Research Topics
Species | Bruno BattistiniSummaryCountry: Canada Publications
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Publications
The many aspects of endothelins in ischemia-reperfusion injury: emergence of a key mediatorB Battistini
Heart and Lung Institute, Laval Hospital, Laval University, Ste Foy, Quebec, Canada
J Invest Surg 11:297-313. 1998..Here we review the evidence supporting a role for ETs in the various etiologies related to ischemia-reperfusion injury, such as is found in heart disease, cerebral ischemia, and organ transplantation...- Modulation and roles of the endothelins in the pathophysiology of pulmonary embolismBruno Battistini
Laval Hospital Research Center, Quebec Heart and Lung Institute, Department of Medicine, Laval University, 2725 Chemin Ste Foy, Sainte Foy, QC G1V 4G5, Canada
Can J Physiol Pharmacol 81:555-69. 2003..Thus, we may consider ET inhibitors as future current therapeutic agents in patients with PE... - Role of the endothelin system in secondary pulmonary hypertension related to air embolism: lessons learned from testing four classes of endothelin blockers in a rat modelB Battistini
Laval Hospital Research Center, Quebec Heart and Lung Institute, Department of Medicine, Laval University, Ste Foy, QC, Canada
J Cardiovasc Pharmacol 44:S386-9. 2004..However, modulation of the central hemodynamic profile is more complex and may limit the usefulness of some ET blockers... - Effects of benazepril, an angiotensin-converting enzyme inhibitor, combined with CGS 35066, a selective endothelin-converting enzyme inhibitor, on arterial blood pressure in normotensive and spontaneously hypertensive ratsBruno Battistini
Laval Hospital Research Center, Quebec Heart and Lung Institute, 2725 Chemin Ste Foy, Ste Foy, QC, Canada G1V 4G5
Clin Sci (Lond) 103:363S-366S. 2002.... - CGS 35601, a triple inhibitor of angiotensin converting enzyme, neutral endopeptidase and endothelin converting enzymeBruno Battistini
Laval Hospital Research Center, Quebec Heart and Lung Institute, Department of Medicine, Laval University, Ste Foy, QC G1V 4G5, Canada
Cardiovasc Drug Rev 23:317-30. 2005..Similar in vivo ACE, NEP, and ECE inhibitory activities were also observed with the orally active prodrug, CGS 37808 (L-tryptophan, N-[[1-[[(2S)-2-(acetylthio)-4-methyl-1-oxopentyl]amino]cyclopentyl]-carbonyl]-, methyl ester... - Roles of endothelins and their receptors in immune complex-induced/polymorphonuclear-mediated lung injury (reversed passive arthus reaction) in CD-1 miceB Battistini
Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, J1H 5N4, Canada
Pulm Pharmacol Ther 11:165-72. 1998..A beneficial ETB-mediated response may exist that naturally interferes with events triggered by the formation of immune complexes such as cell accumulation and their subsequent activation leading to acute lung injury... - Profile of past and current clinical trials involving endothelin receptor antagonists: the novel "-sentan" class of drugBruno Battistini
Laval Hospital Research Center, Quebec Heart and Lung Institute, Department of Medicine, Laval University, Sainte Foy, Canada
Exp Biol Med (Maywood) 231:653-95. 2006..This review is intended to provide a useful reference for those interested in the current state of clinical trials involving ERAs, and to identify lessons that might apply to the design of future trials... - Triple vasopeptidase inhibition normalizes blood pressure in conscious, unrestrained, and spontaneously hypertensive ratsPhilippe Daull
Laval Hospital Research Center, Quebec Heart and Lung Institute, Department of Medicine, Laval University, Ste-Foy, QC, Canada
Am J Hypertens 18:1606-13. 2005..Only then it may constitute a first-in-class approach for the treatment of hypertension and other cardiovascular disorders... - Triple vasopeptidase inhibition of angiotensin-converting enzyme/neutral endopeptidase/endothelin-converting enzyme activities on the hemodynamic profile of chronically instrumented unrestrained conscious spontaneously hypertensive ratsPhilippe Daull
Laval Hospital Research Center, Quebec Heart and Lung Institute, Laval University, Quebec, QC, Canada
J Cardiovasc Pharmacol 44:S398-401. 2004..Additional studies are underway... - Effects of a selective endothelin A receptor antagonist, ABT-627, in healthy normotensive anaesthetized rats developing acute pulmonary air embolismBilal Ayach
Laval Hospital Research Center, Quebec Heart and Lung Institute, Department of Medicine, Laval University, 2725 Chemin Ste-Foy, Ste-Foy, QC G1V 4G5, Canada
Clin Sci (Lond) 103:371S-375S. 2002..These results show that ET(A)-R subtype is involved in the pathogenesis of APAE since a blockade of this receptor subtype attenuated the cardiopulmonary deterioration and improved blood gas exchanges in rats with this disease... - The kinin system mediates hyperalgesia through the inducible bradykinin B1 receptor subtype: evidence in various experimental animal models of type 1 and type 2 diabetic neuropathyBichoy H Gabra
IPS Pharma Inc, Sherbrooke J1H 5N4, QC, Canada
Biol Chem 387:127-43. 2006..Thus, selective antagonism of the inducible BKB1-R subtype may constitute a novel and potential therapeutic approach for the treatment of painful diabetic neuropathy... - Inhibition of type 1 diabetic hyperalgesia in streptozotocin-induced Wistar versus spontaneous gene-prone BB/Worchester rats: efficacy of a selective bradykinin B1 receptor antagonistBichoy H Gabra
