Jan Brun

Summary

Publications

  1. ncbi Lysine 63-polyubiquitination guards against translesion synthesis-induced mutations
    Roland K Chiu
    Department of Radiation Oncology, GROW Research Institute, University of Maastricht, Maastricht, Netherlands
    PLoS Genet 2:e116. 2006
  2. ncbi hMMS2 serves a redundant role in human PCNA polyubiquitination
    Jan Brun
    Centre for Cancer Therapeutics, Ottawa Health Research Institute, Ottawa, ON K1H 8L6, Canada
    BMC Mol Biol 9:24. 2008
  3. ncbi Targeting the ubiquitin proteasome pathway for the treatment of septic shock in patients
    Jan Brun
    Ottawa Health Research Institute, Ottawa, ON, Canada K1Y 4E9
    Crit Care 13:311. 2009
  4. ncbi Regulation of PCNA polyubiquitination in human cells
    Jan Brun
    Ottawa Health Research Institute, Ottawa, ON K1H 8L6, Canada
    BMC Res Notes 3:85. 2010
  5. ncbi Proteasome inhibition as a novel therapy in treating rheumatoid arthritis
    Jan Brun
    Apoptosis Research Centre, Children s Hospital of Eastern Ontario, 401 Smyth Road, Room 3103, Ottawa, ON, Canada
    Med Hypotheses 71:65-72. 2008
  6. ncbi Formation of lysine 63-linked poly-ubiquitin chains protects human lung cells against benzo[a]pyrene-diol-epoxide-induced mutagenicity
    Sabine A S Langie
    Department of Health Risk Analysis and Toxicology NUTRIM, Maastricht University, Maastricht, The Netherlands
    DNA Repair (Amst) 6:852-62. 2007
  7. ncbi Cisplatin induces p53-dependent FLICE-like inhibitory protein ubiquitination in ovarian cancer cells
    Mohammad R Abedini
    Department of Cellular and Molecular Medicine, University of Ottawa, Ontario, Canada
    Cancer Res 68:4511-7. 2008

Collaborators

  • Douglas A Gray
  • Bradly G Wouters
  • Roland K Chiu
  • Mohammad R Abedini
  • Sabine A S Langie
  • Jan Theys
  • Philippe Lambin
  • Benjamin K Tsang
  • Emilie J Muller
  • Richard Bergeron
  • Chantal H M A Ramaekers
  • Roger W L Godschalk
  • Ad M Knaapen
  • Frederik J Van Schooten
  • Chantal Ramaekers
  • Lin Weng

Detail Information

Publications7

  1. ncbi Lysine 63-polyubiquitination guards against translesion synthesis-induced mutations
    Roland K Chiu
    Department of Radiation Oncology, GROW Research Institute, University of Maastricht, Maastricht, Netherlands
    PLoS Genet 2:e116. 2006
    ..Furthermore, we show that polyubiquitination of PCNA occurs in UV-irradiated human cells. Our findings indicate that K63-polyubiquitination guards against environmental carcinogenesis and contributes to genomic stability...
  2. ncbi hMMS2 serves a redundant role in human PCNA polyubiquitination
    Jan Brun
    Centre for Cancer Therapeutics, Ottawa Health Research Institute, Ottawa, ON K1H 8L6, Canada
    BMC Mol Biol 9:24. 2008
    ..Recently, it was shown that PCNA polyubiquitination is conserved in human cells and that this modification is dependent on RAD18, UBC13 and SHPRH. However, the role of hMMS2 in this process was not specifically addressed...
  3. ncbi Targeting the ubiquitin proteasome pathway for the treatment of septic shock in patients
    Jan Brun
    Ottawa Health Research Institute, Ottawa, ON, Canada K1Y 4E9
    Crit Care 13:311. 2009
    ..We posit that administration of proteasome inhibitors may enhance the survival of patients with septic shock...
  4. ncbi Regulation of PCNA polyubiquitination in human cells
    Jan Brun
    Ottawa Health Research Institute, Ottawa, ON K1H 8L6, Canada
    BMC Res Notes 3:85. 2010
    ..The particulars of PCNA ubiquitination have been elucidated in yeast and to a further extent recently in human cells. However, gaps in the detailed mechanism and regulation of PCNA polyubiquitination still persist in human cells...
  5. ncbi Proteasome inhibition as a novel therapy in treating rheumatoid arthritis
    Jan Brun
    Apoptosis Research Centre, Children s Hospital of Eastern Ontario, 401 Smyth Road, Room 3103, Ottawa, ON, Canada
    Med Hypotheses 71:65-72. 2008
    ..Overall, the purpose of our hypothesis is to suggest a realistic and alternative treatment for patients with refractory and non-refractory arthritic disease...
  6. ncbi Formation of lysine 63-linked poly-ubiquitin chains protects human lung cells against benzo[a]pyrene-diol-epoxide-induced mutagenicity
    Sabine A S Langie
    Department of Health Risk Analysis and Toxicology NUTRIM, Maastricht University, Maastricht, The Netherlands
    DNA Repair (Amst) 6:852-62. 2007
    ..These findings indicate that K63-polyubiquitination guards against chemical carcinogenesis by preventing mutagenesis and thus contributing to genomic stability...
  7. ncbi Cisplatin induces p53-dependent FLICE-like inhibitory protein ubiquitination in ovarian cancer cells
    Mohammad R Abedini
    Department of Cellular and Molecular Medicine, University of Ottawa, Ontario, Canada
    Cancer Res 68:4511-7. 2008
    ..Moreover, we showed that Itch (an E3 ligase) forms a complex with FLIP and p53 upon CDDP treatment. These results suggest that p53 facilitates FLIP down-regulation by CDDP-induced FLIP ubiquitination and proteasomal degradation...