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Species | Dan C McIntyreSummaryAffiliation: Carleton University Country: Canada Publications
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Publications
Working and reference memory in seizure-prone and seizure-resistant rats: impact of amygdala kindlingDan C McLntyre
Department of Psychology, Institute for Neuroscience, Carleton University, Ottawa, ON, Canada
Behav Neurosci 118:314-23. 2004....- Kindling: some old and some newDan C McIntyre
Department of Psychology, Institute for Neuroscience, Life Science Research Building, Carleton University, Ottawa, Ont, Canada
Epilepsy Res 50:79-92. 2002..We concluded the review with our recent attempt to discover consistent and unique gene profile differences associated with the different seizure predispositions of the Fast and Slow kindling rat strains... - The parahippocampal cortices and kindlingD C McIntyre
Department of Psychology, Carleton University, Ottawa, Ontario, Canada
Ann N Y Acad Sci 911:343-54. 2000.... - Dorsal hippocampal kindling produces long-lasting changes in the origin of spontaneous discharges in the piriform versus perirhinal cortex in vitroD C McIntyre
Department of Psychology, Institute of Neuroscience, Life Science Research Building Carleton University, Ottawa, Canada
Epilepsy Res 39:191-200. 2000..The enduring changes in A-P area excitability caused by previous generalized kindling highlights the importance of the A-P area in convulsive generalization of limbic-kindled seizures... - Influence of psychogenic and neurogenic stressors on neuroendocrine and central monoamine activity in fast and slow kindling ratsD C McIntyre
Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
Brain Res 840:65-74. 1999..Similarly, DA alterations also were greater in the left medial amygdala in response to stressors. Despite very different behavioral styles, however, the two lines often exhibited similar amine alterations in response to both stressors... - Effect of focal low-frequency stimulation on amygdala-kindled afterdischarge thresholds and seizure profiles in fast- and slow-kindling rat strainsCarys A Carrington
Department of Psychology, Institute for Neuroscience, Carleton University, Ottawa, Ontario, Canada
Epilepsia 48:1604-13. 2007..To determine whether low-frequency, 1-Hz sine-wave stimulation (LFS) applied to a fully kindled amygdala focus would show antiepileptic properties in rats that were either naturally seizure prone (Fast) or seizure resistant (Slow)... - Neurosteroids exhibit differential effects on mIPSCs recorded from normal and seizure prone ratsKerstin Schwabe
Neuroscience Research Institute, Department of Psychology, Carleton University, 1125 Colonel By Dr, Ottawa Ontario, K1S 5B6 Canada
J Neurophysiol 94:2171-81. 2005..As differing GABA(A) receptors are targeted by subsets of interneurons, these data suggest these neurosteroids may selectively modulate one inhibitory input over another... - Differential GABA(A) subunit expression following status epilepticus in seizure-prone and seizure-resistant rats: a putative mechanism for refractory drug responseKrista L Gilby
Department of Psychology, Life Sciences Research Center, Carleton University, Ottawa, Ontario, Canada
Epilepsia 46:3-9. 2005..Second, we investigated whether these strains exhibit distinct molecular responses to KA with respect to GABA(A) receptor subunit expression... - Amygdala amino acid and monoamine levels in genetically Fast and Slow kindling rat strains during massed amygdala kindling: a microdialysis studyRick S Shin
Department of Psychology, Life Sciences Research Building, Carleton University, Ottawa, Ontario, K1S 5B6, Canada
Eur J Neurosci 20:185-94. 2004.... - Genetically seizure-prone or seizure-resistant phenotypes and their associated behavioral comorbiditiesDan C McIntyre
Department of Psychology, Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
Epilepsia 48:30-2. 2007..Behaviorally, the Fast rats appear much like humans with attention deficit hyperactivity disorder (ADHD), showing easy distraction, hyperactivity and impulsivity, compared to Slow rats... - Relation between startle reactivity and sucrose avidity in two rat strains bred for differential seizure susceptibilityDwayne Runke
Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada K1S 5B6
Exp Neurol 229:259-63. 2011..Thus, Fast and Slow rats may be two unique strains with which to further elucidate the genetic and neurobiological mechanisms underlying appetitive and defensive behaviors and their relation to anxiety and seizure sensitivity... - Postnatal epigenetic influences on seizure susceptibility in seizure-prone versus seizure-resistant rat strainsKrista L Gilby
Institute of Neuroscience, Life Sciences Research Center, Carleton University, Ottawa, Ontario, K1S 5B6, Canada
