Edward J Mills

Summary

Affiliation: Canadian College of Naturopathic Medicine
Country: Canada

Publications

  1. ncbi LOST to follow-up Information in Trials (LOST-IT): a protocol on the potential impact
    Elie A Akl
    Department of Medicine, State University of New York at Buffalo, Buffalo, USA
    Trials 10:40. 2009
  2. ncbi Teaching Evidence-Based Complementary and Alternative Medicine (EBCAM); changing behaviours in the face of reticence: a cross-over trial
    Edward Mills
    Department of Research, The Canadian College of Naturopathic Medicine, North York, Canada
    BMC Med Educ 2:2. 2002
  3. ncbi Impact of federal safety advisories on health food store advice
    Edward Mills
    Department of Research, Canadian College of Naturopathic Medicine, 1255 Sheppard Avenue East, North York, Ontario M2K 1E2, Canada
    J Gen Intern Med 19:269-72. 2004
  4. ncbi Health food store recommendations: implications for breast cancer patients
    Edward Mills
    Department of Research, Canadian College of Naturopathic Medicine, North York, Ontario, Canada
    Breast Cancer Res 5:R170-4. 2003
  5. ncbi Emerging issues associated with HIV patients seeking advice from health food stores
    Edward Mills
    Dept of Research, Canadian College of Naturopathic Medicine, North York, ON
    Can J Public Health 94:363-6. 2003
  6. ncbi The safety of over-the-counter niacin. A randomized placebo-controlled trial [ISRCTN18054903]
    Edward Mills
    Department of Research, Canadian College of Naturopathic Medicine, North York, Canada
    BMC Clin Pharmacol 3:4. 2003
  7. ncbi Teaching evidence-based complementary and alternative medicine: 1. A learning structure for clinical decision changes
    Edward J Mills
    Department of Research, The Canadian College of Naturopathic Medicine, North York, Ontario
    J Altern Complement Med 8:207-14. 2002
  8. ncbi Teaching evidence-based complementary and alternative medicine: 2. A conceptual approach to causation-part 2
    Kumanan Wilson
    Department of Medicine, University of Toronto, Ontario, Canada
    J Altern Complement Med 8:385-9. 2002
  9. ncbi Teaching evidence-based complementary and alternative medicine: 5. Interpreting the results of a study on therapy and applying them to a patient
    Kumanan Wilson
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Altern Complement Med 8:867-73. 2002
  10. ncbi Teaching evidence-based complementary and alternative medicine: 4. Appraising the evidence for papers on therapy
    Kumanan Wilson
    Department of Medicine, University of Toronto, Ontario, Canada
    J Altern Complement Med 8:673-9. 2002

Detail Information

Publications62

  1. ncbi LOST to follow-up Information in Trials (LOST-IT): a protocol on the potential impact
    Elie A Akl
    Department of Medicine, State University of New York at Buffalo, Buffalo, USA
    Trials 10:40. 2009
    ..The secondary objectives are to describe, for published RCTs, (1) the reporting of loss to follow-up information, (2) the analytic methods used for handling loss to follow-up information, and (3) the extent of reported loss to follow-up...
  2. ncbi Teaching Evidence-Based Complementary and Alternative Medicine (EBCAM); changing behaviours in the face of reticence: a cross-over trial
    Edward Mills
    Department of Research, The Canadian College of Naturopathic Medicine, North York, Canada
    BMC Med Educ 2:2. 2002
    ..In this study we attempt to determine if a workshop for final year students at a naturopathic college improved their ability to utilize critical appraisal concepts...
  3. ncbi Impact of federal safety advisories on health food store advice
    Edward Mills
    Department of Research, Canadian College of Naturopathic Medicine, 1255 Sheppard Avenue East, North York, Ontario M2K 1E2, Canada
    J Gen Intern Med 19:269-72. 2004
    ..Twenty-two of 34 stores recommended kava kava, 9 of which mentioned safety concerns. Physicians should be aware that federal advisories may not affect sales of unsafe products...
