Francois Benard

Summary

Country: Canada

Publications

  1. ncbi Imaging in breast cancer: Single-photon computed tomography and positron-emission tomography
    Francois Benard
    Metabolic and Functional Imaging Center, Clinical Research Center, Centre Hospitalier Universitaire de Sherbrooke, Fleurimont, QC, Canada
    Breast Cancer Res 7:153-62. 2005
  2. ncbi [18F]Fluorinated estradiol derivatives for oestrogen receptor imaging: impact of substituents, formulation and specific activity on the biodistribution in breast tumour-bearing mice
    Francois Benard
    Sherbrooke Molecular Imaging Center, Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, 3001, 12th Avenue North, Sherbrooke, QC, Canada, J1H 5N4
    Eur J Nucl Med Mol Imaging 35:1473-9. 2008
  3. ncbi [Lys(DOTA)4]BVD15, a novel and potent neuropeptide Y analog designed for Y1 receptor-targeted breast tumor imaging
    Brigitte Guérin
    Department of Nuclear Medicine and Radiobiology, Centre d imagerie moléculaire de Sherbrooke, Universite de Sherbrooke, Quebec, Canada
    Bioorg Med Chem Lett 20:950-3. 2010
  4. ncbi Assessment of human biodistribution and dosimetry of 4-fluoro-11beta-methoxy-16alpha-18F-fluoroestradiol using serial whole-body PET/CT
    Jean Mathieu Beauregard
    Sherbrooke Molecular Imaging Center CIMS, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    J Nucl Med 50:100-7. 2009
  5. ncbi Evaluation of 64Cu-labeled bifunctional chelate-bombesin conjugates
    Samia Ait-Mohand
    Centre d imagerie moléculaire de Sherbrooke, Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke, 3001, 12th North Avenue Sherbrooke, Qubec, Canada, J1H 5N4
    Bioconjug Chem 22:1729-35. 2011
  6. ncbi Image-derived input function in dynamic human PET/CT: methodology and validation with 11C-acetate and 18F-fluorothioheptadecanoic acid in muscle and 18F-fluorodeoxyglucose in brain
    Etienne Croteau
    Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, QC, Canada
    Eur J Nucl Med Mol Imaging 37:1539-50. 2010
  7. ncbi Automated synthesis of 11beta-methoxy-4,16alpha-[16alpha-(18)F]difluoroestradiol (4F-M[(18)F]FES) for estrogen receptor imaging by positron emission tomography
    Naseem Ahmed
    Sherbrooke Molecular Imaging Center CIMS, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4
    Nucl Med Biol 34:459-64. 2007
  8. ncbi Effective specific activities determined by scintillation proximity counting for production runs of [(18)F]FES and 4F-M[(18)F]FES
    Jean Mathieu Beauregard
    Sherbrooke Molecular Imaging Center CIMS, Universite de Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4
    Nucl Med Biol 34:325-9. 2007
  9. ncbi A small animal positron emission tomography study of the effect of chemotherapy and hormonal therapy on the uptake of 2-deoxy-2-[F-18]fluoro-D-glucose in murine models of breast cancer
    Antonio Aliaga
    Sherbrooke Molecular Imaging Center, Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, QC, Canada
    Mol Imaging Biol 9:144-50. 2007
  10. ncbi [11C] acetoacetate utilization by breast and prostate tumors: a PET and biodistribution study in mice
    Simon Authier
    Sherbrooke Molecular Imaging Center, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, 3001, 12th Avenue N, Sherbrooke, QC, Canada, J1H 5N4
    Mol Imaging Biol 10:217-23. 2008

Collaborators

  • Roger Lecomte
  • Brigitte Guérin
  • M hamed Bentourkia
  • Andre C Carpentier
  • Cara L Ferreira
  • Naseem Ahmed
  • Etienne Croteau
  • Johan E van Lier
  • Rejean Langlois
  • Hasrat Ali
  • René Ouellet
  • Jean Mathieu Beauregard
  • Celena Dubuc
  • Patrick Fournier
  • Samia Ait-Mohand
  • Jacques A Rousseau
  • Stephen C Cunnane
  • Sebastien Tremblay
  • Michel Paquette
  • Véronique Dumulon-Perreault
  • Sébastien L Ménard
  • Jules Cadorette
  • Simon Authier
  • Serge Rodrigue
  • Antonio Aliaga
  • Jacques Rousseau
  • Mélanie Archambault
  • Suzanne Gascon
  • Paul Jurek
  • Garry E Kiefer
  • Laurent Hubert
  • Sébastien M Labbé
  • Fabien Pifferi
  • Eric Lavallée
  • Johannes E Van Lier
  • François Normand-Lauzière
  • Guillaume Garcia
  • Frédérique Frisch
  • Xiuli Ci
  • Véronique Dumulon
  • Nicole Cauchon
  • Paul Tone
  • Klaus Klarskov
  • Jean-Mathieu Beauregard
  • René Ouellette
  • Guillaume Tessier
  • Veronique Guertin
  • Richard B Hochberg