Behav Neurosci 123:337-46. 2009..Investigation into mechanisms fundamental to cross-fostering-induced seizure facilitation should help prevent postnatal worsening of pathology in already seizure-prone individuals... - Mapping seizure pathways in the temporal lobeDan C McIntyre
Department of Psychology, Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
Epilepsia 49:23-30. 2008.... - Conceptual, spatial, and cue learning in the Morris water maze in fast or slow kindling rats: attention deficit comorbidityHymie Anisman
Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada, K1S 5B6
J Neurosci 22:7809-17. 2002..These various attributes of the fast rats may serve as a potentially useful animal model of disorders characterized by an attention deficit... - Caloric restriction alters seizure disposition and behavioral profiles in seizure-prone (fast) versus seizure-resistant (slow) ratsAtaa Azarbar
Institute of Neuroscience, Life Sciences Research Center, Carleton University, Ottawa, Ontario, Canada
Behav Neurosci 124:106-14. 2010..These results clearly endorse further investigation into the potential benefits of CR for both epilepsy and ADHD... - Differential noradrenergic influence on seizure expression in genetically Fast and Slow kindling rat strains during massed trial stimulation of the amygdalaRick S Shin
Institute of Neuroscience, Department of Psychology, Life Sciences Research Building, Carleton University, Ottawa, Ontario K1S 5B6, Canada
Neuropharmacology 52:321-32. 2007.... - Ruling out postnatal origins to attention-deficit/hyperactivity disorder (ADHD)-like behaviors in a seizure-prone rat strainKrista L Gilby
Institute of Neuroscience, Life Sciences Research Center, Carleton University, Ottawa, ON, Canada
Behav Neurosci 121:370-9. 2007..Thus, a specific postnatal environment is unlikely to underwrite ADHD-like behaviors in the seizure-prone Fast rats, which implicates a genetic or prenatal origin for the ADHD phenotype... - Neurodevelopment in seizure-prone and seizure-resistant rat strains: recognizing conflicts in managementKrista L Gilby
Neuroscience Institute, Carleton University, Ottawa, Ontario, Canada
Epilepsia 48:114-8. 2007.... - Kindling-based status epilepticus: effect of norepinephrine depletion with 6-hydroxydopamineD C McIntyre
Department of Psychology, Carleton University, Ottawa, Ontario, Canada
Exp Neurol 104:10-4. 1989..The significance of these results compared to other SE models was discussed... - Kindling as a model of human epilepsyDan C McIntyre
Department of Psychology, Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
Can J Neurol Sci 36:S33-5. 2009..Parallels between the human condition, involving both partial and secondarily generalized seizures, and kindling in rats and other animals are drawn and contrasted... - Divergent GABA(A) receptor-mediated synaptic transmission in genetically seizure-prone and seizure-resistant ratsDan C McIntyre
Neuroscience Research Institute, Carleton University, Ottawa, Ontario, Canada K1S 5B6
J Neurosci 22:9922-31. 2002..This suggests that the timing of inhibition, particularly slow inhibitory neurotransmission between nonpyramidal neurons, may be a contributing factor in seizure genesis... - Anxiety in rats selectively bred for Fast and Slow kindling rates: situation-specific outcomesOwen P Kelly
Institute of Neuroscience, Carleton University, Ottawa, Ont, Canada
Stress 6:289-95. 2003..These data indicate the need to differentiate subtypes of anxiety in animal models, and raise the issue that anxiety elicited by specific environmental triggers may interact with genetically determined trait characteristics... - Secondary generalization of hippocampal kindled seizures in rats: examining the role of the piriform cortexMary Ellen Kelly
Department of Psychology, Life Sciences Research Center, Carleton University, Ontario Ottawa K1S 5B6, Canada
Brain Res 957:152-61. 2002..The additional involvement of parahippocampal cortical areas in convulsive expression suggests an important functional association between these cortical regions and the hippocampus in seizure propagation and clinical expression... - Changes in extracellular levels of amygdala amino acids in genetically fast and slow kindling rat strainsRick S Shin
Institute of Neuroscience, Department of Psychology, Life Sciences Research Building, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6, Canada
Brain Res 946:31-42. 2002.... - Strain differences affect the induction of status epilepticus and seizure-induced morphological changesB Xu
Department of Psychology, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1
Eur J Neurosci 20:403-18. 2004..We conclude that genetic factors clearly affect seizure development and related morphological changes in both standard laboratory strains and the selectively bred seizure-prone and seizure-resistant strains... - Assessment of anxiety-like behaviors in female rats bred for differences in kindling susceptibility and amygdala excitabilityDwayne Runke
Department of Psychology, Institute of Neuroscience, Life Sciences Research Building Carleton University, Ottawa, Ontario, Canada