Department of Pharmacology, Faculty of Medicine, University of Sherbrooke, Canada
J Neuropathol Exp Neurol 64:782-9. 2005..Thus, selective antagonism of the inducible BKB1-R subtype may constitute a novel and potential therapeutic approach for the treatment of PDN... - Towards triple vasopeptidase inhibitors for the treatment of cardiovascular diseasesPhilippe Daull
Millenia Hope Inc, Kirkland, Quebec, Canada
J Cardiovasc Pharmacol 50:247-56. 2007..In this review, we historically present the advances made in the comprehension of the different mechanisms of blood pressure regulation and some of the drugs that arose from this understanding... - Effects of a selective bradykinin B1 receptor antagonist on increased plasma extravasation in streptozotocin-induced diabetic rats: distinct vasculopathic profile of major key organsSibi R Lawson
Institute of Pharmacology of Sherbrooke (IPS, School of Medicine, University of Sherbrooke, Sherbrooke, Province of Quebec, Canada J1H 5N4
Eur J Pharmacol 514:69-78. 2005.... - Profile of endothelin isopeptides and markers of oxidative stress alongside the onset of streptozotocin-type I diabetes in ratsOuhida Benrezzak
IPS Pharma Inc, Sherbrooke, QC, Canada
J Cardiovasc Pharmacol 44:S168-72. 2004.... - Inhibition of endothelin-converting enzyme for protection against neointimal proliferation following balloon angioplasty of the rat carotid arteryDung Pham
Laval Hospital Research Center, Department of Medicine, Laval University, Sainte-Foy, QC, Canada
Can J Physiol Pharmacol 80:450-7. 2002..Plasma concentrations of these compounds correlated with the degree of inhibition. These data support the participation of the endothelin system in the rat model of balloon angioplasty and suggest that selective ECEi may be effective... - Inhibition of basal and stimulated release of endothelin-1 from guinea pig tracheal epithelial cells in culture by beta 2-adrenoceptor agonists and cyclic AMP enhancersQuan Yang
Institute of Pharmacology of Sherbrooke, Medical School, University of Sherbrooke, Sherbrooke, QC, J1H 5N4, Canada
Inflammation 30:136-47. 2007.... - Early endothelial dysfunction in cholesterol-fed rabbits: a non-invasive in vivo ultrasound studyMarie Claude Drolet
Groupe de Recherche en Valvulopathies, Institut de Cardiologie de Quebec, Centre de recherche Hopital Laval, Universite Laval, 2725 Chemin Sainte Foy, Sainte Foy, Canada
Cardiovasc Ultrasound 2:10. 2004..Endothelial function in hypercholesterolemic rabbits is usually evaluated ex vivo on isolated aortic rings. In vivo evaluation requires invasive imaging procedures that cannot be repeated serially... - Proinflammatory cytokines are not released in the circulation following acute pulmonary thromboembolism in pigsJohn Tsang
Department of Medicine, University of British Columbia, Vancouver, Canada
J Invest Surg 15:29-35. 2002..We conclude that these cytokines have minimal impact on the systemic circulation during APTE... - Nonpeptidic endothelin-converting enzyme inhibitors and their potential therapeutic applicationsArco Y Jeng
Metabolic and Cardiovascular Diseases Research, Novartis Institute for Biomedical Research, Summit, NJ 07901, USA
Can J Physiol Pharmacol 80:440-9. 2002..Potential clinical applications of these compounds in hypertension, chronic heart failure, restenosis, renal failure, and cerebral vasospasm deduced from studies with relevant animal models are reviewed... - Classification of endothelin receptors and antagonists in clinical developmentAnthony P Davenport
Clinical Pharmacology Unit, University of Cambridge, Level 6, Centre for Clinical Investigation, Box 110, Addenbrooke's Hospital, Cambridge CB2 2QQ, U.K
Clin Sci (Lond) 103:1S-3S. 2002 - The endothelin axis: emerging role in cancerJoel Nelson
University of Pittsburgh School of Medicine, 5200 Centre Avenue, Pittsburgh, PA 15232, USA
Nat Rev Cancer 3:110-6. 2003..The place of ET-receptor antagonists in cancer therapy for a range of malignancies merits further investigation... - Plasma levels of endothelin-1, big endothelin-1 and thromboxane following acute pulmonary air embolismMathieu Simon
Division of Critical Care Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada V6Z 1Y6
Respir Physiol Neurobiol 138:97-106. 2003..These results showed that during APAE, the resulted changes in the pulmonary vascular and airway tones mediated by these potent mediators could explain the observed pulmonary hypertension and the deterioration of gas exchange... - Endothelins regulate mediator production of rat tissue-cultured mucosal mast cells. Up-regulation of Th1 and inhibition of Th2 cytokinesMartin Coulombe
Centre de Recherche, , Institut Universitaire de Cardiologie et de Pneumologie, , 2725 Chemin Sainte-Foy, Sainte-Foy, , Canada G1V 4G5
J Leukoc Biol 71:829-36. 2002..Thus, our data suggest that ETs may play an important role in modulating the cytokine network by regulating Th1/Th2 cytokine production by mast cells... - Long-term effects of ovariectomy and estrogen replacement treatment on endothelial function in mature ratsFarzad Moien-Afshari
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, 2176 Health Sciences Mall, Vancouver, BC, Canada V6T 1Z3
Maturitas 45:213-23. 2003..Apoptosis of endothelial cells is greatest in arteries from male rats. Our data suggests that early ERT treatment may be an important consideration for reducing endothelium-dependent vascular dysfunction...