Research Topics
Species | T MauadSummaryCountry: Brazil Publications
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Publications
Smoking cessation and bronchial epithelial remodelling in COPD: a cross-sectional studyThérèse S Lapperre
Dept of Pulmonology, Leiden University Medical Centre, Leiden, The Netherlands
Respir Res 8:85. 2007..We determined epithelial proliferation and composition in bronchial biopsies from current and ex-smokers with COPD, and its relation to duration of smoking cessation...- Small airway remodeling in acute respiratory distress syndrome: a study in autopsy lung tissueMaina M B Morales
Department of Pathology, Experimental Air Pollution Laboratory LIM05, Sao Paulo University Medical School, Av Dr, Arnaldo 455, Sao Paulo 01246 903, Brazil
Crit Care 15:R4. 2011..To date, however, no study has focused on the morphological airway changes in lungs from human subjects with ARDS. The aim of this study is to evaluate structural and inflammatory changes in distal airways in ARDS patients... - Elastosis and fragmentation of fibers of the elastic system in fatal asthmaT Mauad
Department of Pathology, Faculty of Medicine, Sao Paulo University, Sao Paulo, Brazil
Am J Respir Crit Care Med 160:968-75. 1999..We also suggest that disrupture of fiber attachments at the basement membrane in the superficial layer could impair the mechanism of airway recoil in asthmatic patients... - Chronic exposure to ambient levels of urban particles affects mouse lung developmentThais Mauad
Department of Pathology, Sao Paulo University Medical School, Sao Paulo, SP, Brazil
Am J Respir Crit Care Med 178:721-8. 2008..Chronic exposure to air pollution has been associated with adverse effects on children's lung growth... - Characterization of autopsy-proven fatal asthma patients in São Paulo, BrazilThais Mauad
Faculdade de Medicina da Universidade de Sao Paulo, Patologia, Sao Paulo, Brazil
Rev Panam Salud Publica 23:418-23. 2008..3%) deaths took place outside a hospital. We conclude that this population shares characteristics of severe or poorly controlled asthma, low educational and socioeconomic levels, and lack of medical care and of inhaled steroid use... - Lymphocytic inflammation in childhood bronchiolitis obliteransThais Mauad
Department of Pathology, School of Medicine, Sao Paulo University, Sao Paulo, Brazil
Pediatr Pulmonol 38:233-9. 2004..Further studies are needed to address the role of different cell types in the development of CBO... - Abnormal alveolar attachments with decreased elastic fiber content in distal lung in fatal asthmaThais Mauad
Department of Pathology, Sao Paulo University Medical School, Avenida Dr Arnaldo, 455 CEP 01246 903, Sao Paulo, SP, Brazil
Am J Respir Crit Care Med 170:857-62. 2004..22-1.74] microm; p = 0.003), but not in the distal alveoli. We propose that structural alterations at the peribronchiolar level might contribute to the pathogenesis of some functional abnormalities observed in patients with severe asthma... - Pathologic similarities and differences between asthma and chronic obstructive pulmonary diseaseThais Mauad
Department of Pathology, Sao Paulo University Medical School, Sao Paulo, Brazil
Curr Opin Pulm Med 14:31-8. 2008..At pathological level, inflammatory and structural similarities also occur and may be related to the phenotypic overlaps... - Lung pathology in fatal novel human influenza A (H1N1) infectionThais Mauad
Department of Pathology, Sao Paulo University, Brazil
Am J Respir Crit Care Med 181:72-9. 2010..There are no reports of the systemic human pathology of the novel swine H1N1 influenza (S-OIV) infection... - Pulmonary periarterial inflammation in fatal asthmaC Shiang
Department of Pathology, School of Medicine, Sao Paulo University, Sao Paulo, SP, Brazil
Clin Exp Allergy 39:1499-507. 2009..The objective of this study was to describe the inflammatory cell phenotype of pulmonary artery adventitial inflammation in lung tissue from patients who died of asthma... - Exercise inhibits allergic lung inflammationA C D Silva
