Itzhak Brook

Summary

Publications

  1. ncbi Acute bacterial suppurative parotitis: microbiology and management
    Itzhak Brook
    Georgetown University School of Medicine, Washington, DC, USA
    J Craniofac Surg 14:37-40. 2003
  2. ncbi Microbiology of intracranial abscesses and their associated sinusitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Arch Otolaryngol Head Neck Surg 131:1017-9. 2005
  3. ncbi Antimicrobial resistance in the nasopharyngeal flora of children with acute otitis media and otitis media recurring after amoxicillin therapy
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington DC 20016, USA
    J Med Microbiol 54:83-5. 2005
  4. ncbi Microbiology and management of soft tissue and muscle infections
    Itzhak Brook
    Georgetown University, Schools of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    Int J Surg 6:328-38. 2008
  5. ncbi Rate of eradication of group A beta-hemolytic streptococci in children with pharyngo-tonsillitis by amoxicillin and cefdinir
    Itzhak Brook
    Department of Pediatrics, Georgetown University, Schools of Medicine, Washington, DC 20016, USA
    Int J Pediatr Otorhinolaryngol 73:757-9. 2009
  6. ncbi Cephalosporins in overcoming beta-lactamase-producing bacteria and preservation of the interfering bacteria in the treatment of otitis, sinusitis and tonsillitis
    Itzhak Brook
    Georgetown University School of Medicine, Department of Pediatrics, 4431 Albemarle Street NW, Washington, DC 20016, USA
    Expert Rev Anti Infect Ther 5:939-50. 2007
  7. ncbi Treatment of anaerobic infection
    Itzhak Brook
    Georgetown University School of Medicine, Department of Pediatrics, 4431 Albemarle St NW, Washington, DC 20016, USA
    Expert Rev Anti Infect Ther 5:991-1006. 2007
  8. ncbi Failure to eradicate streptococci and beta-lactamase producing bacteria
    Itzhak Brook
    Department of Pediatrics, Georgetown University, Schools of Medicine, Washington, DC, USA
    Acta Paediatr 97:193-5. 2008
  9. ncbi Recovery of potential pathogens and interfering bacteria in the nasopharynx of otitis media-prone children and their smoking and nonsmoking parents
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Arch Otolaryngol Head Neck Surg 131:509-12. 2005
  10. ncbi Long-term effects on the nasopharyngeal flora of children following antimicrobial therapy of acute otitis media with cefdinir or amoxycillin-clavulanate
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington DC 20016, USA
    J Med Microbiol 54:553-6. 2005

Collaborators

Detail Information

Publications92

  1. ncbi Acute bacterial suppurative parotitis: microbiology and management
    Itzhak Brook
    Georgetown University School of Medicine, Washington, DC, USA
    J Craniofac Surg 14:37-40. 2003
    ..The choice of antimicrobial depends on the etiologic agent. Maintenance of good oral hygiene, adequate hydration, and early and proper therapy of bacterial infection of the oropharynx may reduce the occurrence of suppurative parotitis...
  2. ncbi Microbiology of intracranial abscesses and their associated sinusitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Arch Otolaryngol Head Neck Surg 131:1017-9. 2005
    ..To evaluate the organisms recovered from infected sinuses and associated intracranial abscesses (IAs)...
  3. ncbi Antimicrobial resistance in the nasopharyngeal flora of children with acute otitis media and otitis media recurring after amoxicillin therapy
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington DC 20016, USA
    J Med Microbiol 54:83-5. 2005
    ..025). These data illustrate the higher recovery rate of antimicrobial-resistant Streptococcus pneumoniae and H. influenzae from the nasopharynx of children who had otitis media that recurred after amoxicillin therapy than those with AOM...
  4. ncbi Microbiology and management of soft tissue and muscle infections
    Itzhak Brook
    Georgetown University, Schools of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    Int J Surg 6:328-38. 2008
    ..The infections can progress rapidly and early recognition and proper medical and surgical management is the cornerstone of therapy...