Detail Information

Publications21

  1. ncbi Imaging in breast cancer: Single-photon computed tomography and positron-emission tomography
    Francois Benard
    Metabolic and Functional Imaging Center, Clinical Research Center, Centre Hospitalier Universitaire de Sherbrooke, Fleurimont, QC, Canada
    Breast Cancer Res 7:153-62. 2005
    ....
  2. ncbi [18F]Fluorinated estradiol derivatives for oestrogen receptor imaging: impact of substituents, formulation and specific activity on the biodistribution in breast tumour-bearing mice
    Francois Benard
    Sherbrooke Molecular Imaging Center, Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, 3001, 12th Avenue North, Sherbrooke, QC, Canada, J1H 5N4
    Eur J Nucl Med Mol Imaging 35:1473-9. 2008
    ....
  3. ncbi [Lys(DOTA)4]BVD15, a novel and potent neuropeptide Y analog designed for Y1 receptor-targeted breast tumor imaging
    Brigitte Guérin
    Department of Nuclear Medicine and Radiobiology, Centre d imagerie moléculaire de Sherbrooke, Universite de Sherbrooke, Quebec, Canada
    Bioorg Med Chem Lett 20:950-3. 2010
    ..Our data suggest that [Lys(DOTA)(4)]BVD15 (K(i)=63+/-25 nM vs. K(i)=39+/-34 nM for BVD15) is a potent NPY analog suitable for radiolabeling with metallo positron emitters for PET imaging of breast cancer...
  4. ncbi Assessment of human biodistribution and dosimetry of 4-fluoro-11beta-methoxy-16alpha-18F-fluoroestradiol using serial whole-body PET/CT
    Jean Mathieu Beauregard
    Sherbrooke Molecular Imaging Center CIMS, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    J Nucl Med 50:100-7. 2009
    ..The aim of this study was to assess the biodistribution, dosimetry, and safety of 4FMFES in healthy women...
  5. ncbi Evaluation of 64Cu-labeled bifunctional chelate-bombesin conjugates
    Samia Ait-Mohand
    Centre d imagerie moléculaire de Sherbrooke, Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke, 3001, 12th North Avenue Sherbrooke, Qubec, Canada, J1H 5N4
    Bioconjug Chem 22:1729-35. 2011
    ..Our data also show that (64)Cu-labeled NOTA- and PCTA-BBN peptide conjugates are promising radiotracers for PET imaging of many human cancers overexpressing the GRP receptor...
  6. ncbi Image-derived input function in dynamic human PET/CT: methodology and validation with 11C-acetate and 18F-fluorothioheptadecanoic acid in muscle and 18F-fluorodeoxyglucose in brain
    Etienne Croteau
    Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, QC, Canada
    Eur J Nucl Med Mol Imaging 37:1539-50. 2010
    ..The data were obtained from two different research studies, one using (18)F-FDG for brain imaging and the other using (11)C-acetate and (18)F-fluoro-6-thioheptadecanoic acid ((18)F-FTHA) in femoral muscles...
  7. ncbi Automated synthesis of 11beta-methoxy-4,16alpha-[16alpha-(18)F]difluoroestradiol (4F-M[(18)F]FES) for estrogen receptor imaging by positron emission tomography
    Naseem Ahmed
    Sherbrooke Molecular Imaging Center CIMS, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4
    Nucl Med Biol 34:459-64. 2007
    ..The total preparation time was 110+/-5 min and the product was shown to be stable for at least 6 h...
  8. ncbi Effective specific activities determined by scintillation proximity counting for production runs of [(18)F]FES and 4F-M[(18)F]FES
    Jean Mathieu Beauregard
    Sherbrooke Molecular Imaging Center CIMS, Universite de Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4
    Nucl Med Biol 34:325-9. 2007
    ..A high specific activity is required for successful visualization of ER expression in vivo, particularly for small animal imaging. We describe a simple method for effective specific activity (ESA) measurements of ER-binding ligands...
  9. ncbi A small animal positron emission tomography study of the effect of chemotherapy and hormonal therapy on the uptake of 2-deoxy-2-[F-18]fluoro-D-glucose in murine models of breast cancer
    Antonio Aliaga
    Sherbrooke Molecular Imaging Center, Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, QC, Canada
    Mol Imaging Biol 9:144-50. 2007
    ..We used small animal positron emission tomography (PET) imaging to monitor the time-course of tumor metabolic response to hormone and chemotherapy in a murine model of hormone-sensitive breast cancer...
  10. ncbi [11C] acetoacetate utilization by breast and prostate tumors: a PET and biodistribution study in mice
    Simon Authier
    Sherbrooke Molecular Imaging Center, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, 3001, 12th Avenue N, Sherbrooke, QC, Canada, J1H 5N4
    Mol Imaging Biol 10:217-23. 2008
    ..Our objective was to evaluate [11C]acetoacetate as a potential tracer of ketone body utilization by breast and prostate tumors and to compare it with [11C]acetate...
