Research Topics
| Jean Patrice BaillargeonSummaryCountry: Canada Publications
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Publications
A modern medical quandary: polycystic ovary syndrome, insulin resistance, and oral contraceptive pillsEvanthia Diamanti-Kandarakis
First Department of Medicine, University of Athens, GR-17548 Athens, Greece
J Clin Endocrinol Metab 88:1927-32. 2003- Metformin therapy increases insulin-stimulated release of D-chiro-inositol-containing inositolphosphoglycan mediator in women with polycystic ovary syndromeJean-Patrice Baillargeon
Department of Medicine, , Sherbrooke, J1H SN4 Canada
J Clin Endocrinol Metab 89:242-9. 2004..We conclude that in obese women with PCOS, metformin may improve the action of insulin in part by improving insulin-mediated release of DCI-IPG mediators, as evidenced by increased bioactive DCI-IPG released per unit of insulin... - Brothers of women with polycystic ovary syndrome are characterised by impaired glucose tolerance, reduced insulin sensitivity and related metabolic defectsJ P Baillargeon
Division of Endocrinology, Department of Medicine, Universite de Sherbrooke, Sherbrooke, QC, Canada
Diabetologia 50:2424-32. 2007..Thus, our aim was to assess insulin sensitivity and metabolic parameters in brothers of women with PCOS and male control individuals... - Use of insulin sensitizers in polycystic ovarian syndromeJean Patrice Baillargeon
Universite de Sherbrooke, Canada
Curr Opin Investig Drugs 6:1012-22. 2005.... - Association between the current use of low-dose oral contraceptives and cardiovascular arterial disease: a meta-analysisJean Patrice Baillargeon
Department of Internal Medicine, Universite de Sherbrooke, Endocrine Division, 3001 12th North Avenue, Sherbrooke, Quebec J1H 5N4, Canada
J Clin Endocrinol Metab 90:3863-70. 2005..The long-term cardiovascular safety of widely used oral contraceptives (OCs) is still debated, and no meta-analysis assesses the modern use of OCs and the associated cardiovascular risks... - Altered D-chiro-inositol urinary clearance in women with polycystic ovary syndromeJean Patrice Baillargeon
Department of Medicine, Universite de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada
Diabetes Care 29:300-5. 2006..We hypothesize that a deficiency in D-chiro-inositol (DCI) and/or a DCI-containing IPG (DCI-IPG) may contribute to insulin resistance in humans... - Role of insulin in the hyperandrogenemia of lean women with polycystic ovary syndrome and normal insulin sensitivityJean Patrice Baillargeon
Department of Medicine, Division of Endocrinology, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
Fertil Steril 88:886-93. 2007..To determine the effect of reducing insulin secretion on hyperandrogenemia in lean normoinsulinemic women with polycystic ovary syndrome (PCOS) and normal metabolic insulin sensitivity... - Uncoupling between insulin and release of a D-chiro-inositol-containing inositolphosphoglycan mediator of insulin action in obese women With polycystic ovary syndromeJean Patrice Baillargeon
Department of Medicine, Division of Endocrinology, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
Metab Syndr Relat Disord 8:127-36. 2010..The objective of this study was to compare the release of bioactive DCI-IPG between normal nonobese women and obese PCOS women during stimulation with two different concentrations of insulin when glucose levels are clamped... - Commentary: polycystic ovary syndrome: a syndrome of ovarian hypersensitivity to insulin?Jean-Patrice Baillargeon
Department of Medicine, Division of Endocrinology, , Sherbrooke, , Canada J1H 5N4
J Clin Endocrinol Metab 91:22-4. 2006 - On the suppression of plasma nonesterified fatty acids by insulin during enhanced intravascular lipolysis in humansAndre C Carpentier
Division of Endocrinology, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4
Am J Physiol Endocrinol Metab 289:E849-56. 2005..Our results also suggest that insulin may affect plasma NEFA clearance independently of the suppression of intracellular lipolysis... - Greek hyperinsulinemic women, with or without polycystic ovary syndrome, display altered inositols metabolismJean Patrice Baillargeon
Department of Medicine, Universite Sherbrooke, Sherbrooke, Canada J1H 5N4
Hum Reprod 23:1439-46. 2008.... - Hyperinsulinemia is closely related to low urinary clearance of D-chiro-inositol in men with a wide range of insulin sensitivityMarie Claude Villeneuve
Division of Endocrinology, Department of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
Metabolism 58:62-8. 2009..The apparent discrepancy with PCOS women might be explained by higher insulin levels in men as compared with women and requires confirmation... - Efficacy of intensive multitherapy for patients with type 2 diabetes mellitus: a randomized controlled trialJulie Menard
Diabetes and Metabolism Research Group, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada
CMAJ 173:1457-66. 2005..We sought to determine whether a 1-year intensive multitherapy program resulted in greater goal attainment than usual care among patients with poorly controlled type 2 diabetes mellitus... - Adrenocortical dysregulation as a major player in insulin resistance and onset of obesityClaude Roberge