  5. ncbi Rate of eradication of group A beta-hemolytic streptococci in children with pharyngo-tonsillitis by amoxicillin and cefdinir
    Itzhak Brook
    Department of Pediatrics, Georgetown University, Schools of Medicine, Washington, DC 20016, USA
    Int J Pediatr Otorhinolaryngol 73:757-9. 2009
    ..This study investigated the effect of amoxicillin and cefdinir therapies on the rate of eradication of GABHS from the tonsils of children with acute pharyngo-tonsillitis (PT)...
  6. ncbi Cephalosporins in overcoming beta-lactamase-producing bacteria and preservation of the interfering bacteria in the treatment of otitis, sinusitis and tonsillitis
    Itzhak Brook
    Georgetown University School of Medicine, Department of Pediatrics, 4431 Albemarle Street NW, Washington, DC 20016, USA
    Expert Rev Anti Infect Ther 5:939-50. 2007
    ..The use of some of the cephalosporins that are able to overcome the effect of BLPB and preserve the beneficial interfering bacteria can overcome and modulate these phenomena and achieve better cure of URTIs...
  7. ncbi Treatment of anaerobic infection
    Itzhak Brook
    Georgetown University School of Medicine, Department of Pediatrics, 4431 Albemarle St NW, Washington, DC 20016, USA
    Expert Rev Anti Infect Ther 5:991-1006. 2007
    ....
  8. ncbi Failure to eradicate streptococci and beta-lactamase producing bacteria
    Itzhak Brook
    Department of Pediatrics, Georgetown University, Schools of Medicine, Washington, DC, USA
    Acta Paediatr 97:193-5. 2008
    ....
  9. ncbi Recovery of potential pathogens and interfering bacteria in the nasopharynx of otitis media-prone children and their smoking and nonsmoking parents
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Arch Otolaryngol Head Neck Surg 131:509-12. 2005
    ....
  10. ncbi Long-term effects on the nasopharyngeal flora of children following antimicrobial therapy of acute otitis media with cefdinir or amoxycillin-clavulanate
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington DC 20016, USA
    J Med Microbiol 54:553-6. 2005
    ..In contrast, utilization of a broad-spectrum antimicrobial is associated with prolonged absence of inhibitory organisms and rapid recolonization with pathogens...
  11. ncbi Increased recovery of Moraxella catarrhalis and Haemophilus influenzae in association with group A beta-haemolytic streptococci in healthy children and those with pharyngo-tonsillitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University, School of Medicine, Washington, DC, USA
    J Med Microbiol 55:989-92. 2006
    ..This study demonstrates an association between the recovery of GABHS and H. influenzae and M. catarrhalis from pharyngo-tonsillar cultures of patients with APT and M. catarrhalis from pharyngo-tonsillar cultures of healthy children...
  12. ncbi Eradication of Streptococcus pneumoniae in the nasopharyngeal flora of children with acute otitis media after amoxicillin-clavulanate therapy
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, D C 20016, USA
    Antimicrob Agents Chemother 48:1419-21. 2004
    ..The number of Streptococcus pneumoniae isolates in the 45-mg/kg group was reduced from 12 to 6 and was reduced from 14 to 1 (P = 0.0261) in the 90-mg/kg group...
  13. ncbi Antimicrobial resistance in the nasopharyngeal flora of children with acute maxillary sinusitis and maxillary sinusitis recurring after amoxicillin therapy
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    J Antimicrob Chemother 53:399-402. 2004
    ..To investigate the antimicrobial susceptibility of the organisms isolated from the nasopharynx of children who present with acute maxillary sinusitis (AMS) or maxillary sinusitis that recurred (RMS) after amoxicillin therapy...
  14. ncbi Recovery of interfering bacteria in the nasopharynx following antimicrobial therapy of acute maxillary sinusitis with telithromycin or amoxicillin-clavulanate
    Itzhak Brook
    Georgetown University School of Medicine, Washington, DC 20016, USA
    Antimicrob Agents Chemother 49:4793-4. 2005
    ..However, the number of interfering Prevotella spp. declined more significantly after amoxicillin-clavulanate treatment...
