Bcl-10 protein highly correlates with the expression of phosphorylated p65 NF-kappaB in peripheral T-cell lymphomas and is associated with clinical outcomeJavier Briones
Departments of Clinical Haematology and Pathology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Histopathology 54:478-85. 2009
..The aim was to investigate the relationship between the expression of PKC theta, Bcl-10 and P-p65(Ser536) proteins and their prognostic significance in peripheral T-cell lymphomas (PTCLs)...
- Emerging therapies for B-cell non-Hodgkin lymphoma
Javier Briones
Hematology Service, Hospital Santa Creu i Sant Pau, Mas Casanovas 90, 4th Floor, Room 2, 08040 Barcelona, Spain
Expert Rev Anticancer Ther 9:1305-16. 2009
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- Therapeutic vaccines for non-Hodgkin B-cell lymphoma
Javier Briones
Department of Clinical Hematology, Hospital Santa Creu i Sant Pau, Barcelona, Spain
Clin Transl Oncol 10:543-51. 2008
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- Targeted therapy of BCL6-dependent diffuse large B-cell lymphomas by heat-shock protein 90 inhibition
Javier Briones
Hematology Service, Hospital Santa Creu i Sant Pau, Mas Casanovas 90, Barcelona, Spain
Expert Rev Hematol 3:157-9. 2010
..These data support the use of HSP90 inhibitor PU-H71 for treating patients with BCL6-positive DLBCL...
- Study of kidney function impairment after reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation. A single-center experience
José Luis Piñana
Clinical Hematology and Hematopoietic Transplantation Division, Autonomous University of Barcelona, Barcelona, Spain
Biol Blood Marrow Transplant 15:21-9. 2009
..05). ARF is a frequent complication in patients after Allo-RIC, and it has a negative impact on outcome. Identification of ARF risk factors could help to avoid exposure to nephrotoxic drugs during the follow-up in patients at high risk...
- Comparison of two pretransplant predictive models and a flexible HCT-CI using different cut off points to determine low-, intermediate-, and high-risk groups: the flexible HCT-CI Is the best predictor of NRM and OS in a population of patients undergoing a
Pere Barba
Hematology and Stem Cell Transplantation Division Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
Biol Blood Marrow Transplant 16:413-20. 2010
..In conclusion, our single-center study suggests that the flexible HCT-CI is a good predictor of 2-year NRM and survival after an allo-RIC...
- Degree of mucositis and duration of neutropenia are the major risk factors for early post-transplant febrile neutropenia and severe bacterial infections after reduced-intensity conditioning
Luca Facchini
Hematology Department of the Hospital de la Santa Creu I Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
Eur J Haematol 88:46-51. 2012
..We analyzed the risk factors (RFs) for the development of FN and SBI in the first 100d post-transplant in 195 consecutive adult recipients of a reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation (RIC-allo)...
- The use of tetradecanoylphorbol acetate-stimulated peripheral blood cells enhances the prognostic value of interphase fluorescence in situ hybridization in patients with chronic lymphocytic leukemia
Julio Delgado
Department of Haematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Genes Chromosomes Cancer 49:327-32. 2010
..006). In conclusion, I-FISH-TPA increased the detection rate of 13q deletion and had an improved prognostic value compared with I-FISH-PBMC...
- High clinical and molecular response rates with fludarabine, cyclophosphamide and mitoxantrone in previously untreated patients with advanced stage follicular lymphoma
Silvia Montoto
Department of Hematology, Hospital Clinic, IDIBAPS, Barcelona, Spain
Haematologica 93:207-14. 2008
..The aim of this study was to analyze the efficacy and toxicity of a fludarabine combination as first-line treatment in patients with advanced-stage disease...
- Pulmonary function testing prior to reduced intensity conditioning allogeneic stem cell transplantation in an unselected patient cohort predicts posttransplantation pulmonary complications and outcome
José Luis Piñana
Hematology and Stem Cell Transplantation Division, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Am J Hematol 87:9-14. 2012
..8, 95% CI. 0.98-3.6, P = 0.06 and HR 1.7, 95% CI. 1.1-2.6, P = 0.008). This study emphasizes the valuable role of PFTs in identifying patients at risk for PPC, NRM, and lower OS in the Allo-RIC setting...
- Interleukin-15 enhances rituximab-dependent cytotoxicity against chronic lymphocytic leukemia cells and overcomes transforming growth factor beta-mediated immunosuppression
Esther Moga
Department of Immunology, Hospital Santa Creu i Sant Pau, Barcelona, Spain
Exp Hematol 39:1064-71. 2011
..The IL-15 increases rituximab-mediated ADCC against CLL, and supports the use of such agents with the goal of improving clinical response to chemoimmunotherapy in patients with CLL...
- Beta2-microglobulin is a better predictor of treatment-free survival in patients with chronic lymphocytic leukaemia if adjusted according to glomerular filtration rate
Julio Delgado
Department of Haematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Br J Haematol 145:801-5. 2009
..In all survival models, B2M did not attain independent significance unless GFR-B2M was eliminated from the analysis. In conclusion, GFR-B2M is a better predictor of TFS than unadjusted B2M in CLL patients...
- Emerging therapies for patients with advanced chronic lymphocytic leukaemia
Julio Delgado
Department of Haematology, Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret 167, Barcelona 08025, Spain
Blood Rev 23:217-24. 2009
..For the remaining high risk patients, a number of new compounds are emerging, which could lead to further improvement in their outcome...