  4. ncbi Health food store recommendations: implications for breast cancer patients
    Edward Mills
    Department of Research, Canadian College of Naturopathic Medicine, North York, Ontario, Canada
    Breast Cancer Res 5:R170-4. 2003
    ..Many breast cancer patients use complementary and alternative medicine (CAM). We aimed to determine what advice health food store employees present to individuals seeking treatment options for breast cancer...
  5. ncbi Emerging issues associated with HIV patients seeking advice from health food stores
    Edward Mills
    Dept of Research, Canadian College of Naturopathic Medicine, North York, ON
    Can J Public Health 94:363-6. 2003
    ..To ascertain the recommendations, training and education of health food store employees and determine how they communicate the costs, benefits and risks associated with natural health products for the HIV/AIDS community...
  6. ncbi The safety of over-the-counter niacin. A randomized placebo-controlled trial [ISRCTN18054903]
    Edward Mills
    Department of Research, Canadian College of Naturopathic Medicine, North York, Canada
    BMC Clin Pharmacol 3:4. 2003
    ..Niacin is widely available over the counter (OTC). We sought to determine the safety of 500 mg immediate release niacin, when healthy individuals use them as directed...
  7. ncbi Teaching evidence-based complementary and alternative medicine: 1. A learning structure for clinical decision changes
    Edward J Mills
    Department of Research, The Canadian College of Naturopathic Medicine, North York, Ontario
    J Altern Complement Med 8:207-14. 2002
    ..In order to create communication effectively, an evidence-based approach may provide the common ground required for all schools of thought...
  8. ncbi Teaching evidence-based complementary and alternative medicine: 2. A conceptual approach to causation-part 2
    Kumanan Wilson
    Department of Medicine, University of Toronto, Ontario, Canada
    J Altern Complement Med 8:385-9. 2002
    ..more likely to lead to disease? Is there evidence from several different studies showing the same association? Does withdrawal of the cause result in loss of the effect? Is there a biologic model that can explain the causal relationship?..
  9. ncbi Teaching evidence-based complementary and alternative medicine: 5. Interpreting the results of a study on therapy and applying them to a patient
    Kumanan Wilson
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Altern Complement Med 8:867-73. 2002
    ....
  10. ncbi Teaching evidence-based complementary and alternative medicine: 4. Appraising the evidence for papers on therapy
    Kumanan Wilson
    Department of Medicine, University of Toronto, Ontario, Canada
    J Altern Complement Med 8:673-9. 2002
    ....
  11. ncbi Adherence to HAART: a systematic review of developed and developing nation patient-reported barriers and facilitators
    Edward J Mills
    Centre for International Health and Human Rights Studies, Toronto, Ontario, Canada
    PLoS Med 3:e438. 2006
    ..We systematically reviewed the literature to determine patient-reported barriers and facilitators to adhering to antiretroviral therapy...
  12. ncbi Naturopathic care for anxiety: a randomized controlled trial ISRCTN78958974
    Kieran Cooley
    Department of Research and Clinical Epidemiology, The Canadian College of Naturopathic Medicine, Toronto, Canada
    PLoS ONE 4:e6628. 2009
    ..This study sought to explore the effectiveness of naturopathic care on anxiety symptoms using a randomized trial...
  13. ncbi Naturopathic care for chronic low back pain: a randomized trial
    Orest Szczurko
    Division of Clinical Epidemiology, Canadian College of Naturopathic Medicine, Toronto, Ontario, Canada
    PLoS ONE 2:e919. 2007
    ..Chronic low back pain represents a substantial cost to employers through benefits coverage and days missed due to incapacity. We sought to explore the effectiveness of Naturopathic care on chronic low back pain...
  14. ncbi Teaching evidence-based complementary and alternative medicine: 3. Asking the questions and identifying the information
    Kumanan Wilson
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Altern Complement Med 8:499-506. 2002
    ..This paper suggests practical strategies for successful database searches in support of EBCAM...