  15. ncbi Effect of telithromycin and azithromycin on nasopharyngeal bacterial flora in patients with acute maxillary sinusitis
    Itzhak Brook
    Department of Pediatrics and Medicine, Georgetown University School of Medicine, Washington, DC, USA
    Arch Otolaryngol Head Neck Surg 132:442-5. 2006
    ..The growing resistance of Streptococcus pneumoniae to penicillin and macrolides brought about the development of a new class of antibiotics-the ketolides-that are effective against resistant pneumococci...
  16. ncbi Effects of exposure to smoking on the microbial flora of children and their parents
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC 20016, United States
    Int J Pediatr Otorhinolaryngol 74:447-50. 2010
    ..These studies illustrate the adverse effects of direct and indirect exposure to smoking on colonization with potential pathogens...
  17. ncbi Management of group A beta-hemolytic streptococcal pharyngotonsillitis in children
    Itzhak Brook
    Georgetown University School of Medicine, Washington, DC, USA
    J Fam Pract 55:S1-11; quiz S12. 2006
    ....
  18. ncbi Microbiology and management of myositis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    Int Orthop 28:257-60. 2004
    ..Intensive surgical and medical therapy that includes the administration of intravenous fluids and antimicrobial therapy is an essential element in management of muscle infection...
  19. ncbi The role of anaerobic bacteria in mediastinitis
    Itzhak Brook
    Georgetown University School of Medicine, Washington, DC 20016, USA
    Drugs 66:315-20. 2006
    ..Selection of antibacterials for the treatment of mediastinitis is determined by bacteriological studies...
  20. ncbi Recovery of potential pathogens and interfering bacteria in the nasopharynx of smokers and nonsmokers
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Chest 127:2072-5. 2005
    ....
  21. ncbi Management of human and animal bite wounds: an overview
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Adv Skin Wound Care 18:197-203. 2005
    ..Wound management includes proper local care and, when needed, antimicrobial therapy...
  22. ncbi The role of bacteria in chronic rhinosinusitis
    Itzhak Brook
    Department of Pediatrics and Medicine, Georgetown University School of Medicine, 4431 Albemarle Street Northwest, Washington, DC 20016, USA
    Otolaryngol Clin North Am 38:1171-92. 2005
    ..The bacterial pathogens in acute sinusitis are S. pneumoniae, H. influenzae, and M. catarrhalis, while anaerobic bacteria and S. aureus predominant in CRS...
  23. ncbi Effects of amoxicillin and cefdinir on nasopharyngeal bacterial flora
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Arch Otolaryngol Head Neck Surg 131:785-7. 2005
    ..To compare the effects of cefdinir (14 mg/kg per day) and amoxicillin (90 mg/kg per day) antimicrobial therapy on the nasopharyngeal flora of children with acute otitis media...
  24. ncbi Effect of antimicrobial therapy with amoxicillin and cefprozil on bacterial interference and beta-lactamase production in the adenoids
    Itzhak Brook
    Department of Pediatrics, Georgetown University, Washington, DC, USA
    Ann Otol Rhinol Laryngol 113:902-5. 2004
    ..This study suggests a potential beneficial effect of using an antimicrobial that selectively spares interfering AHS while inhibiting BLPB...
  25. ncbi In vitro effects of penicillin and telithromycin on the expression of Streptococcus pneumoniae capsule
    Itzhak Brook
    Department of Pediatrics and Medicine, Georgetown University and George Washington University, Schools of Medicine, Washington, DC, USA
    J Antimicrob Chemother 58:678-9. 2006
    ..To evaluate the effects of subinhibitory concentrations of penicillin and telithromycin on capsular formation by Streptococcus pneumoniae...
  26. ncbi Bacteriology of acute and chronic ethmoid sinusitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    J Clin Microbiol 43:3479-80. 2005
    ..Twenty-seven aerobes and 41 anaerobes were found in isolates from patients with chronic sinusitis. The predominant isolates were anaerobic gram-negative bacilli and Peptostreptococcus spp...
  27. ncbi Recovery of potential pathogens in the nasopharynx of healthy and otitis media-prone children and their smoking and nonsmoking parents
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Ann Otol Rhinol Laryngol 117:727-30. 2008
    ..This study investigated the frequency of isolation of potential pathogens in the nasopharynx of healthy and otitis media-prone (OMP) children and their smoking or nonsmoking parents...