Physical Therapy, University of Sao Paulo, Sao Paulo, Brazil
Int J Sports Med 33:402-9. 2012..05). The effects of AC before and during the sensitization process inhibit allergic airway inflammation and reduce the production of Th2 cytokines and allergen-specific IgE and IgG1... - Subchronic effects of nasally instilled diesel exhaust particulates on the nasal and airway epithelia in miceK Yoshizaki
Laboratory of Experimental Atmospheric Pollution LPAE, University of Sao Paulo, Avenida Dr Arnaldo 455, Sao Paulo, Brazil
Inhal Toxicol 22:610-7. 2010..Cytokines concentrations in the BAL were detectable, with no differences among the groups. Our data suggest that a low-dose of DEP over 60 days induces respiratory tract inflammation... - Extracellular matrix components and regulators in the airway smooth muscle in asthmaB B Araujo
Dept of Pathology, Sao Paulo University Medical School, Avenida Dr Arnaldo, 455, 01246 903, Sao Paulo SP, Brazil
Eur Respir J 32:61-9. 2008.... - Aerobic exercise attenuates pulmonary injury induced by exposure to cigarette smokeA C Toledo
Faculdade de Medicina da Universidade de Sao Paulo, Av Dr Arnaldo 455, sala 1210, 01256 903, Sao Paulo, Brazil E mail
Eur Respir J 39:254-64. 2012..Our results suggest that regular aerobic physical training of moderate intensity attenuates the development of pulmonary disease induced by cigarette smoke exposure... - Aerobic training reverses airway inflammation and remodelling in an asthma murine modelR A Silva
Dept of Physical Therapy LIM 34, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
Eur Respir J 35:994-1002. 2010..AT reversed airway inflammation and remodelling and T-helper cell 2 response, and improved respiratory mechanics. These results seem to occur due to an increase in the expression of IL-10 and IL-1ra and a decrease of NF-kappaB... - Expression of secretory leukocyte proteinase inhibitor in the submandibular glands of AIDS patientsL A Rocha
Department of Oral Pathology, Faculty of Odontology of Piracicaba University of Campinas, Piracicaba, SP, Brazil
Oral Dis 14:82-8. 2008..This protease inhibitor is also expressed in submandibular glands (SMG), but there are few data on its expression in AIDS patients with infectious conditions... - Histological examination has a major impact on macroscopic necropsy diagnosesF D C Bernardi
Department of Pathology, Sao Paulo University Medical School, Sao Paulo SP 01246-903, Brazil
J Clin Pathol 58:1261-4. 2005..5%).CONCLUSIONS: Histological analysis has a major impact on previously performed gross diagnosis at necropsy, especially in the lungs, liver, and kidneys. Adequate sampling and histological analysis are important for necropsy quality... - Pneumoconiosis after sericite inhalationE Algranti
Division of Medicine, FUNDACENTRO, Sao Paulo, Brazil
Occup Environ Med 62:e2. 2005..Between 1997 and 1999 three sericite plant workers in Parana, Brazil, were diagnosed with pneumoconiosis... - Structural alterations in adult rat carotid bodies exposed to hyperbaric oxygenationM S Leite
Experimental Air Pollution Laboratory, Department of Pathology, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
Undersea Hyperb Med 37:419-32. 2010..Our results show that high O2 exposures may induce structural alterations in glomic cells with signs of lipid peroxidation. We further suggest that deviation of blood flow toward intraglomic capillaries occurs in hyperbaric hyperoxia... - Low tidal volume ventilation induces proinflammatory and profibrogenic response in lungs of ratsPedro Caruso
Alameda Anapurus 631, ZIP 04087 001, Sao Paulo SP, Brasil
Intensive Care Med 29:1808-11. 2003.... - Lung parenchyma remodeling in a murine model of chronic allergic inflammationDebora G Xisto
Universidade Federal do Rio de Janeiro, , , , 21949-900 - Rio de Janeiro - RJ, Brazil
Am J Respir Crit Care Med 171:829-37. 2005..In conclusion, prolonged allergen exposure induced remodeling not only of the airway wall but also of the lung parenchyma, leading to in vivo and in vitro mechanical changes... - Eotaxin-2 and eotaxin-3 expression is associated with persistent eosinophilic bronchial inflammation in patients with asthma after allergen challengeA Janneke Ravensberg