Department of Medicine, Faculty of Medicine, Universite de Sherbrooke, 3001, 12th Ave North, Sherbrooke, QC, Canada J1H 5N4
Am J Physiol Endocrinol Metab 293:E1465-78. 2007.... - Comparison of foot-to-foot and hand-to-foot bioelectrical impedance methods in a population with a wide range of body mass indicesClaudia Gagnon
Department of Medicine, Division of Endocrinology, Centre de Recherche Clinique Etienne Le Bel, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Sherbrooke, Canada
Metab Syndr Relat Disord 8:437-41. 2010..We aimed to compare multifrequency hand-to-foot (HF-BIA) and foot-to-foot (FF-BIA) bioelectrical impedance analysis techniques to assess fat-free mass (FFM) in a population with a wide range of body mass indices (BMI)... - Predictors of success to weight-loss intervention program in individuals at high risk for type 2 diabetesWeilin Kong
Department of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada
Diabetes Res Clin Pract 90:147-53. 2010..These results indicate that a practical WLRT, in combination with early weight-loss response, is helpful to identify subjects with greater chances of success to lifestyle intervention... - Oral hypoglycemic agents for gestational diabetes mellitus?Ana Cristina Maymone
Division of Endocrinology, Department of Medicine, Centre Hospitalier Universitaire de Sherbrooke, 3001, 12th Avenue North, Sherbrooke Quebec J1H 5N4, Canada
Expert Opin Drug Saf 10:227-38. 2011..Oral treatment as a more user-friendly alternative may thus facilitate the control of GDM in some patients... - Insulin and hyperandrogenism in women with polycystic ovary syndromeCatherine G Baptiste
Department of Medicine, Division of Endocrinology, University of Sherbrooke, 3001 12th North Avenue, Sherbrooke, QC J1H 5N4, Canada
J Steroid Biochem Mol Biol 122:42-52. 2010..The present review thus aims at discussing new concepts and findings regarding insulin actions in PCOS women and how it is related to hyperandrogenemia... - Dose-dependent delay of the hypoglycemic effect of short-acting insulin analogs in obese subjects with type 2 diabetes: a pharmacokinetic and pharmacodynamic studyMaude Gagnon-Auger
Department of Medicine, Division of Endocrinology, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
Diabetes Care 33:2502-7. 2010..In obese patients, however, daily dosages are larger and ATBF is decreased. This study assessed the kinetics of a short-acting insulin analog in obese subjects with type 2 diabetes... - Clinically useful predictors of conversion to abnormal glucose tolerance in women with polycystic ovary syndromeMarie Hélène Pesant
Division of Endocrinology, Department of Medicine, University of Sherbrooke, Quebec, Canada
Fertil Steril 95:210-5. 2011.... - Mechanism of insulin-stimulated clearance of plasma nonesterified fatty acids in humansAndre C Carpentier
Division of Endocrinology, Department of Medicine, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4
Am J Physiol Endocrinol Metab 292:E693-701. 2007..We conclude that insulin stimulates plasma NEFA clearance by reducing the endogenous appearance rate of NEFA. The relationship between plasma NEFA level and appearance rate is nonlinear... - Effects of metformin and rosiglitazone, alone and in combination, in nonobese women with polycystic ovary syndrome and normal indices of insulin sensitivityJean-Patrice Baillargeon
Department of Medicine, , Sherbrooke, Quebec, Canada
Fertil Steril 82:893-902. 2004..CONCLUSION(S): These findings suggest that insulin-sensitizing drugs increase ovulatory frequency and ameliorate hyperandrogenemia, even in nonobese women with PCOS who appear to have normal insulin sensitivity... - Impact of health professionals' contact frequency on response to a lifestyle intervention with individuals at high risk for diabetesDanielle R Bouchard
Étienne LeBel Clinical Research Center of the Centre Hospitalier Universitaire de Sherbrooke, and Departement of Medicine, Division of Endocrinology, Universite de Sherbrooke, 3001, 12th North Avenue, Sherbrooke, Quebec, Canada J1H 5N4
Diabetes Res Clin Pract 96:129-34. 2012.... - Prevalence and predictors of vitamin D insufficiency in women of reproductive age living in northern latitudeClaudia Gagnon
Division of Endocrinology, Department of Medicine, Universite de Sherbrooke, 12th Avenue North, Fleurimont, Quebec, Canada
Eur J Endocrinol 163:819-24. 2010..This study assessed the prevalence of vitamin D deficiency (serum 25-hydroxyvitamin D (25OHD) ? 50 nmol/l) and insufficiency (serum 25OHD 51-74 nmol/l) during summer and the predictors of serum 25OHD in young women of reproductive age... - Clinically significant and sustained weight loss is achievable in obese women with polycystic ovary syndrome followed in a regular medical practiceLysanne Pelletier
Department of Medicine, Division of Endocrinology, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
Fertil Steril 94:2665-9. 2010..To determine the proportion of obese women with polycystic ovary syndrome (PCOS) losing clinically significant amounts of weight during a standard follow-up by an endocrinologist... - Metabolically healthy obese women and functional capacityDanielle R Bouchard