  28. ncbi Current issues in the management of acute bacterial sinusitis in children
    Itzhak Brook
    Department of Pediatrics, Georgetown University, Schools of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    Int J Pediatr Otorhinolaryngol 71:1653-61. 2007
    ..To review and summarize recent challenges in the microbiology and treatment of acute bacterial sinusitis (ABS), one of the most common infectious diseases in the pediatric community...
  29. ncbi Increase in the frequency of recovery of meticillin-resistant Staphylococcus aureus in acute and chronic maxillary sinusitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    J Med Microbiol 57:1015-7. 2008
    ..05). These data illustrate that a significant increase occurred in the rate of recovery of MRSA in patients with acute and chronic maxillary sinusitis over the periods studied...
  30. ncbi Microbiology of acute sinusitis of odontogenic origin presenting with periorbital cellulitis in children
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Ann Otol Rhinol Laryngol 116:386-8. 2007
    ..This study was undertaken to evaluate the aerobic and anaerobic microbiology of acute maxillary sinusitis of odontogenic origin presenting with periodontal infection in children...
  31. ncbi Bacteriology of spontaneously draining acute otitis media in children before and after the introduction of pneumococcal vaccination
    Itzhak Brook
    Department of Pediatrics Georgetown, University School of Medicine, Washington, DC, USA
    Pediatr Infect Dis J 28:640-2. 2009
    ..05) in the latter period...
  32. ncbi The effects of treatment of acute otitis media with a low dose vs a high dose of amoxicillin on the nasopharyngeal flora
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Arch Otolaryngol Head Neck Surg 135:458-61. 2009
    ..To compare the effects on the nasopharyngeal flora of therapy of acute otitis media in children with either a low dose or a high dose of amoxicillin...
  33. ncbi Microbiology of acute and chronic maxillary sinusitis in smokers and nonsmokers
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Ann Otol Rhinol Laryngol 120:707-12. 2011
    ..We evaluated the microbiology of sinus aspirates of smokers and nonsmokers with acute and chronic maxillary sinusitis...
  34. ncbi Overcoming penicillin failures in the treatment of Group A streptococcal pharyngo-tonsillitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington DC, USA
    Int J Pediatr Otorhinolaryngol 71:1501-8. 2007
    ..The use of antimicrobials that can overcome and modulate these phenomena and achieve better cure of the infection is described...
  35. ncbi Current management of upper respiratory tract and head and neck infections
    Itzhak Brook
    Departments of Pediatrics and Medicine, Georgetown University School of Medicine, Washington, DC 20016, USA
    Eur Arch Otorhinolaryngol 266:315-23. 2009
    ..In conclusion, the proper management of these infections requires an accurate clinical and bacteriological diagnosis...
  36. ncbi Microbiology of sinusitis
    Itzhak Brook
    Georgetown University School of Medicine, Washington DC, USA
    Proc Am Thorac Soc 8:90-100. 2011
    ..The microbiology of sinusitis is influenced by the previous antimicrobial therapy, vaccinations, and the presence of normal flora capable of interfering with the growth of pathogens...
  37. ncbi A pooled comparison of cefdinir and penicillin in the treatment of group a beta-hemolytic streptococcal pharyngotonsillitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Clin Ther 27:1266-73. 2005
    ..This pooled analysis compared the clinical cure and bacterial eradication rates achieved by cefdinir and penicillin in the treatment of group A beta-hemolytic streptococcal (GABHS) pharngotonsillitis...
  38. ncbi Efficacy of penicillin versus cefdinir in eradication of group A streptococci and tonsillar flora
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington DC, USA
    Antimicrob Agents Chemother 49:4787-8. 2005
    ..01) patients. Inhibiting alpha-hemolytic streptococci were isolated less often from penicillin-treated patients than from cefdinir-treated patients...
  39. ncbi Microbiology of acute and chronic maxillary sinusitis associated with an odontogenic origin
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Laryngoscope 115:823-5. 2005
    ..To study the microbiology of sinusitis associated with odontogenic origin...