  15. ncbi Teaching evidence-based complementary and alternative medicine: 2. A conceptual approach to causation-part 1
    Kumanan Wilson
    Department of Medicine, University of Toronto, Ontario, Canada
    J Altern Complement Med 8:379-83. 2002
    ....
  16. ncbi Primary prevention of cardiovascular mortality and events with statin treatments: a network meta-analysis involving more than 65,000 patients
    Edward J Mills
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    J Am Coll Cardiol 52:1769-81. 2008
    ..This study aimed to evaluate the effectiveness of 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitors (statins) in primary prevention of cardiovascular events...
  17. ncbi Systematically reviewing qualitative studies complements survey design: an exploratory study of barriers to paediatric immunisations
    Edward J Mills
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Health Science Centre, Hamilton, Ontario, Canada
    J Clin Epidemiol 58:1101-8. 2005
    ..We examined surveys addressing parental barriers to vaccinating children to determine if they comprehensively included themes identified in published qualitative studies...
  18. ncbi Adherence to antiretroviral therapy in sub-Saharan Africa and North America: a meta-analysis
    Edward J Mills
    Centre for International Health and Human Rights Studies, Toronto, Ontario, Canada
    JAMA 296:679-90. 2006
    ..Concerns about incomplete adherence among patients living in poverty have been an important consideration in expanding the access to antiretroviral therapy in sub-Saharan Africa...
  19. ncbi Design and methods of the MAINTAIN study: a randomized controlled clinical trial of micronutrient and antioxidant supplementation in untreated HIV infection
    Neera Singhal
    Department of Medicine, University of Ottawa at Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    Contemp Clin Trials 31:604-11. 2010
    ..We discuss here the study design and methods, often used for evaluation of complementary and adjunctive treatments for health maintenance in HIV infection, which are common interventions...
  20. ncbi The effects of green tea consumption on incidence of breast cancer and recurrence of breast cancer: a systematic review and meta-analysis
    Dugald Seely
    Department of Clinical Epidemiology, Canadian College of Naturopathic Medicine, Toronto, Ontario, Canada
    Integr Cancer Ther 4:144-55. 2005
    ..Green tea is widely used by women for the prevention and treatment of breast cancer. The authors aimed to determine the efficacy of green tea ingestion on the risk of breast cancer development and the risk of breast cancer recurrence...
  21. ncbi Life expectancy of persons receiving combination antiretroviral therapy in low-income countries: a cohort analysis from Uganda
    Edward J Mills
    University of Ottawa, Ottawa, Ontario, Canada
    Ann Intern Med 155:209-16. 2011
    ..Little is known about the effect of combination antiretroviral therapy (cART) on life expectancy in sub-Saharan Africa...
  22. ncbi Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis
    Dirk Bassler
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    JAMA 303:1180-7. 2010
    ..Theory and simulation suggest that randomized controlled trials (RCTs) stopped early for benefit (truncated RCTs) systematically overestimate treatment effects for the outcome that precipitated early stopping...
  23. ncbi Traditional Chinese Medicines in the treatment of hepatocellular cancers: a systematic review and meta-analysis
    Ping Wu
    Shanghai Hospital 4, Shanghai, PR China
    J Exp Clin Cancer Res 28:112. 2009
    ..Several Traditional Chinese Medicines (TCM) have been evaluated in clinical trials, but little is known about them outside of China...
  24. ncbi Diagnostic accuracy among the allied health professions: commentary on Grace et Al
    Dugald Seely
    Department of Clinical Epidemiology, The Canadian College of Naturopathic Medicine, North York, Ontario, Canada
    J Altern Complement Med 12:701-2. 2006
  25. ncbi In vitro analysis of the herbal compound Essiac
    Dugald Seely
    Department of Research and Clinical Epidemiology, The Canadian College of Naturopathic Medicine, Toronto, ON, Canada
    Anticancer Res 27:3875-82. 2007
    ..We aimed to address this deficiency by conducting a series of assays to determine some of the purported activities of Essiac in vitro...
