterozygous mice exposed to high-dose radiation
    S M Carlisle
    Radiation Protection Research and Instrumentation Branch, Atomic Energy of Canada Limited, Chalk River Laboratories, Chalk River, Ontario K0J 1J0, Canada
    Radiat Res 173:40-8. 2010
  10. ncbi Radiation-induced teratogenic effects in fetal mice with varying Trp53 function: influence of prior heat stress
    D R Boreham
    Radiation Biology and Health Physics Branch, Atomic Energy of Canada Limited, Chalk River Laboratories, ON, K0J1J0 Canada
    Radiat Res 158:449-57. 2002

Collaborators

Detail Information

Publications17

  1. ncbi Depleted uranium dust from fired munitions: physical, chemical and biological properties
    R E J Mitchel
    Atomic Energy of Canada Limited, Chalk River Laboratories, Chalk River Ontario, K0J 1J0, Canada
    Health Phys 87:57-67. 2004
    ..Kidney damage was not seen with the muscle burdens tested. DU dust produced kidney damage at lower lung burdens and lower urine uranium levels than NU dust, suggesting that other toxic metals in DU dust may contribute to the damage...
  2. ncbi Low-dose radiation exposure and atherosclerosis in ApoE?/? mice
    R E J Mitchel
    Radiological Protection Research and Instrumentation Branch, Atomic Energy of Canada, Chalk River, Ontario, Canada
    Radiat Res 175:665-76. 2011
    ....
  3. ncbi A lower dose threshold for the in vivo protective adaptive response to radiation. Tumorigenesis in chronically exposed normal and Trp53 heterozygous C57BL/6 mice
    R E J Mitchel
    Radiation Biology and Health Physics Branch, Atomic Energy of Canada, Ontario, Canada
    Radiat Res 170:765-75. 2008
    ..Neither protection nor harm was observed in exposed Trp53 heterozygous mice, indicating that reduced Trp53 function raises the lower dose/ dose-rate threshold for both detrimental and protective tumorigenic effects...
  4. ncbi Fractionated, low-dose-rate ionizing radiation exposure and chronic ulcerative dermatitis in normal and Trp53 heterozygous C57BL/6 mice
    R E J Mitchel
    Radiation Biology and Health Physics Branch, Atomic Energy of Canada, Chalk River Ontario, K0J 1J0, Canada
    Radiat Res 168:716-24. 2007
    ..In mice with reduced Trp53 functionality, doses below the threshold can produce detrimental effects...
  5. ncbi Upper dose thresholds for radiation-induced adaptive response against cancer in high-dose-exposed, cancer-prone, radiation-sensitive Trp53 heterozygous mice
    R E J Mitchel
    Radiation Biology and Health Physics Branch, Atomic Energy of Canada Limited, Chalk River Laboratories, Chalk River, Ontario, K0J 1J0 Canada
    Radiat Res 162:20-30. 2004
    ..Res. 159, 320-327, 2003). However, the upper dose thresholds appear to be lower (below 100 mGy) for radiation-induced tumors than for the same tumors appearing spontaneously...
  6. ncbi Skin tumor promotion by Vitamin E in mice: amplification by ionizing radiation and Vitamin C
    R E J Mitchel
    Chalk River Laboratories, Radiation Biology and Health Physics Branch, Atomic Energy of Canada Limited, Chalk River, Ont, Canada KOJ 1JO
    Cancer Detect Prev 27:102-8. 2003
    ....
  7. ncbi Low doses of radiation increase the latency of spontaneous lymphomas and spinal osteosarcomas in cancer-prone, radiation-sensitive Trp53 heterozygous mice
    R E J Mitchel
    Radiation Biology and Health Physics Branch, Atomic Energy of Canada Limited, Chalk River Laboratories, Chalk River, Ontario, K0J 1J0 Canada
    Radiat Res 159:320-7. 2003
    ..That result suggested that this higher dose was in a transition zone between reduced and increased risk, but that the dose at which the transition occurs varies with the tumor type...
  8. ncbi Influence of prior exposure to low-dose adapting radiation on radiation-induced teratogenic effects in fetal mice with varying Trp53 function
    R E J Mitchel
    Radiation Biology and Health Physics Branch, Atomic Energy of Canada Limited, Chalk River Laboratories, Ontario, K0J 1J0 Canada