  40. ncbi Isolation of methicillin resistant Staphylococcus aureus from the surface and core of tonsils in children
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Int J Pediatr Otorhinolaryngol 70:2099-102. 2006
    ..This study investigated the rate of recovery of MRSA as well as other aerobic organisms from tonsils that were removed because of recurrent GABHS infection...
  41. ncbi Recovery of interfering and beta-lactamase-producing bacteria from group A beta-haemolytic streptococci carriers and non-carriers
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington DC, USA
    J Med Microbiol 55:1741-4. 2006
    ..A higher rate of recovery of BLPB was observed only in GABHS carriers who were treated with penicillin for GABHS PT...
  42. ncbi Bacterial infection and antibiotic treatment in chronic rhinosinusitis
    Itzhak Brook
    Georgetown University School of Medicine, Washington, DC, USA
    Clin Allergy Immunol 20:147-62. 2007
    ..In cases where empiric antibiotics have failed, the need for bacterial cultures is even more critical to assure proper treatment and to minimize antibiotic side effects...
  43. ncbi Frequency of recovery of pathogens from the nasopharynx of children with acute maxillary sinusitis before and after the introduction of vaccination with the 7-valent pneumococcal vaccine
    Itzhak Brook
    Department of Pediatrics, Georgetown University, School of Medicine, Washington, DC, USA
    Int J Pediatr Otorhinolaryngol 71:575-9. 2007
    ....
  44. ncbi Recovery of aerobic and anaerobic bacteria in sinus fungal ball
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Otolaryngol Head Neck Surg 145:851-2. 2011
    ..This study demonstrates the recovery of polymicrobial aerobic-anaerobic flora in the sinuses of patients with fungus ball...
  45. ncbi Treatment modalities for bacterial rhinosinusitis
    Itzhak Brook
    Department of Pediatrics and Medicine, Georgetown University School of Medicine, Washington, DC 20016, USA
    Expert Opin Pharmacother 11:755-69. 2010
    ..Accurate diagnosis of rhinosinusitis depends upon clinical assessment. Isolation of the causative agents must be considered in cases failing initial treatment...
  46. ncbi Bacteriology of chronic sinusitis and acute exacerbation of chronic sinusitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC 20016, USA
    Arch Otolaryngol Head Neck Surg 132:1099-101. 2006
    ..To establish the microbiological characteristics of acute exacerbation of chronic sinusitis (AECS)...
  47. ncbi The role of anaerobic bacteria in sinusitis
    Itzhak Brook
    Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    Anaerobe 12:5-12. 2006
    ..These organisms were also recovered in acute sinusitis that was associated with dental infections. The predominant isolates were pigmented Prevotella and Porphyromonas, Fusobacterium and Peptostreptococcus spp...
  48. ncbi Concurrent influenza A and group A beta-hemolytic streptococcal pharyngotonsillitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Ann Otol Rhinol Laryngol 117:310-2. 2008
    ..This report describes our experience in diagnosing a potential mixed GABHS-influenza virus PT in children...
  49. ncbi Clindamycin in dentistry: more than just effective prophylaxis for endocarditis?
    Itzhak Brook
    Georgetown University School of Medicine, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 100:550-8. 2005
    ..This review discusses the microbiologic and clinical evidence supporting the efficacy and safety of clindamycin for the successful management of dental infections...
  50. ncbi Treatment of non-streptococcal tonsillitis with metronidazole
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    Int J Pediatr Otorhinolaryngol 69:65-8. 2005
    ....
  51. ncbi Antibacterial therapy for acute group a streptococcal pharyngotonsillitis: short-course versus traditional 10-day oral regimens
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Paediatr Drugs 4:747-54. 2002
    ..In conclusion, short courses of amoxicillin, cephalosporins, and macrolides provide superior or equal efficacy to a 10-day course of penicillin therapy in the treatment of GABHS pharyngotonsillitis...
  52. ncbi Acute and chronic frontal sinusitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Curr Opin Pulm Med 9:171-4. 2003
    ..Surgery is indicated to treat patients with acute and chronic sinusitis and their complications. Several surgical procedures were recently evaluated, and these are briefly reviewed...