  11. ncbi Comparative study of 64Cu/NOTA-[D-Tyr6,?Ala11,Thi13,Nle14]BBN(6-14) monomer and dimers for prostate cancer PET imaging
    Patrick Fournier
    Centre d imagerie moléculaire de Sherbrooke CIMS, Department of Nuclear Medicine and Radiobiology, Universite de Sherbrooke, 3001, 12th North Avenue, Sherbrooke, Quebec, J1H 5N4, Canada
    EJNMMI Res 2:8. 2012
    ..abstract:..
  12. ncbi Mechanism of reduced myocardial glucose utilization during acute hypertriglyceridemia in rats
    Sébastien L Ménard
    Department of Medicine, Centre Hospitalier Universitaire de Sherbrooke, Universite de Sherbrooke, QC, Canada
    Mol Imaging Biol 11:6-14. 2009
    ..The purpose of the research is to study the effect of acute inhibition of intravascular lipolysis on myocardial substrate selection during hypertriglyceridemia using in vivo radiotracer analysis and positron emission tomography...
  13. ncbi [11C]Acetate rest-stress protocol to assess myocardial perfusion and oxygen consumption reserve in a model of congestive heart failure in rats
    Etienne Croteau
    Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke and Sherbrooke Molecular Imaging Center, Étienne LeBel Clinical Research Center, CHUS, Sherbrooke, QC, Canada
    Nucl Med Biol 39:287-94. 2012
    ..Doxorubicin cardiotoxicity was used to test the usefulness of this approach for the assessment of congestive heart failure...
  14. ncbi Synthesis, characterization, and estrogen receptor binding affinity of flavone-, indole-, and furan-estradiol conjugates
    Naseem Ahmed
    Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, QC, Canada J1H 5N4
    Bioorg Med Chem Lett 17:3212-6. 2007
    ....
  15. ncbi Targeting gastrin-releasing peptide receptors of prostate cancer cells for photodynamic therapy with a phthalocyanine-bombesin conjugate
    Celena Dubuc
    Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, 3001, 12th Avenue North, Sherbrooke, Que, Canada J1H 5N4
    Bioorg Med Chem Lett 18:2424-7. 2008
    ..3, taking bombesin (RBA=100) as unity. The in vitro photodynamic efficacy of the conjugate against PC-3 human prostate cancer cells is improved by a factor 2.5 over the non-conjugated mono-carbohexyl derivative of AlPcS(4)...
  16. ncbi Automated synthesis of 11C-acetoacetic acid, a key alternate brain fuel to glucose
    Sebastien Tremblay
    Research Center on Aging, Sherbrooke University Geriatric Institute, 1036 Belvedere Street South, Sherbrooke, Quebec, Canada J1H 4C4
    Appl Radiat Isot 65:934-40. 2007
    ..HPLC analysis showed < or =3% impurities while residual THF (< or =200 ppm) and ethanol (< or =500 ppm) were well under the tolerable limits for human studies...
  17. ncbi [18F]-fluoroestradiol quantitative PET imaging to differentiate ER+ and ER?-knockdown breast tumors in mice
    Michel Paquette
    Sherbrooke Molecular Imaging Center, Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4
    Nucl Med Biol 39:57-64. 2012
    ....
  18. ncbi Total solid-phase synthesis of NOTA-functionalized peptides for PET imaging
    Brigitte Guérin
    Centre d imagerie moléculaire de Sherbrooke CIMS, Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, 3001, 12th Avenue North, Sherbrooke, Quebec, Canada J1H 5N4
    Org Lett 12:280-3. 2010
    ..Deprotection and cleavage of the resin-bound NOTA peptides were performed with use of trifluoroacetic acid (TFA) in the presence of thioanisole and water to give free NOTA peptides...
  19. ncbi Synthesis and biological activities of nucleoside-estradiol conjugates
    Hasrat Ali
    Department of Nuclear Medicine and Radiobiology, Faculty of Medicine, , Sherbrooke, Quebec, Canada J1H 5N4
    Bioorg Med Chem Lett 16:317-9. 2006
    ..The highest receptor binding affinities (RBA approximately 3) were observed with conjugates coupled via a relative long spacer group, while none of the conjugates exhibited cytotoxicity against either cell lines...
  20. ncbi (18)F-labelling of A-ring substituted 16alpha-fluoro-estradiols as potential radiopharmaceuticals for PET imaging
    Naseem Ahmed
    Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, QC, Canada J1H 5N4
    Steroids 74:42-50. 2009
    ....
  21. ncbi Synthesis of the 7alpha-cyano-(17alpha,20E/Z)-[125I]iodovinyl-19-nortestosterones: potential radioligands for androgen and progesterone receptors
    Hasrat Ali
    Department of Nuclear Medicine and Radiobiology, Faculty of Medicine, , Sherbrooke, Que, Canada J1H 5N4
    Steroids 68:1163-71. 2003
    ..These data indicate that the addition of an electron withdrawing 7alpha-cyano group to 123I-labeled nortestosterone derivatives does not improve their potential to serve as SPECT agents for the imaging of AR densities in the prostate...