  26. ncbi The quality of randomized trial reporting in leading medical journals since the revised CONSORT statement
    Edward J Mills
    Department of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, McMaster University, HSC 2C12, 1200 Main Street West, Hamilton, ON, Canada, L8N 3Z5
    Contemp Clin Trials 26:480-7. 2005
    ..Although reporting of some CONSORT recommendations is high, reporting of several essential recommendations remains suboptimal. Authors need to comply with and journals need to enforce reporting of the revised CONSORT recommendations...
  27. ncbi Epidemiology and reporting of randomized trials employing re-randomization of patient groups: a systematic survey
    Edward J Mills
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada
    Contemp Clin Trials 28:268-75. 2007
    ....
  28. ncbi In the era of systematic reviews, does the size of an individual trial still matter
    Gordon H Guyatt
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    PLoS Med 5:e4. 2008
    ..Others point out that small trials can still be potentially misleading...
  29. ncbi EDTA chelation therapy for cardiovascular disease: a systematic review
    Dugald M R Seely
    Canadian College of Naturopathic Medicine, Toronto, Canada
    BMC Cardiovasc Disord 5:32. 2005
    ..To address this issue we conducted a systematic review to evaluate the best available evidence for the use of EDTA chelation therapy in the treatment of cardiovascular disease...
  30. ncbi Association between change in high density lipoprotein cholesterol and cardiovascular disease morbidity and mortality: systematic review and meta-regression analysis
    Matthias Briel
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main Street West, Hamilton, ON, Canada
    BMJ 338:b92. 2009
    ....
  31. ncbi Disclosure of natural product use to primary care physicians: a cross-sectional survey of naturopathic clinic attendees
    Jason W Busse
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Mayo Clin Proc 80:616-23. 2005
    ..Our findings suggest that disclosure rates could be improved by physicians taking a more active role in asking their patients about natural product use...
  32. ncbi Naturopathic treatment of rotator cuff tendinitis among Canadian postal workers: a randomized controlled trial
    Orest Szczurko
    Canadian College of Naturopathic Medicine, Toronto, Ontario, Canada
    Arthritis Rheum 61:1037-45. 2009
    ..To explore the effectiveness of naturopathic care (NC) on rotator cuff tendinitis using a prospective randomized clinical trial design...
  33. ncbi Attitudes towards fibromyalgia: a survey of Canadian chiropractic, naturopathic, physical therapy and occupational therapy students
    Jason W Busse
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    BMC Complement Altern Med 8:24. 2008
    ....
  34. ncbi Characteristics of pediatric and adolescent patients attending a naturopathic college clinic in Canada
    Kumanan Wilson
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Pediatrics 115:e338-43. 2005
    ..We also determined factors associated with the use of CAM products and vaccination status...
  35. ncbi Closing comment: Evidence-based complementary and alternative medicine: is it a viable concept?
    Kumanan Wilson
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Altern Complement Med 8:875-6. 2002
  36. ncbi Differences in clinical outcomes among hepatitis C genotype 1-infected patients treated with peginterferon alpha-2a or peginterferon alpha-2b plus ribavirin: a meta-analysis
    Eric Druyts
    Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada
    Clin Exp Gastroenterol 5:11-21. 2012
    ....
  37. ncbi Safety of task-shifting for male medical circumcision: a systematic review and meta-analysis
    Nathan Ford
    Centre for Infectious Disease Epidemiology and Research, University of Cape Town, Cape Town, South Africa
    AIDS 26:559-66. 2012
    ..We undertook a systematic review and meta-analysis to review the safety of task-shifting for circumcision in Africa...