  53. ncbi Discrepancies in the recovery of bacteria from multiple sinuses in acute and chronic sinusitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    J Med Microbiol 53:879-85. 2004
    ..These findings illustrate that there are differences in the distribution of organisms in single patients who suffer from infections in multiple sinuses and emphasize the importance of obtaining cultures from all infected sinuses...
  54. ncbi Microbiology of acute exacerbation of chronic sinusitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Ann Otol Rhinol Laryngol 114:573-6. 2005
    ....
  55. ncbi Chronic sinusitis in children and adults: role of bacteria and antimicrobial management
    Itzhak Brook
    Georgetown University School of Medicine, 4431 Albemarle Street NW, Washington, DC 20016, USA
    Curr Allergy Asthma Rep 5:482-90. 2005
    ..The choice of antimicrobial agent in chronic sinusitis should provide coverage for the usual pathogens in acute sinusitis as well as beta-lactamase-producing aerobic and anaerobic organisms...
  56. ncbi Microbiology of recurrent acute rhinosinusitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University, Washington, DC, USA
    Laryngoscope 114:129-31. 2004
    ..We undertook to evaluate the microbiology of recurrent acute rhinosinusitis...
  57. ncbi The role of anaerobic bacteria in cutaneous and soft tissue abscesses and infected cysts
    Itzhak Brook
    Schools of Medicine, Georgetown University, 4431 Albemarle Street NW, Washington, DC 20016, USA
    Anaerobe 13:171-7. 2007
    ..The infections can progress rapidly and early recognition and proper medical and surgical management is the cornerstone of therapy...
  58. ncbi Pericarditis caused by anaerobic bacteria
    Itzhak Brook
    Department of Pediatrics and Medicine, Georgetown University School of Medicine, Washington, DC 20016, USA
    Int J Antimicrob Agents 33:297-300. 2009
    ..Identification of pathogens and determination of their antimicrobial susceptibility and beta-lactamase production are essential for adequate selection of antibiotic therapy effective against these organisms...
  59. ncbi Microbiology and antimicrobial treatment of orbital and intracranial complications of sinusitis in children and their management
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle Street NW, Washington, DC 20016, USA
    Int J Pediatr Otorhinolaryngol 73:1183-6. 2009
    ..Early recognition and appropriate surgical and medical therapy are essential to ensure recovery...
  60. ncbi Recovery of anaerobic bacteria from a glossal abscess in an adolescent
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Pediatr Emerg Care 18:358-9. 2002
    ..The patient recovered following incision and drainage and 14 days of antimicrobial therapy with clindamycin. This report illustrates the recovery of anaerobic bacteria from glossal abscess in an adolescent...
  61. ncbi Pericarditis due to anaerobic bacteria
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Cardiology 97:55-8. 2002
    ..Treatment of pericarditis involving anaerobic bacteria includes the use of antibiotic therapy effective against these organisms...
  62. ncbi Microbiology and antimicrobial management of sinusitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    J Laryngol Otol 119:251-8. 2005
    ..The antimicrobials that are the most effective in management of chronic sinusitis are amoxycillinclavulanate, clindamycin and the combination of metronidazole and a penicillin...
  63. ncbi Microbiology and antimicrobial management of sinusitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle Street NW, Washington, DC 20016, USA
    Otolaryngol Clin North Am 37:253-66, v-vi. 2004
    ..This article summarizes the current information regarding the microbiology of all forms of sinusitis and approaches to antimicrobial therapy...
  64. ncbi Suppurative parotitis caused by anaerobic bacteria in newborns
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Pediatr Infect Dis J 21:81-2. 2002
    ..Peptostreptococcus intermedius and Prevotella melaninogenica were isolated from one child and Prevotella intermedia from the other patient. Complete recovery occurred after 4 weeks of antimicrobial therapy...
  65. ncbi Aerobic and anaerobic microbiology of suppurative sialadenitis
    Itzhak Brook
    Georgetown University School of Medicine, Washington DC, USA
    J Med Microbiol 51:526-9. 2002
    ..and Fusobacterium spp.) and Peptostreptococcus spp. The study highlights the polymicrobial nature and importance of anaerobic bacteria in acute suppurative sialadenitis...