Brain Res 1240:143-52. 2008.... - Parahippocampal networks, intractability, and the chronic epilepsy of kindlingDan C McIntyre
Department of Psychology, Institute for Neuroscience, Carleton University, Ottawa, Ontario, Canada
Adv Neurol 97:77-83. 2006.... - Stressor-induced corticotropin-releasing hormone, bombesin, ACTH and corticosterone variations in strains of mice differentially responsive to stressorsH Anisman
Institute of Neurosciences, Carleton University, Ottawa, Ontario
Stress 2:209-20. 1998.... - Chronic omega-3 supplementation in seizure-prone versus seizure-resistant rat strains: a cautionary taleK L Gilby
Institute of Neuroscience, Life Sciences Research Center, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada K1S 5B6
Neuroscience 163:750-8. 2009..Further, a relationship between circulating NEFA levels and seizure susceptibility has surfaced that advocates caution when treating different genetic backgrounds with omega-3 fatty acids... - Acoustic startle and fear-potentiated startle in rats selectively bred for fast and slow kindling rates: relation to monoamine activityH Anisman
Institute of Neuroscience, Carleton University, Ottawa, Ontario K1S 5B6, Canada
Eur J Neurosci 12:4405-16. 2000..This suggested that relative to Slow rats, dopamine neurons in prefrontal cortex of Fast rats do not react normally to environmental stimuli, and this phenomenon could lead to disturbances of attention or impulsivity... - Effect of clonidine on amygdala kindling in normal and 6-hydroxydopamine-pretreated ratsD C McIntyre
Department of Psychology, Carleton University, Ottawa, Ontario, Canada
Exp Neurol 99:96-106. 1988..The significance of these data, and the involvement of the postsynaptic alpha 2 receptors in the genesis of amygdala kindled seizures, are discussed... - Differential sensitivity of genetically Fast vs. Slow kindling rats strains to GABAergic convulsive agentsRonald J Racine
Psychology Department, McMaster University, Hamilton, Ontario, Canada L8S 4K1
Neuropharmacology 45:918-24. 2003.... - Differential neuroplastic changes in neocortical movement representations and dendritic morphology in epilepsy-prone and epilepsy-resistant rat strains following high-frequency stimulationCorey Flynn
Behavioural Neuroscience Research Group, Department of Psychology, University of Calgary, Calgary, Alberta, Canada T2N 1 N4
Eur J Neurosci 19:2319-28. 2004..The potentiated FAST rats also showed an increase in spine density. Our results suggest that differences in susceptibility to epileptogenesis may result in a differential response to stimulation-induced plasticity... - Animal models of limbic epilepsies: what can they tell us?Douglas A Coulter
Department of Neuroscience, University of Pennsylvania School of Medicine, Children s Hospital of Philadelphia, 19104 4318, USA
Brain Pathol 12:240-56. 2002..We have also provided a brief introduction into how animal models of temporal lobe epilepsy facilitate use of modern state-of-the-art techniques in neurobiology to address critical questions in the pathogenesis of epilepsy... - Activin mRNA induced during amygdala kindling shows a spatiotemporal progression that tracks the spread of seizuresJane A Foster
Section on Functional Neuroanatomy, National Institute of Mental Health, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland 20892 4070, USA
J Comp Neurol 476:91-102. 2004..The data suggest that activin and BDNF transcriptional activities accurately mark excitatory neurons participating in seizure-induced synaptic alterations and may contribute to the enduring changes that underlie the kindled state... - Temporal sequence of ictal discharges propagation in the corticolimbic basal ganglia system during amygdala kindled seizures in freely moving ratsLi Hong Shi
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Epilepsy Res 73:85-97. 2007..Early activation of the SNr (before the STN and hippocampus) points to an important role of the SNr in amygdala kindled seizures and supports the view that different SNr manipulations may be effective ways to control seizures... - Development of play fighting in kindling-prone (FAST) and kindling-resistant (SLOW) rats: how does the retention of phenotypic juvenility affect the complexity of play?Christine J Reinhart
Canadian Centre for Behavioural Neuroscience, Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada T1K 3M4
Dev Psychobiol 45:83-92. 2004..These data suggest that the different components of play fighting do not change uniformly with changes in the neurobehavioral underpinnings of juvenility... - Play fighting between kindling-prone (FAST) and kindling-resistant (SLOW) ratsChristine J Reinhart
Canadian Centre for Behavioural Neuroscience, Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, AB, Canada
J Comp Psychol 120:19-30. 2006..These data suggest that some components of play may be more impervious to changes in social environment than other components...