Centre de Recherche Clinique Etienne Lebel, Centre Hospitalier Universitaire de Sherbrooke, Universite de Sherbrooke, 3001 12th Avenue Nord, Sherbrooke, Quebec, Canada
Metab Syndr Relat Disord 9:225-9. 2011..However, MHO women might have similar risk than non-MHO women for nonmetabolic weight-related co-morbidities, including altered functional capacity... - Intergenerational cycle of obesity and diabetes: how can we reduce the burdens of these conditions on the health of future generations?Marie Claude Battista
Division of Endocrinology, Department of Medicine, University of Sherbrooke, Sherbrooke, QC, Canada
Exp Diabetes Res 2011:596060. 2011..The main interventions designed to reduce maternal obesity and GDM and their ability to break the vicious circle that perpetuates the transmission of obesity and metabolic conditions to the next generations are also addressed... - Integrated obesity care management system -implementation and research protocolJean Patrice Baillargeon
Division of Endocrinology, Department of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
BMC Health Serv Res 7:163. 2007..The current research proposal is aimed at the development and implementation of an innovative, integrated, interdisciplinary obesity care management system involving both primary and secondary care professionals... - Effectiveness of a multidisciplinary program for management of obesity: the Unité d'Enseignement, de Traitement et de Recherche sur l'Obésité (UETRO) database studyCarole N Kamga-Ngandé
Department of Medicine, Division of Endocrinology, Centre de Recherche Clinique Etienne Le Bel, Centre Hospitalier Universitaire de Sherbrooke, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Quebec, Canada
Metab Syndr Relat Disord 7:297-304. 2009..We report here the effectiveness of this program for weight reduction over the first year of follow up... - Reference ranges for total and calculated free and bioavailable testosterone in a young healthy women population with normal menstrual cycles or using oral contraceptionMarie Hélène Pesant
Department of Medicine, Division of Endocrinology, Universite de Sherbrooke, 12th Avenue North, Fleurimont, Quebec, Canada J1H 5N4
Clin Biochem 45:148-50. 2012..Determine reference values for testosterone in women... - Suitability of recommended limits for fasting glucose tests in women with polycystic ovary syndromeClaudia Gagnon
Department of Medicine, Division of Endocrinology, Universite de Sherbrooke, Quebec, Que
CMAJ 176:933-8. 2007..6 mmol/L as a fasting plasma glucose cutoff for detecting abnormal glucose tolerance in women with polycystic ovary syndrome, and then to define the optimal cutoff for this population... - Basic infertility including polycystic ovary syndromeMaryse Brassard
Division of Endocrinology, Department of Medicine, Universite de Sherbrooke, 3001, 12th North Avenue, Sherbrooke, QC J1H 5N4, Canada
Med Clin North Am 92:1163-92, xi. 2008..Losing weight not only improves fertility but also reduces adverse pregnancy outcomes associated with obesity... - Saturated fatty acid exposure induces androgen overproduction in bovine adrenal cellsSylvain Bellanger
Division of Endocrinology, Department of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4
Steroids 77:347-53. 2012..The aim of this study was therefore to determine the effects of in vitro over-exposure to NEFA on androgen synthesis in a bovine adrenocortical cell model... - Insulin sensitizers for polycystic ovary syndromeJean-Patrice Baillargeon
Department of Internal Medicine, , Sherbrooke, Canada
Clin Obstet Gynecol 46:325-40. 2003 - Insulin-stimulated release of D-chiro-inositol-containing inositolphosphoglycan mediator correlates with insulin sensitivity in women with polycystic ovary syndromeKai I Cheang
Department of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298 0533, USA
Metabolism 57:1390-7. 2008..The significant relationship between DCI-IPG release and insulin sensitivity suggests that the DCI-IPG mediator may be a target for therapeutic interventions in PCOS... - Myo-inositol in patients with polycystic ovary syndrome: a novel method for ovulation inductionEnrico Papaleo
IVF Unit, Gynaecological Obstetric Department, IRCCS San Raffaele Hospital, Vita Salute University, Milan, Italy
Gynecol Endocrinol 23:700-3. 2007..We hypothesized that the administration of an isoform of inositol (myo-inositol), belonging to the vitamin B complex, would improve the insulin-receptor activity, restoring normal ovulatory function... - Effects of d-chiro-inositol in lean women with the polycystic ovary syndromeMaria J Iuorno
Department of Medicine, Medical College of Virginia, Virginia, Commonwealth University, Richmond, Virginia, USA
Endocr Pract 8:417-23. 2002.... - Reduced serum glycodelin and insulin-like growth factor-binding protein-1 in women with polycystic ovary syndrome during first trimester of pregnancyDaniela J Jakubowicz
Hospital de Clinicas Caracas, and Central University of Venezuela, Caracas 1040, Venezuela
J Clin Endocrinol Metab 89:833-9. 2004..These decreases are likely to be secondary to hyperinsulinemia and reduced insulin sensitivity...