  38. ncbi Multiple treatment comparison meta-analyses: a step forward into complexity
    Edward J Mills
    Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada
    Clin Epidemiol 3:193-202. 2011
    ..We conclude that MTC meta-analysis is a useful tool in the context of comparative effectiveness and requires further study, as its utility and transparency will likely predict its uptake by the research and clinical community...
  39. ncbi Safety and efficacy of panax ginseng during pregnancy and lactation
    Dugald Seely
    Department of Research and Clinical Epidemiology, The Canadian College of Naturopathic Medicine, Toronto, Canada
    Can J Clin Pharmacol 15:e87-94. 2008
    ..This is one article in a series that systematically reviews the evidence for herbs commonly used during pregnancy and lactation...
  40. ncbi Impact of African herbal medicines on antiretroviral metabolism
    Edward Mills
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    AIDS 19:95-7. 2005
    ..Initiating policies to provide herbal medicines with antiretroviral agents may put patients at risk of treatment failure, viral resistance or drug toxicity...
  41. ncbi An in vivo analysis of the herbal compound essiac
    Blair J N Leonard
    Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    Anticancer Res 26:3057-63. 2006
    ..CONCLUSION: Essiac, administered in established in vivo experimental models, did not significantly demonstrate its purported physiological modifying effects...
  42. ncbi Randomized trials stopped early for harm in HIV/AIDS: a systematic survey
    Edward Mills
    Centre for International Health and Human Rights Studies, North York, Ontario, Canada
    HIV Clin Trials 7:24-33. 2006
    ..We assessed the prevalence of randomized clinical trials (RCTs) stopped early for harm in HIV/AIDS and determined the quality of reporting of methods to inform the decision to stop the trial...
  43. ncbi Mitigation of antiretroviral-induced hyperlipidemia by hepatitis C virus co-infection
    Curtis L Cooper
    Division of Infectious Diseases, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada
    AIDS 21:71-6. 2007
    ..Hyperlipidemia is a recognized complication of HIV antiretroviral therapy. The interactions between HIV, hepatitis C virus (HCV), antiretroviral agents and lipids are not well understood...
  44. ncbi Enrolling women into HIV preventive vaccine trials: an ethical imperative but a logistical challenge
    Edward Mills
    Centre for International Health and Human Rights Studies, Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    PLoS Med 3:e94. 2006
  45. ncbi Safety and efficacy of ginkgo (Ginkgo biloba) during pregnancy and lactation
    Jean Jacques Dugoua
    Department of Clinical Epidemiology, Canadian College of Naturopathic Medicine, Toronto, Canada
    Can J Clin Pharmacol 13:e277-84. 2006
    ..This is one article in a series that systematically reviews the evidence for commonly used herbs during pregnancy and lactation...
  46. ncbi Milk thistle and indinavir: a randomized controlled pharmacokinetics study and meta-analysis
    Edward Mills
    Faculty of Health Sciences, Clinical Epidemiology and Biostatistics, McMaster University, HSC 2C12, 1200 Main Street West, Hamilton, ON, L8N 3Z5, Canada
    Eur J Clin Pharmacol 61:1-7. 2005
    ..To determine whether ingestion of milk thistle affects the pharmacokinetics of indinavir...
  47. ncbi Safety and efficacy of black cohosh (Cimicifuga racemosa) during pregnancy and lactation
    Jean Jacques Dugoua
    Department of Clinical Epidemiology, Canadian College of Naturopathic Medicine, Toronto, Canada
    Can J Clin Pharmacol 13:e257-61. 2006
    ..This is one article in a series that systematically reviews the evidence for commonly used herbs during pregnancy and lactation...
  48. ncbi Safety and efficacy of St. John's wort (hypericum) during pregnancy and lactation
    Jean Jacques Dugoua
    Department of Clinical Epidemiology, Canadian College of Naturopathic Medicine, Toronto, Canada
    Can J Clin Pharmacol 13:e268-76. 2006
    ..This is one article in a series that systematically reviews the evidence for commonly used herbs during pregnancy and lactation...
