Research Topics
Genomes and Genes | Martin KrzywinskiSummaryAffiliation: British Columbia Country: Canada Publications
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Detail Information
Publications
A physical map of the mouse genomeSimon G Gregory
The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Nature 418:743-50. 2002..The human sequence may be used to facilitate construction of other mammalian genome maps using the same strategy...- Circos: an information aesthetic for comparative genomicsMartin Krzywinski
Canada s Michael Smith Genome Sciences Center, Vancouver, British Columbia V5Z 4S6, Canada
Genome Res 19:1639-45. 2009.... - A BAC clone fingerprinting approach to the detection of human genome rearrangementsMartin Krzywinski
BC Cancer Agency Genome Sciences Centre, West 7th Avenue, Vancouver, British Columbia, Canada V5Z 4S6
Genome Biol 8:R224. 2007..Our method has compelling potential for use as a whole-genome method for the identification and characterization of human genome rearrangements... - Automated ordering of fingerprinted clonesStephane Flibotte
Genome Sciences Centre, British Columbia Cancer Research Centre, Vancouver, BC Canada, V5Z 4E6
Bioinformatics 20:1264-71. 2004..Measurements suggest that CORAL performs significantly better than the software currently used by most laboratories to order fingerprinted clones at throughputs far exceeding those that can be achieved manually... - PICS: probabilistic inference for ChIP-seqXuekui Zhang
Department of Statistics, University of British Columbia, Vancouver, BC, Canada
Biometrics 67:151-63. 2011..We then use a simulation study to confirm that PICS compares favorably to these methods and is robust to model misspecification... - A set of BAC clones spanning the human genomeMartin Krzywinski
BC Cancer Agency Genome Sciences Center and BC Cancer Agency, Vancouver, BC V5Z 4E6, Canada
Nucleic Acids Res 32:3651-60. 2004..We have made the clone set publicly available, anticipating that it will generally facilitate FISH or array-CGH-based identification and characterization of chromosomal alterations relevant to disease... - Frequent mutation of histone-modifying genes in non-Hodgkin lymphomaRyan D Morin
Canada s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada
Nature 476:298-303. 2011..Our analysis suggests a previously unappreciated disruption of chromatin biology in lymphomagenesis... - Sequence variant discovery in DNA repair genes from radiosensitive and radiotolerant prostate brachytherapy patientsTrevor J Pugh
Genome Sciences Centre, Provincial Prostate Brachytherapy Program, and Medical Biophysics, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
Clin Cancer Res 15:5008-16. 2009..We investigated whether variants in genes responsible for detecting and repairing DNA damage independently contribute to toxicity following prostate brachytherapy... - Profiling the HeLa S3 transcriptome using randomly primed cDNA and massively parallel short-read sequencingRyan Morin
Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada
Biotechniques 45:81-94. 2008..Analysis of these variants, and previously unannotated splicing events in the HeLa S3 cell line, reveals an overrepresentation of gene categories including those previously implicated in cancer... - Oligonucleotide microarray analysis of genomic imbalance in children with mental retardationJ M Friedman
Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
Am J Hum Genet 79:500-13. 2006..This technology can detect at least twice as many potentially pathogenic de novo copy-number variants as conventional cytogenetic analysis can in people with mental retardation... - Genome-wide relationship between histone H3 lysine 4 mono- and tri-methylation and transcription factor bindingA Gordon Robertson
BC Cancer Agency Genome Sciences Centre, Vancouver, Canada
Genome Res 18:1906-17. 2008.... - A physical map of the chicken genomeJohn W Wallis
Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA
Nature 432:761-4. 2004..This map represents approximately 91% of the chicken genome and enables identification of chicken clones aligned to positions in other sequenced genomes... - Integrated and sequence-ordered BAC- and YAC-based physical maps for the rat genomeMartin Krzywinski
Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, Canada V5Z 4E6
Genome Res 14:766-79. 2004..The fingerprint map is a high-resolution integrative data resource that provides genome-ordered associations among BAC, YAC, and PAC clones and the assembled sequence of the rat genome... - Genome sequence of the Brown Norway rat yields insights into mammalian evolutionRichard A Gibbs
Human Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, MS BCM226, One Baylor Plaza, Houston, Texas 77030, USA <http://www.hgsc.bcm.tmc.edu
Nature 428:493-521. 2004....