    Radiat Res 158:458-63. 2002
    ..We conclude that radiation-induced teratogenesis reflects both Trp53-dependent and independent processes that lead to apoptosis, and these respond differently to prior adapting doses...
  9. ncbi Cancer and non-cancer risks in normal and cancer-prone Trp53 heterozygous mice exposed to high-dose radiation
    S M Carlisle
    Radiation Protection Research and Instrumentation Branch, Atomic Energy of Canada Limited, Chalk River Laboratories, Chalk River, Ontario K0J 1J0, Canada
    Radiat Res 173:40-8. 2010
    ..Increased risk from high acute radiation doses contrasts with the decreased risk seen previously after low doses of radiation in both Trp53 normal and heterozygous female mice...
  10. ncbi Radiation-induced teratogenic effects in fetal mice with varying Trp53 function: influence of prior heat stress
    D R Boreham
    Radiation Biology and Health Physics Branch, Atomic Energy of Canada Limited, Chalk River Laboratories, ON, K0J1J0 Canada
    Radiat Res 158:449-57. 2002
    ..A diminished effect in the absence of functional Trp53 is consistent with an influence of heat on inhibiting DNA repair, but with a diminished probability of apoptosis...
  11. ncbi Teratogenic effects of mild heat stress during mouse embryogenesis: effect of Trp53
    D R Boreham
    Radiation Biology and Health Physics Branch, Atomic Energy of Canada Limited, Chalk River Laboratories, Ontario, K0J 1J0 Canada
    Radiat Res 158:443-8. 2002
    ..The ability of Trp53 to additionally regulate the tail lengthening process was also sensitive to the effects of heat, but that sensitivity again depended on the time of the heat stress during gestation...
  12. ncbi Dose responses for adaption to low doses of (60)Co gamma rays and (3)H beta particles in normal human fibroblasts
    E J Broome
    Radiation Biology and Health Physics, Atomic Energy of Canada Limited, Chalk River, Ontario, Canada, K0J 1J0
    Radiat Res 158:181-6. 2002
    ..The results also show that the RBE for low doses of tritium beta-particle radiation is 1, using adaption as the end point...
  13. ncbi Cytogenetic dose-response and adaptive response in cells of ungulate species exposed to ionizing radiation
    B A Ulsh
    McMaster University Institute of Applied Radiation Sciences, 1280 Main Street West, Hamilton, Ontario, Canada L8S4K1
    J Environ Radioact 74:73-81. 2004
    ..Cytogenetic assays provide affordable and feasible biological effects-based alternatives that are more biologically relevant than traditional contaminant concentration-based radioecological risk assessment...
  14. ncbi A model for the induction of chromosome aberrations through direct and bystander mechanisms
    H Schöllnberger
    Department of Material Sciences, University of Salzburg, Hellbrunnerstrasse 34, A 5020 Salzburg, Austria
    Radiat Prot Dosimetry 122:275-81. 2006
    ..A published model for bystander induced neoplastic transformation was adapted for chromosome aberration induction and used to compare the results obtained with the different models...
  15. ncbi Detrimental and protective bystander effects: a model approach
    H Schöllnberger
    Department of Materials Engineering and Physics and Biophysics, University of Salzburg, Salzburg, Austria
    Radiat Res 168:614-26. 2007
    ..This study is an important step toward a comprehensive model that contains all essential biological mechanisms that can influence dose-response curves at low doses...
  16. ncbi Enhanced biological effectiveness of low energy X-rays and implications for the UK breast screening programme
    J L Redpath
    Br J Radiol 79:854-5; author reply 855-7. 2006
  17. ncbi Explanation of protective effects of low doses of gamma-radiation with a mechanistic radiobiological model
    H Schöllnberger
    Institute of Physics and Biophysics, University of Salzburg, Hellbrunnerstr 34, Austria
    Int J Radiat Biol 78:1159-73. 2002
    ..To link important features of the model to known biological processes...