- NK cells stimulated with IL-15 or CpG ODN enhance rituximab-dependent cellular cytotoxicity against B-cell lymphoma
Esther Moga
Department of Clinical Hematology, Hospital Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
Exp Hematol 36:69-77. 2008
..We have studied the in vitro effect of NK stimulators, such as interleukin-15 (IL-15) and CpG oligodeoxynucleotides A-Class (CpG ODN A), in the enhancement of rituximab-mediated ADCC against B-cell lymphoma...
- Early clinical impact of iron overload in stem cell transplantation. A prospective study
Albert Altes
Department of Haematology, Hospital de Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
Ann Hematol 86:443-7. 2007
..In conclusion, iron burden seems to influence the appearance of toxic-infectious complications during the first 3 months after transplant in AUTO-transplanted patients...
- Reduced-intensity conditioning allogeneic blood stem cell transplantation with fludarabine and oral busulfan with or without pharmacokinetically targeted busulfan dosing in patients with myeloid leukemia ineligible for conventional conditioning
Rodrigo Martino
Division of Clinical Hematology, Hospital de la Sant Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
Biol Blood Marrow Transplant 11:437-47. 2005
..In conclusion, therapeutic dose monitoring of oral Bu in a reduced-intensity conditioning setting does not seem to affect outcome, although further studies may identify very-high-risk patients who benefit from this strategy...
- Fludarabine, cyclophosphamide, and mitoxantrone as initial therapy of chronic lymphocytic leukemia: high response rate and disease eradication
Francesc Bosch
Department of Haematology, Hospital Clinic de Barcelona, Barcelona, Spain
Clin Cancer Res 14:155-61. 2008
..Fludarabine, cyclophosphamide, and mitoxantrone (FCM) results in a high response rate in previously treated patients with chronic lymphocytic leukemia (CLL). The aim of this study was to investigate FCM as frontline therapy in CLL...
- Fludarabine-induced apoptosis in CD19+/CD5+B-CLL cells is a direct and nurse-like-cell independent effect
Luis Martinez-Lostao
Immunology Department, Hospital de Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
Leuk Lymphoma 45:2307-14. 2004
..In conclusion, apoptosis induced by fludarabine in CD19+/CD5+B-CLL cells was due to a direct effect on these cells and not due to its effect in the NLCs...
- Strategies to reduce transplant-related mortality after allogeneic stem cell transplantation in elderly patients: Comparison of reduced-intensity conditioning and unmanipulated peripheral blood stem cells vs a myeloablative regimen and CD34+ cell selectio
Carmen Canals
Clinical Hematology Division, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Exp Hematol 31:1039-43. 2003
..The aim of this study was to compare two approaches used to reduce transplant-related mortality (TRM) after allogeneic peripheral blood stem cell transplantation (allo-PBSCT) in elderly patients...
- T-cell costimulatory molecules in acute-graft-versus host disease: therapeutic implications
Javier Briones
Hematology Service, Hospital Santa Creu i Sant Pau, Mas Casanovas 90, 08041 Barcelona, Spain
Bone Marrow Res 2011:976793. 2011
..We describe how these molecules are involved in acute GVHD and how the blockade of costimulatory molecules may have potential implications for the treatment of patients with acute GVHD...
- CD34+-enriched-CD19+-depleted autologous peripheral blood stem cell transplantation for chronic lymphoproliferative disorders: high purging efficiency but increased risk of severe infections
Albert Altes
Clinical Hematology Division, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
Exp Hematol 30:824-30. 2002
..The main objective of this work was to decrease the incidence of relapse after autologous stem cell transplantation with a "double purging" procedure...
- Prospective phase II trial of extended treatment with rituximab in patients with B-cell post-transplant lymphoproliferative disease
Eva Gonzalez-Barca
Clinical Hematology Department, Hospital Duran i Reynals, Institut Catala d Oncologia, Av Gran Via s n Km 2, 7, 08907 L Hospitalet de Llobregat, Barcelona, Spain
Haematologica 92:1489-94. 2007
..The purpose of this trial was to evaluate the efficacy of treatment with extended doses of rituximab adapted to the response in patients with post-transplant lymphoproliferative disorders after solid organ transplantation...
- International and Italian prognostic indices in follicular lymphoma
Granada Perea
Department of Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Haematologica 88:700-4. 2003
..The Italian Lymphoma Intergroup (ILI) created a new prognostic index specific for FL. The aim of this study was to compare which of these two indices is more useful when applied to a large group of FL patients...
- Antitumor immunity after vaccination with B lymphoma cells overexpressing a triad of costimulatory molecules
Javier Briones
Division of Oncology, Stanford University School of Medicine, Stanford, CA 94305-5151, USA
J Natl Cancer Inst 95:548-55. 2003
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- In vivo antitumor effect of CD40L-transduced tumor cells as a vaccine for B-cell lymphoma
Javier Briones
Division of Oncology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305-5151, USA
Cancer Res 62:3195-9. 2002
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- BLyS and BLyS receptor expression in non-Hodgkin's lymphoma
Javier Briones
Division of Oncology, Stanford University Medical Center, Stanford, CA 94305 5151, USA
Exp Hematol 30:135-41. 2002
..We have studied the tumor cell expression of the BLyS-Receptor (BLyS-R) and the serum BLyS protein levels in patients with different types of non-Hodgkin's lymphomas (NHL)...