  66. ncbi Microbiology and management of endodontic infections in children
    Itzhak Brook
    Georgetown University School of Medicine, Washington DC, USA
    J Clin Pediatr Dent 28:13-7. 2003
    ..These agents include amoxicillin-clavulanate, clindamycin or the combination of metronidazole plus amoxicillin or a macrolide...
  67. ncbi Cutaneous and subcutaneous infections in newborns due to anaerobic bacteria
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    J Perinat Med 30:197-208. 2002
    ..Managements of these infections include surgical debridement and drainage when appropriate as well as topical and systemic use of antimicrobial agents effective against both aerobic and anaerobic bacteria...
  68. ncbi Bacteriology of acute and chronic frontal sinusitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Arch Otolaryngol Head Neck Surg 128:583-5. 2002
    ..The predominant anaerobes included Prevotella species (8), Peptostreptococcus species (6), and Fusobacterium species (4). These findings illustrate the microbiologic features of acute and chronic frontal sinusitis...
  69. ncbi The bacteriology of salivary gland infections
    Itzhak Brook
    Georgetown University School of Medicine, 4431 Albemarle Street NW, Washington, DC 20016, USA
    Oral Maxillofac Surg Clin North Am 21:269-74. 2009
    ..Mycobacterium tuberculosis and atypical mycobacteria are rare causes of infection. The choice of antibiotics should be guided by identification of the etiologic agent...
  70. ncbi Microbiology of infected hemangiomas in children
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle Street NW, Washington, DC 20016, USA
    Pediatr Dermatol 21:113-6. 2004
    ..The polymicrobial etiology of secondarily infected hemangiomas and the association of bacterial flora with the anatomic site of the lesions is thereby demonstrated...
  71. ncbi Infected neonatal cephalohematomas caused by anaerobic bacteria
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    J Perinat Med 33:255-8. 2005
    ..To present the microbiological and clinical features of six children with infected cephalohematomas (IC) caused by anaerobic bacteria...
  72. ncbi Acute and chronic bacterial sinusitis
    Itzhak Brook
    Department of Pediatrics and Medicine, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    Infect Dis Clin North Am 21:427-48, vii. 2007
    ..This article discusses the microbiology and pathogenesis of acute and chronic bacterial sinusitis. The role anaerobic bacterial in chronic and recurrent sinusitis is emphasized, and appropriate antimicrobial regimens are discussed...
  73. ncbi Urinary tract and genito-urinary suppurative infections due to anaerobic bacteria
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington DC 20016, USA
    Int J Urol 11:133-41. 2004
    ..Percutaneous drainage, open surgical drainage or nephectomy might be indicated for abscesses...
  74. ncbi Microbiology and management of infected neck cysts
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    J Oral Maxillofac Surg 63:392-5. 2005
    ..To review and describe the microbiology, diagnosis, and management of infected neck cysts...
  75. ncbi Microbiology and management of infectious gangrene in children
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC 20016, USA
    J Pediatr Orthop 24:587-92. 2004
  76. ncbi Antibiotic resistance of oral anaerobic bacteria and their effect on the management of upper respiratory tract and head and neck infections
    Itzhak Brook
    Georgetown University School of Medicine, Washington, DC, USA
    Semin Respir Infect 17:195-203. 2002
    ..Because anaerobes generally are isolated mixed with aerobic organisms, therapy should provide for adequate coverage of both types of pathogens...
  77. ncbi Recovery of anaerobic bacteria from wounds after lawn-mower injuries
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Pediatr Emerg Care 21:109-10. 2005
    ..This report illustrates the recovery of anaerobic bacteria from children that had wound infection after lawn-mower injury...
  78. ncbi Microbiology and management of deep facial infections and Lemierre syndrome
    Itzhak Brook
    Georgetown University School of Medicine, Washington, D C, USA
    ORL J Otorhinolaryngol Relat Spec 65:117-20. 2003
    ..Management includes surgical drainage and antimicrobial therapy...
  79. ncbi Anaerobic pulmonary infections in children
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Pediatr Emerg Care 20:636-40. 2004
    ..and Bacteroides fragilis group. Management of these infections includes the administration of antimicrobials effective against the anaerobic as well as the aerobic pathogens...