Department of Pulmonology, Lung Function Laboratory C2 P 62, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
J Allergy Clin Immunol 115:779-85. 2005..Eotaxin-2 and eotaxin-3 might play a role in the subsequent persistence of allergen-induced bronchial eosinophilia... - Expression of smooth muscle and extracellular matrix proteins in relation to airway function in asthmaAnnelies M Slats
Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
J Allergy Clin Immunol 121:1196-202. 2008..However, smooth muscle cells express several contractile and structural proteins, and each of these proteins may influence airway function distinctly... - Airway basement membrane perimeter distensibility and airway smooth muscle area in asthmaAlan L James
Department of Pulmonary Physiology, West Australian Sleep Disorders Research Institute, Perth, Western Australia, Australia
J Appl Physiol 104:1703-8. 2008..We conclude that the effects of inflation on the relationship between Pbm and ASM are small and do not account for the differences observed in ASM between cases of asthma and nonasthmatic controls... - Expression of the anaphylatoxin receptors C3aR and C5aR is increased in fatal asthmaLaura Fregonese
Department of Pulmonology, Leiden University Medical Centre, Albinusdreef 2, 2233 ZA Leiden, The Netherlands
J Allergy Clin Immunol 115:1148-54. 2005..Recent studies suggest the involvement of the anaphylatoxins C3a and C5a, generated during complement activation, and their receptors C3aR and C5aR in the pathogenesis of asthma... - Nitric acid-induced bronchiolitis in rats mimics childhood Bronchiolitis obliteransClaudia L B Costa
Department of Pediatrics, School of Medicine, , Avenida Dr. Arnaldo 455, 1st Floor, , SP 01246-903, Brazil
Respiration 72:642-9. 2005..001). CONCLUSIONS: We conclude that this model presents histological similarities with the histological picture of CBO, being suitable for further developmental and therapeutic experimental research in this field... - Pathology and pathophysiology of pulmonary manifestations in leptospirosisMarisa Dolhnikoff
Department of Pathology, School of Medicine, University of Sao Paulo, SP, Brazil
Braz J Infect Dis 11:142-8. 2007..In this review we present the main clinical and pathological manifestations of pulmonary involvement in leptospirosis, with special focus on recent data concerning the pathophysiological mechanisms underlying lung injury... - Differential distribution of inflammatory cells in large and small airways in smokersSalvatore Battaglia
Department of Pulmonology, Leiden University Medical Centre LUMC, Leiden, The Netherlands
J Clin Pathol 60:907-11. 2007..Hypothesis: The content of cells infiltrating the airway wall differs between LA and SA... - Bronchial inflammation and airway responses to deep inspiration in asthma and chronic obstructive pulmonary diseaseAnnelies M Slats
Leiden University Medical Center, Department of Pulmonology C2 P 62, P O Box 9600, 2300 RC Leiden, and Department of Pediatrics, Erasmus University Medical Center Sophia Children s Hospital, Rotterdam, The Netherlands
Am J Respir Crit Care Med 176:121-8. 2007..Airway inflammation has been suggested to alter airway mechanics during deep inspiration... - Effects of residual oil fly ash (ROFA) in mice with chronic allergic pulmonary inflammationFernanda M Arantes-Costa
Department of Medicine, School of Medicine, University of Sao Paulo, Brazil
Toxicol Pathol 36:680-6. 2008..043) and a decrease in the number of ciliated cells in the airway epithelium (p = .017). PM exposure results in pulmonary effects that are more intense in mice with chronic allergic pulmonary inflammation... - Asthma therapy and airway remodelingThais Mauad
Department of Pathology, Sao Paulo University Medical School, Sao Paulo, Brazil