  49. ncbi Natural health product-drug interactions: a systematic review of clinical trials
    Edward Mills
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Ther Drug Monit 27:549-57. 2005
    ..With the exception of St. John wort, clinicians and the public do not have information that permits strong inferences about interactions between NHPs and conventional medications...
  50. ncbi Randomized controlled trials in long-term care residents with dementia: a systematic review
    Edward J Mills
    The University of Oxford
    J Am Med Dir Assoc 4:302-7. 2003
    ..The reporting quality is highly variable in the trials reviewed, and concerns exist surrounding the conduct of several trials...
  51. ncbi Introducing evidence-based complementary and alternative medicine: answering the challenge
    Kumanan Wilson
    J Altern Complement Med 8:103-5. 2002
  52. ncbi Changing attitudes towards polio vaccination: a randomized trial of an evidence-based presentation versus a presentation from a polio survivor
    Kumanan Wilson
    Department of Medicine, University of Toronto, Canada
    Vaccine 23:3010-5. 2005
    ..These findings suggest that confronting deeply held beliefs regarding vaccination may paradoxically strengthen these belief systems...
  53. ncbi The abandoned trials of pre-exposure prophylaxis for HIV: what went wrong?
    Jerome A Singh
    Centre for the AIDS Programme of Research, South Africa
    PLoS Med 2:e234. 2005
  54. ncbi Designing research in vulnerable populations: lessons from HIV prevention trials that stopped early
    Edward J Mills
    Department of Clinical Epidemiology and Biostatistics, McMaster University, HSC-2C12, 1200 Main Street West, Hamilton, ON, Canada L8N 3Z5
    BMJ 331:1403-6. 2005
  55. ncbi HIV/AIDS in African militaries: an ecological analysis
    Oumar Ba
    Faculty of Health Sciences, Simon Fraser University, Vancouver, Canada
    Med Confl Surviv 24:88-100. 2008
    ..4). Population levels predicted military prevalence rates (P < or = 0.001). HIV/AIDS prevalence rates in most African militaries are significantly elevated compared to their host communities...
  56. ncbi A wake-up call for global access to salvage HIV drug regimens
    Edward J Mills
    British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada
    Lancet 370:1885-7. 2007
  57. ncbi Simple, effective interventions are key to improving adherence in marginalized populations
    Edward J Mills
    Clin Infect Dis 45:916-7. 2007
  58. ncbi Problems with use of composite end points in cardiovascular trials: systematic review of randomised controlled trials
    Ignacio Ferreira Gonzalez
    Departament de Medicina, Universitat Autonoma de Barcelona, and Hospital Vall d Hebron, Barcelona 08035, Spain
    BMJ 334:786. 2007
    ....
  59. ncbi In vitro evaluation of human cytochrome P450 and P-glycoprotein-mediated metabolism of some phytochemicals in extracts and formulations of African potato
    Vipin D P Nair
    Division of Pharmaceutics, Faculty of Pharmacy, Rhodes University, Grahamstown, South Africa
    Phytomedicine 14:498-507. 2007
    ..Appropriate measures are therefore necessary to explore the possibility of such in vitro-in vivo correlations...
  60. ncbi The impact of conflict on HIV/AIDS in sub-Saharan Africa
    Edward J Mills
    Centre for International Health and Human Rights Studies, Toronto, Canada
    Int J STD AIDS 17:713-7. 2006
    ..We examine the complexity of monitoring HIV/AIDS in conflict settings. We argue that increased efforts are needed to protect vulnerable populations and design health-delivery systems that are sustainable in settings of conflict...
  61. ncbi HIV infection as a weapon of war
    Edward J Mills
    Lancet Infect Dis 6:752-3. 2006
  62. ncbi Cost-effectiveness of naturopathic care for chronic low back pain
    Patricia M Herman
    Department of Psychology, University of Arizona, Tucson, Arizona, USA
    Altern Ther Health Med 14:32-9. 2008
    ....