  80. ncbi The role of anaerobic bacteria in chronic suppurative otitis media in children: implications for medical therapy
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    Anaerobe 14:297-300. 2008
    ..The medical therapy of CSOM should be directed at the eradication of the pathogenic aerobic and anaerobic organisms...
  81. ncbi Microbiology and management of peritonsillar, retropharyngeal, and parapharyngeal abscesses
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC 20016, USA
    J Oral Maxillofac Surg 62:1545-50. 2004
    ..Death can occur from aspiration, airway obstruction, erosion into major blood vessels, or extension to the mediastinum...
  82. ncbi Unexplained fever in young children: how to manage severe bacterial infection
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC 20057, USA
    BMJ 327:1094-7. 2003
  83. ncbi Microbiology and management of human and animal bite wound infections
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle Street, NW, Washington, DC, USA
    Prim Care 30:25-39, v. 2003
    ..Wound management includes the administration of proper local care and the use of proper antimicrobial agents when needed...
  84. ncbi Joint and bone infections due to anaerobic bacteria in children
    Itzhak Brook
    Pediatr Rehabil 5:11-9. 2002
    ..Treatment of arthritis and osteomyelitis involving anaerobic bacteria includes symptomatic therapy, immobilization in some cases, adequate drainage of purulent material and antibiotic therapy effective to these organisms...
  85. ncbi Bacteriology of chronic maxillary sinusitis associated with nasal polyposis
    Itzhak Brook
    Department of Pediatrics, Otolaryngology and Infectious Diseases, Navy Hospital, Bethesda, MD, USA
    J Med Microbiol 54:595-7. 2005
    ..being predominant. These findings illustrate for the first time the presence of polymicrobial aerobic-anaerobic flora in patients with chronic maxillary sinusitis who had nasal polyposis...
  86. ncbi Eradication of pathogens from the nasopharynx after therapy of acute maxillary sinusitis with low- or high-dose amoxicillin/clavulanic acid
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine and Alachua General and North Florida Regional Hospitals, Gainesville, FL, USA
    Int J Antimicrob Agents 26:416-9. 2005
    ..These data illustrate the superiority of 4.0 g/day amoxicillin/clavulanic acid compared with 1.5 g/day amoxicillin/clavulanic acid in the eradication of S. pneumoniae from the nasopharynx...
  87. ncbi Management of anaerobic infection
    Itzhak Brook
    Expert Rev Anti Infect Ther 2:153-8. 2004
    ..The more suitable agents include penicillins, cephalosporins, carbapenems, chloramphenicol, clindamycin, metronidazole, macrolides, glycopeptides, tetracyclines and quinolones...
  88. ncbi Disease severity in acute bacterial rhinosinusitis is greater in patients infected with Streptococcus pneumoniae than in those infected with Haemophilus influenzae
    Michael Benninger
    Henry Ford Hospital, Detroit, Michigan 48202 2689, USA
    Otolaryngol Head Neck Surg 135:523-8. 2006
    ..A post hoc pooled analysis of four multinational Phase III clinical trials was conducted to compare disease severity in acute bacterial rhinosinusitis caused by S. pneumoniae or H. influenzae...
  89. ncbi Antimicrobial therapies for pulmonary Klebsiella pneumoniae infection in B6D2F1/J mice immunocompromised by use of sublethal irradiation
    David E Bentzel
    Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814, USA
    Comp Med 54:185-92. 2004
    ..pneumoniae pneumonia using a third-generation cephalosporin, with or without an aminoglycoside...
  90. ncbi Recovery of anaerobic bacteria from a case of dissecting cellulitis
    Itzhak Brook
    Int J Dermatol 45:168-9. 2006
  91. ncbi The role of bacterial interference in otitis, sinusitis and tonsillitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University, USA
    Otolaryngol Head Neck Surg 133:139-46. 2005
    ....
  92. ncbi Recovery of methicillin resistant Staphylococcus aureus from a child with acute otitis media
    Itzhak Brook
    Pediatr Infect Dis J 27:372-3. 2008