J Allergy Clin Immunol 120:997-1009; quiz 1010-1. 2007..Progress in this area requires the explicit linking of modern structure-function analysis with innovative biopharmaceutical approaches... - Histology of childhood bronchiolitis obliteransThais Mauad
Department of Pathology, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
Pediatr Pulmonol 33:466-74. 2002..Secondary signs of airway obstruction are invariably present. Mild histological changes may predominate and should be carefully evaluated by the pathologist... - Buflomedil and pentoxifylline in the viability of dorsal cutaneous flaps of rats treated with nicotineRaul J Mauad
Department of Experimental Surgery, School of Medicine, Sao Paulo University, Av Dr Arnaldo 455, 01246 903 Sao Paulo, SP, Brazil
J Plast Reconstr Aesthet Surg 59:387-92. 2006..In this study, we have compared the isolated and associated actions of the vasoactive drugs buflomedil and pentoxifylline in the viability of dorsal cutaneous flaps of rats treated with subcutaneous doses of nicotine... - Simultaneous viral infection and childhood bronchiolitis obliteransMário Hirschheimer
Menino Jesus São Paulo City Children s Hospital, Sao Paulo, Brazil
Braz J Infect Dis 6:146-8. 2002..We report a 13-month-old child with bronchiolitis obliterans following co-infection by RSV and adenovirus, and suggest that complicated evolution of an acute bronchiolitis case can indicate an association of pathogens... - Airway proteoglycans are differentially altered in fatal asthmaMarcus de Medeiros Matsushita
Department of Pathology, School of Medicine, University of Sao Paulo, Brazil
J Pathol 207:102-10. 2005..028). The results show that PGs are differentially expressed in the airways of fatal asthma and may contribute to airway remodelling. These data reinforce the importance of the small airways in airway remodelling in asthma... - Fatal outcome in bronchus-associated lymphoid tissue lymphomaRomulo Loss Mattedi
Departamento de Patologia, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brasil
J Bras Pneumol 33:487-91. 2007.... - Gene expression profile and histopathology of experimental bronchopulmonary dysplasia induced by prolonged oxidative stressGerry T M Wagenaar
Department of Pediatrics, Division of Neonatology, Leiden University Medical Center, Leiden, Netherlands
Free Radic Biol Med 36:782-801. 2004..These findings are not only of fundamental importance in the understanding of the pathophysiology of BPD, but also essential for the development of new therapeutic strategies... - Aerobic exercise decreases chronic allergic lung inflammation and airway remodeling in miceRodolfo P Vieira
Department of Pathology, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
Am J Respir Crit Care Med 176:871-7. 2007..Aerobic conditioning improves exercise capacity and decreases symptoms in patients with asthma. However, its benefits in the context of allergic airway inflammation are poorly understood... - Missed diagnosis in hematological patients-an autopsy studyAna Carolina Galtarossa Xavier
Department of Pathology, Sao Paulo University Medical School, University of Colorado Health and Science Center, Campus Box 8117, PO Box 6511, Aurora, CO 80045, USA
Virchows Arch 446:225-31. 2005..We concluded that critical diagnoses are often missed in highly complex hematological patients especially in the absence of admission to specialized hematology units... - Bronchial CD8 cell infiltrate and lung function decline in asthmaElizabeth L J Van Rensen
Department of Pulmonology, C3-P, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands
Am J Respir Crit Care Med 172:837-41. 2005..This suggests that the inflammatory phenotype in asthma has prognostic relevance, which may require phenotype-specific therapeutic strategies... - Leptospiral pneumoniasMarisa Dolhnikoff
Department of Pathology, University of Sao Paulo, Brazil
Curr Opin Pulm Med 13:230-5. 2007..In this review, we present the main clinical and pathological manifestations of pulmonary involvement in leptospirosis, and recent data on the pathophysiology of lung damage and therapeutic implications...